{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T07:45:24Z","timestamp":1793259924508,"version":"4.5.0"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,8,12]],"date-time":"2017-08-12T00:00:00Z","timestamp":1502496000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Metastasis Rev"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1007\/s10555-017-9685-x","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T22:35:28Z","timestamp":1502490928000},"page":"515-523","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Tumor DNA: an emerging biomarker in head and neck cancer"],"prefix":"10.1007","volume":"36","author":[{"given":"Joseph A.","family":"Bellairs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rifat","family":"Hasina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,12]]},"reference":[{"key":"9685_CR1","doi-asserted-by":"publisher","unstructured":"(2015). The global burden of cancer 2013. JAMA Oncology, 1, 505\u2013527. doi: 10.1001\/jamaoncol.2015.0735 .","DOI":"10.1001\/jamaoncol.2015.0735"},{"key":"9685_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21332","volume":"66","author":"RL Siegel","year":"2016","unstructured":"Siegel, R. L., Miller, K. D., & Jemal, A. (2016). Cancer statistics, 2016. CA Cancer J Clin, 66, 7\u201330. doi: 10.3322\/caac.21332 .","journal-title":"CA Cancer J Clin"},{"key":"9685_CR3","doi-asserted-by":"publisher","first-page":"489","DOI":"10.4065\/83.4.489","volume":"83","author":"S Marur","year":"2008","unstructured":"Marur, S., & Forastiere, A. A. (2008). Head and neck cancer: changing epidemiology, diagnosis, and treatment. Mayo Clinic Proceedings, 83, 489\u2013501. doi: 10.4065\/83.4.489 .","journal-title":"Mayo Clinic Proceedings"},{"key":"9685_CR4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrc2982","volume":"11","author":"CR Leemans","year":"2011","unstructured":"Leemans, C. R., Braakhuis, B. J. M., & Brakenhoff, R. H. (2011). The molecular biology of head and neck cancer. Nature Reviews. Cancer, 11, 9\u201322. doi: 10.1038\/nrc2982 .","journal-title":"Nature Reviews. Cancer"},{"key":"9685_CR5","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1126\/science.1206923","volume":"333","author":"N Agrawal","year":"2011","unstructured":"Agrawal, N., Frederick, M. J., Pickering, C. R., et al. (2011). Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science, 333, 1154\u20131157. doi: 10.1126\/science.1206923 .","journal-title":"Science"},{"key":"9685_CR6","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1126\/science.1235122","volume":"339","author":"B Vogelstein","year":"2013","unstructured":"Vogelstein, B., Papadopoulos, N., Velculescu, V. E., et al. (2013). Cancer genome landscapes. Science, 339, 1546\u20131558. doi: 10.1126\/science.1235122 .","journal-title":"Science"},{"key":"9685_CR7","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1126\/science.1208130","volume":"333","author":"N Stransky","year":"2011","unstructured":"Stransky, N., Egloff, A. M., Tward, A. D., et al. (2011). The mutational landscape of head and neck squamous cell carcinoma. Science, 333, 1157\u20131160. doi: 10.1126\/science.1208130 .","journal-title":"Science"},{"key":"9685_CR8","doi-asserted-by":"publisher","unstructured":"(2015). Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature, 517, 576\u2013582. doi: 10.1038\/nature14129 .","DOI":"10.1038\/nature14129"},{"key":"9685_CR9","doi-asserted-by":"publisher","first-page":"e302","DOI":"10.1016\/S1470-2045(13)70085-8","volume":"14","author":"B Burtness","year":"2013","unstructured":"Burtness, B., Bauman, J. E., & Galloway, T. (2013). Novel targets in HPV-negative head and neck cancer: overcoming resistance to EGFR inhibition. The Lancet Oncology, 14, e302\u2013e309. doi: 10.1016\/S1470-2045(13)70085-8 .","journal-title":"The Lancet Oncology"},{"key":"9685_CR10","doi-asserted-by":"publisher","first-page":"8418","DOI":"10.1158\/1078-0432.CCR-05-1247","volume":"11","author":"EEW Cohen","year":"2005","unstructured":"Cohen, E. E. W., Kane, M. A., List, M. A., et al. (2005). Phase II trial of gefitinib 250 mg daily in patients with recurrent and\/or metastatic squamous cell carcinoma of the head and neck. Clinical Cancer Research, 11, 8418\u20138424. doi: 10.1158\/1078-0432.CCR-05-1247 .","journal-title":"Clinical Cancer Research"},{"key":"9685_CR11","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1200\/JCO.2004.06.075","volume":"22","author":"D Soulieres","year":"2004","unstructured":"Soulieres, D., Senzer, N. N., Vokes, E. E., et al. (2004). Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. Journal of Clinical Oncology, 22, 77\u201385. doi: 10.1200\/JCO.2004.06.075 .","journal-title":"Journal of Clinical Oncology"},{"key":"9685_CR12","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.mayocp.2015.12.017","volume":"91","author":"S Marur","year":"2016","unstructured":"Marur, S., & Forastiere, A. A. (2016). Head and neck squamous cell carcinoma: update on epidemiology, diagnosis, and treatment. Mayo Clinic Proceedings, 91, 386\u2013396. doi: 10.1016\/j.mayocp.2015.12.017 .","journal-title":"Mayo Clinic Proceedings"},{"key":"9685_CR13","doi-asserted-by":"publisher","first-page":"F12","DOI":"10.1016\/j.vaccine.2012.07.055","volume":"5","author":"D Forman","year":"2012","unstructured":"Forman, D., de Martel, C., Lacey, C. J., et al. (2012). Global burden of human papillomavirus and related diseases. Vaccine 30. Supplement, 5, F12\u2013F23. doi: 10.1016\/j.vaccine.2012.07.055 .","journal-title":"Supplement"},{"key":"9685_CR14","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1002\/cncr.22963","volume":"110","author":"EM Sturgis","year":"2007","unstructured":"Sturgis, E. M., & Cinciripini, P. M. (2007). Trends in head and neck cancer incidence in relation to smoking prevalence. Cancer, 110, 1429\u20131435. doi: 10.1002\/cncr.22963 .","journal-title":"Cancer"},{"key":"9685_CR15","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1001\/jama.2012.101","volume":"307","author":"ML Gillison","year":"2012","unstructured":"Gillison, M. L., Broutian, T., Pickard, R. K. L., et al. (2012). Prevalence of oral HPV infection in the United States, 2009\u20132010. JAMA, 307, 693\u2013703. doi: 10.1001\/jama.2012.101 .","journal-title":"JAMA"},{"key":"9685_CR16","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/jnci\/djn011","volume":"100","author":"C Fakhry","year":"2008","unstructured":"Fakhry, C., Westra, W. H., Li, S., et al. (2008). Improved survival of patients with human papillomavirus\u2013positive head and neck squamous cell carcinoma in a prospective clinical trial. JNCI J Natl Cancer Inst, 100, 261\u2013269. doi: 10.1093\/jnci\/djn011 .","journal-title":"JNCI J Natl Cancer Inst"},{"key":"9685_CR17","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/S1470-2045(10)70017-6","volume":"11","author":"S Marur","year":"2010","unstructured":"Marur, S., D\u2019Souza, G., Westra, W. H., & Forastiere, A. A. (2010). HPV-associated head and neck cancer: a virus-related cancer epidemic. The Lancet Oncology, 11, 781\u2013789. doi: 10.1016\/S1470-2045(10)70017-6 .","journal-title":"The Lancet Oncology"},{"key":"9685_CR18","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/gm453","volume":"5","author":"M Lechner","year":"2013","unstructured":"Lechner, M., Frampton, G. M., Fenton, T., et al. (2013). Targeted next-generation sequencing of head and neck squamous cell carcinoma identifies novel genetic alterations in HPV+ and HPV- tumors. Genome Medicine, 5, 49. doi: 10.1186\/gm453 .","journal-title":"Genome Medicine"},{"key":"9685_CR19","first-page":"5452","volume":"59","author":"YMD Lo","year":"1999","unstructured":"Lo, Y. M. D., Chan, L. Y. S., Chan, A. T. C., et al. (1999). Quantitative and temporal correlation between circulating cell-free Epstein-Barr virus DNA and tumor recurrence in nasopharyngeal carcinoma. Cancer Research, 59, 5452\u20135455.","journal-title":"Cancer Research"},{"key":"9685_CR20","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1007\/s00405-013-2805-5","volume":"271","author":"P Sun","year":"2014","unstructured":"Sun, P., Chen, C., Cheng, Y.