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CS cines can further include retrospective temporal resolution interpolation (INTP<jats:sub>TR<\/jats:sub>) to improve the frame count per heartbeat, and the impact of INTP<jats:sub>TR<\/jats:sub> on biventricular functional measurements is unknown. We investigated the impact of INTP<jats:sub>TR<\/jats:sub> on left and right ventricular volumetry and strain measurements of CS cines. Nineteen patients with 51 different CS acquisitions were prospectively enrolled. CS cines were acquired at rest, under adenosine stress, oxygen inhalation or while under general anaesthesia with mechanical ventilation. From the same CS acquisition, a dataset with and without INTP<jats:sub>TR<\/jats:sub> were generated by the scanner. The outputs were separated and analysed by blinded readers for left and right ventricular volumetry, as well as systolic and diastolic strain parameters using feature-tracking techniques. Measurements were compared between the INTP<jats:sub>TR<\/jats:sub> and non-INTP<jats:sub>TR<\/jats:sub> outputs. Similar measurements were obtained for biventricular volumes and ejection fraction independent of INTP<jats:sub>TR<\/jats:sub>. Peak strain was significantly underestimated on INTP<jats:sub>TR<\/jats:sub> cines for both longitudinal and circumferential orientations (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Nevertheless, good-to-excellent correlations were observed between the two measurements (<jats:italic>r<\/jats:italic>\u2009&gt;\u20090.65, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), and there was still a high area under the curve (AUC\u2009\u2265\u20090.95, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) for detecting abnormal patients defined by strain analysis on the standard segmented cine. INTP<jats:sub>TR<\/jats:sub> especially negatively influenced strain rates analysis, as many strain rate curves were deemed unusable with this technique. These findings were consistent independent if the patient was in a resting, stress or anaesthetized condition. Although INTP<jats:sub>TR<\/jats:sub> is a feature which improves temporal resolution on CS cines, quantification of biventricular strain and strain rates is not feasible or comparable, thus, feature tracking analysis should be performed on non-INTP<jats:sub>TR<\/jats:sub> data. However, volumetry and ejection fraction analysis are consistent independent of which output is analysed.<\/jats:p>","DOI":"10.1007\/s10554-025-03348-3","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T23:11:26Z","timestamp":1739574686000},"page":"591-602","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Retrospective temporal resolution interpolation alters myocardial strain quantification on compressed sensing cine CMR"],"prefix":"10.1007","volume":"41","author":[{"given":"Leonard","family":"Grob","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Schwerzmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"Schweizer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan P.","family":"Huettenmoser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scilla","family":"Dozio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian T.","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Boscolo Berto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Gr\u00e4ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik P.","family":"Guensch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kady","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"issue":"1","key":"3348_CR1","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12968-014-0065-1","volume":"16","author":"KJ Barkauskas","year":"2014","unstructured":"Barkauskas KJ, Rajiah P, Ashwath R, Hamilton JI, Chen Y, Ma D et al (2014) Quantification of left ventricular functional parameter values using 3D spiral bSSFP and through-time non-cartesian GRAPPA. 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