{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:04:25Z","timestamp":1789621465667,"version":"build-2803163510"},"reference-count":204,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173074"],"award-info":[{"award-number":["82173074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Natural Science Foundation","award":["7232127"],"award-info":[{"award-number":["7232127"]}]},{"name":"Capital's Funds for Health Improvement and Research","award":["2024-2-4017"],"award-info":[{"award-number":["2024-2-4017"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Metastasis Rev"],"DOI":"10.1007\/s10555-025-10297-9","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T06:52:40Z","timestamp":1761375160000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lymphatic metastasis in pancreatic cancer: from bedside to bench and back"],"prefix":"10.1007","volume":"44","author":[{"given":"Haoyu","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangbo","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeru","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,25]]},"reference":[{"issue":"1","key":"10297_CR1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","volume":"74","author":"RL Siegel","year":"2024","unstructured":"Siegel, R. L., Giaquinto, A. N., & Jemal, A. (2024). Cancer statistics, 2024. CA: A Cancer Journal for Clinicians, 74(1), 12\u201349. https:\/\/doi.org\/10.3322\/caac.21820","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"2","key":"10297_CR2","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1097\/00006676-199708000-00007","volume":"15","author":"SB Hosch","year":"1997","unstructured":"Hosch, S. B., Knoefel, W. T., Metz, S., Stoecklein, N., Niendorf, A., Broelsch, C. E., & Izbicki, J. R. (1997). Early lymphatic tumor cell dissemination in pancreatic cancer: Frequency and prognostic significance. Pancreas, 15(2), 154\u2013159. https:\/\/doi.org\/10.1097\/00006676-199708000-00007","journal-title":"Pancreas"},{"issue":"9","key":"10297_CR3","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1245\/s10434-006-9016-x","volume":"13","author":"RE Schwarz","year":"2006","unstructured":"Schwarz, R. E., & Smith, D. D. (2006). Extent of lymph node retrieval and pancreatic cancer survival: Information from a large US population database. Annals Of Surgical Oncology, 13(9), 1189\u20131200. https:\/\/doi.org\/10.1245\/s10434-006-9016-x","journal-title":"Annals Of Surgical Oncology"},{"issue":"9","key":"10297_CR4","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1002\/jhbp.1159","volume":"29","author":"SK Min","year":"2022","unstructured":"Min, S. K., You, Y., Choi, D. W., Han, I. W., Shin, S. H., Yoon, S., Jung, J. H., Yoon, S. J., & Heo, J. S. (2022). Prognosis of pancreatic head cancer with different patterns of lymph node metastasis. Journal of Hepato-Biliary-Pancreatic Sciences, 29(9), 1004\u20131013. https:\/\/doi.org\/10.1002\/jhbp.1159","journal-title":"Journal of Hepato-Biliary-Pancreatic Sciences"},{"issue":"10","key":"10297_CR5","doi-asserted-by":"publisher","first-page":"2701","DOI":"10.1002\/cam4.853","volume":"5","author":"JY Lin","year":"2016","unstructured":"Lin, J. Y., Zhang, X. M., Kou, J. T., Fa, H., Zhang, X. X., Dai, Y., & He, Q. (2016). Analysis of prognostic factors for pancreatic head cancer according to para-aortic lymph node. Cancer Medicine, 5(10), 2701\u20132707. https:\/\/doi.org\/10.1002\/cam4.853","journal-title":"Cancer Medicine"},{"issue":"6","key":"10297_CR6","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1016\/j.surg.2022.08.020","volume":"172","author":"A Nie\u00dfen","year":"2022","unstructured":"Nie\u00dfen, A., Schimmack, S., Lewosinska, M., Hinz, U., Bechtiger, F. A., Hackert, T., B\u00fcchler, M. W., & Strobel, O. (2022). Lymph node metastases and recurrence in pancreatic neuroendocrine neoplasms. Surgery, 172(6), 1791\u20131799. https:\/\/doi.org\/10.1016\/j.surg.2022.08.020","journal-title":"Surgery"},{"issue":"1","key":"10297_CR7","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15886-6","volume":"11","author":"C Zhang","year":"2020","unstructured":"Zhang, C., Zhang, L., Xu, T., Xue, R., Yu, L., Zhu, Y., Wu, Y., Zhang, Q., Li, D., Shen, S., Tan, D., Bai, F., & Zhang, H. (2020). Mapping the spreading routes of lymphatic metastases in human colorectal cancer. Nature Communications, 11(1), Article 1993. https:\/\/doi.org\/10.1038\/s41467-020-15886-6","journal-title":"Nature Communications"},{"issue":"4","key":"10297_CR8","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1172\/JCI96153","volume":"2","author":"MB Siegel","year":"2018","unstructured":"Siegel, M. B., He, X., Hoadley, K. A., Hoyle, A., Pearce, J. B., Garrett, A. L., Kumar, S., Moylan, V. J., Brady, C. M., Van Swearingen, A. E., Marron, D., Gupta, G. P., Thorne, L. B., Kieran, N., Livasy, C., Mardis, E. R., Parker, J. S., Chen, M., Anders, C. K., & Perou, C. M. (2018). Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer. Journal of Clinical Investigation, 2(4), 1371\u20131383. https:\/\/doi.org\/10.1172\/JCI96153","journal-title":"Journal of Clinical Investigation"},{"issue":"4","key":"10297_CR9","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1172\/JCI96149","volume":"128","author":"I Ullah","year":"2018","unstructured":"Ullah, I., Karthik, G. M., Alkodsi, A., Kj\u00e4llquist, U., St\u00e5lhammar, G., L\u00f6vrot, J., Martinez, N. F., Lagergren, J., Hautaniemi, S., Hartman, J., & Bergh, J. (2018). Evolutionary history of metastatic breast cancer reveals minimal seeding from axillary lymph nodes. Journal of Clinical Investigation, 128(4), 1355\u20131370. https:\/\/doi.org\/10.1172\/JCI96149","journal-title":"Journal of Clinical Investigation"},{"issue":"3","key":"10297_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030627","volume":"10","author":"H Zhou","year":"2021","unstructured":"Zhou, H., Lei, P. J., & Padera, T. P. (2021). Progression of metastasis through lymphatic system. Cells, 10(3), Article 627. https:\/\/doi.org\/10.3390\/cells10030627","journal-title":"Cells"},{"issue":"3","key":"10297_CR11","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.pan.2015.02.011","volume":"15","author":"M Beuran","year":"2015","unstructured":"Beuran, M., Negoi, I., Paun, S., Ion, A. D., Bleotu, C., Negoi, R. I., & Hostiuc, S. (2015). The epithelial to mesenchymal transition in pancreatic cancer: A systematic review. Pancreatology, 15(3), 217\u2013225. https:\/\/doi.org\/10.1016\/j.pan.2015.02.011","journal-title":"Pancreatology"},{"key":"10297_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2012.00209","volume":"2","author":"E Karamitopoulou","year":"2013","unstructured":"Karamitopoulou, E. (2013). Tumor budding cells, cancer stem cells and epithelial-mesenchymal transition-type cells in pancreatic cancer. Frontiers in Oncology, 2, Article 209. https:\/\/doi.org\/10.3389\/fonc.2012.00209","journal-title":"Frontiers in Oncology"},{"key":"10297_CR13","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1038\/nrc1456","volume":"4","author":"CH Heldin","year":"2004","unstructured":"Heldin, C. H., Rubin, K., Pietras, K., & \u00d6stman, A. (2004). High interstitial fluid pressure-An obstacle in cancer therapy. Nature Reviews Cancer, 4, 806\u2013813. https:\/\/doi.org\/10.1038\/nrc1456","journal-title":"Nature Reviews Cancer"},{"key":"10297_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2022.111362","volume":"145","author":"G N\u00e6vdal","year":"2022","unstructured":"N\u00e6vdal, G., Rofstad, E. K., S\u00f8reide, K., & Evje, S. (2022). Fluid-sensitive migration mechanisms predict association between metastasis and high interstitial fluid pressure in pancreatic cancer. Journal of Biomechanics, 145, Article 111362. https:\/\/doi.org\/10.1016\/j.jbiomech.2022.111362","journal-title":"Journal of Biomechanics"},{"key":"10297_CR15","doi-asserted-by":"publisher","first-page":"48060","DOI":"10.18632\/oncotarget.18231","volume":"8","author":"LMK Andersen","year":"2017","unstructured":"Andersen, L. M. K., Wegner, C. S., Simonsen, T. G., Huang, R., Gaustad, J. V., Hauge, A., Galappathi, K., & Rofstad, E. K. (2017). Lymph node metastasis and the physicochemical micro-environment of pancreatic ductal adenocarcinoma xenografts. Oncotarget, 8, 48060\u201348074. https:\/\/doi.org\/10.18632\/oncotarget.18231","journal-title":"Oncotarget"},{"issue":"2","key":"10297_CR16","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/s41568-019-0221-x","volume":"20","author":"G Follain","year":"2020","unstructured":"Follain, G., Herrmann, D., Harlepp, S., Hyenne, V., Osmani, N., Warren, S. C., Timpson, P., & Goetz, J. G. (2020). Fluids and their mechanics in tumour transit: Shaping metastasis. Nature Reviews Cancer, 20(2), 107\u2013124. https:\/\/doi.org\/10.1038\/s41568-019-0221-x","journal-title":"Nature Reviews Cancer"},{"issue":"6","key":"10297_CR17","doi-asserted-by":"publisher","first-page":"2729","DOI":"10.1158\/0008-5472.CAN-06-4102","volume":"67","author":"RK Jain","year":"2007","unstructured":"Jain, R. K., Tong, R. T., & Munn, L. L. (2007). Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: Insights from a mathematical model. Cancer Research, 67(6), 2729\u20132735. https:\/\/doi.org\/10.1158\/0008-5472.CAN-06-4102","journal-title":"Cancer Research"},{"issue":"1","key":"10297_CR18","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1146\/annurev-bioeng-071813-105259","volume":"16","author":"RK Jain","year":"2014","unstructured":"Jain, R. K., Martin, J. D., & Stylianopoulos, T. (2014). The role of mechanical forces in tumor growth and therapy. Annual Review of Biomedical Engineering, 16(1), 321\u2013346. https:\/\/doi.org\/10.1146\/annurev-bioeng-071813-105259","journal-title":"Annual Review of Biomedical Engineering"},{"issue":"6","key":"10297_CR19","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.ccr.2007.04.020","volume":"11","author":"JD Shields","year":"2007","unstructured":"Shields, J. D., Fleury, M. E., Yong, C., Tomei, A. A., Randolph, G. J., & Swartz, M. A. (2007). Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling. Cancer Cell, 11(6), 526\u2013538. https:\/\/doi.org\/10.1016\/j.ccr.2007.04.020","journal-title":"Cancer Cell"},{"issue":"16","key":"10297_CR20","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1091\/mbc.E18-03-0164","volume":"29","author":"R Li","year":"2018","unstructured":"Li, R., Serrano, J. C., Xing, H., Lee, T. A., Azizgolshani, H., Zaman, M., & Kamm, R. D. (2018). Interstitial flow promotes macrophage polarization toward an M2 phenotype. Molecular Biology of The Cell, 29(16), 1927\u20131940. https:\/\/doi.org\/10.1091\/mbc.E18-03-0164","journal-title":"Molecular Biology of The Cell"},{"issue":"5","key":"10297_CR21","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.remn.2015.10.006","volume":"35","author":"M Beisani","year":"2016","unstructured":"Beisani, M., Roca, I., Cardenas, R., Blanco, L., Abu-Suboh, M., Dot, J., Armengol, J. R., Olsina, J. J., Balsells, J., Charco, R., & Castell, J. (2016). Initial experience in sentinel lymph node detection in pancreatic cancer. Revista Espa\u00f1ola De Medicina Nuclear E Imagen Molecular, 35(5), 287\u2013291. https:\/\/doi.org\/10.1016\/j.remn.2015.10.006","journal-title":"Revista Espa\u00f1ola De Medicina Nuclear E Imagen Molecular"},{"issue":"3","key":"10297_CR22","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.ccr.2012.01.007.PMID:22439937;PMCID:PMC3371414","volume":"21","author":"PP Provenzano","year":"2012","unstructured":"Provenzano, P. P., Cuevas, C., Chang, A. E., Goel, V. K., Von Hoff, D. D., & Hingorani, S. R. (2012Mar 20). Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell, 21(3), 418\u2013429. https:\/\/doi.org\/10.1016\/j.ccr.2012.01.007.PMID:22439937;PMCID:PMC3371414","journal-title":"Cancer Cell"},{"issue":"27","key":"10297_CR23","doi-asserted-by":"publisher","first-page":"3185","DOI":"10.1200\/JCO.20.00590","volume":"20","author":"E Van Cutsem","year":"2020","unstructured":"Van Cutsem, E., Tempero, M. A., Sigal, D., Oh, D. Y., Fazio, N., Macarulla, T., Hitre, E., Hammel, P., Hendifar, A. E., Bates, S. E., Li, C. P., Hingorani, S. R., de la Fouchardiere, C., Kasi, A., Heinemann, V., Maraveyas, A., Bahary, N., Layos, L., Sahai, V., \u2026 Bullock, A. J. (2020). Randomized phase III trial of pegvorhyaluronidase alfa with nab-paclitaxel plus gemcitabine for patients with hyaluronan-high metastatic pancreatic adenocarcinoma. Journal of Clinical Oncology, 20(27), 3185\u20133194. https:\/\/doi.org\/10.1200\/JCO.20.00590","journal-title":"Journal of Clinical Oncology"},{"key":"10297_CR24","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/s41416-021-01330-z","volume":"125","author":"AL Magnussen","year":"2021","unstructured":"Magnussen, A. L., & Mills, I. G. (2021). Vascular normalisation as the stepping stone into tumour microenvironment transformation. British Journal of Cancer, 125, 324\u2013336. https:\/\/doi.org\/10.1038\/s41416-021-01330-z","journal-title":"British Journal of Cancer"},{"issue":"5","key":"10297_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11050588","volume":"11","author":"MG van Mackelenbergh","year":"2019","unstructured":"van Mackelenbergh, M. G., Stroes, C. I., Spijker, R., van Eijck, C. H. J., Wilmink, J. W., Bijlsma, M. F., & van Laarhoven, H. W. M. (2019). Clinical trials targeting the stroma in pancreatic cancer: A systematic review and meta-analysis. Cancers, 11(5), Article 588. https:\/\/doi.org\/10.3390\/cancers11050588","journal-title":"Cancers"},{"key":"10297_CR26","doi-asserted-by":"publisher","first-page":"2308","DOI":"10.1038\/s12276-023-01114-w","volume":"55","author":"Y Choi","year":"2023","unstructured":"Choi, Y., & Jung, K. (2023). Normalization of the tumor microenvironment by harnessing vascular and immune modulation to achieve enhanced cancer therapy. Experimental and Molecular Medicine, 55, 2308\u20132319. https:\/\/doi.org\/10.1038\/s12276-023-01114-w","journal-title":"Experimental and Molecular Medicine"},{"issue":"3","key":"10297_CR27","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1111\/cas.13138","volume":"108","author":"H Wei","year":"2017","unstructured":"Wei, H., Wang, F., Wang, Y., Li, T., Xiu, P., Zhong, J., Sun, X., & Li, J. (2017). Verteporfin suppresses cell survival, angiogenesis and vasculogenic mimicry of pancreatic ductal adenocarcinoma via disrupting the YAP-TEAD complex. Cancer Science, 108(3), 478\u2013487. https:\/\/doi.org\/10.1111\/cas.13138","journal-title":"Cancer Science"},{"key":"10297_CR28","doi-asserted-by":"publisher","unstructured":"Zhang, J., Liu, C., Mo, X., Shi, H., Li, S. (2017) Mechanisms by which CXCR4\/CXCL12 cause metastatic behavior in pancreatic cancer. Oncol Lett. 2018 Feb;15(2):1771\u20131776. https:\/\/doi.org\/10.3892\/ol.2017.7512. Epub 2017 Dec 5. PMID: 29434873; PMCID: PMC5777106.","DOI":"10.3892\/ol.2017.7512"},{"issue":"1","key":"10297_CR29","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.jss.2010.03.001","volume":"171","author":"K Cui","year":"2011","unstructured":"Cui, K., Zhao, W., Wang, C., Wang, A., Zhang, B., Zhou, W., Yu, J., Sun, Z., & Li, S. (2011). The CXCR4-CXCL12 pathway facilitates the progression of pancreatic cancer via induction of angiogenesis and lymphangiogenesis. Journal of Surgical Research, 171(1), 143\u2013150. https:\/\/doi.org\/10.1016\/j.jss.2010.03.001","journal-title":"Journal of Surgical Research"},{"key":"10297_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00518","volume":"10","author":"RH Farnsworth","year":"2019","unstructured":"Farnsworth, R. H., Karnezis, T., Maciburko, S. J., Mueller, S. N., & Stacker, S. A. (2019). The interplay between lymphatic vessels and chemokines. Frontiers in Immunology, 10, Article 518. https:\/\/doi.org\/10.3389\/fimmu.2019.00518","journal-title":"Frontiers in Immunology"},{"issue":"8","key":"10297_CR31","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1084\/jem.20111627","volume":"210","author":"S Das","year":"2013","unstructured":"Das, S., et al. (2013). Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses. Journal of Experimental Medicine, 210(8), 1509\u20131528. https:\/\/doi.org\/10.1084\/jem.20111627","journal-title":"Journal of Experimental Medicine"},{"issue":"1","key":"10297_CR32","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1002\/med.21855","volume":"42","author":"S Rezzola","year":"2022","unstructured":"Rezzola, S., Sigmund, E. C., Halin, C., & Ronca, R. (2022). The lymphatic vasculature: An active and dynamic player in cancer progression. Medicinal Research Reviews, 42(1), 576\u2013614. https:\/\/doi.org\/10.1002\/med.21855","journal-title":"Medicinal Research Reviews"},{"issue":"1","key":"10297_CR33","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s10585-021-10120-z","volume":"39","author":"SP Leong","year":"2022","unstructured":"Leong, S. P., Naxerova, K., Keller, L., Pantel, K., & Witte, M. (2022). Molecular mechanisms of cancer metastasis via the lymphatic versus the blood vessels. Clinical & Experimental Metastasis, 39(1), 159\u2013179. https:\/\/doi.org\/10.1007\/s10585-021-10120-z","journal-title":"Clinical & Experimental Metastasis"},{"issue":"31","key":"10297_CR34","doi-asserted-by":"publisher","first-page":"10729","DOI":"10.3748\/wjg.v20.i31.10729.PMID:25152576;PMCID:PMC4138453","volume":"20","author":"LM Knab","year":"2014","unstructured":"Knab, L. M., Grippo, P. J., & Bentrem, D. J. (2014Aug 21). Involvement of eicosanoids in the pathogenesis of pancreatic cancer: The roles of cyclooxygenase-2 and 5-lipoxygenase. World Journal of Gastroenterology, 20(31), 10729\u201310739. https:\/\/doi.org\/10.3748\/wjg.v20.i31.10729.PMID:25152576;PMCID:PMC4138453","journal-title":"World Journal of Gastroenterology"},{"issue":"2","key":"10297_CR35","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.ccr.2011.12.026","volume":"21","author":"T Karnezis","year":"2012","unstructured":"Karnezis, T., Shayan, R., Caesar, C., Roufail, S., Harris, N. C., Ardipradja, K., Zhang, Y. F., Williams, S. P., Farnsworth, R. H., Chai, M. G., Rupasinghe, T. W., Tull, D. L., Baldwin, M. E., Sloan, E. K., Fox, S. B., Achen, M. G., & Stacker, S. A. (2012Feb 14). VEGF-D promotes tumor metastasis by regulating prostaglandins produced by the collecting lymphatic endothelium. Cancer Cell, 21(2), 181\u2013195. https:\/\/doi.org\/10.1016\/j.ccr.2011.12.026. PMID: 22340592.","journal-title":"Cancer Cell"},{"issue":"5","key":"10297_CR36","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1172\/JCI44751","volume":"121","author":"D Kerjaschki","year":"2011","unstructured":"Kerjaschki, D., Bago-Horvath, Z., Rudas, M., Sexl, V., Schneckenleithner, C., Wolbank, S., Bartel, G., Krieger, S., Kalt, R., Hantusch, B., Keller, T., Nagy-Bojarszky, K., Huttary, N., Raab, I., Lackner, K., Krautgasser, K., Schachner, H., Kaserer, K., Rezar, S., \u2026 Krupitza, G. (2011). Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse. Journal of Clinical Investigation, 121(5), 2000\u20132012. https:\/\/doi.org\/10.1172\/JCI44751","journal-title":"Journal of Clinical Investigation"},{"issue":"1","key":"10297_CR37","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3338-x","volume":"17","author":"S Zhang","year":"2017","unstructured":"Zhang, S., Zhang, D., Gong, M., Wen, L., Liao, C., & Zou, L. (2017). High lymphatic vessel density and presence of lymphovascular invasion both predict poor prognosis in breast cancer. Bmc Cancer, 17(1), Article 335. https:\/\/doi.org\/10.1186\/s12885-017-3338-x","journal-title":"Bmc Cancer"},{"issue":"2","key":"10297_CR38","doi-asserted-by":"publisher","first-page":"2863","DOI":"10.18632\/oncotarget.13752","volume":"8","author":"S Zhang","year":"2017","unstructured":"Zhang, S., Zhang, D., Yi, S., Gong, M., Lu, C., Cai, Y., Tang, X., & Zou, L. (2017). The relationship of lymphatic vessel density, lymphovascular invasion, and lymph node metastasis in breast cancer: A systematic review and meta-analysis. Oncotarget, 8(2), 2863\u20132873. https:\/\/doi.org\/10.18632\/oncotarget.13752","journal-title":"Oncotarget"},{"issue":"35","key":"10297_CR39","doi-asserted-by":"publisher","first-page":"9473","DOI":"10.1016\/j.biomaterials.2014.07.064","volume":"35","author":"S Wang","year":"2014","unstructured":"Wang, S., Zhang, Q., Luo, X. F., Li, J., He, H., Yang, F., Di, Y., Jin, C., Jiang, X. G., Shen, S., & Fu, deL. (2014). Magnetic graphene-based nanotheranostic agent for dual-modality mapping guided photothermal therapy in regional lymph nodal metastasis of pancreatic cancer. Biomaterials, 35(35), 9473\u20139483. https:\/\/doi.org\/10.1016\/j.biomaterials.2014.07.064","journal-title":"Biomaterials"},{"issue":"9","key":"10297_CR40","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1158\/1535-7163.MCT-20-0963","volume":"20","author":"CA Wang","year":"2021","unstructured":"Wang, C. A., Li, C. F., Huang, R. C., Li, Y. H., Liou, J. P., & Tsai, S. J. (2021). Suppression of extracellular vesicle VEGF-C-mediated lymphangiogenesis and pancreatic cancer early dissemination by a selective HDAC1\/2 inhibitor. Molecular Cancer Therapeutics, 20(9), 1550\u20131560. https:\/\/doi.org\/10.1158\/1535-7163.MCT-20-0963","journal-title":"Molecular Cancer Therapeutics"},{"issue":"6","key":"10297_CR41","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2022.13542","volume":"24","author":"S Hao","year":"2022","unstructured":"Hao, S., Han, W., Ji, Y., Sun, H., Shi, H., Ma, J., Yip, J., & Ding, Y. (2022). BANCR positively regulates the HIF-1\u03b1\/VEGF-C\/VEGFR-3 pathway in a hypoxic microenvironment to promote lymphangiogenesis in pancreatic cancer cells. Oncology Letters, 24(6), Article 422. https:\/\/doi.org\/10.3892\/ol.2022.13542","journal-title":"Oncology Letters"},{"issue":"1","key":"10297_CR42","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01205-6","volume":"19","author":"Y Kong","year":"2020","unstructured":"Kong, Y., Li, Y., Luo, Y., Zhu, J., Zheng, H., Gao, B., Guo, X., Li, Z., Chen, R., & Chen, C. (2020). CircNFIB1 inhibits lymphangiogenesis and lymphatic metastasis via the miR-486-5p\/PIK3R1\/VEGF-C axis in pancreatic cancer. Molecular Cancer, 19(1), Article 82. https:\/\/doi.org\/10.1186\/s12943-020-01205-6","journal-title":"Molecular Cancer"},{"issue":"5574","key":"10297_CR43","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1126\/science.1071420","volume":"296","author":"TP Padera","year":"2002","unstructured":"Padera, T. P., Kadambi, A., di Tomaso, E., Carreira, C. M., Brown, E. B., Boucher, Y., Choi, N. C., Mathisen, D., Wain, J., Mark, E. J., Munn, L. L., & Jain, R. K. (2002). Lymphatic metastasis in the absence of functional intratumor lymphatics. Science, 296(5574), 1883\u20131886. https:\/\/doi.org\/10.1126\/science.1071420","journal-title":"Science"},{"issue":"4","key":"10297_CR44","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.ccr.2004.08.034","volume":"6","author":"R Cao","year":"2004","unstructured":"Cao, R., Bj\u00f6rndahl, M. A., Religa, P., Clasper, S., Garvin, S., Galter, D., Meister, B., Ikomi, F., Tritsaris, K., Dissing, S., Ohhashi, T., Jackson, D. G., & Cao, Y. (2004). PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis. Cancer Cell, 6(4), 333\u2013345. https:\/\/doi.org\/10.1016\/j.ccr.2004.08.034","journal-title":"Cancer Cell"},{"issue":"9","key":"10297_CR45","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1007\/s00535-023-02012-8","volume":"58","author":"M Peng","year":"2023","unstructured":"Peng, M., Li, H., Cao, H., Huang, Y., Yu, W., Shen, C., & Gu, J. (2023). Dual FGFR and VEGFR inhibition synergistically restrain hexokinase 2-dependent lymphangiogenesis and immune escape in intrahepatic cholangiocarcinoma. Journal of Gastroenterology, 58(9), 908\u2013924. https:\/\/doi.org\/10.1007\/s00535-023-02012-8","journal-title":"Journal