{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T11:07:30Z","timestamp":1775473650902,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001734","name":"Copenhagen University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Cardiovasc Imaging"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Left ventricular diastolic dysfunction (LVDD) is common in chronic kidney disease (CKD) and is suggested to be linked to worse renal prognosis. We investigated the associations between both the ratio of early mitral inflow velocity to early diastolic tissue velocity (E\/e\u2019) and LVDD grades with the risk of end-stage kidney disease (ESKD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cohort study included individuals with non-dialysis-dependent CKD from the nephrology outpatient clinics at Rigshospitalet and Herlev-Gentofte hospital, Copenhagen. All participants underwent a thorough, protocolized echocardiographic examination. The outcome was time to ESKD (defined as dialysis treatment or kidney transplantation).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 731 participants were included. Mean age was 57\u2009\u00b1\u200913 years and 39% were female. During a median follow-up of 3.8 years (IQR: 3.3;4.5), 102 individuals reached ESKD. In multivariable Cox regression models, both increasing continuous E\/e\u2019 (HR\u2009=\u20091.09 [95%CI:1.03;1.15], P\u2009=\u20090.004, per 1 unit increase) and E\/e\u2019 &gt; 14 (HR\u2009=\u20093.44 [95%CI:1.44;8.26], P\u2009=\u20090.005) (reference E\/e\u2019 &lt; 8) were associated with ESKD, while E\/e\u2019 8\u201314 was not. Compared with no or indeterminate LVDD, LVDD grades 2 or 3 were associated with ESKD (HR\u2009=\u20092.92 [95% CI:1.44;5.94], P\u2009=\u20090.003), while LVDD grade 1 was not. E\/e\u2019 &gt; 14 and LVDD grade 2 or 3 demonstrated similar predictive accuracy with excellent specificity and negative predictive values, but poor positive predictive values and sensitivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prominent LVDD assessed by E\/e\u2019 and LVDD grades was independently associated with worse renal prognosis and had similar predictive accuracy in patients with non-dialysis dependent CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                    <jats:p>Diastolic dysfunction and the risk of ESKD among patients with non-dialysis-dependent CKD. The CPH-CKD study is a prospective cohort study of non-dialysis dependent CKD patients. All participants were systematically examined with a pre-defined protocolized echocardiography and followed for median 3.8 years- A total of 731 were included in the study sample and 102 developed ESKD. We found a significant, independent association between LVDD assessed by E\/e\u2019 and LVDD grades and worse renal prognosis in patients with non-dialysis dependent CKD. E\/e\u2019 and LVDD grading had similar predictive accuracy. Abbreviations: CKD (chronic kidney disease), ESKD (end-stage kidney disease), E\/e\u2019 (ratio of early mitral inflow velocity to early diastolic tissue velocity), LVDD (left ventricular diastolic dysfunction).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10554-025-03601-9","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T06:11:12Z","timestamp":1767939072000},"page":"613-622","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diastolic dysfunction and the risk of end-stage kidney disease among patients with non-dialysis-dependent chronic kidney disease"],"prefix":"10.1007","volume":"42","author":[{"given":"Mathilde Zeuthen","family":"Pedersen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristoffer Grundtvig","family":"Skaarup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nino Emanuel","family":"Landler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flemming Javier","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklas Dyrby","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats Christian H\u00f8jbjerg","family":"Lassen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Christoffersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen Linnea Freese","family":"Ballegaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida Maria Hjelm","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasha Saurbrey","family":"Bjergfelt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Bro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Feldt-Rasmussen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ditte","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tor","family":"Biering-S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"3601_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1093\/eurheartj\/ehi020","volume":"26","author":"LG Bongartz","year":"2005","unstructured":"Bongartz LG, Cramer MJ, Doevendans PA, Joles JA, Braam B (2005) The severe cardiorenal syndrome: \u2018Guyton revisited\u2019. 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Chief investigator and steering committee chair of the Sanofi Pasteur financed \u201cNUDGE-FLU\u201d trial. Chief investigator and steering committee chair of the Sanofi Pasteur financed \u201cDANFLU-1\u201d trial. Chief investigator and steering committee chair of the Sanofi Pasteur financed \u201cDANFLU-2\u201d trial. Steering Committee member of \u201cLUX-Dx TRENDS Evaluates Diagnostics Sensors in Heart Failure Patients Receiving Boston Scientific\u2019s Investigational ICM System\u201d trial. Adviso-ry Board: Sanofi Pasteur, Amgen and GSK. Speaker Honorarium: Novartis, Sanofi Pasteur and GSK. Research grants: GE Healthcare and Sanofi Pasteur. The remaining authors have nothing to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}