{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:25:09Z","timestamp":1789457109824,"version":"build-2803163510"},"reference-count":172,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"This study was supported by JSPS (Japan Society for the Promotion of Science) KAKENHI Grants-in-Aid for Scientific Research: Grant Number","award":["21KK0296"],"award-info":[{"award-number":["21KK0296"]}]},{"name":"This study was supported by JSPS (Japan Society for the Promotion of Science) KAKENHI Grants-in-Aid for Scientific Research: Grant Number","award":["21KK0296"],"award-info":[{"award-number":["21KK0296"]}]},{"DOI":"10.13039\/501100001786","name":"The University of Adelaide","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001786","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Metastasis Rev"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Epithelial ovarian cancer (EOC) is often diagnosed in advanced stage with peritoneal dissemination. Recent studies indicate that aberrant accumulation of collagen fibers in tumor stroma has a variety of effects on tumor progression. We refer to remodeled fibrous stroma with altered expression of collagen molecules, increased stiffness, and highly oriented collagen fibers as tumor-associated fibrosis (TAF). TAF contributes to EOC cell invasion and metastasis in the intraperitoneal cavity. However, an understanding of molecular events involved is only just beginning to emerge. Further development in this field will lead to new strategies to treat EOC. In this review, we focus on the recent findings on how the TAF contributes to EOC malignancy. Furthermore, we will review the recent initiatives and future therapeutic strategies for targeting TAF in EOC.<\/jats:p>","DOI":"10.1007\/s10555-024-10169-8","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T02:02:31Z","timestamp":1711591351000},"page":"1037-1053","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Tumor-associated fibrosis: a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination"],"prefix":"10.1007","volume":"43","author":[{"given":"Hiroki","family":"Fujimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Yoshihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Rodgers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Iyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumasa","family":"Mogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiri","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sae","family":"Hayakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maia","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Kitami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaname","family":"Uno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Koya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Yamakita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Nawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Enomoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"Ricciardelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kajiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"issue":"1","key":"10169_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21590","volume":"70","author":"RL Siegel","year":"2020","unstructured":"Siegel, R. L., Miller, K. D., & Jemal, A. (2020). Cancer statistics, 2020. CA: A Cancer Journal for Clinicians, 70(1), 7\u201330. https:\/\/doi.org\/10.3322\/caac.21590","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"3","key":"10169_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71(3), 209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"10169_CR3","doi-asserted-by":"publisher","unstructured":"Buy, J. N., Moss, A. A., Ghossain, M. A., Sciot, C., Malbec, L., Vadrot, D., \u2026 Decroix, Y. (1988). Peritoneal implants from ovarian tumors: CT findings. Radiology, 169(3), 691\u2013694. https:\/\/doi.org\/10.1148\/radiology.169.3.3186993","DOI":"10.1148\/radiology.169.3.3186993"},{"issue":"3","key":"10169_CR4","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.ygyno.2013.09.013","volume":"131","author":"AB Arie","year":"2013","unstructured":"Arie, A. B., McNally, L., Kapp, D. S., & Teng, N. N. H. (2013). The omentum and omentectomy in epithelial ovarian cancer: A reappraisal: Part II\u2014The role of omentectomy in the staging and treatment of apparent early stage epithelial ovarian cancer. Gynecologic oncology, 131(3), 784\u2013790. https:\/\/doi.org\/10.1016\/j.ygyno.2013.09.013","journal-title":"Gynecologic oncology"},{"issue":"3","key":"10169_CR5","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.ygyno.2013.09.014","volume":"131","author":"A Ben Arie","year":"2013","unstructured":"Ben Arie, A., McNally, L., Kapp, D. S., & Teng, N. N. H. (2013). The omentum and omentectomy in epithelial ovarian cancer: A reappraisal. Part I\u2014Omental function and history of omentectomy. Gynecologic oncology, 131(3), 780\u2013783. https:\/\/doi.org\/10.1016\/j.ygyno.2013.09.014","journal-title":"Gynecologic oncology"},{"key":"10169_CR6","doi-asserted-by":"publisher","unstructured":"Heintz, A. P. M., Odicino, F., Maisonneuve, P., Quinn, M. A., Benedet, J. L., Creasman, W. T., \u2026 Beller, U. (2006). Carcinoma of the ovary. FIGO 26th annual report on the results of treatment in gynecological cancer. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 95 Suppl 1, S161\u201392. https:\/\/doi.org\/10.1016\/S0020-7292(06)60033-7","DOI":"10.1016\/S0020-7292(06)60033-7"},{"key":"10169_CR7","doi-asserted-by":"publisher","unstructured":"Amate, P., Huchon, C., Dessapt, A. L., Bensaid, C., Medioni, J., Le Fr\u00e8re Belda, M.-A., \u2026 L\u00e9curu, F. R. (2013). Ovarian cancer: Sites of recurrence. International journal of gynecological cancer: official journal of the International Gynecological Cancer Society, 23(9), 1590\u20131596. https:\/\/doi.org\/10.1097\/IGC.0000000000000007","DOI":"10.1097\/IGC.0000000000000007"},{"key":"10169_CR8","doi-asserted-by":"publisher","unstructured":"Gaitskell, K., Hermon, C., Barnes, I., Pirie, K., Floud, S., Green, J., \u2026 Reeves, G. K. (2022). Ovarian cancer survival by stage, histotype, and pre-diagnostic lifestyle factors, in the prospective UK Million Women Study. Cancer epidemiology, 76(102074), 102074. https:\/\/doi.org\/10.1016\/j.canep.2021.102074","DOI":"10.1016\/j.canep.2021.102074"},{"issue":"7353","key":"10169_CR9","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/nature10166","volume":"474","author":"Cancer Genome Atlas Research Network","year":"2011","unstructured":"Cancer Genome Atlas Research Network. (2011). Integrated genomic analyses of ovarian carcinoma. Nature, 474(7353), 609\u2013615. https:\/\/doi.org\/10.1038\/nature10166","journal-title":"Nature"},{"key":"10169_CR10","doi-asserted-by":"publisher","unstructured":"Tothill, R. W., Tinker, A. V., George, J., Brown, R., Fox, S. B., Lade, S., \u2026 Bowtell, D. D. L. (2008). Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome. Clinical cancer research: an official journal of the American Association for Cancer Research, 14(16), 5198\u20135208. https:\/\/doi.org\/10.1158\/1078-0432.CCR-08-0196","DOI":"10.1158\/1078-0432.CCR-08-0196"},{"key":"10169_CR11","doi-asserted-by":"publisher","unstructured":"Vargas, H. A., Micc\u00f2, M., Hong, S. I., Goldman, D. A., Dao, F., Weigelt, B., \u2026 Sala, E. (2015). Association between morphologic CT imaging traits and prognostically relevant gene signatures in women with high-grade serous ovarian cancer: a hypothesis-generating study. Radiology, 274(3), 742\u2013751. https:\/\/doi.org\/10.1148\/radiol.14141477","DOI":"10.1148\/radiol.14141477"},{"issue":"2","key":"10169_CR12","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.ygyno.2018.11.014","volume":"152","author":"Q Zhang","year":"2019","unstructured":"Zhang, Q., Wang, C., & Cliby, W. A. (2019). Cancer-associated stroma significantly contributes to the mesenchymal subtype signature of serous ovarian cancer. Gynecologic Oncology, 152(2), 368\u2013374. https:\/\/doi.org\/10.1016\/j.ygyno.2018.11.014","journal-title":"Gynecologic Oncology"},{"key":"10169_CR13","doi-asserted-by":"publisher","unstructured":"Xu, S., Xu, H., Wang, W., Li, S., Li, H., Li, T., \u2026 Liu, L. (2019). The role of collagen in cancer: from bench to bedside. Journal of Translational Medicine, 17(1), 309. https:\/\/doi.org\/10.1186\/s12967-019-2058-1","DOI":"10.1186\/s12967-019-2058-1"},{"issue":"7","key":"10169_CR14","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1152\/physiolgenomics.00158.2013","volume":"46","author":"B Rybinski","year":"2014","unstructured":"Rybinski, B., Franco-Barraza, J., & Cukierman, E. (2014). The wound healing, chronic fibrosis, and cancer progression triad. Physiological Genomics, 46(7), 223\u2013244. https:\/\/doi.org\/10.1152\/physiolgenomics.00158.2013","journal-title":"Physiological Genomics"},{"issue":"4","key":"10169_CR15","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/j.ajpath.2013.01.009","volume":"182","author":"JS Byun","year":"2013","unstructured":"Byun, J. S., & Gardner, K. (2013). Wounds that will not heal: Pervasive cellular reprogramming in cancer. The American Journal of Pathology, 182(4), 1055\u20131064. https:\/\/doi.org\/10.1016\/j.ajpath.2013.01.009","journal-title":"The American Journal of Pathology"},{"issue":"24","key":"10169_CR16","doi-asserted-by":"publisher","first-page":"4516","DOI":"10.1111\/febs.14586","volume":"285","author":"GM Sundaram","year":"2018","unstructured":"Sundaram, G. M., Quah, S., & Sampath, P. (2018). Cancer: The dark side of wound healing. The FEBS Journal, 285(24), 