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The aim of this study was to evaluate CMR-based AR and MR quantification methods by quantifying AR and MR in participants without valvular heart disease in the population-based Hamburg City Health Study (HCHS). CMR was performed at 3T in the HCHS population. Aortic valve regurgitation volume (CMR-ARV) was directly obtained from 2D transaortic flow measurements. Mitral valve regurgitation volumes (CMR-MRV) were calculated by subtracting aortic forward flow volumes by Flow CMR from left ventricular stroke volumes by Cine CMR as currently recommended and by a method to account for potential confounding effects of AR on MR calculations (CMR-MRV\n                    <jats:sub>MOD<\/jats:sub>\n                    ). Absence of AR and MR were assessed by echocardiography as reference technique. The final CMR study population consisted of 1,874 participants (1,261 without any AR, 1,028 without any MR). Median age of the final study population was 66.0 [58.0, 71.0] years, and 41.1% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009770) of participants were female. Median CMR-ARV was 0.7 [0.2, 1.7] ml in participants without any AR. Median CMR-MRV was 9.4 [4.0, 17.0] ml and median CMR-MRV\n                    <jats:sub>MOD<\/jats:sub>\n                    was 8.7 [4.0, 15.2] ml in participants without any MR, as defined by echocardiography. Unlike accurate, direct ARV measurements by Flow CMR, the currently recommended CMR approach for MRV quantification seems to be affected by a systematic error. MRV measurements by CMR require cautious interpretation, taking into account site specific features.\n                  <\/jats:p>","DOI":"10.1007\/s10554-025-03538-z","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T05:42:15Z","timestamp":1759988535000},"page":"2343-2352","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of aortic and mitral valve regurgitation volumes by cardiovascular magnetic resonance in participants without valvular heart disease in the Hamburg City Health Study population"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5956-0051","authenticated-orcid":false,"given":"Katharina A.","family":"Riedl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0667-6178","authenticated-orcid":false,"given":"Georgios","family":"Koliopanos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan N.","family":"Albrecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ersin","family":"Cavus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Per","family":"Wenzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Sinn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bjoern P.","family":"Schoennagel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar K.","family":"Lund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Adam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulus","family":"Kirchhof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Blankenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8386-5397","authenticated-orcid":false,"given":"Andreas","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Muellerleile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"3538_CR1","doi-asserted-by":"publisher","first-page":"3515","DOI":"10.1093\/eurheartj\/ehw229","volume":"37","author":"JL d\u2019Arcy","year":"2016","unstructured":"d\u2019Arcy JL, Coffey S, Loudon MA, Kennedy A, Pearson-Stuttard J et al (2016) Large-scale community echocardiographic screening reveals a major burden of undiagnosed valvular heart disease in older people: the oxvalve population cohort study. 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PK is listed as inventor on two issued patents held by University of Hamburg (Atrial Fibrillation Therapy WO 2015140571, Markers for Atrial Fibrillation WO 2016012783). AZ is listed as co-inventor of an international patent on the use of a computing device to estimate the probability of myocardial infarction (International Publication Number WO2022043229A1), and is scientific director and CEO of Cardio-CARE, a program by the K\u00fchne Foundation and shareholder of the ART-EMIS Hamburg GmbH. BPS is co-founder and stake-holder of northh Medical GmbH. All other authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The local ethics committee of the Landesaerztekammer Hamburg (State of Hamburg Chamber of Medical Practitioners, PV5131) did not have objections against the conduct of the Hamburg City Health Study (HCHS). The study has been registered at ClinicalTrial.gov (NCT03934957).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All participants provided written informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent of participate"}}]}}