-K., et al. (2014). Serologic biomarkers of Epstein-Barr virus correlate with TNM classification according to the seventh edition of the UICC\/AJCC staging system for nasopharyngeal carcinoma. Eur Arch Oto-Rhino-Laryngol Off J Eur Fed Oto-Rhino-Laryngol Soc EUFOS Affil Ger Soc Oto-Rhino-Laryngol - Head Neck Surg, 271, 2545\u20132554. doi: 10.1007\/s00405-013-2805-5 .","journal-title":"Eur Arch Oto-Rhino-Laryngol Off J Eur Fed Oto-Rhino-Laryngol Soc EUFOS Affil Ger Soc Oto-Rhino-Laryngol - Head Neck Surg"},{"key":"9685_CR21","doi-asserted-by":"crossref","first-page":"596","DOI":"10.6004\/jnccn.2011.0053","volume":"9","author":"DG Pfister","year":"2011","unstructured":"Pfister, D. G., Ang, K.-K., Brizel, D. M., et al. (2011). Head and neck cancers. Journal of the National Comprehensive Cancer Network, 9, 596\u2013650.","journal-title":"Journal of the National Comprehensive Cancer Network"},{"key":"9685_CR22","doi-asserted-by":"crossref","first-page":"917","DOI":"10.6004\/jnccn.2013.0113","volume":"11","author":"DG Pfister","year":"2013","unstructured":"Pfister, D. G., Ang, K.-K., Brizel, D. M., et al. (2013). Head and neck cancers, version 2.2013. Journal of the National Comprehensive Cancer Network, 11, 917\u2013923.","journal-title":"Journal of the National Comprehensive Cancer Network"},{"key":"9685_CR23","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1056\/NEJMoa0912217","volume":"363","author":"KK Ang","year":"2010","unstructured":"Ang, K. K., Harris, J., Wheeler, R., et al. (2010). Human papillomavirus and survival of patients with Oropharyngeal cancer. The New England Journal of Medicine, 363, 24\u201335. doi: 10.1056\/NEJMoa0912217 .","journal-title":"The New England Journal of Medicine"},{"key":"9685_CR24","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1200\/JCO.2012.44.0164","volume":"31","author":"B O\u2019Sullivan","year":"2013","unstructured":"O\u2019Sullivan, B., Huang, S. H., Siu, L. L., et al. (2013). Deintensification candidate subgroups in human papillomavirus\u2013related oropharyngeal cancer according to minimal risk of distant metastasis. Journal of Clinical Oncology, 31, 543\u2013550. doi: 10.1200\/JCO.2012.44.0164 .","journal-title":"Journal of Clinical Oncology"},{"key":"9685_CR25","doi-asserted-by":"publisher","first-page":"6005","DOI":"10.1200\/jco.2013.31.15_suppl.6005","volume":"31","author":"S Marur","year":"2013","unstructured":"Marur, S., Li, S., Cmelak, A., et al. (2013). E 1308: a phase II trial of induction chemotherapy (IC) followed by cetuximab with low dose versus standard dose IMRT in patients with human papilloma virus (HPV)-associated resectable squamous cell carcinoma of the oropharynx (OPSCC). Journal of Clinical Oncology, 31, 6005\u20136005. doi: 10.1200\/jco.2013.31.15_suppl.6005 .","journal-title":"Journal of Clinical Oncology"},{"key":"9685_CR26","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1016\/j.ejca.2014.07.001","volume":"50","author":"L Masterson","year":"2014","unstructured":"Masterson, L., Moualed, D., Liu, Z. W., et al. (2014). De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma: a systematic review and meta-analysis of current clinical trials. European Journal of Cancer, 50, 2636\u20132648. doi: 10.1016\/j.ejca.2014.07.001 .","journal-title":"European Journal of Cancer"},{"key":"9685_CR27","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/S1368-8375(00)00066-X","volume":"37","author":"LP Kowalski","year":"2001","unstructured":"Kowalski, L. P., & Carvalho, A. L. (2001). Influence of time delay and clinical upstaging in the prognosis of head and neck cancer. Oral Oncology, 37, 94\u201398. doi: 10.1016\/S1368-8375(00)00066-X .","journal-title":"Oral Oncology"},{"key":"9685_CR28","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1002\/1097-0142(19890815)64:4<932::AID-CNCR2820640428>3.0.CO;2-Y","volume":"64","author":"J Guggenheimer","year":"1989","unstructured":"Guggenheimer, J., Verbin, R. S., Johnson, J. T., et al. (1989). Factors delaying the diagnosis of oral and oropharyngeal carcinomas. Cancer, 64, 932\u2013935. doi: 10.1002\/1097-0142(19890815)64:4<932::AID-CNCR2820640428>3.0.CO;2-Y .","journal-title":"Cancer"},{"key":"9685_CR29","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S1368-8375(97)00088-2","volume":"34","author":"P Allison","year":"1998","unstructured":"Allison, P., Franco, E., Black, M., & Feine, J. (1998). The role of professional diagnostic delays in the prognosis of upper aerodigestive tract carcinoma. Oral Oncology, 34, 147\u2013153. doi: 10.1016\/S1368-8375(97)00088-2 .","journal-title":"Oral Oncology"},{"key":"9685_CR30","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1056\/NEJMoa1113205","volume":"366","author":"M Gerlinger","year":"2012","unstructured":"Gerlinger, M., Rowan, A. J., Horswell, S., et al. (2012). Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. The New England Journal of Medicine, 366, 883\u2013892. doi: 10.1056\/NEJMoa1113205 .","journal-title":"The New England Journal of Medicine"},{"key":"9685_CR31","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1126\/science.278.5340.1054","volume":"278","author":"D Sidransky","year":"1997","unstructured":"Sidransky, D. (1997). Nucleic acid-based methods for the detection of cancer. Science, 278, 1054\u20131058. doi: 10.1126\/science.278.5340.1054 .","journal-title":"Science"},{"key":"9685_CR32","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1126\/science.2024123","volume":"252","author":"D Sidransky","year":"1991","unstructured":"Sidransky, D., Von Eschenbach, A., Tsai, Y. C., et al. (1991). Identification of p53 gene mutations in bladder cancers and urine samples. Science, 252, 706\u2013709.","journal-title":"Science"},{"key":"9685_CR33","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1126\/science.1566048","volume":"256","author":"D Sidransky","year":"1992","unstructured":"Sidransky, D., Tokino, T., Hamilton, S. R., et al. (1992). Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors. Science, 256, 102\u2013105.","journal-title":"Science"},{"key":"9685_CR34","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/S0002-9610(05)80092-3","volume":"168","author":"JO Boyle","year":"1994","unstructured":"Boyle, J. O., Mao, L., Brennan, J. A., et al. (1994). Gene mutations in saliva as molecular markers for head and neck squamous cell carcinomas. American Journal of Surgery, 168, 429\u2013432. doi: 10.1016\/S0002-9610(05)80092-3 .","journal-title":"American Journal of Surgery"},{"key":"9685_CR35","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/S0140-6736(97)02174-0","volume":"350","author":"YMD Lo","year":"1997","unstructured":"Lo, Y. M. D., Corbetta, N., Chamberlain, P. F., et al. (1997). Presence of fetal DNA in maternal plasma and serum. The Lancet, 350, 485\u2013487. doi: 10.1016\/S0140-6736(97)02174-0 .","journal-title":"The Lancet"},{"key":"9685_CR36","doi-asserted-by":"publisher","first-page":"16266","DOI":"10.1073\/pnas.0808319105","volume":"105","author":"HC Fan","year":"2008","unstructured":"Fan, H. C., Blumenfeld, Y. J., Chitkara, U., et al. (2008). Noninvasive diagnosis of fetal aneuploidy by shotgun sequencing DNA from maternal blood. Proceedings of the National Academy of Sciences, 105, 16266\u201316271. doi: 10.1073\/pnas.0808319105 .","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"9685_CR37","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1196\/annals.1368.037","volume":"1075","author":"D Antonatos","year":"2006","unstructured":"Antonatos, D., Patsilinakos, S., Spanodimos, S., et al. (2006). Cell-free DNA levels as a prognostic marker in acute myocardial infarction. Annals of the New York Academy of Sciences, 1075, 278\u2013281. doi: 10.1196\/annals.1368.037 .","journal-title":"Annals of the New York Academy of Sciences"},{"key":"9685_CR38","doi-asserted-by":"publisher","unstructured":"A D, C V, D A, et al (2009) Cell-free DNA levels in acute myocardial infarction patients during hospitalization. Acta Cardiologica 64:51\u201357. doi: 10.2143\/AC.64.1.2034362 .","DOI":"10.2143\/AC.64.1.2034362"},{"key":"9685_CR39","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.cca.2012.08.001","volume":"414","author":"H Macher","year":"2012","unstructured":"Macher, H., Egea-Guerrero, J. J., Revuelto-Rey, J., et al. (2012). Role of early cell-free DNA levels decrease as a predictive marker of fatal outcome after severe traumatic brain injury. Clinica Chimica Acta, 414, 12\u201317. doi: 10.1016\/j.cca.2012.08.001 .","journal-title":"Clinica Chimica Acta"},{"key":"9685_CR40","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.cca.2010.11.036","volume":"412","author":"N-W Tsai","year":"2011","unstructured":"Tsai, N.