4516\u20134534. https:\/\/doi.org\/10.1111\/febs.14586","journal-title":"The FEBS Journal"},{"issue":"648","key":"10169_CR17","doi-asserted-by":"publisher","first-page":"eaay8690","DOI":"10.1126\/scisignal.aay8690","volume":"13","author":"L MacCarthy-Morrogh","year":"2020","unstructured":"MacCarthy-Morrogh, L., & Martin, P. (2020). The hallmarks of cancer are also the hallmarks of wound healing. Science Signaling, 13(648), eaay8690. https:\/\/doi.org\/10.1126\/scisignal.aay8690","journal-title":"Science Signaling"},{"key":"10169_CR18","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/s0065-230x(08)60341-3","volume":"16","author":"A Haddow","year":"1972","unstructured":"Haddow, A. (1972). Molecular repair, wound healing, and carcinogenesis: Tumor production a possible overhealing? Advances in Cancer Research, 16, 181\u2013234. https:\/\/doi.org\/10.1016\/s0065-230x(08)60341-3","journal-title":"Advances in Cancer Research"},{"issue":"8","key":"10169_CR19","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1038\/nrm2455","volume":"9","author":"M Sch\u00e4fer","year":"2008","unstructured":"Sch\u00e4fer, M., & Werner, S. (2008). Cancer as an overhealing wound: An old hypothesis revisited. Nature reviews. Molecular Cell Biology, 9(8), 628\u2013638. https:\/\/doi.org\/10.1038\/nrm2455","journal-title":"Nature reviews. Molecular Cell Biology"},{"issue":"Pt 23","key":"10169_CR20","doi-asserted-by":"publisher","first-page":"5591","DOI":"10.1242\/jcs.116392","volume":"125","author":"FR Balkwill","year":"2012","unstructured":"Balkwill, F. R., Capasso, M., & Hagemann, T. (2012). The tumor microenvironment at a glance. Journal of Cell Science, 125(Pt 23), 5591\u20135596. https:\/\/doi.org\/10.1242\/jcs.116392","journal-title":"Journal of Cell Science"},{"issue":"15","key":"10169_CR21","doi-asserted-by":"publisher","first-page":"2909","DOI":"10.1111\/febs.14842","volume":"286","author":"E Huet","year":"2019","unstructured":"Huet, E., Jaroz, C., Nguyen, H. Q., Belkacemi, Y., de la Taille, A., Stavrinides, V., & Whitaker, H. (2019). Stroma in normal and cancer wound healing. The FEBS Journal, 286(15), 2909\u20132920. https:\/\/doi.org\/10.1111\/febs.14842","journal-title":"The FEBS Journal"},{"issue":"1","key":"10169_CR22","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1042\/bst20160387","volume":"45","author":"B Erdogan","year":"2017","unstructured":"Erdogan, B., & Webb, D. J. (2017). Cancer-associated fibroblasts modulate growth factor signaling and extracellular matrix remodeling to regulate tumor metastasis. Biochemical Society Transactions, 45(1), 229\u2013236. https:\/\/doi.org\/10.1042\/bst20160387","journal-title":"Biochemical Society Transactions"},{"issue":"4","key":"10169_CR23","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1055\/s-2006-948556","volume":"24","author":"C Ricciardelli","year":"2006","unstructured":"Ricciardelli, C., & Rodgers, R. J. (2006). Extracellular matrix of ovarian tumors. Seminars in Reproductive Medicine, 24(4), 270\u2013282. https:\/\/doi.org\/10.1055\/s-2006-948556","journal-title":"Seminars in Reproductive Medicine"},{"issue":"12","key":"10169_CR24","doi-asserted-by":"publisher","first-page":"a005058","DOI":"10.1101\/cshperspect.a005058","volume":"3","author":"P Lu","year":"2011","unstructured":"Lu, P., Takai, K., Weaver, V. M., & Werb, Z. (2011). Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harbor Perspectives in Biology, 3(12), a005058\u2013a005058. https:\/\/doi.org\/10.1101\/cshperspect.a005058","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"issue":"1","key":"10169_CR25","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.cell.2010.03.015","volume":"141","author":"K Kessenbrock","year":"2010","unstructured":"Kessenbrock, K., Plaks, V., & Werb, Z. (2010). Matrix metalloproteinases: Regulators of the tumor microenvironment. Cell, 141(1), 52\u201367. https:\/\/doi.org\/10.1016\/j.cell.2010.03.015","journal-title":"Cell"},{"issue":"7","key":"10169_CR26","doi-asserted-by":"publisher","first-page":"3403","DOI":"10.3390\/ijms22073403","volume":"22","author":"P Carey","year":"2021","unstructured":"Carey, P., Low, E., Harper, E., & Stack, M. S. (2021). Metalloproteinases in ovarian cancer. International Journal of Molecular Sciences, 22(7), 3403. https:\/\/doi.org\/10.3390\/ijms22073403","journal-title":"International Journal of Molecular Sciences"},{"issue":"2","key":"10169_CR27","doi-asserted-by":"publisher","first-page":"R55","DOI":"10.1530\/REP-14-0546","volume":"150","author":"L Al-Alem","year":"2015","unstructured":"Al-Alem, L., & Curry, T. E., Jr. (2015). Ovarian cancer: Involvement of the matrix metalloproteinases. Reproduction, 150(2), R55-64. https:\/\/doi.org\/10.1530\/REP-14-0546","journal-title":"Reproduction"},{"key":"10169_CR28","unstructured":"Belotti, D., Paganoni, P., Manenti, L., Garofalo, A., Marchini, S., Taraboletti, G., & Giavazzi, R. (2003). Matrix metalloproteinases (MMP9 and MMP2) induce the release of vascular endothelial growth factor (VEGF) by ovarian carcinoma cells: implications for ascites formation. Cancer research, 63(17), 5224\u20135229. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14500349. Accessed 22 Aug 2023"},{"issue":"5","key":"10169_CR29","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.ceb.2004.07.010","volume":"16","author":"JD Mott","year":"2004","unstructured":"Mott, J. D., & Werb, Z. (2004). Regulation of matrix biology by matrix metalloproteinases. Current Opinion in Cell Biology, 16(5), 558\u2013564. https:\/\/doi.org\/10.1016\/j.ceb.2004.07.010","journal-title":"Current Opinion in Cell Biology"},{"issue":"2","key":"10169_CR30","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1101\/gad.14.2.163","volume":"14","author":"Q Yu","year":"2000","unstructured":"Yu, Q., & Stamenkovic, I. (2000). Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-\u03b2 and promotes tumor invasion and angiogenesis. Genes & Development, 14(2), 163\u2013176. https:\/\/doi.org\/10.1101\/gad.14.2.163","journal-title":"Genes & Development"},{"issue":"1","key":"10169_CR31","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s13770-016-0007-0","volume":"14","author":"L Cai","year":"2017","unstructured":"Cai, L., Xiong, X., Kong, X., & Xie, J. (2017). The role of the lysyl oxidases in tissue repair and remodeling: A concise review. Tissue Engineering and Regenerative Medicine, 14(1), 15\u201330. https:\/\/doi.org\/10.1007\/s13770-016-0007-0","journal-title":"Tissue Engineering and Regenerative Medicine"},{"issue":"3","key":"10169_CR32","doi-asserted-by":"publisher","first-page":"491","DOI":"10.3390\/cancers13030491","volume":"13","author":"YFI Setargew","year":"2021","unstructured":"Setargew, Y. F. I., Wyllie, K., Grant, R. D., Chitty, J. L., & Cox, T. R. (2021). Targeting lysyl oxidase family meditated matrix cross-linking as an anti-stromal therapy in solid tumours. Cancers, 13(3), 491. https:\/\/doi.org\/10.3390\/cancers13030491","journal-title":"Cancers"},{"issue":"1","key":"10169_CR33","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.ygyno.2017.05.001","volume":"146","author":"M De Donato","year":"2017","unstructured":"De Donato, M., Petrillo, M., Martinelli, E., Filippetti, F., Zannoni, G. F., Scambia, G., & Gallo, D. (2017). Uncovering the role of nuclear Lysyl oxidase (LOX) in advanced high grade serous ovarian cancer. Gynecologic Oncology, 146(1), 170\u2013178. https:\/\/doi.org\/10.1016\/j.ygyno.2017.05.001","journal-title":"Gynecologic Oncology"},{"key":"10169_CR34","doi-asserted-by":"publisher","unstructured":"Ji, F., Wang, Y., Qiu, L., Li, S., Zhu, J., Liang, Z., \u2026 Di, W. (2013). Hypoxia inducible factor 1\u03b1-mediated LOX expression correlates with migration and invasion in epithelial ovarian cancer. International Journal of Oncology, 42(5), 1578\u20131588. https:\/\/doi.org\/10.3892\/ijo.2013.1878","DOI":"10.3892\/ijo.2013.1878"},{"issue":"5","key":"10169_CR35","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.3892\/or.2014.3448","volume":"32","author":"Y Wang","year":"2014","unstructured":"Wang, Y., Ma, J., Shen, H., Wang, C., Sun, Y., Howell, S. B., & Lin, X. (2014). Reactive oxygen species promote ovarian cancer progression via the HIF-1\u03b1\/LOX\/E-cadherin pathway. Oncology Reports, 32(5), 2150\u20132158. https:\/\/doi.org\/10.3892\/or.2014.3448","journal-title":"Oncology Reports"},{"issue":"12","key":"10169_CR36","doi-asserted-by":"publisher","first-page":"e23538","DOI":"10.1002\/jcla.23538","volume":"34","author":"M Ye","year":"2020","unstructured":"Ye, M., Zhou, J., Gao, Y., Pan, S., & Zhu, X. (2020). The prognostic value of the lysyl oxidase family in ovarian cancer. Journal of Clinical Laboratory Analysis, 34(12), e23538. https:\/\/doi.org\/10.1002\/jcla.23538","journal-title":"Journal of Clinical Laboratory Analysis"},{"issue":"4","key":"10169_CR37","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.3390\/cancers14041049","volume":"14","author":"S Ishihara","year":"2022","unstructured":"Ishihara, S., & Haga, H. (2022). Matrix stiffness contributes to cancer progression by regulating transcription factors. Cancers, 14(4), 1049. https:\/\/doi.org\/10.3390\/cancers14041049","journal-title":"Cancers"},{"key":"10169_CR38","doi-asserted-by":"publisher","unstructured":"Ouellette, J. N., Drifka, C. R., Pointer, K. B., Liu, Y., Lieberthal, T. J., Kao, W. J., \u2026 Eliceiri, K. W. (2021). Navigating the collagen jungle: The biomedical potential of fiber organization in cancer. Bioengineering (Basel, Switzerland), 8(2), 