{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:43:23Z","timestamp":1791283403635,"version":"4.1.0"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T00:00:00Z","timestamp":1173139200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Metastasis Rev"],"published-print":{"date-parts":[[2007,3,20]]},"DOI":"10.1007\/s10555-007-9047-1","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T15:46:46Z","timestamp":1173109606000},"page":"129-139","source":"Crossref","is-referenced-by-count":97,"title":["The molecular identity and characterization of a Proton-Coupled Folate Transporter\u2014PCFT; biological ramifications and impact on the activity of pemetrexed\u201412 06 06"],"prefix":"10.1007","volume":"26","author":[{"given":"Rongbao","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. David","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,3,6]]},"reference":[{"key":"9047_CR1","doi-asserted-by":"crossref","first-page":"7431","DOI":"10.1038\/sj.onc.1206946","volume":"22","author":"R. Zhao","year":"2003","unstructured":"Zhao, R., & Goldman, I. D. (2003). Resistance to antifolates. Oncogene, 22, 7431\u20137457.","journal-title":"Oncogene"},{"key":"9047_CR2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0083-6729(03)01012-4","volume":"66","author":"L. H. Matherly","year":"2003","unstructured":"Matherly, L. H., & Goldman, D. I. (2003). Membrane transport of folates. Vitamins and Hormones, 66, 403\u2013456.","journal-title":"Vitamins and Hormones"},{"key":"9047_CR3","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1158\/1078-0432.CCR-1066-03","volume":"10","author":"R. Zhao","year":"2004","unstructured":"Zhao, R., Gao, F., Hanscom, M., & Goldman, I. D. (2004). A prominent low-pH methotrexate transport activity in human solid tumor cells: Contribution to the preservation of methotrexate pharmacological activity in HeLa cells lacking the reduced folate carrier. Clinical Cancer Research, 10, 718\u2013727.","journal-title":"Clinical Cancer Research"},{"key":"9047_CR4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bbamem.2005.07.003","volume":"1715","author":"R. Zhao","year":"2005","unstructured":"Zhao, R., Hanscom, M., & Goldman, I. D. (2005). The relationship between folate transport activity at low pH and reduced folate carrier function in human Huh7 hepatoma cells. Biochimica et Biophysica Acta, 1715, 57\u201364.","journal-title":"Biochimica et Biophysica Acta"},{"key":"9047_CR5","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.cell.2006.09.041","volume":"127","author":"A. Qiu","year":"2006","unstructured":"Qiu, A., Jansen, M., Sakaris, A., Min, S. H., Chattopadhyay, S., Tsai, E., et al. (2006). Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell, 127, 917\u2013928.","journal-title":"Cell"},{"key":"9047_CR6","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1200\/JCO.2003.11.136","volume":"21","author":"N. J. Vogelzang","year":"2003","unstructured":"Vogelzang, N. J., Rusthoven, J. J., Symanowski, J., Denham, C., Kaukel, E., Ruffie, P., et al. (2003). Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. Journal of Clinical Oncology, 21, 2636\u20132644.","journal-title":"Journal of Clinical Oncology"},{"key":"9047_CR7","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1200\/JCO.2004.08.163","volume":"22","author":"N. Hanna","year":"2004","unstructured":"Hanna, N., Shepherd, F. A., Fossella, F. V., Pereira, J. R., De Marinis, F., Von Pawel, J., et al. (2004). Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. Journal of Clinical Oncology, 22, 1589\u20131597.","journal-title":"Journal of Clinical Oncology"},{"key":"9047_CR8","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1093\/ajcn\/32.4.846","volume":"32","author":"C. H. Halsted","year":"1979","unstructured":"Halsted, C. H. (1979). The intestinal absorption of folates. American Journal of Clinical Nutrition, 32, 846\u2013855.","journal-title":"American Journal of Clinical Nutrition"},{"key":"9047_CR9","first-page":"1979","volume-title":"Physiology of the gastrointestinal tract","author":"J. B. Mason","year":"1994","unstructured":"Mason, J. B., & Rosenberg, I. H. (1994). Intestinal absorption of folate. In L. R. Johnson (Ed.), Physiology of the gastrointestinal tract (pp. 1979\u20131995). New York: Raven."