-W., Lin, T.-K., Chen, S.-D., et al. (2011). The value of serial plasma nuclear and mitochondrial DNA levels in patients with acute ischemic stroke. Clinica Chimica Acta, 412, 476\u2013479. doi: 10.1016\/j.cca.2010.11.036 .","journal-title":"Clinica Chimica Acta"},{"key":"9685_CR41","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/25292","volume":"396","author":"C Lengauer","year":"1998","unstructured":"Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1998). Genetic instabilities in human cancers. Nature, 396, 643\u2013649. doi: 10.1038\/25292 .","journal-title":"Nature"},{"key":"9685_CR42","doi-asserted-by":"publisher","unstructured":"Leary RJ, Sausen M, Kinde I, et al (2012) Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing. Sci Transl med 4:162ra154\u2013162ra154. doi: 10.1126\/scitranslmed.3004742 .","DOI":"10.1126\/scitranslmed.3004742"},{"key":"9685_CR43","first-page":"1659","volume":"61","author":"S Jahr","year":"2001","unstructured":"Jahr, S., Hentze, H., Englisch, S., et al. (2001). DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Research, 61, 1659\u20131665.","journal-title":"Cancer Research"},{"key":"9685_CR44","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S0009-8981(01)00665-9","volume":"313","author":"M Stroun","year":"2001","unstructured":"Stroun, M., Lyautey, J., Lederrey, C., et al. (2001). About the possible origin and mechanism of circulating DNA: apoptosis and active DNA release. Clinica Chimica Acta, 313, 139\u2013142. doi: 10.1016\/S0009-8981(01)00665-9 .","journal-title":"Clinica Chimica Acta"},{"key":"9685_CR45","doi-asserted-by":"publisher","first-page":"224ra24","DOI":"10.1126\/scitranslmed.3007094","volume":"6","author":"C Bettegowda","year":"2014","unstructured":"Bettegowda, C., Sausen, M., Leary, R. J., et al. (2014). Detection of circulating tumor DNA in early- and late-stage human malignancies. Science Translational Medicine, 6, 224ra24. doi: 10.1126\/scitranslmed.3007094 .","journal-title":"Science Translational Medicine"},{"key":"9685_CR46","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1053\/j.gastro.2008.05.039","volume":"135","author":"F Diehl","year":"2008","unstructured":"Diehl, F., Schmidt, K., Durkee, K. H., et al. (2008). Analysis of mutations in DNA isolated from plasma and stool of colorectal cancer patients. Gastroenterology, 135, 489\u2013498.e7. doi: 10.1053\/j.gastro.2008.05.039 .","journal-title":"Gastroenterology"},{"key":"9685_CR47","doi-asserted-by":"publisher","unstructured":"Kinde I, Bettegowda C, Wang Y, et al (2013) Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers. Sci Transl med 5:167ra4\u2013167ra4. doi: 10.1126\/scitranslmed.3004952 .","DOI":"10.1126\/scitranslmed.3004952"},{"key":"9685_CR48","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1038\/nm.1789","volume":"14","author":"F Diehl","year":"2008","unstructured":"Diehl, F., Schmidt, K., Choti, M. A., et al. (2008). Circulating mutant DNA to assess tumor dynamics. Nature Medicine, 14, 985\u2013990. doi: 10.1038\/nm.1789 .","journal-title":"Nature Medicine"},{"key":"9685_CR49","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1093\/jnci\/djp240","volume":"101","author":"M Holdhoff","year":"2009","unstructured":"Holdhoff, M., Schmidt, K., Donehower, R., & Diaz, L. A. (2009). Analysis of circulating tumor DNA to confirm somatic KRAS mutations. JNCI J Natl Cancer Inst, 101, 1284\u20131285. doi: 10.1093\/jnci\/djp240 .","journal-title":"JNCI J Natl Cancer Inst"},{"key":"9685_CR50","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1200\/JCO.2012.45.2011","volume":"32","author":"LA Diaz","year":"2014","unstructured":"Diaz, L. A., & Bardelli, A. (2014). Liquid