{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:24:47Z","timestamp":1789683887351,"version":"4.0.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007176","name":"Scuola Superiore Sant'Anna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007176","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Cardiovasc Imaging"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Non-dilated left ventricular cardiomyopathy (NDLVC) has been defined as non-ischemic LV scarring and\/or fatty replacement and\/or hypokinesia, without LV dilation. We tried to identify specific criteria for LV dilation and dysfunction to implement this definition. We identified all non-ischemic cardiomyopathy patients undergoing a cardiovascular magnetic resonance scan from 2012 to 2022 with LV ejection fraction (LVEF)\u2009&lt;\u200955% and\/or non-ischemic late gadolinium enhancement (LGE) and\/or fatty replacement, and without specific etiologies. The primary endpoint was a composite of all-cause death, sustained ventricular tachycardia or fibrillation. The cohort included 388 patients (32% women, median age 55 years [interquartile range 43\u201363]). Over 4.3 years (1.9-7.0), 59 patients (15%) developed a primary endpoint event. The risk increased exponentially with LVEDVi values, with inflection points approaching the upper reference limit of LVEDVi (&lt;\u200996 mL\/m<jats:sup>2<\/jats:sup> in women, &lt;\u2009105 mL\/m<jats:sup>2<\/jats:sup> in men). Using these criteria, we identified NDLVC in 237 patients (61%). Among them, LVEF was the only univariate predictor of outcome. Patients with LVEF\u2009\u2265\u200945% (<jats:italic>n<\/jats:italic>\u2009=\u2009212) or \u2265\u200940% (<jats:italic>n<\/jats:italic>\u2009=\u2009223) had a longer survival than those with LVEF\u2009&lt;\u200945% or &lt;\u200940% (<jats:italic>p<\/jats:italic>\u2009=\u20090.025 and <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, respectively). NDLVC patients, identified by non-ischemic LV scarring and\/or fatty replacement and\/or hypokinesia and LVEDVi\u2009&lt;\u200996 mL\/m<jats:sup>2<\/jats:sup> (women) or &lt;\u2009105 mL\/m<jats:sup>2<\/jats:sup> (men), have a lower risk of death or ventricular arrhythmias than patients with dilated cardiomyopathy. LVEF\u2009&lt;\u200945% or &lt;\u200940% further stratified outcome. The definition of NDLVC could incorporate these LVEDVi and LVEF cut-points to identify a population of patients with a homogeneous risk of death or ventricular arrhythmias.<\/jats:p>","DOI":"10.1007\/s10554-025-03474-y","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T08:43:24Z","timestamp":1753951404000},"page":"1749-1758","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A prognostically meaningful definition of non-dilated left ventricular cardiomyopathy"],"prefix":"10.1007","volume":"41","author":[{"given":"Alberto","family":"Aimo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignazio Alessio","family":"Gueli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Alderotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Bellisario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Todiere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrysanthos","family":"Grigoratos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"De Gori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Clemente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Panichella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Vergaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Giannoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Botto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Vittorini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Passino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Donato","family":"Aquaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Cademartiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Emdin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Barison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"3474_CR1","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1093\/eurheartj\/ehad194","volume":"44","author":"E Arbelo","year":"2023","unstructured":"Arbelo E, Protonotarios A, Gimeno JR et al (2023) 2023 ESC guidelines for the management of cardiomyopathies. 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