{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:51:07Z","timestamp":1791345067902,"version":"4.3.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Cardiovasc Imaging"],"DOI":"10.1007\/s10554-026-03760-3","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T05:39:00Z","timestamp":1782711540000},"page":"1903-1912","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac Troponin release, myocardial function and inflammation in patients with takotsubo syndrome: a cardiac magnetic resonance study"],"prefix":"10.1007","volume":"42","author":[{"given":"Luca","family":"Arcari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Camastra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Ciolina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Sclafani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Belmonte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"De Santis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Castiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Francone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Danti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Sbarbati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Maestrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Cacciotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"3760_CR1","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1016\/J.JACC.2022.03.366","volume":"79","author":"L Arcari","year":"2022","unstructured":"Arcari L, N\u00fa\u00f1ez-Gil IJ, Stiermaier T et al (2022) Gender Differences in Takotsubo Syndrome. J Am Coll Cardiol 79:2085\u20132093. https:\/\/doi.org\/10.1016\/J.JACC.2022.03.366","journal-title":"J Am Coll Cardiol"},{"key":"3760_CR2","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/J.JACC.2024.05.075","volume":"84","author":"M Almendro-Delia","year":"2024","unstructured":"Almendro-Delia M, L\u00f3pez-Flores L, Uribarri A et al (2024) Recovery of Left Ventricular Function and Long-Term Outcomes in Patients With Takotsubo Syndrome. J Am Coll Cardiol 84:1163\u20131174. https:\/\/doi.org\/10.1016\/J.JACC.2024.05.075","journal-title":"J Am Coll Cardiol"},{"key":"3760_CR3","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1253\/circj.72.106","volume":"72","author":"T Kume","year":"2008","unstructured":"Kume T, Kawamoto T, Okura H et al (2008) Local release of catecholamines from the hearts of patients with tako-tsubo-like left ventricular dysfunction. Circ J 72:106\u2013108","journal-title":"Circ J"},{"key":"3760_CR4","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.jcmg.2024.03.007","volume":"17","author":"F Santoro","year":"2024","unstructured":"Santoro F, Selvaggi P, D\u2019apollo R et al (2024) Neurometabolic Features of Takotsubo Syndrome: A Brain 18F-FDG PET Case Control-Prospective Study. JACC Cardiovasc Imaging 17:1003\u20131005. https:\/\/doi.org\/10.1016\/j.jcmg.2024.03.007","journal-title":"JACC Cardiovasc Imaging"},{"key":"3760_CR5","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1161\/CIRCULATIONAHA.112.111591","volume":"126","author":"H Paur","year":"2012","unstructured":"Paur H, Wright PT, Sikkel MB et al (2012) High Levels of Circulating Epinephrine Trigger Apical Cardiodepression in a 2-Adrenergic Receptor\/Gi-Dependent Manner: A New Model of Takotsubo Cardiomyopathy. Circulation 126:697\u2013706. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.112.111591","journal-title":"Circulation"},{"key":"3760_CR6","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1016\/J.JACC.2020.10.060","volume":"77","author":"AR Lyon","year":"2021","unstructured":"Lyon AR, Citro R, Schneider B et al (2021) Pathophysiology of Takotsubo Syndrome: JACC State-of-the-Art Review. J Am Coll Cardiol 77:902\u2013921. https:\/\/doi.org\/10.1016\/J.JACC.2020.10.060","journal-title":"J Am Coll Cardiol"},{"key":"3760_CR7","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-025-01211-5","author":"E Omerovic","year":"2026","unstructured":"Omerovic E, Redfors B (2026) Takotsubo syndrome: pathophysiological insights and innovations in patient care. Nat Rev Cardiol. https:\/\/doi.org\/10.1038\/s41569-025-01211-5. 