of Gastroenterology"},{"issue":"19","key":"10297_CR46","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14194612","volume":"14","author":"X Zhou","year":"2022","unstructured":"Zhou, X., Zhong, F., Yan, Y., Wu, S., Wang, H., Liu, J., Li, F., Cui, D., & Xu, M. (2022). Pancreatic cancer cell-derived exosomes promote lymphangiogenesis by downregulating ABHD11-AS1 expression. Cancers, 14(19), Article 4612. https:\/\/doi.org\/10.3390\/cancers14194612","journal-title":"Cancers"},{"issue":"6282","key":"10297_CR47","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1126\/science.aaf1328","volume":"352","author":"F Pucci","year":"2016","unstructured":"Pucci, F., et al. (2016). SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions. Science, 352(6282), 242\u2013246. https:\/\/doi.org\/10.1126\/science.aaf1328","journal-title":"Science"},{"issue":"8","key":"10297_CR48","doi-asserted-by":"publisher","first-page":"2196","DOI":"10.1097\/JS9.0000000000000469","volume":"109","author":"Ningzhen Fu","year":"2023","unstructured":"Fu, Ningzhen, et al. (2023). A deep-learning radiomics-based lymph node metastasis predictive model for pancreatic cancer: A diagnostic study. International Journal of Surgery, 109(8), 2196\u20132203. https:\/\/doi.org\/10.1097\/JS9.0000000000000469","journal-title":"International Journal of Surgery"},{"issue":"5","key":"10297_CR49","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1245\/s10434-011-2154-9","volume":"19","author":"MK Chung","year":"2012","unstructured":"Chung, M. K., Do, I. G., Jung, E., Son, Y. I., Jeong, H. S., & Baek, C. H. (2012). Lymphatic vessels and high endothelial venules are increased in the sentinel lymph nodes of patients with oral squamous cell carcinoma before the arrival of tumor cells. Annals Of Surgical Oncology, 19(5), 1595\u20131601. https:\/\/doi.org\/10.1245\/s10434-011-2154-9","journal-title":"Annals Of Surgical Oncology"},{"issue":"11","key":"10297_CR50","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/nri3298","volume":"12","author":"JP Girard","year":"2012","unstructured":"Girard, J. P., Moussion, C., & F\u00f6rster, R. (2012). HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes. Nature Reviews Immunology, 12(11), 762\u2013773. https:\/\/doi.org\/10.1038\/nri3298","journal-title":"Nature Reviews Immunology"},{"issue":"21","key":"10297_CR51","doi-asserted-by":"publisher","first-page":"10365","DOI":"10.1158\/0008-5472.CAN-06-2977","volume":"66","author":"CN Qian","year":"2006","unstructured":"Qian, C. N., Berghuis, B., Tsarfaty, G., Bruch, M., Kort, E. J., Ditlev, J., Tsarfaty, I., Hudson, E., Jackson, D. G., Petillo, D., Chen, J., Resau, J. H., & Teh, B. T. (2006). Preparing the \u201csoil\u201d: The primary tumor induces vasculature reorganization in the sentinel lymph node before the arrival of metastatic cancer cells. Cancer Research, 66(21), 10365\u201310376. https:\/\/doi.org\/10.1158\/0008-5472.CAN-06-2977","journal-title":"Cancer Research"},{"key":"10297_CR52","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.ebiom.2018.11.061","volume":"39","author":"SM Chai","year":"2019","unstructured":"Chai, S. M., & Lee, S. Y. (2019). High endothelial venules and pancreatic ductal adenocarcinoma: A potential game changer. EBioMedicine, 39, 29\u201330. https:\/\/doi.org\/10.1016\/j.ebiom.2018.11.061","journal-title":"EBioMedicine"},{"key":"10297_CR53","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.ebiom.2018.11.030","volume":"38","author":"B Bahmani","year":"2018","unstructured":"Bahmani, B., Uehara, M., Ordikhani, F., Li, X., Jiang, L., Banouni, N., Ichimura, T., Kasinath, V., Eskandari, S. K., Annabi, N., Bromberg, J. S., Shultz, L. D., Greiner, D. L., & Abdi, R. (2018). Ectopic high endothelial venules in pancreatic ductal adenocarcinoma: A unique site for targeted delivery. EBioMedicine, 38, 79\u201388. https:\/\/doi.org\/10.1016\/j.ebiom.2018.11.030","journal-title":"EBioMedicine"},{"key":"10297_CR54","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/978-1-4939-8709-2_7","volume":"1845","author":"E Jones","year":"2018","unstructured":"Jones, E., Gallimore, A., & Ager, A. (2018). Defining high endothelial venules and tertiary lymphoid structures in cancer. Methods in Molecular Biology, 1845, 99\u2013118. https:\/\/doi.org\/10.1007\/978-1-4939-8709-2_7. PMID: 30141010.","journal-title":"Methods in Molecular Biology"},{"issue":"10","key":"10297_CR55","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1186\/1479-5876-10-206.PMID:23035663;PMCID:PMC3551724","volume":"4","author":"SY Lee","year":"2012","unstructured":"Lee, S. Y., Chao-Nan, Q., Seng, O. A., Peiyi, C., Bernice, W. H., Swe, M. S., Chii, W. J., Jacqueline, H. S., & Chee, S. K. (2012Oct). Changes in specialized blood vessels in lymph nodes and their role in cancer metastasis. Journal of Translational Medicine, 4(10), 206. https:\/\/doi.org\/10.1186\/1479-5876-10-206.PMID:23035663;PMCID:PMC3551724","journal-title":"Journal of Translational Medicine"},{"issue":"3","key":"10297_CR56","doi-asserted-by":"publisher","first-page":"342","DOI":"10.4161\/cbt.27328","volume":"15","author":"H Shen","year":"2014","unstructured":"Shen, H., Wang, X., Shao, Z., Liu, K., Xia, X. Y., Zhang, H. Z., Song, K., Song, Y., & Shang, Z. J. (2014). Alterations of high endothelial venules in primary and metastatic tumors are correlated with lymph node metastasis of oral and pharyngeal carcinoma. Cancer Biology & Therapy, 15(3), 342\u2013349. https:\/\/doi.org\/10.4161\/cbt.27328","journal-title":"Cancer Biology & Therapy"},{"issue":"1","key":"10297_CR57","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/j.1365-2249.2006.03289.x","volume":"148","author":"H Pandha","year":"2007","unstructured":"Pandha, H., Rigg, A., John, J., & Lemoine, N. (2007). Loss of expression of antigen-presenting molecules in human pancreatic cancer and pancreatic cancer cell lines. Clinical and Experimental Immunology, 148(1), 127\u2013135. https:\/\/doi.org\/10.1111\/j.1365-2249.2006.03289.x","journal-title":"Clinical and Experimental Immunology"},{"issue":"2 Pt 1","key":"10297_CR58","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1158\/1078-0432.498.11.2","volume":"11","author":"E Ryschich","year":"2005","unstructured":"Ryschich, E., N\u00f6tzel, T., Hinz, U., Autschbach, F., Ferguson, J., Simon, I., Weitz, J., Fr\u00f6hlich, B., Klar, E., B\u00fcchler, M. W., & Schmidt, J. (2005Jan 15). Control of T-cell-mediated immune response by HLA class I in human pancreatic carcinoma. Clinical Cancer Research, 11(2 Pt 1), 498\u2013504. PMID: 15701833.","journal-title":"Clinical Cancer Research"},{"issue":"7806","key":"10297_CR59","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41586-020-2229-5","volume":"581","author":"K Yamamoto","year":"2020","unstructured":"Yamamoto, K., Venida, A., Yano, J., Biancur, D. E., Kakiuchi, M., Gupta, S., Sohn, A. S. W., Mukhopadhyay, S., Lin, E. Y., Parker, S. J., Banh, R. S., Paulo, J. A., Wen, K. W., Debnath, J., Kim, G. E., Mancias, J. D., Fearon, D. T., Perera, R. M., & Kimmelman, A. C. (2020). Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. Nature, 581(7806), 100\u2013105. https:\/\/doi.org\/10.1038\/s41586-020-2229-5","journal-title":"Nature"},{"issue":"1","key":"10297_CR60","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27349-7","volume":"12","author":"Y Deng","year":"2021","unstructured":"Deng, Y., Xia, X., Zhao, Y., Zhao, Z., Martinez, C., Yin, W., Yao, J., Hang, Q., Wu, W., Zhang, J., Yu, Y., Xia, W., Yao, F., Zhao, D., Sun, Y., Ying, H., Hung, M. C., & Ma, L. (2021). Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance. Nature Communications, 12(1), Article 7041. https:\/\/doi.org\/10.1038\/s41467-021-27349-7","journal-title":"Nature Communications"},{"issue":"1","key":"10297_CR61","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2022.2080329","volume":"11","author":"RB Baleeiro","year":"2022","unstructured":"Baleeiro, R. B., Bouwens, C. J., Liu, P., Di Gioia, C., Dunmall, L. S. C., Nagano, A., Gangeswaran, R., Chelala, C., Kocher, H. M., Lemoine, N. R., & Wang, Y. (2022). MHC class II molecules on pancreatic cancer cells indicate a potential for neo-antigen-based immunotherapy. Oncoimmunology, 11(1), Article 2080329. https:\/\/doi.org\/10.1080\/2162402X.2022.2080329","journal-title":"Oncoimmunology"},{"issue":"4","key":"10297_CR62","doi-asserted-by":"publisher","first-page":"402","DOI":"10.15386\/mpr-2116","volume":"94","author":"A Mucileanu","year":"2021","unstructured":"Mucileanu, A., Chira, R., & Mircea, P. A. (2021). PD-1\/PD-L1 expression in pancreatic cancer and its implication in novel therapies. Medicine And Pharmacy Reports, 94(4), 402\u2013410. https:\/\/doi.org\/10.15386\/mpr-2116","journal-title":"Medicine And Pharmacy Reports"},{"issue":"3","key":"10297_CR63","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014006","volume":"98","author":"Y Hu","year":"2019","unstructured":"Hu, Y., Chen, W., Yan, Z., Ma, J., Zhu, F., & Huo, J. (2019). Prognostic value of PD-L1 expression in patients with pancreatic cancer: A PRISMA-compliant meta-analysis. Medicine (Baltimore), 98(3), Article e14006. https:\/\/doi.org\/10.1097\/MD.0000000000014006","journal-title":"Medicine (Baltimore)"},{"issue":"6","key":"10297_CR64","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2023.13847","volume":"25","author":"G Sun","year":"2023","unstructured":"Sun, G., et al. (2023). Distribution characteristics and clinical significance of infiltrating T cells in the tumor microenvironment of pancreatic cancer. Oncology Letters, 25(6), Article 261. https:\/\/doi.org\/10.3892\/ol.2023.13847","journal-title":"Oncology Letters"},{"key":"10297_CR65","doi-asserted-by":"publisher","unstructured":"Zhou J, Lyu N, Wang Q, Yang M, Kimchi ET, Cheng K, Joshi T, Tukuli AR, Staveley-O'Carroll KF, Li G. A novel role of TGFBI in macrophage polarization and macrophage-induced pancreatic cancer growth and therapeutic resistance. Cancer Lett. 2023 Dec 1;578:216457. https:\/\/doi.org\/10.1016\/j.canlet.2023.216457. Epub 2023 Oct 19. PMID: 37865162.","DOI":"10.1016\/j.canlet.2023.216457"},{"key":"10297_CR66","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.215751","volume":"548","author":"Z He","year":"2022","unstructured":"He, Z., Wang, J., Zhu, C., Xu, J., Chen, P., Jiang, X., Chen, Y., Jiang, J., & Sun, C. (2022). Exosome-derived FGD5-AS1 promotes tumor-associated macrophage M2 polarization-mediated pancreatic cancer cell proliferation and metastasis. Cancer Letters, 548, Article 215751. https:\/\/doi.org\/10.1016\/j.canlet.2022.215751","journal-title":"Cancer Letters"},{"issue":"7986","key":"10297_CR67","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/s41586-023-06685-2","volume":"623","author":"N Caronni","year":"2023","unstructured":"Caronni, N., et al. (2023). IL-1\u03b2+ macrophages fuel pathogenic inflammation in pancreatic cancer. Nature, 623(7986), 415\u2013422. https:\/\/doi.org\/10.1038\/s41586-023-06685-2","journal-title":"Nature"},{"issue":"3","key":"10297_CR68","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.ccell.2020.02.008.PMID:32183949;PMCID:PMC7181337","volume":"37","author":"S Hegde","year":"2020","unstructured":"Hegde, S., Krisnawan, V. E., Herzog, B. H., Zuo, C., Breden, M. A., Knolhoff, B. L., Hogg, G. D., Tang, J. P., Baer, J. M., Mpoy, C., Lee, K. B., Alexander, K. A., Rogers, B. E., Murphy, K. M., Hawkins, W. G., Fields, R. C., DeSelm, C. J., Schwarz, J. K., & DeNardo, D. G. (2020Mar 16). Dendritic cell paucity leads to dysfunctional immune surveillance in pancreatic cancer. Cancer Cell, 37(3), 289-307.e9. https:\/\/doi.org\/10.1016\/j.ccell.2020.02.008.PMID:32183949;PMCID:PMC7181337","journal-title":"Cancer Cell"},{"issue":"1","key":"10297_CR69","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2023.2204015","volume":"12","author":"C Tian","year":"2023","unstructured":"Tian, C., Yuan, H., Lu, Y., He, H., Li, Q., Li, S., Yang, J., Wang, M., Xu, R., Liu, Q., & Xiang, M. (2023). CARD9 deficiency promotes pancreatic cancer growth by blocking dendritic cell maturation via SLC6A8-mediated creatine transport. Oncoimmunology, 12(1), Article 2204015. https:\/\/doi.org\/10.1080\/2162402X.2023.2204015","journal-title":"Oncoimmunology"},{"key":"10297_CR70","doi-asserted-by":"publisher","unstructured":"van Pul, KM., Vuylsteke, RJCLM., van de Ven, R., Te Velde, EA., Rutgers, EJT., van den Tol, PM., Stockmann, HBAC., de Gruijl, TD. (2019) Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node. J Immunother Cancer. 7(1):133. https:\/\/doi.org\/10.1186\/s40425-019-0605-1. PMID: 31118093; PMCID: PMC6530094.","DOI":"10.1186\/s40425-019-0605-1"},{"issue":"14","key":"10297_CR71","doi-asserted-by":"publisher","first-page":"1152551","DOI":"10.3389\/fimmu.2023.1152551.PMID:37033931;PMCID:PMC10076755","volume":"23","author":"ZN Senturk","year":"2023","unstructured":"Senturk, Z. N., Akdag, I., Deniz, B., & Sayi-Yazgan, A. (2023Mar). Pancreatic cancer: Emerging field of regulatory B-cell-targeted immunotherapies. Frontiers in Immunology, 23(14), 1152551. https:\/\/doi.org\/10.3389\/fimmu.2023.1152551.PMID:37033931;PMCID:PMC10076755","journal-title":"Frontiers in Immunology"},{"issue":"1","key":"10297_CR72","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2020.1845424","volume":"9","author":"F Marcon","year":"2020","unstructured":"Marcon, F., Zuo, J., Pearce, H., Nicol, S., Margielewska-Davies, S., Farhat, M., Mahon, B., Middleton, G., Brown, R., Roberts, K. J., & Moss, P. (2020). NK cells in pancreatic cancer demonstrate impaired cytotoxicity and a regulatory IL-10 phenotype. Oncoimmunology, 9(1), Article 1845424. https:\/\/doi.org\/10.1080\/2162402X.2020.1845424","journal-title":"Oncoimmunology"},{"issue":"9","key":"10297_CR73","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.it.2021.07.003","volume":"42","author":"SE Acton","year":"2021","unstructured":"Acton, S. E., et al. (2021). Communication, construction, and fluid control: Lymphoid organ fibroblastic reticular cell and conduit networks. Trends in Immunology, 42(9), 782\u2013794. https:\/\/doi.org\/10.1016\/j.it.2021.07.003","journal-title":"Trends in Immunology"},{"issue":"7","key":"10297_CR74","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022639","volume":"6","author":"SM Soudja","year":"2011","unstructured":"Soudja, S. M., Henri, S., Mello, M., Chasson, L., Mas, A., Wehbe, M., Auphan-Anezin, N., Leserman, L., Van den Eynde, B., & Schmitt-Verhulst, A. M. (2011). Disrupted lymph node and splenic stroma in mice with induced inflammatory melanomas is associated with impaired recruitment of T and dendritic cells. PLoS One, 6(7), Article e22639. https:\/\/doi.org\/10.1371\/journal.pone.0022639","journal-title":"PLoS One"},{"issue":"3","key":"10297_CR75","doi-asserted-by":"publisher","first-page":"2954","DOI":"10.3892\/ol.2017.6537","volume":"14","author":"J Gao","year":"2017","unstructured":"Gao, J., Zhao, L., Liu, L., Yang, Y., Guo, B., & Zhu, B. (2017). Disrupted fibroblastic reticular cells and interleukin-7 expression in tumor draining lymph nodes. Oncology Letters, 14(3), 2954\u20132960. https:\/\/doi.org\/10.3892\/ol.2017.6537","journal-title":"Oncology Letters"},{"issue":"1","key":"10297_CR76","doi-asserted-by":"publisher","DOI":"10.1080\/08941939.2022.2129884","volume":"36","author":"HM Kolbeinsson","year":"2023","unstructured":"Kolbeinsson, H. M., et al. (2023). Pancreatic cancer: A review of current treatment and novel therapies. Journal of Investigative Surgery, 36(1), Article 2129884. https:\/\/doi.org\/10.1080\/08941939.2022.2129884","journal-title":"Journal of Investigative Surgery"},{"issue":"1","key":"10297_CR77","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41571-018-0112-1","volume":"16","author":"O Strobel","year":"2019","unstructured":"Strobel, O., et al. (2019). Optimizing the outcomes