{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T08:15:49Z","timestamp":1773389749995,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Cardiovasc Imaging"],"DOI":"10.1007\/s10554-025-03437-3","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T07:54:33Z","timestamp":1749110073000},"page":"423-434","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of contrast medium volume on myocardial extracellular volume measurement accuracy in first-generation photon-counting detector CT"],"prefix":"10.1007","volume":"42","author":[{"given":"Takanori","family":"Kokawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Takafuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Sakuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kakuya","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"3437_CR1","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s13244-023-01506-6","volume":"14","author":"G Cundari","year":"2023","unstructured":"Cundari G, Galea N, Mergen V, Alkadhi H, Eberhard M (2023) Myocardial extracellular volume quantification with computed tomography-current status and future outlook. Insights Imaging 14:156","journal-title":"Insights Imaging"},{"key":"3437_CR2","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.jcmg.2017.04.006","volume":"11","author":"S Nakamori","year":"2018","unstructured":"Nakamori S, Dohi K, Ishida M et al (2018) Native T1 mapping and extracellular volume mapping for the assessment of diffuse myocardial fibrosis in dilated cardiomyopathy. JACC Cardiovasc Imaging 11:48\u201359","journal-title":"JACC Cardiovasc Imaging"},{"key":"3437_CR3","doi-asserted-by":"publisher","first-page":"4163","DOI":"10.2147\/IJGM.S350673","volume":"15","author":"L Liang","year":"2022","unstructured":"Liang L, Wang X, Yu Y et al (2022) T1 mapping and extracellular volume in cardiomyopathy showing left ventricular hypertrophy: differentiation between hypertrophic cardiomyopathy and hypertensive heart disease. Int J Gen Med 15:4163\u20134173","journal-title":"Int J Gen Med"},{"key":"3437_CR4","doi-asserted-by":"publisher","DOI":"10.1148\/ryct.220327","volume":"5","author":"M Kidoh","year":"2023","unstructured":"Kidoh M, Oda S, Takashio S et al (2023) Cardiac MRI-derived extracellular volume fraction versus myocardium-to-lumen R1 ratio at postcontrast T1 mapping for detecting cardiac amyloidosis. Radiol Cardiothorac Imaging 5:e220327","journal-title":"Radiol Cardiothorac Imaging"},{"key":"3437_CR5","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1148\/radiol.12112458","volume":"264","author":"MS Nacif","year":"2012","unstructured":"Nacif MS, Kawel N, Lee JJ et al (2012) Interstitial myocardial fibrosis assessed as extracellular volume fraction with low-radiation-dose cardiac CT. Radiology 264:876\u2013883","journal-title":"Radiology"},{"key":"3437_CR6","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1148\/radiol.2016151289","volume":"280","author":"H-J Lee","year":"2016","unstructured":"Lee H-J, Im DJ, Youn J-C et al (2016) Myocardial extracellular volume fraction with dual-energy equilibrium contrast-enhanced cardiac CT in nonischemic cardiomyopathy: a prospective comparison with cardiac MR imaging. Radiology 280:49\u201357","journal-title":"Radiology"},{"key":"3437_CR7","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jcct.2023.12.006","volume":"18","author":"N Oyama-Manabe","year":"2024","unstructured":"Oyama-Manabe N, Oda S, Ohta Y, Takagi H, Kitagawa K, Jinzaki M (2024) Myocardial late enhancement and extracellular volume with single-energy, dual-energy, and photon-counting computed tomography. J Cardiovasc Comput Tomogr 18:3\u201310","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"3437_CR8","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.jcct.2016.02.001","volume":"10","author":"Y Kurita","year":"2016","unstructured":"Kurita Y, Kitagawa K, Kurobe Y et al (2016) Estimation of myocardial extracellular volume fraction with cardiac CT in subjects without clinical coronary artery disease: a feasibility study. J Cardiovasc Comput Tomogr 10:237\u2013241","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"3437_CR9","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s11886-018-0961-3","volume":"20","author":"PR Scully","year":"2018","unstructured":"Scully PR, Bastarrika G, Moon JC, Treibel TA (2018) Myocardial extracellular volume quantification by cardiovascular magnetic resonance and computed tomography. Curr Cardiol Rep 20:15","journal-title":"Curr Cardiol Rep"},{"key":"3437_CR10","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.jcct.2020.01.013","volume":"14","author":"M Takafuji","year":"2020","unstructured":"Takafuji M, Kitagawa K, Nakamura S et al (2020) Feasibility of extracellular volume fraction calculation using myocardial CT delayed enhancement with low contrast media administration. J Cardiovasc Comput Tomogr 14:524\u2013528","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"3437_CR11","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13244-025-01944-4","volume":"16","author":"T Kokawa","year":"2025","unstructured":"Kokawa T, Kitagawa K, Nakamura S, Takafuji M, Oya T, Sakuma H (2025) Myocardial late enhancement using dual-source CT: intraindividual comparison of single-energy shuttle and dual-energy acquisition. Insights Imaging 16:64","journal-title":"Insights Imaging"},{"key":"3437_CR12","doi-asserted-by":"publisher","DOI":"10.1148\/ryct.2019180003","volume":"1","author":"S Oda","year":"2019","unstructured":"Oda S, Emoto T, Nakaura T et al (2019) Myocardial late iodine enhancement and extracellular volume quantification with dual-layer spectral detector dual-energy cardiac CT. Radiol Cardiothorac Imaging 1:e180003","journal-title":"Radiol Cardiothorac Imaging"},{"key":"3437_CR13","doi-asserted-by":"publisher","first-page":"454","DOI":"10.2214\/AJR.21.26654","volume":"218","author":"NY Kim","year":"2022","unstructured":"Kim NY, Im DJ, Youn JC et al (2022) Synthetic extracellular volume fraction derived using virtual unenhanced attenuation of blood on contrast-enhanced cardiac dual-energy CT in nonischemic cardiomyopathy. AJR Am J Roentgenol 218:454\u2013461","journal-title":"AJR Am J Roentgenol"},{"key":"3437_CR14","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/s00330-019-06418-y","volume":"30","author":"T Emoto","year":"2020","unstructured":"Emoto T, Kidoh M, Oda S et al (2020) Myocardial extracellular volume quantification in cardiac CT: comparison of the effects of two different iterative reconstruction algorithms with MRI as a reference standard. Eur Radiol 30:691\u2013701","journal-title":"Eur Radiol"},{"key":"3437_CR15","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.020655","volume":"10","author":"M Suzuki","year":"2021","unstructured":"Suzuki M, Toba T, Izawa Y et al (2021) Prognostic impact of myocardial extracellular volume fraction assessment using dual-energy computed tomography in patients treated with aortic valve replacement for severe aortic stenosis. J Am Heart Assoc 10:e020655","journal-title":"J Am Heart Assoc"},{"key":"3437_CR16","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.jcct.2019.12.032","volume":"14","author":"Y Ohta","year":"2020","unstructured":"Ohta Y, Kishimoto J, Kitao S et al (2020) Investigation of myocardial extracellular volume fraction in heart failure patients using iodine map with rapid-kV switching dual-energy CT: Segmental comparison with MRI T1 mapping. J Cardiovasc Comput Tomogr 14:349\u2013355","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"3437_CR17","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1148\/radiol.2016152601","volume":"279","author":"A Pourmorteza","year":"2016","unstructured":"Pourmorteza A, Symons R, Sandfort V et al (2016) Abdominal imaging with contrast-enhanced photon-counting CT: first human experience. Radiology 279:239\u2013245","journal-title":"Radiology"},{"key":"3437_CR18","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1088\/1361-6560\/62\/1\/202","volume":"62","author":"R Symons","year":"2017","unstructured":"Symons R, Cork TE, Sahbaee P et al (2017) Low-dose lung cancer screening with photon-counting CT: a feasibility study. Phys Med Biol 62:202\u2013213","journal-title":"Phys Med Biol"},{"key":"3437_CR19","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1148\/radiol.2018172656","volume":"289","author":"MJ Willemink","year":"2018","unstructured":"Willemink MJ, Persson M, Pourmorteza A, Pelc NJ, Fleischmann D (2018) Photon-counting CT: technical principles and clinical prospects. Radiology 289:293\u2013312","journal-title":"Radiology"},{"key":"3437_CR20","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1148\/radiol.212579","volume":"303","author":"K Rajendran","year":"2022","unstructured":"Rajendran K, Petersilka M, Henning A et al (2022) First clinical photon-counting detector CT system: technical evaluation. Radiology 303:130\u2013138","journal-title":"Radiology"},{"key":"3437_CR21","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1148\/rg.2019180115","volume":"39","author":"S Leng","year":"2019","unstructured":"Leng S, Bruesewitz M, Tao S et al (2019) Photon-counting detector CT: system design and clinical applications of an emerging technology. Radiographics 39:729\u2013743","journal-title":"Radiographics"},{"issue":"6","key":"3437_CR22","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1097\/RLI.0000000000000851","volume":"57","author":"V