23:","journal-title":"Nat Rev Cardiol"},{"key":"3760_CR8","doi-asserted-by":"publisher","DOI":"10.1093\/EHJCI\/JEAD035","author":"L Arcari","year":"2023","unstructured":"Arcari L, Camastra G, Ciolina F et al (2023) Myocardial oedema contributes to interstitial expansion and associates with mechanical and electrocardiographic changes in takotsubo syndrome: a CMR T1 and T2 mapping study. Eur Hear J - Cardiovasc Imaging. https:\/\/doi.org\/10.1093\/EHJCI\/JEAD035","journal-title":"Eur Hear J - Cardiovasc Imaging"},{"key":"3760_CR9","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1161\/CIRCULATIONAHA.118.037975","volume":"139","author":"C Scally","year":"2019","unstructured":"Scally C, Abbas H, Ahearn T et al (2019) Myocardial and Systemic Inflammation in Acute Stress-Induced (Takotsubo) Cardiomyopathy. Circulation 139:1581\u20131592. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.118.037975","journal-title":"Circulation"},{"key":"3760_CR10","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/ejhf.424","volume":"18","author":"AR Lyon","year":"2016","unstructured":"Lyon AR, Bossone E, Schneider B et al (2016) Current state of knowledge on Takotsubo syndrome: a Position Statement from the Taskforce on Takotsubo Syndrome of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 18:8\u201327. https:\/\/doi.org\/10.1002\/ejhf.424","journal-title":"Eur J Heart Fail"},{"key":"3760_CR11","doi-asserted-by":"publisher","unstructured":"Couch LS, Garrard JW, Henry JA et al (2024) Comparison of troponin and natriuretic peptides in Takotsubo syndrome and acute coronary syndrome: a meta-analysis. Open Hear 11. https:\/\/doi.org\/10.1136\/OPENHRT-2024-002607","DOI":"10.1136\/OPENHRT-2024-002607"},{"key":"3760_CR12","doi-asserted-by":"publisher","unstructured":"St\u00e4hli BE, Schindler M, Schweiger V et al (2024) Cardiac troponin elevation and mortality in takotsubo syndrome: New insights from the international takotsubo registry. Eur J Clin Invest 54. https:\/\/doi.org\/10.1111\/ECI.14317","DOI":"10.1111\/ECI.14317"},{"key":"3760_CR13","doi-asserted-by":"publisher","unstructured":"O\u2019Brien AT, Gil KE, Varghese J et al (2022) T2 mapping in myocardial disease: a comprehensive review. J Cardiovasc Magn Reson 24. https:\/\/doi.org\/10.1186\/S12968-022-00866-0","DOI":"10.1186\/S12968-022-00866-0"},{"key":"3760_CR14","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1093\/EHJCI\/JEX230","volume":"19","author":"M Spieker","year":"2018","unstructured":"Spieker M, Katsianos E, Gastl M et al (2018) T2 mapping cardiovascular magnetic resonance identifies the presence of myocardial inflammation in patients with dilated cardiomyopathy as compared to endomyocardial biopsy. Eur Hear J Cardiovasc Imaging 19:574\u2013582. https:\/\/doi.org\/10.1093\/EHJCI\/JEX230","journal-title":"Eur Hear J Cardiovasc Imaging"},{"key":"3760_CR15","doi-asserted-by":"publisher","unstructured":"Arcari L, Tini G, Zuccanti M et al (2025) Clinical characteristics and outcomes of Takotsubo syndrome in patients with chronic obstructive pulmonary disease. Eur J Intern Med 132. https:\/\/doi.org\/10.1016\/J.EJIM.2024.10.026","DOI":"10.1016\/J.EJIM.2024.10.026"},{"key":"3760_CR16","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.032128","author":"F Santoro","year":"2024","unstructured":"Santoro F, N\u00fa\u00f1ez Gil IJ, Arcari L et al (2024) Neurological Disorders in Takotsubo Syndrome: Clinical Phenotypes and Outcomes. J Am Heart Assoc. https:\/\/doi.org\/10.1161\/JAHA.123.032128","journal-title":"J Am Heart Assoc"},{"key":"3760_CR17","doi-asserted-by":"publisher","unstructured":"Arcari L, Camastra G, Ciolina F et al (2025) Cardiac magnetic resonance in patients with Takotsubo syndrome: Clinical correlates of T2 mapping. Int J Cardiol 419. https:\/\/doi.org\/10.1016\/J.IJCARD.2024.132716","DOI":"10.1016\/J.IJCARD.2024.132716"},{"key":"3760_CR18","doi-asserted-by":"publisher","unstructured":"Puntmann VO, Valbuena S, Hinojar R et al (2018) Society for Cardiovascular Magnetic Resonance (SCMR) expert consensus for CMR imaging endpoints in clinical research: Part i - Analytical validation and clinical qualification. J Cardiovasc Magn Reson 20(1):67. https:\/\/doi.org\/10.1186\/s12968-018-0484-5","DOI":"10.1186\/s12968-018-0484-5"},{"key":"3760_CR19","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1093\/CLINCHEM\/HVAA281","volume":"67","author":"IA