17. https:\/\/doi.org\/10.3390\/bioengineering8020017","DOI":"10.3390\/bioengineering8020017"},{"issue":"1","key":"10169_CR39","doi-asserted-by":"publisher","first-page":"a004978","DOI":"10.1101\/cshperspect.a004978","volume":"3","author":"S Ricard-Blum","year":"2011","unstructured":"Ricard-Blum, S. (2011). The collagen family. Cold Spring Harbor Perspectives in Biology, 3(1), a004978. https:\/\/doi.org\/10.1101\/cshperspect.a004978","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"issue":"101704","key":"10169_CR40","doi-asserted-by":"publisher","first-page":"101704","DOI":"10.1016\/j.tice.2021.101704","volume":"74","author":"M Sarwar","year":"2022","unstructured":"Sarwar, M., Sykes, P. H., Chitcholtan, K., & Evans, J. J. (2022). Collagen I dysregulation is pivotal for ovarian cancer progression. Tissue & cell, 74(101704), 101704. https:\/\/doi.org\/10.1016\/j.tice.2021.101704","journal-title":"Tissue & cell"},{"key":"10169_CR41","doi-asserted-by":"publisher","unstructured":"Liu, M., Zhang, X., Long, C., Xu, H., Cheng, X., Chang, J., \u2026 Wang, X. (2018). Collagen-based three-dimensional culture microenvironment promotes epithelial to mesenchymal transition and drug resistance of human ovarian cancer in vitro. RSC Advances, 8(16), 8910\u20138919. https:\/\/doi.org\/10.1039\/c7ra13742g","DOI":"10.1039\/c7ra13742g"},{"key":"10169_CR42","doi-asserted-by":"publisher","unstructured":"Wang, M., Wang, J., Liu, J., Zhu, L., Ma, H., Zou, J., \u2026 Wang, K. (2020). Systematic prediction of key genes for ovarian cancer by co-expression network analysis. Journal of Cellular and Molecular Medicine, 24(11), 6298\u20136307. https:\/\/doi.org\/10.1111\/jcmm.15271","DOI":"10.1111\/jcmm.15271"},{"key":"10169_CR43","doi-asserted-by":"publisher","unstructured":"Ganapathi, M. K., Jones, W. D., Sehouli, J., Michener, C. M., Braicu, I. E., Norris, E. J., \u2026 Ganapathi, R. N. (2016). Expression profile of COL2A1 and the pseudogene SLC6A10P predicts tumor recurrence in high-grade serous ovarian cancer. International journal of cancer. Journal International du Cancer, 138(3), 679\u2013688. https:\/\/doi.org\/10.1002\/ijc.29815","DOI":"10.1002\/ijc.29815"},{"key":"10169_CR44","doi-asserted-by":"publisher","unstructured":"Clarke, C. J., Berg, T. J., Birch, J., Ennis, D., Mitchell, L., Cloix, C., \u2026 Norman, J. C. (2016). The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis. Current Biology: CB, 26(6), 755\u2013765. https:\/\/doi.org\/10.1016\/j.cub.2016.01.045","DOI":"10.1016\/j.cub.2016.01.045"},{"key":"10169_CR45","doi-asserted-by":"publisher","unstructured":"Kenny, H. A., Krausz, T., Yamada, S. D., & Lengyel, E. (2007). Use of a novel 3D culture model to elucidate the role of mesothelial cells, fibroblasts and extra-cellular matrices on adhesion and invasion of ovarian cancer cells to the omentum. International journal of cancer. Journal International du Cancer, 121(7), 1463\u20131472. https:\/\/doi.org\/10.1002\/ijc.22874","DOI":"10.1002\/ijc.22874"},{"issue":"1","key":"10169_CR46","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.ygyno.2004.06.046","volume":"95","author":"JK Bar","year":"2004","unstructured":"Bar, J. K., Grelewski, P., Popiela, A., Noga, L., & Rabczy\u00f1ski, J. (2004). Type IV collagen and CD44v6 expression in benign, malignant primary and metastatic ovarian tumors: Correlation with Ki-67 and p53 immunoreactivity. Gynecologic Oncology, 95(1), 23\u201331. https:\/\/doi.org\/10.1016\/j.ygyno.2004.06.046","journal-title":"Gynecologic Oncology"},{"key":"10169_CR47","doi-asserted-by":"publisher","unstructured":"Anttila, M., Kosma, V. M., Ji, H., Wei-Ling, X., Puolakka, J., Juhola, M., \u2026 Syrj\u00e4nen, K. (1998). Clinical significance of alpha-catenin, collagen IV, and Ki-67 expression in epithelial ovarian cancer. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 16(8), 2591\u20132600. https:\/\/doi.org\/10.1200\/JCO.1998.16.8.2591","DOI":"10.1200\/JCO.1998.16.8.2591"},{"issue":"4","key":"10169_CR48","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1158\/0008-5472.can-03-2928","volume":"64","author":"W-L Yang","year":"2004","unstructured":"Yang, W.-L., Godwin, A. K., & Xu, X.-X. (2004). Tumor necrosis factor-alpha-induced matrix proteolytic enzyme production and basement membrane remodeling by human ovarian surface epithelial cells: Molecular basis linking ovulation and cancer risk. Cancer Research, 64(4), 1534\u20131540. https:\/\/doi.org\/10.1158\/0008-5472.can-03-2928","journal-title":"Cancer Research"},{"issue":"1","key":"10169_CR49","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1158\/1541-7786.MCR-14-0334","volume":"13","author":"CW Brown","year":"2015","unstructured":"Brown, C. W., Brodsky, A. S., & Freiman, R. N. (2015). Notch3 overexpression promotes anoikis resistance in epithelial ovarian cancer via upregulation of COL4A2. Molecular Cancer Research: MCR, 13(1), 78\u201385. https:\/\/doi.org\/10.1158\/1541-7786.MCR-14-0334","journal-title":"Molecular Cancer Research: MCR"},{"key":"10169_CR50","doi-asserted-by":"publisher","unstructured":"Uno, K., Iyoshi, S., Yoshihara, M., Kitami, K., Mogi, K., Fujimoto, H., \u2026 Kajiyama, H. (2022). Metastatic voyage of ovarian cancer cells in ascites with the assistance of various cellular components. International Journal of Molecular Sciences, 23(8), 4383. https:\/\/doi.org\/10.3390\/ijms23084383","DOI":"10.3390\/ijms23084383"},{"issue":"7","key":"10169_CR51","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.molmed.2013.04.001","volume":"19","author":"P Chen","year":"2013","unstructured":"Chen, P., Cescon, M., & Bonaldo, P. (2013). Collagen VI in cancer and its biological mechanisms. Trends in Molecular Medicine, 19(7), 410\u2013417. https:\/\/doi.org\/10.1016\/j.molmed.2013.04.001","journal-title":"Trends in Molecular Medicine"},{"key":"10169_CR52","unstructured":"Ho, C.-M., Chang, T.-H., Yen, T.-L., Hong, K.-J., & Huang, S.-H. (2021). Collagen type VI regulates the CDK4\/6-p-Rb signaling pathway and promotes ovarian cancer invasiveness, stemness, and metastasis. American Journal of Cancer Research, 11(3), 668\u2013690. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/33791147. Accessed 22 Aug 2023"},{"key":"10169_CR53","doi-asserted-by":"publisher","unstructured":"Sherman-Baust, C. A., Weeraratna, A. T., Rangel, L. B. A., Pizer, E. S., Cho, K. R., Schwartz, D. R., \u2026 Morin, P. J. (2003). Remodeling of the extracellular matrix through overexpression of collagen VI contributes to cisplatin resistance in ovarian cancer cells. Cancer Cell, 3(4), 377\u2013386. https:\/\/doi.org\/10.1016\/s1535-6108(03)00058-8","DOI":"10.1016\/s1535-6108(03)00058-8"},{"key":"10169_CR54","doi-asserted-by":"publisher","unstructured":"Pietil\u00e4, E. A., Gonzalez-Molina, J., Moyano-Galceran, L., Jamalzadeh, S., Zhang, K., Lehtinen, L., \u2026 Lehti, K. (2021). Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance. Nature Communications, 12(1), 3904. https:\/\/doi.org\/10.1038\/s41467-021-24009-8","DOI":"10.1038\/s41467-021-24009-8"},{"key":"10169_CR55","doi-asserted-by":"publisher","unstructured":"Nallanthighal, S., Rada, M., Heiserman, J. P., Cha, J., Sage, J., Zhou, B., \u2026 Cheon, D.-J. (2020). Inhibition of collagen XI alpha 1-induced fatty acid oxidation triggers apoptotic cell death in cisplatin-resistant ovarian cancer. Cell Death & Disease, 11(4), 258. https:\/\/doi.org\/10.1038\/s41419-020-2442-z","DOI":"10.1038\/s41419-020-2442-z"},{"key":"10169_CR56","doi-asserted-by":"publisher","unstructured":"Cheon, D.-J., Tong, Y., Sim, M.-S., Dering, J., Berel, D., Cui, X., \u2026 Orsulic, S. (2014). A collagen-remodeling gene signature regulated by TGF-\u03b2 signaling is associated with metastasis and poor survival in serous ovarian cancer. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, 20(3), 711\u2013723. https:\/\/doi.org\/10.1158\/1078-0432.CCR-13-1256","DOI":"10.1158\/1078-0432.CCR-13-1256"},{"key":"10169_CR57","doi-asserted-by":"publisher","unstructured":"Wu, Y.-H., Huang, Y.-F., Chang, T.-H., & Chou, C.-Y. (2017). Activation of TWIST1 by COL11A1 promotes chemoresistance and inhibits apoptosis in ovarian cancer cells by modulating NF\u2010\u03baB\u2010mediated IKK\u03b2 expression. International journal of cancer. Journal International du Cancer, 141(11), 2305\u20132317. https:\/\/doi.org\/10.1002\/ijc.30932","DOI":"10.1002\/ijc.30932"},{"key":"10169_CR58","doi-asserted-by":"publisher","unstructured":"Li, S.-L., Ye, F., Cai, W.-J., Hu, H.-D., Hu, P., Ren, H., \u2026 Zhang, D.-Z. (2010). Quantitative proteome analysis of multidrug resistance in human ovarian cancer cell line. Journal of Cellular Biochemistry, 109(4), 625\u2013633. https:\/\/doi.org\/10.1002\/jcb.22413","DOI":"10.1002\/jcb.22413"},{"key":"10169_CR59","unstructured":"Hata, K., Fujiwaki, R., Nakayama, K., & Miyazaki, K. (2001). Expression of the Endostatin gene in epithelial ovarian cancer. Clinical cancer research: an official journal of the American Association for Cancer Research, 7(8), 2405\u20132409. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11489819. Accessed 22 Aug 2023"},{"key":"10169_CR60","doi-asserted-by":"publisher","unstructured":"Gant, K. L., Jambor, A. N., Li, Z., Rentchler, E. C., Weisman, P., Li, L., \u2026 Campagnola, P. J. (2021). Evaluation of collagen alterations in early precursor lesions of high grade serous ovarian cancer by Second Harmonic Generation microscopy and mass spectrometry. Cancers, 13(11), 2794. https:\/\/doi.org\/10.3390\/cancers13112794","DOI":"10.3390\/cancers13112794"},{"issue":"1","key":"10169_CR61","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13045-022-01252-0","volume":"15","author":"Y Jiang","year":"2022","unstructured":"Jiang, Y., Zhang, H., Wang, J., Liu, Y., Luo, T., & Hua, H. (2022). Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy. Journal of Hematology & Oncology, 15(1), 34. https:\/\/doi.org\/10.1186\/s13045-022-01252-0","journal-title":"Journal of Hematology & Oncology"},{"key":"10169_CR62","doi-asserted-by":"publisher","unstructured":"Kalli, M., & Stylianopoulos, T. (2018). Defining the role of solid stress and matrix stiffness in cancer cell proliferation and metastasis. Frontiers in Oncology, 8. https:\/\/doi.org\/10.3389\/fonc.2018.00055","DOI":"10.3389\/fonc.2018.00055"},{"key":"10169_CR63","doi-asserted-by":"publisher","first-page":"718834","DOI":"10.3389\/fcell.2021.718834","volume":"9","author":"Y Fan","year":"2021","unstructured":"Fan, Y., Sun, Q., Li, X., Feng, J., Ao, Z., Li, X., & Wang, J. (2021). Substrate stiffness modulates the growth, phenotype, and chemoresistance of ovarian cancer cells. Frontiers in Cell and Developmental Biology, 9, 718834. https:\/\/doi.org\/10.3389\/fcell.2021.718834","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"10169_CR64","doi-asserted-by":"publisher","unstructured":"Mieulet, V., Garnier, C., Kieffer, Y., Guilbert, T., Nemati, F., Marangoni, E., \u2026 Mechta-Grigoriou, F. (2021). Stiffness increases with myofibroblast content and collagen density in mesenchymal high grade serous ovarian cancer. Scientific Reports, 11(1), 4219. https:\/\/doi.org\/10.1038\/s41598-021-83685-0","DOI":"10.1038\/s41598-021-83685-0"},{"key":"10169_CR65","doi-asserted-by":"publisher","unstructured":"Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., \u2026 Piccolo, S. (2011). Role of YAP\/TAZ in mechanotransduction. Nature, 474(7350), 179\u2013183. https:\/\/doi.org\/10.1038\/nature10137","DOI":"10.1038\/nature10137"},{"key":"10169_CR66","doi-asserted-by":"publisher","unstructured":"Hall, C. A., Wang, R., Miao, J., Oliva, E., Shen, X., Wheeler, T., \u2026 Goode, S. (2010). Hippo pathway effector Yap is an ovarian cancer oncogene. Cancer Research, 70(21), 8517\u20138525. https:\/\/doi.org\/10.1158\/0008-5472.CAN-10-1242","DOI":"10.1158\/0008-5472.CAN-10-1242"},{"issue":"3","key":"10169_CR67","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.3892\/ol.2016.4829","volume":"12","author":"G Chen","year":"2016","unstructured":"Chen, G., Xie, J., Huang, P., & Yang, Z. (2016). Overexpression of TAZ promotes cell proliferation, migration and epithelial-mesenchymal transition in ovarian cancer. Oncology Letters, 12(3), 1821\u20131825. https:\/\/doi.org\/10.3892\/ol.2016.4829","journal-title":"Oncology Letters"},{"key":"10169_CR68","doi-asserted-by":"publisher","unstructured":"McKenzie, A. J., Hicks, S. R., Svec, K. V., Naughton, H., Edmunds, Z. L., & Howe, A. K. (2018). The mechanical microenvironment regulates ovarian cancer cell morphology, migration, and spheroid disaggregation. Scientific Reports, 8(1). https:\/\/doi.org\/10.1038\/s41598-018-25589-0","DOI":"10.1038\/s41598-018-25589-0"},{"key":"10169_CR69","doi-asserted-by":"publisher","unstructured":"McKenzie, A. J., Hicks, S. R., Svec, K. V., Naughton, H., Edmunds, Z. L., & Howe, A. K. (2017, December 21). The mechanical microenvironment regulates ovarian cancer cell morphology, migration, and spheroid disaggregation. bioRxiv. bioRxiv. https:\/\/doi.org\/10.1101\/238311","DOI":"10.1101\/238311"},{"key":"10169_CR70","doi-asserted-by":"publisher","unstructured":"Calvo, F., Ege, N., Grande-Garcia, A., Hooper, S., Jenkins, R. P., Chaudhry, S. I., \u2026 Sahai, E. (2013). Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts. Nature Cell Biology, 15(6), 637\u2013646. https:\/\/doi.org\/10.1038\/ncb2756","DOI":"10.1038\/ncb2756"},{"issue":"3","key":"10169_CR71","doi-asserted-by":"publisher","first-page":"e91770","DOI":"10.1371\/journal.pone.0091770","volume":"9","author":"Y Xia","year":"2014","unstructured":"Xia, Y., Chang, T., Wang, Y., Liu, Y., Li, W., Li, M., & Fan, H.-Y. (2014). YAP promotes ovarian cancer cell tumorigenesis and is indicative of a poor prognosis for ovarian cancer patients. PLoS ONE, 9(3), e91770. https:\/\/doi.org\/10.1371\/journal.pone.0091770","journal-title":"PLoS ONE"},{"key":"10169_CR72","doi-asserted-by":"publisher","unstructured":"Wei, X., Lou, H., Zhou, D., Jia, Y., Li, H., Huang, Q., \u2026 Gao, Q. (2021). TAGLN mediated stiffness-regulated ovarian cancer progression via RhoA\/ROCK pathway. Journal of Experimental & Clinical Cancer Research: CR, 40(1), 292. https:\/\/doi.org\/10.1186\/s13046-021-02091-6","DOI":"10.1186\/s13046-021-02091-6"},{"issue":"4","key":"10169_CR73","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/j.bpj.2020.07.003","volume":"119","author":"J Chang","year":"2020","unstructured":"Chang, J., Pang, E. M., Adebowale, K., Wisdom, K. M., & Chaudhuri, O. (2020). Increased stiffness inhibits invadopodia formation and cell migration in 3D. Biophysical Journal, 119(4), 726\u2013736. https:\/\/doi.org\/10.1016\/j.bpj.2020.07.003","journal-title":"Biophysical Journal"},{"key":"10169_CR74","doi-asserted-by":"publisher","unstructured":"Natarajan, S., Foreman, K. M., Soriano, M. I., Rossen, N. S., Shehade, H., Fregoso, D. R., \u2026 Rankin, E. B. (2019). Collagen remodeling in the hypoxic tumor-mesothelial niche promotes ovarian cancer metastasis. Cancer Research, 79(9), 2271\u20132284. https:\/\/doi.org\/10.1158\/0008-5472.can-18-2616","DOI":"10.1158\/0008-5472.can-18-2616"},{"issue":"4","key":"10169_CR75","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.tibtech.2015.01.004","volume":"33","author":"R Malik","year":"2015","unstructured":"Malik, R., Lelkes, P. I., & Cukierman, E. (2015). Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer. Trends in Biotechnology, 33(4), 230\u2013236. https:\/\/doi.org\/10.1016\/j.tibtech.2015.01.004","journal-title":"Trends in Biotechnology"},{"issue":"2","key":"10169_CR76","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1242\/dmm.004077","volume":"4","author":"TR Cox","year":"2011","unstructured":"Cox, T. R., & Erler, J. T. (2011). Remodeling and homeostasis of the extracellular matrix: Implications for fibrotic diseases and cancer. Disease Models & Mechanisms, 4(2), 165\u2013178. https:\/\/doi.org\/10.1242\/dmm.004077","journal-title":"Disease Models & Mechanisms"},{"issue":"1","key":"10169_CR77","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/1741-7015-4-38","volume":"4","author":"PP Provenzano","year":"2006","unstructured":"Provenzano, P. P., Eliceiri, K. W., Campbell, J. M., Inman, D. R., White, J. G., & Keely, P. J. (2006). Collagen reorganization at the tumor-stromal interface facilitates local invasion. BMC Medicine, 4(1), 38. https:\/\/doi.org\/10.1186\/1741-7015-4-38","journal-title":"BMC Medicine"},{"issue":"1","key":"10169_CR78","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s40170-020-00221-w","volume":"8","author":"EA Brett","year":"2020","unstructured":"Brett, E. A., Sauter, M. A., Machens, H.-G., & Duscher, D. (2020). Tumor-associated collagen signatures: Pushing tumor boundaries. Cancer & Metabolism, 8(1), 14. https:\/\/doi.org\/10.1186\/s40170-020-00221-w","journal-title":"Cancer & Metabolism"},{"key":"10169_CR79","doi-asserted-by":"publisher","unstructured":"Han, W., Chen, S., Yuan, W., Fan, Q., Tian, J., Wang, X., \u2026 Liu, L. (2016). Oriented collagen fibers direct tumor cell intravasation. Proceedings of the National Academy of Sciences of the United States of America, 113(40), 11208\u201311213. https:\/\/doi.org\/10.1073\/pnas.1610347113","DOI":"10.1073\/pnas.1610347113"},{"issue":"5","key":"10169_CR80","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.bpj.2017.01.007","volume":"112","author":"A Ray","year":"2017","unstructured":"Ray, A., Slama, Z. M., Morford, R. K., Madden, S. A., & Provenzano, P. P. (2017). Enhanced directional migration of cancer stem cells in 3D aligned collagen matrices. Biophysical Journal, 112(5), 1023\u20131036. https:\/\/doi.org\/10.1016\/j.bpj.2017.01.007","journal-title":"Biophysical Journal"},{"key":"10169_CR81","doi-asserted-by":"publisher","unstructured":"Xi, G., Qiu, L., Xu, S., Guo, W., Fu, F., Kang, D., \u2026 Chen, J. (2021). Computer-assisted quantification of tumor-associated collagen signatures to improve the prognosis prediction of breast cancer. BMC Medicine, 19(1), 273. https:\/\/doi.org\/10.1186\/s12916-021-02146-7","DOI":"10.1186\/s12916-021-02146-7"},{"key":"10169_CR82","doi-asserted-by":"publisher","unstructured":"Conklin, M. W., Eickhoff, J. C., Riching, K. M., Pehlke, C. A., Eliceiri, K. W., Provenzano, P. P., \u2026 Keely, P. J. (2011). Aligned collagen is a prognostic signature for survival in human breast carcinoma. The American Journal of Pathology, 178(3), 1221\u20131232. https:\/\/doi.org\/10.1016\/j.ajpath.2010.11.076","DOI":"10.1016\/j.ajpath.2010.11.076"},{"issue":"6","key":"10169_CR83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1117\/1.JBO.23.6.066501","volume":"23","author":"KR Campbell","year":"2018","unstructured":"Campbell, K. R., Chaudhary, R., Handel, J. M., Patankar, M. S., & Campagnola, P. J. (2018). Polarization-resolved second harmonic generation imaging of human ovarian cancer. Journal of Biomedical Optics, 23(6), 1\u20138. https:\/\/doi.org\/10.1117\/1.JBO.23.6.066501","journal-title":"Journal of Biomedical Optics"},{"key":"10169_CR84","doi-asserted-by":"publisher","unstructured":"Tilbury, K. B., Campbell, K. R., Eliceiri, K. W., Salih, S. M., Patankar, M., & Campagnola, P. J. (2017). Stromal alterations in ovarian cancers via wavelength dependent Second Harmonic Generation microscopy and optical scattering. BMC Cancer, 17(1). https:\/\/doi.org\/10.1186\/s12885-017-3090-2","DOI":"10.1186\/s12885-017-3090-2"},{"key":"10169_CR85","doi-asserted-by":"publisher","unstructured":"Wen, B., Campbell, K. R., Tilbury, K., Nadiarnykh, O., Brewer, M. A., Patankar, M., \u2026 Campagnola, P. J. (2016). 