},{"key":"9047_CR10","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev.physiol.66.032102.144611","volume":"66","author":"H. M. Said","year":"2004","unstructured":"Said, H. M. (2004). Recent advances in carrier-mediated intestinal absorption of water-soluble vitamins. Annual Review of Physiology, 66, 419\u2013446.","journal-title":"Annual Review of Physiology"},{"key":"9047_CR11","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1172\/JCI112205","volume":"76","author":"C. M. Schron","year":"1985","unstructured":"Schron C. M., Washington, C., Jr., & Blitzer, B. L. (1985). The transmembrane pH gradient drives uphill folate transport in rabbit jejunum. Direct evidence for folate\/hydroxyl exchange in brush border membrane vesicles. Journal of Clinical Investigation, 76, 2030\u20132033.","journal-title":"Journal of Clinical Investigation"},{"key":"9047_CR12","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/03091909009028758","volume":"14","author":"G. T. McEwan","year":"1990","unstructured":"McEwan, G. T., Lucas, M. L., Denvir, M., Raj, M., McColl, K. E., Russell, R. I., et al. (1990). A combined TDDA\u2013PVC pH and reference electrode for use in the upper small intestine. Journal of Medical Engineering & Technology, 14, 16\u201320.","journal-title":"Journal of Medical Engineering & Technology"},{"key":"9047_CR13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0005-2736(95)00261-8","volume":"1280","author":"M. Ikuma","year":"1996","unstructured":"Ikuma, M., Hanai, H., Kaneko, E., Hayashi, H., & Hoshi, T. (1996). Effects of aging on the microclimate pH of the rat jejunum. Biochimica et Biophysica Acta, 1280, 19\u201326.","journal-title":"Biochimica et Biophysica Acta"},{"key":"9047_CR14","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1203\/00006450-198711000-00002","volume":"22","author":"H. M. Said","year":"1987","unstructured":"Said, H. M., Smith, R., & Redha, R. (1987). Studies on the intestinal surface acid microclimate: Developmental aspects. Pediatric Research, 22, 497\u2013499.","journal-title":"Pediatric Research"},{"key":"9047_CR15","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0005-2736(90)90008-C","volume":"1023","author":"D. W. Horne","year":"1990","unstructured":"Horne, D. W. (1990). Na+ and pH dependence of 5-methyltetrahydrofolic acid and methotrexate transport in freshly isolated hepatocytes. Biochimica et Biophysica Acta. Biomembranes, 1023, 47\u201355.","journal-title":"Biochimica et Biophysica Acta. Biomembranes"},{"key":"9047_CR16","first-page":"394","volume":"29","author":"Y. H. Han","year":"2001","unstructured":"Han, Y. H., Kato, Y., Watanabe, Y., Terao, K., Asoh, Y., & Sugiyama, Y. (2001). Carrier-mediated hepatobiliary transport of a novel antifolate, N-[4-[(2,4-dianninopteridine-6-yl)methyl]-3,4-dihydro-2H-1,4-benzothiazin-7-yl]carbonyl-L-homoglutamic acid, in rats. Drug Metabolism and Disposition, 29, 394\u2013400.","journal-title":"Drug Metabolism and Disposition"},{"key":"9047_CR17","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0005-2736(88)90243-X","volume":"937","author":"S. D. Bhandari","year":"1988","unstructured":"Bhandari, S. D., Joshi, S. K., & McMartin, K. E. (1988). Folate binding and transport by rat kidney brush-border membrane vesicles. Biochimica et Biophysica Acta, 937, 211\u2013218.","journal-title":"Biochimica et Biophysica Acta"},{"key":"9047_CR18","doi-asserted-by":"crossref","first-page":"20676","DOI":"10.1074\/jbc.M002328200","volume":"275","author":"C. D. Chancy","year":"2000","unstructured":"Chancy, C. D., Kekuda, R., Huang, W., Prasad, P. D., Kuhnel, J. M., Sirotnak, F. M., et al. (2000). Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor alpha in mammalian retinal pigment epithelium. Journal of Biological Chemistry, 275, 20676\u201320684.","journal-title":"Journal of Biological Chemistry"},{"key":"9047_CR19","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0003-9861(02)00663-X","volume":"410","author":"S. Cai","year":"2003","unstructured":"Cai, S., & Horne, D. W. (2003). Transport of 5-formyltetrahydrofolate into primary cultured rat astrocytes. Archives of Biochemistry and Biophysics, 410, 161\u2013166.","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"9047_CR20","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0006-8993(02)03988-4","volume":"962","author":"S. Cai","year":"2003","unstructured":"Cai, S., & Horne, D. W. (2003). Transport of 5-formyltetrahydrofolate into primary cultured cerebellar granule cells. Brain Research, 962, 151\u2013158.","journal-title":"Brain Research"},{"key":"9047_CR21","doi-asserted-by":"crossref","first-page":"C289","DOI":"10.1152\/ajpcell.1998.274.1.C289","volume":"274","author":"C. K. Kumar","year":"1998","unstructured":"Kumar, C. K., Nguyen, T. T., Gonzales, F. B., & Said, H. M. (1998). Comparison of intestinal folate carrier clone expressed in IEC-6 cells and in Xenopus oocytes. American Journal of Physiology, 274, C289\u2013C294.","journal-title":"American Journal of Physiology"},{"key":"9047_CR22","doi-asserted-by":"crossref","first-page":"C1579","DOI":"10.1152\/ajpcell.2001.281.5.C1579","volume":"281","author":"A. Rajgopal","year":"2001","unstructured":"Rajgopal, A., Sierra, E. E., Zhao, R., & Goldman, I. D. (2001). Expression of the reduced folate carrier SLC19A1 in IEC-6 cells results in two distinct transport activities. American Journal of Physiology. Cell Physiology, 281, C1579\u2013C1586.","journal-title":"American Journal of Physiology. Cell Physiology"},{"key":"9047_CR23","doi-asserted-by":"crossref","first-page":"6226","DOI":"10.1074\/jbc.272.10.6226","volume":"272","author":"C. K. Kumar","year":"1997","unstructured":"Kumar, C. K., Moyer, M. P., Dudeja, P. K., & Said, H. M. (1997). A protein-tyrosine kinase-regulated, pH-dependent, carrier-mediated uptake system for folate in human normal colonic epithelial cell line NCM460. Journal of Biological Chemistry, 272, 6226\u20136231.","journal-title":"Journal of Biological Chemistry"},{"key":"9047_CR24","first-page":"355","volume":"39","author":"M. L. Vincent","year":"1985","unstructured":"Vincent, M. L., Russell, R. M., & Sasak, V. (1985). Folic acid uptake characteristics of a human colon carcinoma cell line, Caco-2. A newly-described cellular model for small intestinal epithelium. Human Nutrition. Clinical Nutrition, 39, 355\u2013360.","journal-title":"Human Nutrition. Clinical Nutrition"},{"key":"9047_CR25","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/0016-5085(89)90897-4","volume":"96","author":"I. J. Hidalgo","year":"1989","unstructured":"Hidalgo, I. J., Raub, T. J., & Borchardt, R. T. (1989). Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology, 96, 736\u2013749.","journal-title":"Gastroenterology"},{"key":"9047_CR26","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/1097-4652(200009)184:3<364::AID-JCP11>3.0.CO;2-N","volume":"184","author":"J. M. Kuhnel","year":"2000","unstructured":"Kuhnel, J. M., Chiao, J. H., & Sirotnak, F. M. (2000). Contrasting effects of oncogene expression on two carrier-mediated systems internalizing folate compounds in Fisher rat 3T3 cells. Journal of Cellular Physiology, 184, 364\u2013372.","journal-title":"Journal of Cellular Physiology"},{"key":"9047_CR27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1006\/abbi.2001.2528","volume":"394","author":"D. W. Horne","year":"2001","unstructured":"Horne, D. W., & Reed, K. A. (2001). Transport of methotrexate into PC-3 human prostate cancer cells. Archives of Biochemistry and Biophysics, 394, 39\u201344.","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"9047_CR28","first-page":"1709","volume":"50","author":"G. B. Henderson","year":"1990","unstructured":"Henderson, G. B., & Strauss, B. P. (1990). Characteristics of a novel transport system for folate compounds in wild-type and methotrexate-resistant L1210 cells. Cancer Research, 50, 1709\u20131714.","journal-title":"Cancer Research"},{"key":"9047_CR29","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/S0006-2952(97)00673-4","volume":"55","author":"E. E. Sierra","year":"1998","unstructured":"Sierra, E. E., & Goldman, I. D. (1998). Characterization