Katrukha","year":"2021","unstructured":"Katrukha IA, Katrukha AG (2021) Myocardial Injury and the Release of Troponins I and T in the Blood of Patients. Clin Chem 67:124\u2013130. https:\/\/doi.org\/10.1093\/CLINCHEM\/HVAA281","journal-title":"Clin Chem"},{"key":"3760_CR20","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1093\/eurheartj\/ehp140","volume":"30","author":"A Rolf","year":"2009","unstructured":"Rolf A, Nef HM, Mollmann H et al (2009) Immunohistological basis of the late gadolinium enhancement phenomenon in tako-tsubo cardiomyopathy. Eur Heart J 30:1635\u20131642. https:\/\/doi.org\/10.1093\/eurheartj\/ehp140","journal-title":"Eur Heart J"},{"key":"3760_CR21","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1093\/EHJACC\/ZUAB028","volume":"10","author":"MG Del Buono","year":"2021","unstructured":"Del Buono MG, Montone RA, Meucci MC et al (2021) Left ventricular end-diastolic pressure predicts in-hospital outcomes in takotsubo syndrome. Eur Hear J Acute Cardiovasc care 10:661\u2013667. https:\/\/doi.org\/10.1093\/EHJACC\/ZUAB028","journal-title":"Eur Hear J Acute Cardiovasc care"},{"key":"3760_CR22","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.jjcc.2014.08.012","volume":"65","author":"H Shionimya","year":"2015","unstructured":"Shionimya H, Koyama S, Tanada Y et al (2015) Left ventricular end-diastolic pressure and ejection fraction correlate independently with high-sensitivity cardiac troponin-T concentrations in stable heart failure. J Cardiol 65:526\u2013530. https:\/\/doi.org\/10.1016\/j.jjcc.2014.08.012","journal-title":"J Cardiol"},{"key":"3760_CR23","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1161\/01.CIR.0000084543.79097.34","volume":"108","author":"TB Horwich","year":"2003","unstructured":"Horwich TB, Patel J, MacLellan WR, Fonarow GC (2003) Cardiac troponin I is associated with impaired hemodynamics, progressive left ventricular dysfunction, and increased mortality rates in advanced heart failure. Circulation 108:833\u2013838. https:\/\/doi.org\/10.1161\/01.CIR.0000084543.79097.34","journal-title":"Circulation"},{"key":"3760_CR24","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1007\/S00424-007-0354-8","volume":"455","author":"MHM Hessel","year":"2008","unstructured":"Hessel MHM, Van Der Atsma DE et al (2008) Release of cardiac troponin I from viable cardiomyocytes is mediated by integrin stimulation. Pflugers Arch 455:979\u2013986. https:\/\/doi.org\/10.1007\/S00424-007-0354-8","journal-title":"Pflugers Arch"},{"key":"3760_CR25","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/J.JACC.2010.06.016","volume":"56","author":"RD Kociol","year":"2010","unstructured":"Kociol RD, Pang PS, Gheorghiade M et al (2010) Troponin Elevation in Heart Failure: Prevalence, Mechanisms, and Clinical Implications. J Am Coll Cardiol 56:1071\u20131078. https:\/\/doi.org\/10.1016\/J.JACC.2010.06.016","journal-title":"J Am Coll Cardiol"},{"key":"3760_CR26","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1097\/SHK.0000000000000811","volume":"47","author":"M Ostermann","year":"2017","unstructured":"Ostermann M, Ayis S, Tuddenham E et al (2017) Cardiac Troponin Release is Associated with Biomarkers of Inflammation and Ventricular Dilatation during Critical Illness. Shock 47:702\u2013708. https:\/\/doi.org\/10.1097\/SHK.0000000000000811","journal-title":"Shock"},{"key":"3760_CR27","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1136\/annrheumdis-2018-213661","volume":"77","author":"L Winau","year":"2018","unstructured":"Winau L, Hinojar Baydes R, Braner A et al (2018) High-sensitive troponin is associated with subclinical imaging biosignature of inflammatory cardiovascular involvement in systemic lupus erythematosus. Ann Rheum Dis 77:1590\u20131598. https:\/\/doi.org\/10.1136\/annrheumdis-2018-213661","journal-title":"Ann Rheum Dis"},{"key":"3760_CR28","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12968-021-00762-z","volume":"23","author":"L Arcari","year":"2021","unstructured":"Arcari L, Engel J, Freiwald T et al (2021) Cardiac biomarkers in chronic kidney disease are independently associated with myocardial edema and diffuse