3D texture analysis for classification of second harmonic generation images of human ovarian cancer. Scientific Reports, 6, 35734. https:\/\/doi.org\/10.1038\/srep35734","DOI":"10.1038\/srep35734"},{"issue":"6","key":"10169_CR86","doi-asserted-by":"publisher","first-page":"e202000498","DOI":"10.1002\/jbio.202000498","volume":"14","author":"J Yan","year":"2021","unstructured":"Yan, J., Zhao, Y., Lin, F., Qu, J., Liu, Q., Pan, Y., & Liu, L. (2021). Monitoring the extracellular matrix remodeling of high-grade serous ovarian cancer with nonlinear optical microscopy. Journal of Biophotonics, 14(6), e202000498. https:\/\/doi.org\/10.1002\/jbio.202000498","journal-title":"Journal of Biophotonics"},{"issue":"6","key":"10169_CR87","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.3390\/cancers12061390","volume":"12","author":"S Alkmin","year":"2020","unstructured":"Alkmin, S., Brodziski, R., Simon, H., Hinton, D., Goldsmith, R. H., Patankar, M., & Campagnola, P. J. (2020). Role of collagen fiber morphology on ovarian cancer cell migration using image-based models of the extracellular matrix. Cancers, 12(6), 1390. https:\/\/doi.org\/10.3390\/cancers12061390","journal-title":"Cancers"},{"key":"10169_CR88","doi-asserted-by":"publisher","unstructured":"Sneider, A., Kiemen, A., Kim, J. H., Wu, P.-H., Habibi, M., White, M., \u2026 Wirtz, D. (2022). Deep learning identification of stiffness markers in breast cancer. Biomaterials, 285(121540), 121540. https:\/\/doi.org\/10.1016\/j.biomaterials.2022.121540","DOI":"10.1016\/j.biomaterials.2022.121540"},{"key":"10169_CR89","doi-asserted-by":"publisher","unstructured":"Jia, H., Janjanam, J., Wu, S. C., Wang, R., Pano, G., Celestine, M., \u2026 Labelle, M. (2019). The tumor cell-secreted matricellular protein WISP1 drives pro-metastatic collagen linearization. The EMBO Journal, 38(16), e101302. https:\/\/doi.org\/10.15252\/embj.2018101302","DOI":"10.15252\/embj.2018101302"},{"key":"10169_CR90","doi-asserted-by":"publisher","unstructured":"Li, Y., Wang, F., Liu, T., Lv, N., Yuan, X., & Li, P. (2022). WISP1 induces ovarian cancer via the IGF1\/\u03b1v\u03b23\/Wnt axis. Journal of Ovarian Research, 15(1). https:\/\/doi.org\/10.1186\/s13048-022-01016-x","DOI":"10.1186\/s13048-022-01016-x"},{"issue":"3","key":"10169_CR91","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s00429-004-0446-6","volume":"209","author":"S Wilkosz","year":"2005","unstructured":"Wilkosz, S., Ireland, G., Khwaja, N., Walker, M., Butt, R., de Giorgio-Miller, A., & Herrick, S. E. (2005). A comparative study of the structure of human and murine greater omentum. Anatomy and Embryology, 209(3), 251\u2013261. https:\/\/doi.org\/10.1007\/s00429-004-0446-6","journal-title":"Anatomy and Embryology"},{"issue":"2","key":"10169_CR92","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1002\/ar.1090880205","volume":"88","author":"PH Simer","year":"1944","unstructured":"Simer, P. H. (1944). The drainage of particulate matter from the peritoneal cavity by lymphatics. The Anatomical Record, 88(2), 175\u2013192. https:\/\/doi.org\/10.1002\/ar.1090880205","journal-title":"The Anatomical Record"},{"key":"10169_CR93","doi-asserted-by":"publisher","unstructured":"Nieman, K. M., Kenny, H. A., Penicka, C. V., Ladanyi, A., Buell-Gutbrod, R., Zillhardt, M. R., \u2026 Lengyel, E. (2011). Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nature Medicine, 17(11), 1498\u20131503. https:\/\/doi.org\/10.1038\/nm.2492","DOI":"10.1038\/nm.2492"},{"issue":"7","key":"10169_CR94","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.it.2017.03.002","volume":"38","author":"S Meza-Perez","year":"2017","unstructured":"Meza-Perez, S., & Randall, T. D. (2017). Immunological functions of the omentum. Trends in Immunology, 38(7), 526\u2013536. https:\/\/doi.org\/10.1016\/j.it.2017.03.002","journal-title":"Trends in Immunology"},{"key":"10169_CR95","doi-asserted-by":"publisher","unstructured":"Ma, X. (2020, April 6). The omentum, a niche for premetastatic ovarian cancer. The journal of experimental medicine. Rockefeller University Press. https:\/\/doi.org\/10.1084\/jem.20192312","DOI":"10.1084\/jem.20192312"},{"key":"10169_CR96","doi-asserted-by":"publisher","unstructured":"Etzerodt, A., Moulin, M., Doktor, T. K., Delfini, M., Mossadegh-Keller, N., Bajenoff, M., \u2026 Lawrence, T. (2020). Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer. The Journal of Experimental Medicine, 217(4). https:\/\/doi.org\/10.1084\/jem.20191869","DOI":"10.1084\/jem.20191869"},{"key":"10169_CR97","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.reth.2019.07.008","volume":"11","author":"V Di Nicola","year":"2019","unstructured":"Di Nicola, V. (2019). Omentum a powerful biological source in regenerative surgery. Regenerative Therapy, 11, 182\u2013191. https:\/\/doi.org\/10.1016\/j.reth.2019.07.008","journal-title":"Regenerative Therapy"},{"issue":"15","key":"10169_CR98","doi-asserted-by":"publisher","first-page":"3725","DOI":"10.1158\/1078-0432.CCR-16-0028","volume":"22","author":"AR Chin","year":"2016","unstructured":"Chin, A. R., & Wang, S. E. (2016). Cancer tills the premetastatic field: Mechanistic basis and clinical implications. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, 22(15), 3725\u20133733. https:\/\/doi.org\/10.1158\/1078-0432.CCR-16-0028","journal-title":"Clinical Cancer Research: An Official Journal of the American Association for Cancer Research"},{"key":"10169_CR99","doi-asserted-by":"publisher","unstructured":"Mogi, K., Yoshihara, M., Iyoshi, S., Kitami, K., Uno, K., Tano, S., \u2026 Kajiyama, H. (2021). Ovarian cancer-associated mesothelial cells: Transdifferentiation to minions of cancer and orchestrate developing peritoneal dissemination. Cancers, 13(6), 1352. https:\/\/doi.org\/10.3390\/cancers13061352","DOI":"10.3390\/cancers13061352"},{"key":"10169_CR100","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/978-0-387-98094-2_16","volume":"149","author":"HA Kenny","year":"2009","unstructured":"Kenny, H. A., Dogan, S., Zillhardt, M., Mitra, A. K., Yamada, S. D., Krausz, T., & Lengyel, E. (2009). Organotypic models of metastasis: A three-dimensional culture mimicking the human peritoneum and omentum for the study of the early steps of ovarian cancer metastasis. Cancer Treatment and Research, 149, 335\u2013351. https:\/\/doi.org\/10.1007\/978-0-387-98094-2_16","journal-title":"Cancer Treatment and Research"},{"key":"10169_CR101","doi-asserted-by":"publisher","unstructured":"Rickard, B. P., Conrad, C., Sorrin, A. J., Ruhi, M. K., Reader, J. C., Huang, S. A., \u2026 Rizvi, I. (2021). Malignant ascites in ovarian cancer: Cellular, acellular, and biophysical determinants of molecular characteristics and therapy response. Cancers, 13(17), 4318. https:\/\/doi.org\/10.3390\/cancers13174318","DOI":"10.3390\/cancers13174318"},{"key":"10169_CR102","doi-asserted-by":"publisher","unstructured":"Santin, A. D., Bellone, S., Ravaggi, A., Roman, J., Smith, C. V., Pecorelli, S., \u2026 Parham, G. P. (2001). Increased levels of interleukin-10 and transforming growth factor-\u03b2 in the plasma and ascitic fluid of patients with advanced ovarian cancer. British Journal of Obstetrics and Gynaecology, 108(8), 804\u2013808. https:\/\/doi.org\/10.1016\/s0306-5456(00)00206-0","DOI":"10.1016\/s0306-5456(00)00206-0"},{"issue":"3\u20134","key":"10169_CR103","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1007\/s10555-012-9375-7","volume":"31","author":"Y Drabsch","year":"2012","unstructured":"Drabsch, Y., & ten Dijke, P. (2012). TGF-\u03b2 signalling and its role in cancer progression and metastasis. Cancer Metastasis Reviews, 31(3\u20134), 553\u2013568. https:\/\/doi.org\/10.1007\/s10555-012-9375-7","journal-title":"Cancer Metastasis Reviews"},{"issue":"11","key":"10169_CR104","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1038\/nrc3603","volume":"13","author":"M Pickup","year":"2013","unstructured":"Pickup, M., Novitskiy, S., & Moses, H. L. (2013). The roles of TGF\u03b2 in the tumour microenvironment. Nature Reviews. Cancer, 13(11), 788\u2013799. https:\/\/doi.org\/10.1038\/nrc3603","journal-title":"Nature Reviews. Cancer"},{"issue":"2","key":"10169_CR105","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s10585-021-10077-z","volume":"38","author":"A Kumari","year":"2021","unstructured":"Kumari, A., Shonibare, Z., Monavarian, M., Arend, R. C., Lee, N. Y., Inman, G. J., & Mythreye, K. (2021). TGF\u03b2 signaling networks in ovarian cancer progression and plasticity. Clinical & Experimental Metastasis, 38(2), 139\u2013161. https:\/\/doi.org\/10.1007\/s10585-021-10077-z","journal-title":"Clinical & Experimental Metastasis"},{"key":"10169_CR106","doi-asserted-by":"publisher","unstructured":"Kenny, H. A., Chiang, C.-Y., White, E. A., Schryver, E. M., Habis, M., Romero, I. L., \u2026 Lengyel, E. (2014). Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion. The Journal of Clinical Investigation, 124(10), 4614\u20134628. https:\/\/doi.org\/10.1172\/jci74778","DOI":"10.1172\/jci74778"},{"issue":"8","key":"10169_CR107","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1158\/1535-7163.mct-14-0135","volume":"13","author":"K Sugiyama","year":"2014","unstructured":"Sugiyama, K., Kajiyama, H., Shibata, K., Yuan, H., Kikkawa, F., & Senga, T. (2014). Expression of the miR200 family of microRNAs in mesothelial cells suppresses the dissemination of ovarian cancer cells. Molecular Cancer Therapeutics, 13(8), 2081\u20132091. https:\/\/doi.org\/10.1158\/1535-7163.mct-14-0135","journal-title":"Molecular Cancer Therapeutics"},{"issue":"2","key":"10169_CR108","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s00441-007-0455-x","volume":"330","author":"H Kajiyama","year":"2007","unstructured":"Kajiyama, H., Shibata, K., Ino, K., Nawa, A., Mizutani, S., & Kikkawa, F. (2007). Possible involvement of SDF-1alpha\/CXCR4-DPPIV axis in TGF-beta1-induced enhancement of migratory potential in human peritoneal mesothelial cells. Cell and Tissue Research, 330(2), 221\u2013229. https:\/\/doi.org\/10.1007\/s00441-007-0455-x","journal-title":"Cell and Tissue Research"},{"key":"10169_CR109","doi-asserted-by":"publisher","unstructured":"Kajiyama, H., Shibata, K., Terauchi, M., Ino, K., Nawa, A., & Kikkawa, F. (2008). Involvement of SDF-1alpha\/CXCR4 axis in the enhanced peritoneal metastasis of epithelial ovarian carcinoma. International journal of cancer. Journal International du Cancer, 122(1), 91\u201399. https:\/\/doi.org\/10.1002\/ijc.23083","DOI":"10.1002\/ijc.23083"},{"key":"10169_CR110","doi-asserted-by":"publisher","unstructured":"Cai, J., Tang, H., Xu, L., Wang, X., Yang, C., Ruan, S., \u2026 Wang, Z. (2012). Fibroblasts in omentum activated by tumor cells promote ovarian cancer growth, adhesion and invasiveness. Carcinogenesis, 33(1), 20\u201329. https:\/\/doi.org\/10.1093\/carcin\/bgr230","DOI":"10.1093\/carcin\/bgr230"},{"issue":"2","key":"10169_CR111","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1093\/carcin\/bgz083","volume":"41","author":"H Tang","year":"2020","unstructured":"Tang, H., Chu, Y., Huang, Z., Cai, J., & Wang, Z. (2020). The metastatic phenotype shift toward myofibroblast of adipose-derived mesenchymal stem cells promotes ovarian cancer progression. Carcinogenesis, 41(2), 182\u2013193. https:\/\/doi.org\/10.1093\/carcin\/bgz083","journal-title":"Carcinogenesis"},{"key":"10169_CR112","doi-asserted-by":"publisher","unstructured":"Motohara, T., Masuda, K., Morotti, M., Zheng, Y., El-Sahhar, S., Chong, K. Y., \u2026 Ahmed, A. A. (2019). An evolving story of the metastatic voyage of ovarian cancer cells: Cellular and molecular orchestration of the adipose-rich metastatic microenvironment. Oncogene, 38(16), 2885\u20132898. https:\/\/doi.org\/10.1038\/s41388-018-0637-x","DOI":"10.1038\/s41388-018-0637-x"},{"issue":"1","key":"10169_CR113","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.canlet.2011.01.011","volume":"303","author":"Y Zhang","year":"2011","unstructured":"Zhang, Y., Tang, H., Cai, J., Zhang, T., Guo, J., Feng, D., & Wang, Z. (2011). Ovarian cancer-associated fibroblasts contribute to epithelial ovarian carcinoma metastasis by promoting angiogenesis, lymphangiogenesis and tumor cell invasion. Cancer Letters, 303(1), 47\u201355. https:\/\/doi.org\/10.1016\/j.canlet.2011.01.011","journal-title":"Cancer Letters"},{"key":"10169_CR114","doi-asserted-by":"publisher","unstructured":"Nakamura, K., Sawada, K., Kobayashi, M., Miyamoto, M., Shimizu, A., Yamamoto, M., \u2026 Kimura, T. (2019). Role of the exosome in ovarian cancer progression and its potential as a therapeutic target. Cancers, 11(8), 1147. https:\/\/doi.org\/10.3390\/cancers11081147","DOI":"10.3390\/cancers11081147"},{"issue":"1","key":"10169_CR115","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/s12943-019-1049-4","volume":"18","author":"W Feng","year":"2019","unstructured":"Feng, W., Dean, D. C., Hornicek, F. J., Shi, H., & Duan, Z. (2019). Exosomes promote pre-metastatic niche formation in ovarian cancer. Molecular Cancer, 18(1), 124. https:\/\/doi.org\/10.1186\/s12943-019-1049-4","journal-title":"Molecular Cancer"},{"key":"10169_CR116","doi-asserted-by":"publisher","unstructured":"Cho, J. A., Park, H., Lim, E. H., Kim, K. H., Choi, J. S., Lee, J. H., \u2026 Lee, K. W. (2011). Exosomes from ovarian cancer cells induce adipose tissue-derived mesenchymal stem cells to acquire the physical and functional characteristics of tumor-supporting myofibroblasts. Gynecologic Oncology, 123(2), 379\u2013386. https:\/\/doi.org\/10.1016\/j.ygyno.2011.08.005","DOI":"10.1016\/j.ygyno.2011.08.005"},{"key":"10169_CR117","doi-asserted-by":"publisher","unstructured":"Giusti, I., Francesco, M. D., Ascenzo, S. D., Palmerini, M. G., Macchiarelli, G., Carta, G., & Dolo, V. (2018). Ovarian cancer-derived extracellular vesicles affect normal human fibroblast behavior. Cancer Biology & Therapy, 1\u201344. https:\/\/doi.org\/10.1080\/15384047.2018.1451286","DOI":"10.1080\/15384047.2018.1451286"},{"issue":"1","key":"10169_CR118","doi-asserted-by":"publisher","first-page":"8686","DOI":"10.1038\/s41598-020-65628-3","volume":"10","author":"AH Lee","year":"2020","unstructured":"Lee, A. H., Ghosh, D., Quach, N., Schroeder, D., & Dawson, M. R. (2020). Ovarian cancer exosomes trigger differential biophysical response in tumor-derived fibroblasts. Scientific Reports, 10(1), 8686. https:\/\/doi.org\/10.1038\/s41598-020-65628-3","journal-title":"Scientific Reports"},{"key":"10169_CR119","doi-asserted-by":"publisher","unstructured":"Han, Q., Tan, S., Gong, L., Li, G., Wu, Q., Chen, L., \u2026 Wang, Z. (2023). Omental cancer\u2010associated fibroblast\u2010derived exosomes with low microRNA\u201029c\u20103p promote ovarian cancer peritoneal metastasis. Cancer Rcience, 114(5), 1929\u20131942. https:\/\/doi.org\/10.1111\/cas.15726","DOI":"10.1111\/cas.15726"},{"issue":"7","key":"10169_CR120","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.7150\/jca.83663","volume":"14","author":"Y Zhu","year":"2023","unstructured":"Zhu, Y., Wang, C., Ma, Z., Li, F., Xu, C., Pan, W., & Liu, A. (2023). Role of exosomes in the invasion and metastasis of ovarian cancer and application potential of clinical diagnosis and treatment. Journal of Cancer, 14(7), 1141\u20131150. https:\/\/doi.org\/10.7150\/jca.83663","journal-title":"Journal of Cancer"},{"issue":"1","key":"10169_CR121","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1084\/jem.20181170","volume":"216","author":"W Lee","year":"2019","unstructured":"Lee, W., Ko, S. Y., Mohamed, M. S., Kenny, H. A., Lengyel, E., & Naora, H. (2019). Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum. The Journal of Experimental Medicine, 216(1), 176\u2013194. https:\/\/doi.org\/10.1084\/jem.20181170","journal-title":"The Journal of Experimental Medicine"},{"key":"10169_CR122","doi-asserted-by":"publisher","unstructured":"Yoshihara, M., Kajiyama, H., Yokoi, A., Sugiyama, M., Koya, Y., Yamakita, Y., \u2026 Kikkawa, F. (2020). Ovarian cancer-associated mesothelial cells induce acquired platinum-resistance in peritoneal metastasis via the FN1\/Akt signaling pathway. International Journal of Cancer. Journal International du Cancer, 146(8), 2268\u20132280. https:\/\/doi.org\/10.1002\/ijc.32854","DOI":"10.1002\/ijc.32854"},{"key":"10169_CR123","doi-asserted-by":"publisher","unstructured":"Li, W., Zhang, X., Wang, J., Li, M., Cao, C., Tan, J., \u2026 Gao, Q. (2017). TGF\u03b21 in fibroblasts-derived exosomes promotes epithelial-mesenchymal transition of ovarian cancer cells. Oncotarget, 8(56), 96035\u201396047. https:\/\/doi.org\/10.18632\/oncotarget.21635","DOI":"10.18632\/oncotarget.21635"},{"issue":"1","key":"10169_CR124","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.canlet.2009.09.017","volume":"291","author":"D Vergara","year":"2010","unstructured":"Vergara, D., Merlot, B., Lucot, J.-P., Collinet, P., Vinatier, D., Fournier, I., & Salzet, M. (2010). Epithelial-mesenchymal transition in ovarian cancer. Cancer letters, 291(1), 59\u201366. https:\/\/doi.org\/10.1016\/j.canlet.2009.09.017","journal-title":"Cancer letters"},{"key":"10169_CR125","doi-asserted-by":"publisher","unstructured":"Huang, Y.-L., Liang, C.-Y., Ritz, D., Coelho, R., Septiadi, D., Estermann, M., \u2026 Heinzelmann-Schwarz, V. (2020). Collagen-rich omentum is a premetastatic niche for integrin \u03b12-mediated peritoneal metastasis. eLife, 9. https:\/\/doi.org\/10.7554\/eLife.59442","DOI":"10.7554\/eLife.59442"},{"key":"10169_CR126","doi-asserted-by":"publisher","unstructured":"Gertych, A., Walts, A. E., Cheng, K., Liu, M., John, J., Lester, J., \u2026 Orsulic, S. (2022). Dynamic changes in the extracellular matrix in primary, metastatic, and recurrent ovarian cancers. Cells (Basel, Switzerland), 11(23), 3769. https:\/\/doi.org\/10.3390\/cells11233769","DOI":"10.3390\/cells11233769"},{"key":"10169_CR127","doi-asserted-by":"publisher","unstructured":"Loizzi, V., Del Vecchio, V., Gargano, G., De Liso, M., Kardashi, A., Naglieri, E., \u2026 Cormio, G. (2017). Biological pathways involved in tumor angiogenesis and bevacizumab based anti-angiogenic therapy with special references to ovarian cancer. International Journal of Molecular Sciences, 18(9), 1967. https:\/\/doi.org\/10.3390\/ijms18091967","DOI":"10.3390\/ijms18091967"},{"key":"10169_CR128","doi-asserted-by":"publisher","unstructured":"Chauhan, V. P., Martin, J. D., Liu, H., Lacorre, D. A., Jain, S. R., Kozin, S. V., \u2026 Jain, R. K. (2013). Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels. Nature communications, 4, 2516. https:\/\/doi.org\/10.1038\/ncomms3516","DOI":"10.1038\/ncomms3516"},{"key":"10169_CR129","doi-asserted-by":"publisher","unstructured":"Wang, X., Du, Z.-W., Xu, T.-M., Wang, X.-J., Li, W., Gao, J.