Mergen","year":"2022","unstructured":"Mergen V, Sartoretti T, Klotz E et al (2022) Extracellular volume quantification with cardiac late enhancement scanning using dual-source photon-counting detector CT. Investig Radiol 57(6):406\u2013411","journal-title":"Investig Radiol"},{"key":"3437_CR23","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.222030","volume":"307","author":"GJ Aquino","year":"2023","unstructured":"Aquino GJ, O\u2019Doherty J, Schoepf UJ et al (2023) Myocardial characterization with extracellular volume mapping with a first-generation photon-counting detector CT with MRI reference. Radiology 307:e222030","journal-title":"Radiology"},{"key":"3437_CR24","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s41747-024-00469-7","volume":"8","author":"C Gnasso","year":"2024","unstructured":"Gnasso C, Pinos D, Schoepf UJ et al (2024) Impact of reconstruction parameters on the accuracy of myocardial extracellular volume quantification on a first-generation, photon-counting detector CT. Eur Radiol Exp 8:70","journal-title":"Eur Radiol Exp"},{"key":"3437_CR25","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jcct.2018.10.028","volume":"13","author":"Y Ohta","year":"2019","unstructured":"Ohta Y, Kitao S, Yunaga H et al (2019) Quantitative evaluation of non-ischemic dilated cardiomyopathy by late iodine enhancement using rapid kV switching dual-energy computed tomography: A feasibility study. J Cardiovasc Comput Tomogr 13:148\u2013156","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"3437_CR26","doi-asserted-by":"publisher","first-page":"310","DOI":"10.21037\/qims-21-344","volume":"12","author":"P Liu","year":"2022","unstructured":"Liu P, Lin L, Xu C et al (2022) Quantitative analysis of late iodine enhancement using dual-layer spectral detector computed tomography: comparison with magnetic resonance imaging. Quant Imaging Med Surg 12:310\u2013320","journal-title":"Quant Imaging Med Surg"},{"key":"3437_CR27","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1532-429X-13-16","volume":"13","author":"EB Schelbert","year":"2011","unstructured":"Schelbert EB, Testa SM, Meier CG et al (2011) Myocardial extravascular extracellular volume fraction measurement by gadolinium cardiovascular magnetic resonance in humans: slow infusion versus bolus. J Cardiovasc Magn Reson 13:16","journal-title":"J Cardiovasc Magn Reson"},{"key":"3437_CR28","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1007\/s10554-017-1191-2","volume":"33","author":"N Al-Wakeel-Marquard","year":"2017","unstructured":"Al-Wakeel-Marquard N, Rastin S, Muench F et al (2017) Cardiac T1 mapping in congenital heart disease: bolus vs. infusion protocols for measurements of myocardial extracellular volume fraction. Int J Cardiovasc Imaging 33:1961\u20131968","journal-title":"Int J Cardiovasc Imaging"},{"key":"3437_CR29","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.jcct.2014.06.004","volume":"8","author":"Y Kurobe","year":"2014","unstructured":"Kurobe Y, Kitagawa K, Ito T et al (2014) Myocardial delayed enhancement with dual-source CT: advantages of targeted spatial frequency filtration and image averaging over half-scan reconstruction. J Cardiovasc Comput Tomogr 8:289\u2013298","journal-title":"J Cardiovasc Comput Tomogr"}],"container-title":["The International Journal of Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10554-025-03437-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10554-025-03437-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10554-025-03437-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T05:29:31Z","timestamp":1773379771000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10554-025-03437-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,5]]},"references-count":29,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["3437"],"URL":"https:\/\/doi.org\/10.1007\/s10554-025-03437-3","relation":{},"ISSN":["1875-8312"],"issn-type":[{"value":"1875-8312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,5]]},"assertion":[{"value":"9 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Department of Advanced Diagnostic Imaging, to which Dr. Nakamura and Dr. Kitagawa belong, is an endowment department supported by an unrestricted grant from Siemens Healthcare K.K. All other authors report that they have no relationships relevant to the content of this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent for participation in the study was obtained from each patient.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors affirm that human research participants provided informed consent for publication of the images in Figures.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}