{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:27:26Z","timestamp":1789457246182,"version":"build-2803163510"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Bern"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Cardiovasc Imaging"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>A five-grade severity scheme has been introduced for echocardiographic grading of tricuspid regurgitation (TR). Although higher TR grades have been associated with worse prognosis, it is unknown whether they can help determining patient eligibility for transcatheter tricuspid valve interventions (TTVI) and correspond to different anatomical phenotypes. The aim of our study was to investigate the relationship between TR severity and tricuspid valve (TV) anatomy and determine the screening failure rate for TTVI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The anatomy of TV, right heart and venae cavae in patients with significant TR having undergone cardiac CT scan, was investigated using 3-mensio software and correlated with TR severity determined by echocardiography.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>One hundred patients from two tertiary centers were retrospectively included into the present analysis. Nine patients had moderate, 40 severe, 22 massive and 29 torrential TR. Pre-screening eligibility assessment showed comparable screening failure rates among patients with severe, massive and torrential TR for the Cardioband (35.0% vs. 40.9% vs. 34.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.79), TricValve (50.0% vs. 63.6% vs. 55.1%, <jats:italic>p<\/jats:italic>\u2009=\u20090.27), EVOQUE (30.0% vs. 27.3% vs. 31.1%, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.84), Cardiovalve (50.0% vs. 36.4% vs. 44.8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.37) and LuX-Valve (20.0% vs. 27.3% vs. 24.1%, <jats:italic>p<\/jats:italic>\u2009=\u20090.26) systems. No significant differences in CT-derived tricuspid annulus area, perimeter and diameter were observed between patients with severe, massive and torrential TR, while right atrium (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and right ventricle length (<jats:italic>p<\/jats:italic>\u2009=\u20090.014) significantly increased with progressive TR severity.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>CT imaging evaluation suggests similar eligibility rates for current TTVI devices and comparable TV anatomical phenotypes between patients with severe, massive, and torrential TR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Graphical abstract<\/jats:title>\n            <jats:p>CT-based pre-screening assessment for transcatheter tricuspid valve interventions according to TR severity.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10554-025-03505-8","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T04:27:06Z","timestamp":1756873626000},"page":"2013-2023","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["CT assessment of right heart anatomy across tricuspid regurgitation severity grades: implications for transcatheter interventions"],"prefix":"10.1007","volume":"41","author":[{"given":"Domenico","family":"Angellotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polydoros \u039d.","family":"Kampaktsis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Sticchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari","family":"Vivekanantham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Bartkowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Franzone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Pilgrim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Brugger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Windecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Gr\u00e4ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susheel K.","family":"Kodali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca T.","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Khalique","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Praz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"3505_CR1","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.jcmg.2018.06.014","volume":"12","author":"Y Topilsky","year":"2019","unstructured":"Topilsky Y, Maltais S, Medina Inojosa J, Oguz D, Michelena H, Maalouf J et al (2019) Burden of tricuspid regurgitation in patients diagnosed in the community setting. 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Dr Franzone reports speaker fees from Edwards Lifesciences. Dr Pilgrim reports research, travel or educational grants to the institution without personal remuneration from Biotronik, Boston Scientific, Edwards Lifesciences, Medtronic and ATSens; speaker fees and consultancy fees to the institution from Biotronik, Boston Scientific, Edwards Lifesciences, Abbott, Medtronic, Biosensors, and Highlife; and has received personal fees from Biotronik, Medtronic, Abbott, Edwards Lifesciences, and HighLife SAS. Dr Windecker has received research and educational grants to the institution from Abbott, Amgen, AstraZeneca, BMS, Bayer, Biotronik, Boston Scientific, Cardinal Health, CardioValve, CSL Behring, Daiichi-Sankyo, Edwards Lifesciences, Guerbet, InfraRedx, Johnson & Johnson, Medicure, Medtronic, Novartis, Polares, OrPha Suisse, Pfizer, Regeneron, Sanofi, Sinomed, Terumo, and V-Wave; has served as an unpaid advisory board member and\/or unpaid member of the steering\/executive group of trials funded by Abbott, Abiomed, Amgen, AstraZeneca, BMS, Boston Scientific, Biotronik, Cardiovalve, Edwards Lifesciences, Med Alliance, Medtronic, Novartis, Polares, Sinomed, V-Wave, and Xeltis but has not received personal payments by pharmaceutical companies or device manufacturers; and has been a member of the steering\/executive committee group of several investigator-initiated trials that receive funding by industry without impact on his personal remuneration. Dr. Gr\u00e4ni received funding from the Swiss National Science Foundation, InnoSuisse, Center for Artificial Intelligence in Medicine University Bern, GAMBIT foundation, Novartis Foundation for Medical-Biological Research, Swiss Heart Foundation, outside of the submitted work. Dr. Gr\u00e4ni serves as Editor-in-Chief of The International Journal of Cardiovascular Imaging, Springer. Dr Kodali reports institutional research grants from Edwards Lifesciences, Medtronic, Abbott, Boston Scientific, and JenaValve; he is a consultant to Admedus, TriCares, TriFlo, X-Dot, MicroInterventional Devices, Supira, Adona, Tioga, Helix Valve Repair, and Moray Medical and serves on advisory boards for Dura Biotech, Thubrikar Aortic Valve Inc., Phillips, Medtronic, and Boston Scientific. Dr Hahn reports speaker fees from Abbott Structural, Baylis Medical, Edwards Lifesciences, and Philips Healthcare; she has institutional consulting contracts for which she receives no direct compensation with Abbott Structural, Edwards Lifesciences, Medtronic, and Novartis; she is Chief Scientific Officer for the Echocardiography Core Laboratory at the Cardiovascular Research Foundation for multiple industry-sponsored tricuspid valve trials, for which she receives no direct industry compensation. Dr. Praz has received travel expenses from Edwards Lifesciences, Abbott Vascular, Polares Medical, and Medira. All other authors have reported that they have no relationships relevant to the contents of this article to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}