biopsies: genotyping circulating tumor DNA. Journal of Clinical Oncology, 32, 579\u2013586. doi: 10.1200\/JCO.2012.45.2011 .","journal-title":"Journal of Clinical Oncology"},{"key":"9685_CR51","doi-asserted-by":"publisher","first-page":"9236","DOI":"10.1073\/pnas.96.16.9236","volume":"96","author":"B Vogelstein","year":"1999","unstructured":"Vogelstein, B., & Kinzler, K. W. (1999). Digital PCR. Proceedings of the National Academy of Sciences, 96, 9236\u20139241. doi: 10.1073\/pnas.96.16.9236 .","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"9685_CR52","doi-asserted-by":"publisher","first-page":"8817","DOI":"10.1073\/pnas.1133470100","volume":"100","author":"D Dressman","year":"2003","unstructured":"Dressman, D., Yan, H., Traverso, G., et al. (2003). Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations. Proceedings of the National Academy of Sciences, 100, 8817\u20138822. doi: 10.1073\/pnas.1133470100 .","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"9685_CR53","doi-asserted-by":"crossref","unstructured":"Liu Q, Sommer SS (2000) Pyrophosphorolysis-activated polymerization (PAP): application to allele-specific amplification. BioTechniques 29:1072\u20131076, 1078, 1080 passim.","DOI":"10.2144\/00295rr03"},{"key":"9685_CR54","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1002\/hed.21941","volume":"34","author":"AC Nichols","year":"2012","unstructured":"Nichols, A. C., Lowes, L. E., Szeto, C. C. T., et al. (2012). Detection of circulating tumor cells in advanced head and neck cancer using the CellSearch system. Head & Neck, 34, 1440\u20131444. doi: 10.1002\/hed.21941 .","journal-title":"Head & Neck"},{"key":"9685_CR55","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1007\/s12032-015-0579-x","volume":"32","author":"Z Wang","year":"2015","unstructured":"Wang, Z., Cui, K., Xue, Y., et al. (2015). Prognostic value of circulating tumor cells in patients with squamous cell carcinoma of the head and neck: a systematic review and meta-analysis. Med Oncol Northwood Lond Engl, 32, 164. doi: 10.1007\/s12032-015-0579-x .","journal-title":"Med Oncol Northwood Lond Engl"},{"key":"9685_CR56","doi-asserted-by":"publisher","first-page":"16368","DOI":"10.1073\/pnas.0507904102","volume":"102","author":"F Diehl","year":"2005","unstructured":"Diehl, F., Li, M., Dressman, D., et al. (2005). Detection and quantification of mutations in the plasma of patients with colorectal tumors. Proceedings of the National Academy of Sciences of the United States of America, 102, 16368\u201316373. doi: 10.1073\/pnas.0507904102 .","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"9685_CR57","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/nmeth850","volume":"3","author":"M Li","year":"2006","unstructured":"Li, M., Diehl, F., Dressman, D., et al. (2006). BEAMing up for detection and quantification of rare sequence variants. Nature Methods, 3, 95\u201397. doi: 10.1038\/nmeth850 .","journal-title":"Nature Methods"},{"key":"9685_CR58","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1136\/gutjnl-2014-308859","volume":"65","author":"T Reinert","year":"2016","unstructured":"Reinert, T., Sch\u00f8ler, L. V., Thomsen, R., et al. (2016). Analysis of circulating tumour DNA to monitor disease burden following colorectal cancer surgery. Gut, 65, 625\u2013634. doi: 10.1136\/gutjnl-2014-308859 .","journal-title":"Gut"},{"key":"9685_CR59","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1093\/jjco\/hyf011","volume":"32","author":"K Ito","year":"2002","unstructured":"Ito, K., Hibi, K., Ando, H., et al. (2002). Usefulness of analytical CEA doubling time and half-life time for overlooked synchronous metastases in colorectal carcinoma. Japanese Journal of Clinical Oncology, 32, 54\u201358. doi: 10.1093\/jjco\/hyf011 .","journal-title":"Japanese Journal of Clinical Oncology"},{"key":"9685_CR60","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/172460089901400207","volume":"14","author":"T Yoshimasu","year":"1999","unstructured":"Yoshimasu, T., Maebeya, S., Suzuma, T., et al. (1999). Disappearance curves for