of pancreatic cancer surgery. Nature reviews. Clinical oncology, 16(1), 11\u201326. https:\/\/doi.org\/10.1038\/s41571-018-0112-1","journal-title":"Nature reviews. Clinical oncology"},{"issue":"2","key":"10297_CR78","first-page":"307","volume":"73","author":"JG Fortner","year":"1973","unstructured":"Fortner, J. G. (1973). Regional resection of cancer of the pancreas: A new surgical approach. Surgery, 73(2), 307\u2013320.","journal-title":"Surgery"},{"issue":"2","key":"10297_CR79","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1097\/00000658-198808000-00014","volume":"208","author":"O Ishikawa","year":"1988","unstructured":"Ishikawa, O., et al. (1988). Practical usefulness of lymphatic and connective tissue clearance for the carcinoma of the pancreas head. Annals Of Surgery, 208(2), 215\u2013220. https:\/\/doi.org\/10.1097\/00000658-198808000-00014","journal-title":"Annals Of Surgery"},{"issue":"5","key":"10297_CR80","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1002\/1097-0142(19890901)64:5<1132::aid-cncr2820640528>3.0.co;2-v","volume":"64","author":"T Manabe","year":"1989","unstructured":"Manabe, T., et al. (1989). Radical pancreatectomy for ductal cell carcinoma of the head of the pancreas. Cancer, 64(5), 1132\u20131137. https:\/\/doi.org\/10.1002\/1097-0142(19890901)64:5%3c1132::aid-cncr2820640528%3e3.0.co;2-v","journal-title":"Cancer"},{"issue":"4","key":"10297_CR81","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1097\/00000658-199810000-00007","volume":"228","author":"S Pedrazzoli","year":"1998","unstructured":"Pedrazzoli, S., et al. (1998). Standard versus extended lymphadenectomy associated with pancreatoduodenectomy in the surgical treatment of adenocarcinoma of the head of the pancreas: A multicenter, prospective, randomized study. Lymphadenectomy Study Group. Annals Of Surgery, 228(4), 508\u2013517. https:\/\/doi.org\/10.1097\/00000658-199810000-00007","journal-title":"Annals Of Surgery"},{"issue":"23","key":"10297_CR82","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124507","volume":"3","author":"MF Fransen","year":"2018","unstructured":"Fransen, M. F., et al. (2018). Tumor-draining lymph nodes are pivotal in PD-1\/PD-L1 checkpoint therapy. JCI Insight, 3(23), Article e124507. https:\/\/doi.org\/10.1172\/jci.insight.124507","journal-title":"JCI Insight"},{"issue":"36","key":"10297_CR83","doi-asserted-by":"publisher","first-page":"5135","DOI":"10.2217\/fon-2021-0533","volume":"17","author":"M Karunakaran","year":"2021","unstructured":"Karunakaran, M., & Barreto, S. G. (2021). Surgery for pancreatic cancer: Current controversies and challenges. Future oncology (London, England), 17(36), 5135\u20135162. https:\/\/doi.org\/10.2217\/fon-2021-0533","journal-title":"Future oncology (London, England)"},{"issue":"35","key":"10297_CR84","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000026918","volume":"100","author":"Z Wang","year":"2021","unstructured":"Wang, Z., et al. (2021). Optimal extent of lymphadenectomy for radical surgery of pancreatic head adenocarcinoma: 2-year survival rate results of single-center, prospective, randomized controlled study. Medicine, 100(35), Article e26918. https:\/\/doi.org\/10.1097\/MD.0000000000026918","journal-title":"Medicine"},{"issue":"1","key":"10297_CR85","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-023-07337-6","volume":"24","author":"P Heger","year":"2023","unstructured":"Heger, P., Hackert, T., Diener, M. K., Fei\u00dft, M., Klose, C., D\u00f6rr-Harim, C., M\u00f6hlenbrock, F., B\u00fcchler, M. W., & Mihaljevic, A. L. (2023). Conventional partial pancreatoduodenectomy versus an extended pancreatoduodenectomy (triangle operation) for pancreatic head cancers-study protocol for the randomised controlled TRIANGLE trial. Trials, 24(1), Article 363. https:\/\/doi.org\/10.1186\/s13063-023-07337-6","journal-title":"Trials"},{"key":"10297_CR86","doi-asserted-by":"publisher","unstructured":"Farnell, MB., Pearson, RK., Sarr, MG., DiMagno, EP., Burgart, LJ., Dahl, TR., Foster, N., Sargent, DJ. (2005). Pancreas Cancer Working Group. A prospective randomized trial comparing standard pancreatoduodenectomy with pancreatoduodenectomy with extended lymphadenectomy in resectable pancreatic head adenocarcinoma. Surgery. 138(4):618\u201328; discussion 628\u201330. https:\/\/doi.org\/10.1016\/j.surg.2005.06.044. PMID: 16269290.","DOI":"10.1016\/j.surg.2005.06.044"},{"issue":"3","key":"10297_CR87","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1007\/s00534-011-0466-6","volume":"19","author":"Y Nimura","year":"2012","unstructured":"Nimura, Y., Nagino, M., Takao, S., Takada, T., Miyazaki, K., Kawarada, Y., Miyagawa, S., Yamaguchi, A., Ishiyama, S., Takeda, Y., Sakoda, K., Kinoshita, T., Yasui, K., Shimada, H., & Katoh, H. (2012). Standard versus extended lymphadenectomy in radical pancreatoduodenectomy for ductal adenocarcinoma of the head of the pancreas: Long-term results of a Japanese multicenter randomized controlled trial. Journal of Hepato-Biliary-Pancreatic Sciences, 19(3), 230\u2013241. https:\/\/doi.org\/10.1007\/s00534-011-0466-6","journal-title":"Journal of Hepato-Biliary-Pancreatic Sciences"},{"key":"10297_CR88","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s10353-015-0371-3","volume":"48","author":"J Sperling","year":"2016","unstructured":"Sperling, J., Schuld, J., Hechler, A. M., et al. (2016). Extended versus standard lymphadenectomy in patients undergoing pancreaticoduodenectomy for periampullary adenocarcinoma: A prospective randomized single center trial. European Surgery, 48, 26\u201333. https:\/\/doi.org\/10.1007\/s10353-015-0371-3","journal-title":"European Surgery"},{"key":"10297_CR89","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.jare.2022.09.011","volume":"49","author":"W Wang","year":"2023","unstructured":"Wang, W., et al. (2023). Long-term outcomes of standard versus extended lymphadenectomy in pancreatoduodenectomy for pancreatic ductal adenocarcinoma: A Chinese multi-center prospective randomized controlled trial. Journal of Advanced Research, 49, 151\u2013157. https:\/\/doi.org\/10.1016\/j.jare.2022.09.011","journal-title":"Journal of Advanced Research"},{"issue":"3","key":"10297_CR90","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.surg.2014.06.016","volume":"156","author":"JAMG Tol","year":"2014","unstructured":"Tol, J. A. M. G., et al. (2014). Definition of a standard lymphadenectomy in surgery for pancreatic ductal adenocarcinoma: A consensus statement by the International Study Group on Pancreatic Surgery (ISGPS). Surgery, 156(3), 591\u2013600. https:\/\/doi.org\/10.1016\/j.surg.2014.06.016","journal-title":"Surgery"},{"key":"10297_CR91","doi-asserted-by":"publisher","unstructured":"Gockel, Ines .et al. (2007) Resection of the mesopancreas (RMP): A new surgical classification of a known anatomical space. World journal of surgical oncology, 5(44).\u00a0https:\/\/doi.org\/10.1186\/1477-7819-5-44","DOI":"10.1186\/1477-7819-5-44"},{"issue":"3","key":"10297_CR92","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s00423-020-01873-4","volume":"405","author":"G Quero","year":"2020","unstructured":"Quero, G., et al. (2020). Total mesopancreas excision for periampullary malignancy: A single-center propensity score-matched comparison of long-term outcomes. Langenbeck\u2019s Archives Of Surgery, 405(3), 303\u2013312. https:\/\/doi.org\/10.1007\/s00423-020-01873-4","journal-title":"Langenbeck's Archives Of Surgery"},{"issue":"4","key":"10297_CR93","doi-asserted-by":"publisher","first-page":"389","DOI":"10.14701\/ahbps.2020.24.4.389","volume":"24","author":"MJ Kang","year":"2020","unstructured":"Kang, M. J., & Kim, S.-W. (2020). En bloc proximal peri-mesenteric clearance for pancreatic head cancer surgery. Annals Of Hepato-Biliary-Pancreatic Surgery, 24(4), 389\u2013395. https:\/\/doi.org\/10.14701\/ahbps.2020.24.4.389","journal-title":"Annals Of Hepato-Biliary-Pancreatic Surgery"},{"key":"10297_CR94","unstructured":"Agrawal, Manish K et al. (2010). Mesopancreas: Myth or reality?. JOP : Journal of the pancreas, 11(3):230\u20133."