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RM received speakers fees from Philips, Bayer, Siemens and Bristol Myers Squibb.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the Declaration of Helsinki and received approval from the local institutional review board and ethics committee for both cohorts.","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from participants in the prospective cohort. 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