-L., \u2026 Zhu, H. (2021). HIF-1\u03b1 is a rational target for future ovarian cancer therapies. Frontiers in Oncology, 11, 785111. https:\/\/doi.org\/10.3389\/fonc.2021.785111","DOI":"10.3389\/fonc.2021.785111"},{"issue":"1","key":"10169_CR130","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/s41389-017-0011-9","volume":"7","author":"V Petrova","year":"2018","unstructured":"Petrova, V., Annicchiarico-Petruzzelli, M., Melino, G., & Amelio, I. (2018). The hypoxic tumour microenvironment. Oncogenesis, 7(1), 10. https:\/\/doi.org\/10.1038\/s41389-017-0011-9","journal-title":"Oncogenesis"},{"key":"10169_CR131","doi-asserted-by":"publisher","unstructured":"Wei, R., Lv, M., Li, F., Cheng, T., Zhang, Z., Jiang, G., \u2026 Xi, L. (2017). Human CAFs promote lymphangiogenesis in ovarian cancer via the Hh-VEGF-C signaling axis. Oncotarget, 8(40), 67315\u201367328. https:\/\/doi.org\/10.18632\/oncotarget.18621","DOI":"10.18632\/oncotarget.18621"},{"issue":"1","key":"10169_CR132","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s10585-021-10120-z","volume":"39","author":"SP Leong","year":"2022","unstructured":"Leong, S. P., Naxerova, K., Keller, L., Pantel, K., & Witte, M. (2022). Molecular mechanisms of cancer metastasis via the lymphatic versus the blood vessels. Clinical & Experimental Metastasis, 39(1), 159\u2013179. https:\/\/doi.org\/10.1007\/s10585-021-10120-z","journal-title":"Clinical & Experimental Metastasis"},{"key":"10169_CR133","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.redox.2016.12.011","volume":"11","author":"J Morry","year":"2017","unstructured":"Morry, J., Ngamcherdtrakul, W., & Yantasee, W. (2017). Oxidative stress in cancer and fibrosis: Opportunity for therapeutic intervention with antioxidant compounds, enzymes, and nanoparticles. Redox Biology, 11, 240\u2013253. https:\/\/doi.org\/10.1016\/j.redox.2016.12.011","journal-title":"Redox Biology"},{"key":"10169_CR134","doi-asserted-by":"publisher","unstructured":"Ding, D.-N., Xie, L.-Z., Shen, Y., Li, J., Guo, Y., Fu, Y., \u2026 Han, F.-J. (2021). Insights into the role of oxidative stress in ovarian cancer. Oxidative Medicine and Cellular Longevity, 2021, 1\u201320. https:\/\/doi.org\/10.1155\/2021\/8388258","DOI":"10.1155\/2021\/8388258"},{"key":"10169_CR135","doi-asserted-by":"publisher","unstructured":"Liu, W.-J., Huang, Y.-X., Wang, W., Zhang, Y., Liu, B.-J., Qiu, J.-G., \u2026 Liu, L.-Z. (2021). NOX4 signaling mediates cancer development and therapeutic resistance through HER3 in ovarian cancer cells. Cells (Basel, Switzerland), 10(7), 1647. https:\/\/doi.org\/10.3390\/cells10071647","DOI":"10.3390\/cells10071647"},{"key":"10169_CR136","doi-asserted-by":"publisher","unstructured":"Hu, Y., Taylor-Harding, B., Raz, Y., Haro, M., Recouvreux, M. S., Taylan, E., \u2026 Orsulic, S. (2020). Are epithelial ovarian cancers of the mesenchymal subtype actually intraperitoneal metastases to the ovary? Frontiers in Cell and Developmental Biology, 8. https:\/\/doi.org\/10.3389\/fcell.2020.00647","DOI":"10.3389\/fcell.2020.00647"},{"key":"10169_CR137","doi-asserted-by":"publisher","unstructured":"Winter, W. E., 3rd, Maxwell, G. L., Tian, C., Carlson, J. W., Ozols, R. F., Rose, P. G., \u2026 Gynecologic Oncology Group Study. (2007). Prognostic factors for stage III epithelial ovarian cancer: A Gynecologic Oncology Group Study. Journal of clinical oncology: official journal of the American Society of Clinical Oncology, 25(24), 3621\u20133627. https:\/\/doi.org\/10.1200\/JCO.2006.10.2517","DOI":"10.1200\/JCO.2006.10.2517"},{"key":"10169_CR138","doi-asserted-by":"publisher","unstructured":"Miku\u0142a-Pietrasik, J., Witucka, A., Paku\u0142a, M., Uruski, P., Begier-Krasi\u0144ska, B., Niklas, A., \u2026 Ksi\u0105\u017cek, K. (2019). Comprehensive review on how platinum- and taxane-based chemotherapy of ovarian cancer affects biology of normal cells. Cellular and molecular life sciences: CMLS, 76(4), 681\u2013697. https:\/\/doi.org\/10.1007\/s00018-018-2954-1","DOI":"10.1007\/s00018-018-2954-1"},{"issue":"12","key":"10169_CR139","doi-asserted-by":"publisher","first-page":"471","DOI":"10.3390\/cancers10120471","volume":"10","author":"G Yeldag","year":"2018","unstructured":"Yeldag, G., Rice, A., & Del R\u00edo Hern\u00e1ndez, A. (2018). Chemoresistance and the self-maintaining tumor microenvironment. Cancers, 10(12), 471. https:\/\/doi.org\/10.3390\/cancers10120471","journal-title":"Cancers"},{"key":"10169_CR140","doi-asserted-by":"publisher","unstructured":"Zheng, H.-C. (2017). The molecular mechanisms of chemoresistance in cancers. Oncotarget, 8(35), 59950\u201359964. https:\/\/doi.org\/10.18632\/oncotarget.19048","DOI":"10.18632\/oncotarget.19048"},{"issue":"12","key":"10169_CR141","doi-asserted-by":"publisher","first-page":"6532","DOI":"10.3390\/ijms22126532","volume":"22","author":"S Morand","year":"2021","unstructured":"Morand, S., Devanaboyina, M., Staats, H., Stanbery, L., & Nemunaitis, J. (2021). Ovarian cancer immunotherapy and personalized medicine. International Journal of Molecular Sciences, 22(12), 6532. https:\/\/doi.org\/10.3390\/ijms22126532","journal-title":"International Journal of Molecular Sciences"},{"key":"10169_CR142","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m3773","volume":"371","author":"L Kuroki","year":"2020","unstructured":"Kuroki, L., & Guntupalli, S. R. (2020). Treatment of epithelial ovarian cancer. BMJ (Clinical Research ed.), 371, m3773. https:\/\/doi.org\/10.1136\/bmj.m3773","journal-title":"BMJ (Clinical Research ed.)"},{"issue":"6","key":"10169_CR143","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/s41571-018-0007-1","volume":"15","author":"KC Valkenburg","year":"2018","unstructured":"Valkenburg, K. C., de Groot, A. E., & Pienta, K. J. (2018). Targeting the tumour stroma to improve cancer therapy. Nature Reviews. Clinical Oncology, 15(6), 366\u2013381. https:\/\/doi.org\/10.1038\/s41571-018-0007-1","journal-title":"Nature Reviews. Clinical Oncology"},{"key":"10169_CR144","doi-asserted-by":"publisher","unstructured":"Zhao, Y., Cao, J., Melamed, A., Worley, M., Gockley, A., Jones, D., \u2026 Xu, L. (2019). Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma. Proceedings of the National Academy of Sciences of the United States of America, 116(6), 2210\u20132219. https:\/\/doi.org\/10.1073\/pnas.1818357116","DOI":"10.1073\/pnas.1818357116"},{"key":"10169_CR145","doi-asserted-by":"publisher","unstructured":"Stylianopoulos, T., Martin, J. D., Chauhan, V. P., Jain, S. R., Diop-Frimpong, B., Bardeesy, N., \u2026 Jain, R. K. (2012). Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors. Proceedings of the National Academy of Sciences of the United States of America, 109(38), 15101\u201315108. https:\/\/doi.org\/10.1073\/pnas.1213353109","DOI":"10.1073\/pnas.1213353109"},{"key":"10169_CR146","doi-asserted-by":"publisher","unstructured":"Ko, S. Y., & Naora, H. (2014). Therapeutic strategies for targeting the ovarian tumor stroma. World Journal of Clinical Cases, 2(6), 194\u2013200. https:\/\/doi.org\/10.12998\/wjcc.v2.i6.194","DOI":"10.12998\/wjcc.v2.i6.194"},{"key":"10169_CR147","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3389\/fonc.2013.00251","volume":"3","author":"J Chien","year":"2013","unstructured":"Chien, J., Kuang, R., Landen, C., & Shridhar, V. (2013). Platinum-sensitive recurrence in ovarian cancer: The role of tumor microenvironment. Frontiers in Oncology, 3, 251. https:\/\/doi.org\/10.3389\/fonc.2013.00251","journal-title":"Frontiers in Oncology"},{"key":"10169_CR148","doi-asserted-by":"publisher","unstructured":"Tatsuki, S., Shoji, T., Abe, M., Tomabechi, H., Takatori, E., Kaido, Y., \u2026 Baba, T. (2022). Efficacy and safety of platinum rechallenge in patients with platinum-resistant ovarian, Fallopian tube or primary peritoneal cancer: A multicenter retrospective study. Anticancer Research, 42(9), 4603\u20134610. https:\/\/doi.org\/10.21873\/anticanres.15964","DOI":"10.21873\/anticanres.15964"},{"issue":"4","key":"10169_CR149","doi-asserted-by":"publisher","first-page":"e006401","DOI":"10.1136\/jitc-2022-006401","volume":"11","author":"MM Melssen","year":"2023","unstructured":"Melssen, M. M., Sheybani, N. D., Leick, K. M., & Slingluff, C. L., Jr. (2023). Barriers to immune cell infiltration in tumors. Journal for Immunotherapy of Cancer, 11(4), e006401. https:\/\/doi.org\/10.1136\/jitc-2022-006401","journal-title":"Journal for Immunotherapy of Cancer"},{"key":"10169_CR150","doi-asserted-by":"publisher","unstructured":"Nicolas-Boluda, A., Vaquero, J., Vimeux, L., Guilbert, T., Barrin, S., Kantari-Mimoun, C., \u2026 Donnadieu, E. (2021). Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment. eLife, 10. https:\/\/doi.org\/10.7554\/eLife.58688","DOI":"10.7554\/eLife.58688"},{"key":"10169_CR151","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3389\/fphar.2014.00051","volume":"5","author":"ML Mancini","year":"2014","unstructured":"Mancini, M. L., & Sonis, S. T. (2014). Mechanisms of cellular fibrosis associated with cancer regimen-related toxicities. Frontiers in Pharmacology, 5, 51. https:\/\/doi.org\/10.3389\/fphar.2014.00051","journal-title":"Frontiers in Pharmacology"},{"issue":"2","key":"10169_CR152","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.ygyno.2012.11.007","volume":"128","author":"J Hynninen","year":"2013","unstructured":"Hynninen, J., Lavonius, M., Oksa, S., Gr\u00e9nman, S., Carp\u00e9n, O., & Auranen, A. (2013). Is perioperative visual estimation of intra-abdominal tumor spread reliable in ovarian cancer surgery after neoadjuvant chemotherapy? Gynecologic Oncology, 128(2), 229\u2013232. https:\/\/doi.org\/10.1016\/j.ygyno.2012.11.007","journal-title":"Gynecologic Oncology"},{"key":"10169_CR153","doi-asserted-by":"publisher","unstructured":"Samrao, D., Wang, D., Ough, F., Lin, Y. G., Liu, S., Menesses, T., \u2026 Mhawech-Fauceglia, P. (2012). Histologic parameters predictive of disease outcome in women with advanced stage ovarian carcinoma treated with neoadjuvant chemotherapy. Translational Oncology, 5(6), 469\u2013474. https:\/\/doi.org\/10.1593\/tlo.12265","DOI":"10.1593\/tlo.12265"},{"key":"10169_CR154","doi-asserted-by":"publisher","unstructured":"Kaukonen, R., Mai, A., Georgiadou, M., Saari, M., De Franceschi, N., Betz, T., \u2026 Ivaska, J. (2016). Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription. Nature Communications, 7(1), 12237. https:\/\/doi.org\/10.1038\/ncomms12237","DOI":"10.1038\/ncomms12237"},{"issue":"1","key":"10169_CR155","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1186\/s12943-022-01670-1","volume":"21","author":"M Xu","year":"2022","unstructured":"Xu, M., Zhang, T., Xia, R., Wei, Y., & Wei, X. (2022). Targeting the tumor stroma for cancer therapy. Molecular Cancer, 21(1), 208. https:\/\/doi.org\/10.1186\/s12943-022-01670-1","journal-title":"Molecular Cancer"},{"issue":"1","key":"10169_CR156","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00262-007-0365-5","volume":"57","author":"V Hofmeister","year":"2008","unstructured":"Hofmeister, V., Schrama, D., & Becker, J. C. (2008). Anti-cancer therapies targeting the tumor stroma. Cancer Immunology, Immunotherapy: CII, 57(1), 1\u201317. https:\/\/doi.org\/10.1007\/s00262-007-0365-5","journal-title":"Cancer Immunology, Immunotherapy: CII"},{"issue":"2","key":"10169_CR157","doi-asserted-by":"publisher","first-page":"165","DOI":"10.4254\/wjh.v7.i2.165","volume":"7","author":"F Heindryckx","year":"2015","unstructured":"Heindryckx, F., & Gerwins, P. (2015). Targeting the tumor stroma in hepatocellular carcinoma. World Journal of Hepatology, 7(2), 165\u2013176. https:\/\/doi.org\/10.4254\/wjh.v7.i2.165","journal-title":"World Journal of Hepatology"},{"issue":"2","key":"10169_CR158","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1158\/0008-5472.CAN-18-1334","volume":"79","author":"KY Elahi-Gedwillo","year":"2019","unstructured":"Elahi-Gedwillo, K. Y., Carlson, M., Zettervall, J., & Provenzano, P. P. (2019). Antifibrotic therapy disrupts stromal barriers and modulates the immune landscape in pancreatic ductal adenocarcinoma. Cancer Research, 79(2), 372\u2013386. https:\/\/doi.org\/10.1158\/0008-5472.CAN-18-1334","journal-title":"Cancer Research"},{"key":"10169_CR159","doi-asserted-by":"publisher","first-page":"33","DOI":"10.2147\/OTT.S38111","volume":"7","author":"A Neesse","year":"2013","unstructured":"Neesse, A., Krug, S., Gress, T. M., Tuveson, D. A., & Michl, P. (2013). Emerging concepts in pancreatic cancer medicine: Targeting the tumor stroma. OncoTargets and Therapy, 7, 33\u201343. https:\/\/doi.org\/10.2147\/OTT.S38111","journal-title":"OncoTargets and Therapy"},{"issue":"1","key":"10169_CR160","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s12079-017-0419-1","volume":"12","author":"J Hutchenreuther","year":"2018","unstructured":"Hutchenreuther, J., & Leask, A. (2018). Why target the tumor stroma in melanoma? Journal of Cell Communication and Signaling, 12(1), 113\u2013118. https:\/\/doi.org\/10.1007\/s12079-017-0419-1","journal-title":"Journal of Cell Communication and Signaling"},{"issue":"3","key":"10169_CR161","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1172\/JCI31487","volume":"117","author":"TA Wynn","year":"2007","unstructured":"Wynn, T. A. (2007). Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. The Journal of Clinical Investigation, 117(3), 524\u2013529. https:\/\/doi.org\/10.1172\/JCI31487","journal-title":"The Journal of Clinical Investigation"},{"issue":"7","key":"10169_CR162","doi-asserted-by":"publisher","first-page":"2686","DOI":"10.1158\/1078-0432.CCR-04-1946","volume":"11","author":"T Suganuma","year":"2005","unstructured":"Suganuma, T., Ino, K., Shibata, K., Kajiyama, H., Nagasaka, T., Mizutani, S., & Kikkawa, F. (2005). Functional expression of the angiotensin II type 1 receptor in human ovarian carcinoma cells and its blockade therapy resulting in suppression of tumor invasion, angiogenesis, and peritoneal dissemination. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, 11(7), 2686\u20132694. https:\/\/doi.org\/10.1158\/1078-0432.CCR-04-1946","journal-title":"Clinical Cancer Research: An Official Journal of the American Association for Cancer Research"},{"key":"10169_CR163","doi-asserted-by":"publisher","unstructured":"McCloskey, C. W., Cook, D. P., Kelly, B. S., Azzi, F., Allen, C. H., Forsyth, A., \u2026 Vanderhyden, B. C. (2020, February 1). Metformin abrogates age-associated ovarian fibrosis. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research. American Association for Cancer Research (AACR). https:\/\/doi.org\/10.1158\/1078-0432.CCR-19-0603","DOI":"10.1158\/1078-0432.CCR-19-0603"},{"issue":"7503","key":"10169_CR164","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1136\/bmj.38415.708634.F7","volume":"330","author":"JMM Evans","year":"2005","unstructured":"Evans, J. M. M., Donnelly, L. A., Emslie-Smith, A. M., Alessi, D. R., & Morris, A. D. (2005). Metformin and reduced risk of cancer in diabetic patients. BMJ (Clinical Research ed.), 330(7503), 1304\u20131305. https:\/\/doi.org\/10.1136\/bmj.38415.708634.F7","journal-title":"BMJ (Clinical Research ed.)"},{"issue":"12","key":"10169_CR165","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1093\/annonc\/mdw410","volume":"27","author":"C Coyle","year":"2016","unstructured":"Coyle, C., Cafferty, F. H., Vale, C., & Langley, R. E. (2016). Metformin as an adjuvant treatment for cancer: A systematic review and meta-analysis. Annals of Oncology, 27(12), 2184\u20132195. https:\/\/doi.org\/10.1093\/annonc\/mdw410","journal-title":"Annals of Oncology"},{"key":"10169_CR166","doi-asserted-by":"publisher","unstructured":"Urpilainen, E., Puistola, U., Boussios, S., & Karihtala, P. (2020). Metformin and ovarian cancer: The evidence. Annals of Translational Medicine, 8(24), 1711. https:\/\/doi.org\/10.21037\/atm-20-1060","DOI":"10.21037\/atm-20-1060"},{"key":"10169_CR167","doi-asserted-by":"publisher","unstructured":"Guglielmi, V., Cardellini, M., Cinti, F., Corgosinho, F., Cardolini, I., D\u2019Adamo, M., \u2026 Sbraccia, P. (2015). Omental adipose tissue fibrosis and insulin resistance in severe obesity. Nutrition & Diabetes, 5(8), e175. https:\/\/doi.org\/10.1038\/nutd.2015.22","DOI":"10.1038\/nutd.2015.22"},{"issue":"2","key":"10169_CR168","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1093\/abbs\/gmx106","volume":"50","author":"N Saini","year":"2018","unstructured":"Saini, N., & Yang, X. (2018). Metformin as an anti-cancer agent: Actions and mechanisms targeting cancer stem cells. Acta biochimica et biophysica Sinica, 50(2), 133\u2013143. https:\/\/doi.org\/10.1093\/abbs\/gmx106","journal-title":"Acta biochimica et biophysica Sinica"},{"key":"10169_CR169","doi-asserted-by":"publisher","unstructured":"Fielding, C. A., Jones, G. W., McLoughlin, R. M., McLeod, L., Hammond, V. J., Uceda, J., \u2026 Jones, S. A. (2014). Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity, 40(1), 40\u201350. https:\/\/doi.org\/10.1016\/j.immuni.2013.10.022","DOI":"10.1016\/j.immuni.2013.10.022"},{"key":"10169_CR170","doi-asserted-by":"publisher","unstructured":"Yang, X., Huang, M., Zhang, Q., Chen, J., Li, J., Han, Q., \u2026 Han, B. (2021). Metformin antagonizes ovarian cancer cells malignancy through MSLN mediated IL-6\/STAT3 signaling. Cell Transplantation, 30, 9636897211027820. https:\/\/doi.org\/10.1177\/09636897211027819","DOI":"10.1177\/09636897211027819"},{"key":"10169_CR171","doi-asserted-by":"publisher","unstructured":"Brown, J. R., Chan, D. K., Shank, J. J., Griffith, K. A., Fan, H., Szulawski, R., \u2026 Buckanovich, R. J. (2020). Phase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer. JCI Insight, 5(11). https:\/\/doi.org\/10.1172\/jci.insight.133247","DOI":"10.1172\/jci.insight.133247"},{"issue":"8","key":"10169_CR172","doi-asserted-by":"publisher","first-page":"4144","DOI":"10.3390\/ijms23084144","volume":"23","author":"J Thorlacius-Ussing","year":"2022","unstructured":"Thorlacius-Ussing, J., Jensen, C., Madsen, E. A., Nissen, N. I., Manon-Jensen, T., Chen, I. M., Johansen, J. S., Diab, H. M. H., J\u00f8rgensen, L. N., Karsdal, M. A., & Willumsen, N. (2022). Type XX collagen is elevated in circulation of patients with solid tumors. International Journal of Molecular Sciences, 23(8), 4144. https:\/\/doi.org\/10.3390\/ijms23084144","journal-title":"International Journal of Molecular Sciences"}],"container-title":["Cancer and Metastasis Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10555-024-10169-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10555-024-10169-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10555-024-10169-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T04:10:52Z","timestamp":1722831052000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10555-024-10169-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,28]]},"references-count":172,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10169"],"URL":"https:\/\/doi.org\/10.1007\/s10555-024-10169-8","relation":{},"ISSN":["0167-7659","1573-7233"],"issn-type":[{"value":"0167-7659","type":"print"},{"value":"1573-7233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,28]]},"assertion":[{"value":"22 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}