fibrosis by cardiovascular magnetic resonance. J Cardiovasc Magn Reson 23:71. https:\/\/doi.org\/10.1186\/s12968-021-00762-z","journal-title":"J Cardiovasc Magn Reson"},{"key":"3760_CR29","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/J.ATHEROSCLEROSIS.2018.05.017","volume":"274","author":"F Santoro","year":"2018","unstructured":"Santoro F, Costantino MD, Guastafierro F et al (2018) Inflammatory patterns in Takotsubo cardiomyopathy and acute coronary syndrome: A propensity score matched analysis. Atherosclerosis 274:157\u2013161. https:\/\/doi.org\/10.1016\/J.ATHEROSCLEROSIS.2018.05.017","journal-title":"Atherosclerosis"},{"key":"3760_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/00325481.2026.2616899","volume":"138","author":"L Arcari","year":"2026","unstructured":"Arcari L, Netti L, Camastra G et al (2026) Microvascular dysfunction in Takotsubo syndrome: a systematic review. Postgrad Med 138:1\u201314. https:\/\/doi.org\/10.1080\/00325481.2026.2616899","journal-title":"Postgrad Med"},{"key":"3760_CR31","doi-asserted-by":"publisher","unstructured":"Sans-Rosell\u00f3 J, Fern\u00e1ndez-Peregrina E, Duran-Cambra A et al (2021) Coronary Microvascular Dysfunction in Takotsubo Syndrome Assessed by Angiography-Derived Index of Microcirculatory Resistance: A Pressure-Wire-Free Tool. J Clin Med 10. https:\/\/doi.org\/10.3390\/JCM10194331","DOI":"10.3390\/JCM10194331"},{"key":"3760_CR32","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1093\/EHJACC\/ZUAE115","volume":"13","author":"JKE Airaksinen","year":"2024","unstructured":"Airaksinen JKE, Tuominen T, Paana T et al (2024) Novel troponin fragmentation assay to discriminate between Takotsubo syndrome and acute myocardial infarction. Eur Hear J Acute Cardiovasc Care 13:782\u2013788. https:\/\/doi.org\/10.1093\/EHJACC\/ZUAE115","journal-title":"Eur Hear J Acute Cardiovasc Care"},{"key":"3760_CR33","doi-asserted-by":"publisher","unstructured":"Airaksinen KEJ, Paana T, Vasankari T et al (2024) Composition of cardiac troponin release differs after marathon running and myocardial infarction. Open Hear 11. https:\/\/doi.org\/10.1136\/OPENHRT-2024-002954","DOI":"10.1136\/OPENHRT-2024-002954"},{"key":"3760_CR34","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.ahj.2025.04.020","volume":"289","author":"B Bruns","year":"2025","unstructured":"Bruns B, Elsous N, Burghaus I et al (2025) Rationale and design of the cyclosporine in Takotsubo syndrome (CIT) trial. Am Heart J 289:147\u2013157. https:\/\/doi.org\/10.1016\/j.ahj.2025.04.020","journal-title":"Am Heart J"},{"key":"3760_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/J.AHJ.2024.08.019","author":"F Santoro","year":"2024","unstructured":"Santoro F, Stiermaier T, Gil IJN et al (2024) Renin angiotensin system inhibitors and outcome in patients with Takotsubo syndrome: a propensity score analysis of the GEIST registry. Am Heart J. https:\/\/doi.org\/10.1016\/J.AHJ.2024.08.019","journal-title":"Am Heart J"},{"key":"3760_CR36","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1001\/JAMA.2020.9389","volume":"324","author":"A Jabbar","year":"2020","unstructured":"Jabbar A, Ingoe L, Junejo S et al (2020) Effect of Levothyroxine on Left Ventricular Ejection Fraction in Patients With Subclinical Hypothyroidism and Acute Myocardial Infarction: A Randomized Clinical Trial. JAMA 324:249\u2013258. https:\/\/doi.org\/10.1001\/JAMA.2020.9389","journal-title":"JAMA"}],"container-title":["The International Journal of Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10554-026-03760-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10554-026-03760-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10554-026-03760-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:19:12Z","timestamp":1791343152000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10554-026-03760-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":36,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["3760"],"URL":"https:\/\/doi.org\/10.1007\/s10554-026-03760-3","relation":{},"ISSN":["1875-8312"],"issn-type":[{"value":"1875-8312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]},"assertion":[{"value":"20 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}