tumor markers after resection of intrathoracic malignancies. The International Journal of Biological Markers, 14, 99\u2013105.","journal-title":"The International Journal of Biological Markers"},{"key":"9685_CR61","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1093\/annonc\/mdl120","volume":"17","author":"JM Riedinger","year":"2006","unstructured":"Riedinger, J. M., Wafflart, J., Ricolleau, G., et al. (2006). CA 125 half-life and CA 125 nadir during induction chemotherapy are independent predictors of epithelial ovarian cancer outcome: results of a French multicentric study. Annals of Oncology, 17, 1234\u20131238. doi: 10.1093\/annonc\/mdl120 .","journal-title":"Annals of Oncology"},{"key":"9685_CR62","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1056\/NEJMoa1213261","volume":"368","author":"S-J Dawson","year":"2013","unstructured":"Dawson, S.-J., Tsui, D. W. Y., Murtaza, M., et al. (2013). Analysis of circulating tumor DNA to monitor metastatic breast cancer. The New England Journal of Medicine, 368, 1199\u20131209. doi: 10.1056\/NEJMoa1213261 .","journal-title":"The New England Journal of Medicine"},{"key":"9685_CR63","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.1016\/j.ejca.2014.08.002","volume":"50","author":"TP McVeigh","year":"2014","unstructured":"McVeigh, T. P., Hughes, L. M., Miller, N., et al. (2014). The impact of Oncotype DX testing on breast cancer management and chemotherapy prescribing patterns in a tertiary referral centre. European Journal of Cancer, 50, 2763\u20132770. doi: 10.1016\/j.ejca.2014.08.002 .","journal-title":"European Journal of Cancer"},{"key":"9685_CR64","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.molonc.2014.12.003","volume":"9","author":"R Lebofsky","year":"2015","unstructured":"Lebofsky, R., Decraene, C., Bernard, V., et al. (2015). Circulating tumor DNA as a non-invasive substitute to metastasis biopsy for tumor genotyping and personalized medicine in a prospective trial across all tumor types. Molecular Oncology, 9, 783\u2013790. doi: 10.1016\/j.molonc.2014.12.003 .","journal-title":"Molecular Oncology"},{"key":"9685_CR65","doi-asserted-by":"publisher","first-page":"11198","DOI":"10.1038\/srep11198","volume":"5","author":"SC-H Tsao","year":"2015","unstructured":"Tsao, S. C.-H., Weiss, J., Hudson, C., et al. (2015). Monitoring response to therapy in melanoma by quantifying circulating tumour DNA with droplet digital PCR for BRAF and NRAS mutations. Scientific Reports, 5, 11198. doi: 10.1038\/srep11198 .","journal-title":"Scientific Reports"},{"key":"9685_CR66","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1001\/jamaoto.2014.1338","volume":"140","author":"SM Ahn","year":"2014","unstructured":"Ahn, S. M., Chan, J. Y. K., Zhang, Z., et al. (2014). Saliva and plasma quantitative polymerase chain reaction\u2013based detection and surveillance of human papillomavirus\u2013related head and neck cancer. JAMA Otolaryngol Neck Surg, 140, 846\u2013854. doi: 10.1001\/jamaoto.2014.1338 .","journal-title":"JAMA Otolaryngol Neck Surg"},{"key":"9685_CR67","doi-asserted-by":"publisher","unstructured":"Wang Y, Springer S, Mulvey CL, et al (2015) Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas. Sci Transl Med 7:293ra104. doi: 10.1126\/scitranslmed.aaa8507 .","DOI":"10.1126\/scitranslmed.aaa8507"}],"container-title":["Cancer and Metastasis Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10555-017-9685-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10555-017-9685-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10555-017-9685-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T06:19:41Z","timestamp":1569997181000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10555-017-9685-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,12]]},"references-count":67,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["9685"],"URL":"https:\/\/doi.org\/10.1007\/s10555-017-9685-x","relation":{},"ISSN":["0167-7659","1573-7233"],"issn-type":[{"value":"0167-7659","type":"print"},{"value":"1573-7233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,12]]}}}