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In addition, two groups of 20 BMI-matched patients were created, one of which underwent CTA using the standard PCD-CT protocol and the other using EID-CT, and these were compared with the new protocols. CNR was calculated. Overall quality, luminal contrast, vessel sharpness, and artifacts were rated by four radiologists. LD enabled\u2009~\u200940% dose-reduction compared to EID-CT (3.3\u2009\u00b1\u20090.8 versus 5.3\u2009\u00b1\u20090.4mGy;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) but higher CNR (33.5\u2009\u00b1\u20096.1 vs. 25.1\u2009\u00b1\u20096.4;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). CNR of LC (26.3\u2009\u00b1\u20095.6) and LD\/LC (25.6\u2009\u00b1\u20099.1) did not differ significantly to EID-CT (25.1\u2009\u00b1\u20096.4;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.99). Image quality of LC was deemed superior to EID-CT (5 [5\u20135] vs. 4 [4\u20134];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). LD (4 [4\u20135]) and LD\/LC (4 [4\u20134]) demonstrated comparable image quality to EID-CT (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.52\/0.94). In conclusion even the LD\/LC protocol provided image quality comparable to EID-CT despite substantial reduction of radiation and contrast agent dose. Special dose-reduced and contrast-reduced protocols are feasible without compromising diagnostic image quality.\n                  <\/jats:p>","DOI":"10.1007\/s10554-026-03757-y","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T05:01:44Z","timestamp":1781845304000},"page":"1891-1901","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Retrospective assessment of low-dose and low-contrast agent protocols for photon-counting CT angiography of the aorta"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1817-6214","authenticated-orcid":false,"given":"Jan-Lucca","family":"Hennes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Krompa\u00df","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henner","family":"Huflage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Pannenbecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin Saam","family":"Dazeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Peter","family":"Grunz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Hartung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten Alexander","family":"Bley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Gruschwitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"issue":"5","key":"3757_CR1","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/s41569-020-00472-6","volume":"18","author":"E Bossone","year":"2021","unstructured":"Bossone E, Eagle KA (2021) Epidemiology and management of aortic disease: aortic aneurysms and acute aortic syndromes. 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