of folate transport mediated by a low pH route in mouse L1210 leukemia cells with defective reduced folate carrier function. Biochemical Pharmacology, 55, 1505\u20131512.","journal-title":"Biochemical Pharmacology"},{"key":"9047_CR30","doi-asserted-by":"crossref","first-page":"8106","DOI":"10.1074\/jbc.273.14.8106","volume":"273","author":"Y. G. Assaraf","year":"1998","unstructured":"Assaraf, Y. G., Babani, S., & Goldman, I. D. (1998). Increased activity of a novel low pH folate transporter associated with lipoplilic antifolate resistance in Chinese hamster ovary cells. Journal of Biological Chemistry, 273, 8106\u20138111.","journal-title":"Journal of Biological Chemistry"},{"key":"9047_CR31","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1139\/y05-129","volume":"84","author":"E. Keating","year":"2006","unstructured":"Keating, E., Lemos, C., Azevedo, I., & Martel, F. (2006). Comparison of folic acid uptake characteristics by human placental choriocarcinoma cells at acidic and physiological pH. Canadian Journal of Physiology and Pharmacology, 84, 247\u2013255.","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"key":"9047_CR32","doi-asserted-by":"crossref","first-page":"17460","DOI":"10.1074\/jbc.272.28.17460","volume":"272","author":"Y. G. Assaraf","year":"1997","unstructured":"Assaraf, Y. G., & Goldman, I. D. (1997). Loss of folic acid exporter function with markedly augmented folate accumulation in lipophilic antifolate-resistant mammalian cells. Journal of Biological Chemistry, 272, 17460\u201317466.","journal-title":"Journal of Biological Chemistry"},{"key":"9047_CR33","doi-asserted-by":"crossref","first-page":"11165","DOI":"10.1074\/jbc.272.17.11165","volume":"272","author":"J. H. Chiao","year":"1997","unstructured":"Chiao, J. H., Roy, K., Tolner, B., Yang, C. H., & Sirotnak, F. M. (1997) RFC-1 gene expression regulates folate absorption in mouse small intestine. Journal of Biological Chemistry, 272, 11165\u201311170.","journal-title":"Journal of Biological Chemistry"},{"key":"9047_CR34","doi-asserted-by":"crossref","first-page":"C65","DOI":"10.1152\/ajpcell.00533.2004","volume":"288","author":"Y. Wang","year":"2005","unstructured":"Wang, Y., Rajgopal, A., Goldman, I. D., & Zhao, R. (2005). Preservation of folate transport activity with a low-pH optimum in rat IEC-6 intestinal epithelial cell lines that lack reduced folate carrier function. American Journal of Physiology. Cell Physiology, 288, C65\u2013C71.","journal-title":"American Journal of Physiology. Cell Physiology"},{"key":"9047_CR35","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0021-9258(17)42301-5","volume":"269","author":"K. H. Dixon","year":"1994","unstructured":"Dixon, K. H., Lanpher, B. C., Chiu, J., Kelley, K., & Cowan, K. H. (1994). A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells. Journal of Biological Chemistry, 269, 17\u201320.","journal-title":"Journal of Biological Chemistry"},{"key":"9047_CR36","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/0005-2736(96)00005-3","volume":"1281","author":"H. M. Said","year":"1996","unstructured":"Said, H. M., Nguyen, T. T., Dyer, D. L., Cowan, K. H., & Rubin, S. A. (1996). Intestinal folate transport, identification of a cDNA involved in folate transport and the functional expression and distribution of its mRNA. Biochimica et Biophysica Acta. Biomembranes, 1281, 164\u2013172.","journal-title":"Biochimica et Biophysica Acta. Biomembranes"},{"key":"9047_CR37","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1053\/gast.1997.v112.pm9041240","volume":"112","author":"T. T Nguyen","year":"1997","unstructured":"Nguyen, T. T, Dyer, D. L., Dunning, D. D., Rubin, S. A., Grant, K. E., & Said, H. M. (1997). Human intestinal folate transport: Cloning, expression, and distribution of complementary RNA. Gastroenterology, 112, 783\u2013791.","journal-title":"Gastroenterology"},{"key":"9047_CR38","doi-asserted-by":"crossref","first-page":"6256","DOI":"10.1158\/1078-0432.CCR-04-0645","volume":"10","author":"Y. Wang","year":"2004","unstructured":"Wang, Y., Zhao, R., & Goldman, I. D. (2004). Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier. Clinical Cancer Research, 10, 6256\u20136264.","journal-title":"Clinical Cancer Research"},{"key":"9047_CR39","doi-asserted-by":"crossref","first-page":"C1889","DOI":"10.1152\/ajpcell.2000.279.6.C1889","volume":"279","author":"H. M. Said","year":"2000","unstructured":"Said, H. M., Chatterjee, N., Haq, R. U., Subramanian, V. S., Ortiz, A., Matherly, L. H., et al. (2000). Adaptive regulation of intestinal folate uptake: effect of dietary folate deficiency. American Journal of Physiology. Cell Physiology, 279, C1889\u2013C1895.","journal-title":"American Journal of Physiology. Cell Physiology"},{"key":"9047_CR40","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1074\/jbc.M412662200","volume":"280","author":"M. Liu","year":"2005","unstructured":"Liu, M., Ge, Y., Cabelof, D. C., Aboukameel, A., Heydari, A. R., Mohammad, R., et al. (2005). Structure and regulation of the murine reduced folate carrier gene: Identification of four noncoding exons and promoters and regulation by dietary folates. Journal of Biological Chemistry, 280, 5588\u20135597.","journal-title":"Journal of Biological Chemistry"},{"key":"9047_CR41","doi-asserted-by":"crossref","first-page":"G1068","DOI":"10.1152\/ajpgi.00188.2003","volume":"285","author":"K. Balamurugan","year":"2003","unstructured":"Balamurugan, K., & Said, H. M. (2003). Ontogenic regulation of folate transport across rat jejunal brush-border membrane. American Journal of Physiology: Gastrointestinal and Liver Physiology, 285, G1068\u2013G1073.","journal-title":"American Journal of Physiology: Gastrointestinal and Liver Physiology"},{"key":"9047_CR42","doi-asserted-by":"crossref","first-page":"16269","DOI":"10.1074\/jbc.274.23.16269","volume":"274","author":"P. L. Ferguson","year":"1999","unstructured":"Ferguson, P. L., & Flintoff, W. F. (1999). Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion. Journal of Biological Chemistry, 274, 16269\u201316278.","journal-title":"Journal of Biological Chemistry"},{"key":"9047_CR43","doi-asserted-by":"crossref","first-page":"C189","DOI":"10.1152\/ajpcell.00594.2005","volume":"291","author":"K. Balamurugan","year":"2006","unstructured":"Balamurugan, K., & Said, H. M. (2006). Role of reduced folate carrier in intestinal folate uptake. American Journal of Physiology. Cell Physiology, 291, C189\u2013C193.","journal-title":"American Journal of Physiology. Cell Physiology"},{"key":"9047_CR44","doi-asserted-by":"crossref","first-page":"31925","DOI":"10.1074\/jbc.274.45.31925","volume":"274","author":"B. Dutta","year":"1999","unstructured":"Dutta, B., Huang, W., Molero, M., Kekuda, R., Leibach, F. H., Devoe, L. D., et al. (1999). Cloning of the human thiamine transporter, a member of the folate transporter family. Journal of Biological Chemistry, 274, 31925\u201331929.","journal-title":"Journal of Biological Chemistry"},{"key":"9047_CR45","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0925-4439(01)00073-4","volume":"1537","author":"A. Rajgopal","year":"2001","unstructured":"Rajgopal, A., Edmondson, A., Goldman, I. D., & Zhao, R. (2001). SLC19A3 encodes a second thiamine transporter, ThTr2. Biochimica et Biophysica Acta, 1537, 175\u2013178.","journal-title":"Biochimica et Biophysica Acta"},{"key":"9047_CR46","doi-asserted-by":"crossref","first-page":"8735","DOI":"10.1158\/1078-0432.CCR-04-0932","volume":"10","author":"R. Zhao","year":"2005","unstructured":"Zhao, R., Chattopadhyay, S., Hanscom, M., & Goldman, I. D. (2005). Antifolate resistance in a HeLa cell line associated with impaired transport independent of the reduced folate carrier. Clinical Cancer Research, 10, 8735\u20138742.","journal-title":"Clinical Cancer Research"},{"key":"9047_CR47","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.cell.2005.06.025","volume":"122","author":"M. Shayeghi","year":"2005","unstructured":"Shayeghi, M., Latunde-Dada, G. O., Oakhill, J. S., Laftah, A. H., Takeuchi, K., Halliday, N., et al. (2005). Identification of an intestinal heme transporter. Cell, 122, 789\u2013801.","journal-title":"Cell"},{"key":"9047_CR48","doi-asserted-by":"crossref","first-page":"22966","DOI":"10.1074\/jbc.M200374200","volume":"277","author":"M. Boll","year":"2002","unstructured":"Boll, M., Foltz, M., Rubio-Aliaga, I., Kottra, G., & Daniel, H. (2002). Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters. Journal of Biological Chemistry, 277, 22966\u201322973.","journal-title":"Journal of Biological Chemistry"},{"key":"9047_CR49","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/368563a0","volume":"368","author":"Y. J. Fei","year":"1994","unstructured":"Fei, Y. J., Kanai, Y., Nussberger, S., Ganapathy, V., Leibach, F. H., Romero, M. F., et al. (1994). Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature, 368, 563\u2013566.","journal-title":"Nature"},{"key":"9047_CR50","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/41343","volume":"388","author":"H. Gunshin","year":"1997","unstructured":"Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., et al. (1997). Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature, 388, 482\u2013488.","journal-title":"Nature"},{"key":"9047_CR51","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1124\/jpet.103.060194","volume":"308","author":"T. Nozawa","year":"2004","unstructured":"Nozawa, T., Imai, K., Nezu, J., Tsuji, A., & Tamai, I. (2004). Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. Journal of Pharmacology and Experimental Therapeutics, 308, 438\u2013445.","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"9047_CR52","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/00005792-200201000-00004","volume":"81","author":"J. Geller","year":"2002","unstructured":"Geller, J., Kronn, D., Jayabose, S., & Sandoval, C. (2002). Hereditary folate malabsorption: Family report and review of the literature. Medicine (Baltimore), 81, 51\u201368.","journal-title":"Medicine (Baltimore)"},{"key":"9047_CR53","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1056\/NEJMoa043160","volume":"352","author":"V. T. Ramaekers","year":"2005","unstructured":"Ramaekers, V. T., Rothenberg, S. P., Sequeira, J. M., Opladen, T., Blau, N., Quadros, E. V., et al. (2005). Autoantibodies to folate receptors in the cerebral folate deficiency syndrome. New England Journal of Medicine, 352, 1985\u20131991.","journal-title":"New England Journal of Medicine"},{"key":"9047_CR54","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1023\/A:1018829920158","volume":"16","author":"D. Wu","year":"1999","unstructured":"Wu, D., & Pardridge, W. M. (1999). Blood-brain barrier transport of reduced folic acid. Pharmaceutical Research, 16, 415\u2013419.","journal-title":"Pharmaceutical Research"},{"key":"9047_CR55","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1126\/science.1167256","volume":"187","author":"R. Spector","year":"1975","unstructured":"Spector, R., & Lorenzo, A. V. (1975). Folate transport by the choroid plexus in vitro. Science, 187, 540\u2013542.","journal-title":"Science"},{"key":"9047_CR56","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1152\/ajplegacy.1975.229.3.777","volume":"229","author":"R. Spector","year":"1975","unstructured":"Spector, R., & Lorenzo, A. V. (1975). Folate transport in the central nervous system. American Journal of Physiology, 229, 777\u2013782.","journal-title":"American Journal of Physiology"},{"key":"9047_CR57","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1042\/bj2800267","volume":"280","author":"J. Holm","year":"1991","unstructured":"Holm, J., Hansen, S. I., Hoier-Madsen, M., & Bostad, L. (1991). High-affinity folate binding in human choroid plexus. Characterization of radioligand binding, immunoreactivity, molecular heterogeneity and hydrophobic domain of the binding protein. Biochemical Journal, 280, 267\u2013271.","journal-title":"Biochemical Journal"},{"key":"9047_CR58","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0005-2736(01)00340-6","volume":"1513","author":"Y. Wang","year":"2001","unstructured":"Wang, Y., Zhao, R., Russell, R. G., & Goldman, I. D. (2001). Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis. Biochimica et Biophysica Acta, 1513, 49\u201354.","journal-title":"Biochimica et Biophysica Acta"},{"key":"9047_CR59","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1126\/science.1310359","volume":"255","author":"R. G. W. Anderson","year":"1992","unstructured":"Anderson R. G. W., Kamen, B. A., Rothberg, K. G., & Lacey, S. W. (1992). Potocytosis: sequestration and transport of small molecules by caveolae. Science, 255, 410\u2013411.","journal-title":"Science"},{"key":"9047_CR60","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1083\/jcb.98.5.1757","volume":"98","author":"R. F. Murphy","year":"1984","unstructured":"Murphy, R. F., Powers, S., & Cantor, C. R. (1984). Endosome pH measured in single cells by dual fluorescence flow cytometry: Rapid acidification of insulin to pH 6. Journal of Cell Biology, 98, 1757\u20131762.","journal-title":"Journal of Cell Biology"},{"key":"9047_CR61","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0167-4889(94)90184-8","volume":"1222","author":"P. D. Prasad","year":"1994","unstructured":"Prasad, P. D., Mahesh, V. B., Leibach, F. H., & Ganapathy, V. (1994). Functional coupling between a bafilomycin A1-sensitive proton pump and a probenecid-sensitive folate transporter in human placental choriocarcinoma cells. Biochimica et Biophysica Acta. Molecular Cell Research, 1222, 309\u2013314.","journal-title":"Biochimica et Biophysica Acta. Molecular Cell Research"},{"key":"9047_CR62","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1007\/s00424-003-1073-4","volume":"447","author":"M. Boll","year":"2004","unstructured":"Boll, M., Daniel, H., & Gasnier, B. (2004). The SLC36 family: Proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis. Pflugers Archiv, 447, 776\u2013779.","journal-title":"Pflugers Archiv"},{"key":"9047_CR63","doi-asserted-by":"crossref","first-page":"7206","DOI":"10.1073\/pnas.121183498","volume":"98","author":"C. Sagne","year":"2001","unstructured":"Sagne, C., Agulhon, C., Ravassard, P., Darmon, M., Hamon, M., El Mestikawy, S., et al. (2001). Identification and characterization of a lysosomal transporter for small neutral amino acids. Proceedings of the National Academy of Sciences of the United States of America, 98, 7206\u20137211.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"9047_CR64","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/S0022-3476(96)70057-4","volume":"129","author":"M. Poncz","year":"1996","unstructured":"Poncz, M., & Cohen, A. (1996). Long-term treatment of congenital folate malabsorption. Jornal de Pediatria, 129, 948.","journal-title":"Jornal de Pediatria"},{"key":"9047_CR65","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0167-8140(84)80077-8","volume":"2","author":"J. L. Wike-Hooley","year":"1984","unstructured":"Wike-Hooley, J. L., Haveman, J., & Reinhold, H. S. (1984). The relevance of tumour pH to the treatment of malignant disease. Radiotherapy and Oncology, 2, 343\u2013366.","journal-title":"Radiotherapy and Oncology"},{"key":"9047_CR66","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nm0297-177","volume":"3","author":"G. Helmlinger","year":"1997","unstructured":"Helmlinger, G., Yuan, F., Dellian, M., & Jain, R. K. (1997). Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation. Natural Medicines, 3, 177\u2013182.","journal-title":"Natural Medicines"},{"key":"9047_CR67","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0006-2952(98)00306-2","volume":"57","author":"N. Raghunand","year":"1999","unstructured":"Raghunand, N., Altbach, M. I., van Sluis, R., Baggett, B., Taylor, C. W., Bhujwalla, Z. M., et al. (1999). Plasmalemmal pH-gradients in drug-sensitive and drug-resistant MCF-7 human breast carcinoma xenografts measured by 31P magnetic resonance spectroscopy. Biochemical Pharmacology, 57, 309\u2013312.","journal-title":"Biochemical Pharmacology"},{"key":"9047_CR68","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1158\/0008-5472.CAN-03-3953","volume":"64","author":"R. Zhao","year":"2004","unstructured":"Zhao, R., Hanscom, M., Chattopadhyay, S., & Goldman, I. D. (2004). Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier; association with the presence of a secondary transport pathway. Cancer Research, 64, 3313\u20133319.","journal-title":"Cancer Research"},{"key":"9047_CR69","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1158\/1535-7163.MCT-05-0243","volume":"5","author":"S. Chattopadhyay","year":"2006","unstructured":"Chattopadhyay, S., Zhao, R., Krupenko, S. A., Krupenko, N., & Goldman, I. D. (2006). The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line. Molecular Cancer Therapeutics, 5, 438\u2013449.","journal-title":"Molecular Cancer Therapeutics"},{"key":"9047_CR70","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0006-2952(01)00532-9","volume":"61","author":"R. Zhao","year":"2001","unstructured":"Zhao, R., Gao, F., & Goldman, I. D. (2001). Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells. Biochemical Pharmacology, 61, 857\u2013865.","journal-title":"Biochemical Pharmacology"},{"key":"9047_CR71","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0009-2797(87)90091-3","volume":"63","author":"G. Sievers","year":"1987","unstructured":"Sievers, G., Hakli, H., Luhtala, J., & Tenhunen, R. (1987). Optical and EPR spectroscopy studies on haem arginate, a new compound used for treatment of porphyria. Chemico-biological Interactions, 63, 105\u2013114.","journal-title":"Chemico-biological Interactions"},{"key":"9047_CR72","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1021\/bi00277a002","volume":"22","author":"R. F. Pasternack","year":"1983","unstructured":"Pasternack, R. F., Gibbs, E. J., Hoeflin, E., Kosar, W. P., Kubera, G., Skowronek, C. A., et al. (1983). Hemin binding to serum proteins and the catalysis of interprotein transfer. Biochemistry, 22, 1753\u20131758.","journal-title":"Biochemistry"},{"key":"9047_CR73","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1006\/abbi.1993.1566","volume":"307","author":"T. H. Schmitt","year":"1993","unstructured":"Schmitt, T. H., Frezzatti, W. A., Jr., & Schreier, S. (1993). Hemin-induced lipid membrane disorder and increased permeability: A molecular model for the mechanism of cell lysis. Archives of Biochemistry and Biophysics, 307, 96\u2013103.","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"9047_CR74","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/S0140-6736(06)68582-6","volume":"367","author":"M. Eichholzer","year":"2006","unstructured":"Eichholzer, M., Tonz, O., & Zimmermann, R. (2006). Folic acid: A public health challenge. Lancet, 367, 1352\u20131361.","journal-title":"Lancet"},{"key":"9047_CR75","first-page":"3687","volume":"6","author":"R. Zhao","year":"2000","unstructured":"Zhao, R., Babani, S., Gao, F., Liu, L., & Goldman, I. D. (2000). The mechanism of transport of the multitargeted antifolate, MTA-LY231514, and its cross resistance pattern in cell with impaired transport of methotrexate. Clinical Cancer Research, 6, 3687\u20133695.","journal-title":"Clinical Cancer Research"},{"key":"9047_CR76","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1016\/0006-2952(79)90599-9","volume":"28","author":"F. M. Sirotnak","year":"1979","unstructured":"Sirotnak, F. M., Chello, P. L., Moccio, D. M., Kisliuk, R. L., Combepine, G., Gaumont, Y., et al. (1979). Stereospecificity at carbon 6 of formyltetrahydrofolate as a competitive inhibitor of transport and cytotoxicity of methotrexate in vitro. Biochemical Pharmacology, 28, 2993\u20132997.","journal-title":"Biochemical Pharmacology"}],"container-title":["Cancer and Metastasis Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10555-007-9047-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10555-007-9047-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10555-007-9047-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T17:19:11Z","timestamp":1628529551000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10555-007-9047-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,6]]},"references-count":76,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,3,20]]}},"alternative-id":["9047"],"URL":"https:\/\/doi.org\/10.1007\/s10555-007-9047-1","relation":{},"ISSN":["0167-7659","1573-7233"],"issn-type":[{"value":"0167-7659","type":"print"},{"value":"1573-7233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,6]]}}}