},{"issue":"5","key":"10297_CR95","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1067\/msy.2003.146","volume":"133","author":"SM Strasberg","year":"2003","unstructured":"Strasberg, S. M., et al. (2003). Radical antegrade modular pancreatosplenectomy. Surgery, 133(5), 521\u2013527. https:\/\/doi.org\/10.1067\/msy.2003.146","journal-title":"Surgery"},{"issue":"2","key":"10297_CR96","doi-asserted-by":"publisher","first-page":"144","DOI":"10.21873\/cdp.10088","volume":"2","author":"E Kyros","year":"2022","unstructured":"Kyros, E., Davakis, S., Charalabopoulos, A., Tsourouflis, G., Papalampros, A., Felekouras, E., & Nikiteas, N. (2022). Role and efficacy of robotic-assisted radical antegrade modular pancreatosplenectomy (RAMPS) in left-sided pancreatic cancer. Cancer Diagnosis & Prognosis, 2(2), 144\u2013149. https:\/\/doi.org\/10.21873\/cdp.10088","journal-title":"Cancer Diagnosis & Prognosis"},{"issue":"11","key":"10297_CR97","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1002\/jhbp.1120","volume":"29","author":"J Watanabe","year":"2022","unstructured":"Watanabe, J., et al. (2022). The efficacy of radical antegrade modular pancreatosplenectomy: A systematic review and meta-analysis. Journal of Hepato-Biliary-Pancreatic Sciences, 29(11), 1156\u20131165. https:\/\/doi.org\/10.1002\/jhbp.1120","journal-title":"Journal of Hepato-Biliary-Pancreatic Sciences"},{"issue":"1","key":"10297_CR98","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s12893-017-0259-1","volume":"17","author":"Feng Cao","year":"2017","unstructured":"Cao, Feng, et al. (2017). Radical antegrade modular pancreatosplenectomy versus standard procedure in the treatment of left-sided pancreatic cancer: A systemic review and meta-analysis. BMC Surgery, 17(1), 67. https:\/\/doi.org\/10.1186\/s12893-017-0259-1","journal-title":"BMC Surgery"},{"issue":"6","key":"10297_CR99","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.cell.2023.02.021","volume":"186","author":"MK Rahim","year":"2023","unstructured":"Rahim, M. K., et al. (2023). Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes. Cell, 186(6), 1127-1143.e18. https:\/\/doi.org\/10.1016\/j.cell.2023.02.021","journal-title":"Cell"},{"issue":"10","key":"10297_CR100","doi-asserted-by":"publisher","first-page":"2910","DOI":"10.21037\/gs-21-201","volume":"10","author":"J Wang","year":"2021","unstructured":"Wang, J., Lyu, S. C., Zhu, J. Q., Li, X. L., Lang, R., & He, Q. (2021). Extended lymphadenectomy benefits patients with borderline resectable pancreatic head cancer-A single-center retrospective study. Gland Surgery, 10(10), 2910\u20132924. https:\/\/doi.org\/10.21037\/gs-21-201","journal-title":"Gland Surgery"},{"key":"10297_CR101","doi-asserted-by":"publisher","unstructured":"Versteijne, E., Suker, M., Groothuis, K., Akkermans-Vogelaar, JM., Besselink, MG., Bonsing, BA., Buijsen, J., Busch, OR., Creemers, GM., van Dam, RM., Eskens, FALM., Festen, S., de Groot, JWB., Groot Koerkamp, B., de Hingh, IH., Homs, MYV., van Hooft, JE., Kerver, ED., Luelmo, SAC., Neelis, KJ., Nuyttens, J., Paardekooper, GMRM., Patijn, GA., van der Sangen, MJC., de Vos-Geelen J., Wilmink, JW., Zwinderman, AH., Punt, CJ., van Eijck, CH., van Tienhoven, G. (2020) Dutch Pancreatic Cancer Group. Preoperative chemoradiotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer: Results of the Dutch randomized phase III PREOPANC trial.\u00a0Journal of Clinical Oncology, 38(16):1763\u20131773. https:\/\/doi.org\/10.1200\/JCO.19.02274. Epub 2020 Feb 27. PMID: 32105518; PMCID: PMC8265386.","DOI":"10.1200\/JCO.19.02274"},{"issue":"14","key":"10297_CR102","doi-asserted-by":"publisher","DOI":"10.1172\/JCI191944","volume":"135","author":"JM Bryant","year":"2025","unstructured":"Bryant, J. M., Ruffolo, L., Soares, K., Hoffe, S., & Lowy, A. M. (2025). Evolving concepts in adjuvant\/neoadjuvant therapy for resectable pancreas cancer. Journal of Clinical Investigation, 135(14), Article e191944. https:\/\/doi.org\/10.1172\/JCI191944","journal-title":"Journal of Clinical Investigation"},{"key":"10297_CR103","doi-asserted-by":"publisher","unstructured":"Ahmad, S. A., Duong, M., Sohal, D. P. S., Gandhi, N. S., Beg, M. S., Wang-Gillam, A., Wade, J. L., 3rd., Chiorean, E. G., Guthrie, K. A., Lowy, A. M., Philip, P. A., & Hochster, H. S. (2020). Surgical outcome results from SWOG S1505: A randomized clinical trial of mFOLFIRINOX versus gemcitabine\/nab-paclitaxel for perioperative treatment of resectable pancreatic ductal adenocarcinoma. Annals of Surgery, 272(3), 481\u2013486. https:\/\/doi.org\/10.1097\/SLA.0000000000004155","DOI":"10.1097\/SLA.0000000000004155"},{"issue":"17","key":"10297_CR104","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.1200\/JCO-24-01378","volume":"43","author":"L Schwarz","year":"2025","unstructured":"Schwarz, L., Bachet, J. B., Meurisse, A., Bouch\u00e9, O., Assenat, E., Piessen, G., Hammel, P., Regenet, N., Taieb, J., Turrini, O., Paye, F., Turpin, A., Souche, F. R., Laurent, C., Kianmanesh, R., Michel, P., Vernerey, D., Mabrut, J. Y., & Turco, C. (2025). Neoadjuvant FOLF(IRIN)OX chemotherapy for resectable pancreatic adenocarcinoma: A multicenter randomized noncomparative phase II trial (PANACHE01 FRENCH08 PRODIGE48 study). Journal of Clinical Oncology, 43(17), 1984\u20131996. https:\/\/doi.org\/10.1200\/JCO-24-01378","journal-title":"Journal of Clinical Oncology"},{"issue":"6","key":"10297_CR105","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1016\/j.surg.2018.12.009","volume":"165","author":"JI Portuondo","year":"2019","unstructured":"Portuondo, J. I., Massarweh, N. N., Zhang, Q., Chai, C. Y., & Tran Cao, H. S. (2019). Nodal downstaging as a treatment goal for node-positive pancreatic cancer. Surgery, 165(6), 1144\u20131150. https:\/\/doi.org\/10.1016\/j.surg.2018.12.009","journal-title":"Surgery"},{"issue":"1","key":"10297_CR106","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1158\/1078-0432.CCR-19-1864","volume":"26","author":"C Mota Reyes","year":"2020","unstructured":"Mota Reyes, C., Teller, S., Muckenhuber, A., Konukiewitz, B., Safak, O., Weichert, W., Friess, H., Ceyhan, G. O., & Demir, I. E. (2020). Neoadjuvant therapy remodels the pancreatic cancer microenvironment via depletion of protumorigenic immune cells. Clinical Cancer Research, 26(1), 220\u2013231. https:\/\/doi.org\/10.1158\/1078-0432.CCR-19-1864","journal-title":"Clinical Cancer Research"},{"key":"10297_CR107","doi-asserted-by":"publisher","unstructured":"Piper, M., Hoen, M., Darragh, LB., Knitz, MW., Nguyen, D., Gadwa, J., Durini, G., Karakoc, I., Grier, A., Neupert, B., Van Court, B., Abdelazeem, KNM., Yu, J., Olimpo, NA.., Corbo, S., Ross, RB., Pham, TT., Joshi, M., Kedl, RM., Saviola, AJ., Amann, M., Uma\u00f1a, P., Codarri Deak, L., Klein, C., D'Alessandro, A., Karam, SD. (2023). Simultaneous targeting of PD-1 and IL-2R\u03b2\u03b3 with radiation therapy inhibits pancreatic cancer growth and metastasis. Cancer Cell, 41(5):950\u2013969.e6. https:\/\/doi.org\/10.1016\/j.ccell.2023.04.001. Epub 2023 Apr 27. PMID: 37116489; PMCID: PMC10246400.","DOI":"10.1016\/j.ccell.2023.04.001"},{"issue":"5","key":"10297_CR108","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17050747","volume":"17","author":"E Orlandi","year":"2025","unstructured":"Orlandi, E., Vecchia, S., Anselmi, E., Toscani, I., Guasconi, M., Perrone, G., Citterio, C., Banchini, F., & Giuffrida, M. (2025). Neoadjuvant treatment in localized pancreatic cancer of the elderly: A systematic review of the current literature. Cancers, 17(5), Article 747. https:\/\/doi.org\/10.3390\/cancers17050747","journal-title":"Cancers"},{"issue":"16","key":"10297_CR109","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15164174","volume":"15","author":"AJ Jain","year":"2023","unstructured":"Jain, A. J., Maxwell, J. E., Katz, M. H. G., & Snyder, R. A. (2023). Surgical considerations for neoadjuvant therapy for pancreatic adenocarcinoma. Cancers, 15(16), Article 4174. https:\/\/doi.org\/10.3390\/cancers15164174","journal-title":"Cancers"},{"issue":"1","key":"10297_CR110","doi-asserted-by":"publisher","first-page":"80","DOI":"10.33696\/signaling.2.037.PMID:34355216;PMCID:PMC8336067","volume":"2","author":"SP Goyal","year":"2021","unstructured":"Goyal, S. P., Vojnic, M., Yang, J. I., Jose, J., Newman, E., & Saif, M. W. (2021). Neoadjuvant therapy (NAT) in localized pancreatic cancer: Should we do it and what should we do? Journal of Cellular Signaling, 2(1), 80\u201384. https:\/\/doi.org\/10.33696\/signaling.2.037.PMID:34355216;PMCID:PMC8336067","journal-title":"Journal of Cellular Signaling"},{"issue":"3","key":"10297_CR111","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s00268-021-06410-y","volume":"46","author":"AA Javed","year":"2022","unstructured":"Javed, A. A., Ding, D., Baig, E., Wright, M. J., Teinor, J. A., Mansoor, D., Thompson, E., Hruban, R. H., Narang, A., Burns, W. R., 3rd., Burkhart, R. A., Lafaro, K., Weiss, M. J., Cameron, J. L., Wolfgang, C. L., & He, J. (2022). Accurate Nodal Staging in Pancreatic Cancer in the Era of Neoadjuvant Therapy. World Journal of Surgery, 46(3), 667\u2013677. https:\/\/doi.org\/10.1007\/s00268-021-06410-y","journal-title":"World Journal of Surgery"},{"issue":"3","key":"10297_CR112","doi-asserted-by":"publisher","first-page":"21","DOI":"10.21037\/cco-21-175","volume":"11","author":"M Taherian","year":"2022","unstructured":"Taherian, M., & Wang, H. (2022). Critical issues in pathologic evaluation of pancreatic ductal adenocarcinoma resected after neoadjuvant treatment: A narrative review. Chinese Clinical Oncology, 11(3), 21. https:\/\/doi.org\/10.21037\/cco-21-175","journal-title":"Chinese Clinical Oncology"},{"issue":"9","key":"10297_CR113","doi-asserted-by":"publisher","first-page":"14535","DOI":"10.1002\/jcp.28160","volume":"234","author":"V Das","year":"2019","unstructured":"Das, V., et al. (2019). The basics of epithelial-mesenchymal transition (EMT): A study from a structure, dynamics, and functional perspective. Journal of Cellular Physiology, 234(9), 14535\u201314555. https:\/\/doi.org\/10.1002\/jcp.28160","journal-title":"Journal of Cellular Physiology"},{"issue":"12","key":"10297_CR114","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1186\/1471-2407-12-521.PMID:23151184;PMCID:PMC3552976","volume":"14","author":"NR Shin","year":"2012","unstructured":"Shin, N. R., Jeong, E. H., Choi, C. I., Moon, H. J., Kwon, C. H., Chu, I. S., Kim, G. H., Jeon, T. Y., Kim, D. H., Lee, J. H., & Park, D. Y. (2012). Overexpression of Snail is associated with lymph node metastasis and poor prognosis in patients with gastric cancer. BMC Cancer, 14(12), 521. https:\/\/doi.org\/10.1186\/1471-2407-12-521.PMID:23151184;PMCID:PMC3552976","journal-title":"BMC Cancer"},{"issue":"1","key":"10297_CR115","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3668-8","volume":"17","author":"HH Lee","year":"2017","unstructured":"Lee, H. H., Lee, S. H., Song, K. Y., Na, S. J., O, J. H., Park, J. M., Jung, E. S., Choi, M. G., & Park, C. H. (2017). Evaluation of slug expression is useful for predicting lymph node metastasis and survival in patients with gastric cancer. BMC Cancer, 17(1), Article 670. https:\/\/doi.org\/10.1186\/s12885-017-3668-8","journal-title":"BMC Cancer"},{"issue":"10","key":"10297_CR116","first-page":"1483","volume":"124","author":"SM Lu","year":"2011","unstructured":"Lu, S. M., Yu, L., Tian, J. J., Ma, J. K., Li, J. F., Xu, W., & Wang, H. B. (2011May). Twist modulates lymphangiogenesis and correlates with lymph node metastasis in supraglottic carcinoma. Chinese Medical Journal (Engl), 124(10), 1483\u20131487. PMID: 21740802.","journal-title":"Chinese Medical Journal (Engl)"},{"issue":"2B","key":"10297_CR117","first-page":"1355","volume":"28","author":"DL Ou","year":"2008","unstructured":"Ou, D. L., Chien, H. F., Chen, C. L., Lin, T. C., & Lin, L. I. (2008). Role of Twist in head and neck carcinoma with lymph node metastasis. Anticancer Research, 28(2B), 1355\u20131359.","journal-title":"Anticancer Research"},{"key":"10297_CR118","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/589423","volume":"2013","author":"N Wang","year":"2013","unstructured":"Wang, N., Luo, H. J., Yin, G. B., Dong, C. R., Xu, M., Chen, G. G., & Liu, Z. M. (2013). Overexpression of HIF-2\u03b1, TWIST, and CXCR4 is associated with lymph node metastasis in papillary thyroid carcinoma. Clinical and Developmental Immunology, 2013, Article 589423. https:\/\/doi.org\/10.1155\/2013\/589423","journal-title":"Clinical and Developmental Immunology"},{"key":"10297_CR119","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.bbrc.2023.04.080","volume":"664","author":"F Wu","year":"2023","unstructured":"Wu, F., et al. (2023). Neuroglobin inhibits pancreatic cancer proliferation and metastasis by targeting the GNAI1\/EGFR\/AKT\/ERK signaling axis. Biochemical and Biophysical Research Communications, 664, 108\u2013116. https:\/\/doi.org\/10.1016\/j.bbrc.2023.04.080","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"1","key":"10297_CR120","doi-asserted-by":"publisher","first-page":"382","DOI":"10.3892\/or.2020.7600","volume":"44","author":"W Li","year":"2020","unstructured":"Li, W., et al. (2020). Curcumin inhibits pancreatic cancer cell invasion and EMT by interfering with tumor-stromal crosstalk under hypoxic conditions via the IL-6\/ERK\/NF-\u03baB axis. Oncology Reports, 44(1), 382\u2013392. https:\/\/doi.org\/10.3892\/or.2020.7600","journal-title":"Oncology Reports"},{"issue":"1","key":"10297_CR121","doi-asserted-by":"publisher","first-page":"371","DOI":"10.3892\/or.2020.7595","volume":"44","author":"J Yoshida","year":"2020","unstructured":"Yoshida, J., et al. (2020). Metformin inhibits TGF-\u03b21-induced epithelial-mesenchymal transition and liver metastasis of pancreatic cancer cells. Oncology Reports, 44(1), 371\u2013381. https:\/\/doi.org\/10.3892\/or.2020.7595","journal-title":"Oncology Reports"},{"key":"10297_CR122","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2024.107274","volume":"146","author":"J Zhao","year":"2024","unstructured":"Zhao, J., et al. (2024). Riboflavin protects against pancreatic cancer metastasis by targeting TGF-\u03b2 receptor 1. Bioorganic Chemistry, 146, Article 107274. https:\/\/doi.org\/10.1016\/j.bioorg.2024.107274","journal-title":"Bioorganic Chemistry"},{"key":"10297_CR123","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2022.121493","volume":"280","author":"G Sezer","year":"2022","unstructured":"Sezer, G., et al. (2022). Indomethacin prevents TGF-\u03b2-induced epithelial-to-mesenchymal transition in pancreatic cancer cells; evidence by Raman spectroscopy. Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy, 280, Article 121493. https:\/\/doi.org\/10.1016\/j.saa.2022.121493","journal-title":"Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy"},{"issue":"8","key":"10297_CR124","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.1158\/1535-7163.MCT-08-0182","volume":"7","author":"TP Padera","year":"2008","unstructured":"Padera, T. P., et al. (2008). Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib. Molecular Cancer Therapeutics, 7(8), 2272\u20132279. https:\/\/doi.org\/10.1158\/1535-7163.MCT-08-0182","journal-title":"Molecular Cancer Therapeutics"},{"issue":"6","key":"10297_CR125","doi-asserted-by":"publisher","first-page":"600","DOI":"10.2174\/156800910791859489","volume":"10","author":"P Ulivi","year":"2010","unstructured":"Ulivi, P., et al. (2010). In vitro and in vivo antitumor efficacy of docetaxel and sorafenib combination in human pancreatic cancer cells. Current Cancer Drug Targets, 10(6), 600\u2013610. https:\/\/doi.org\/10.2174\/156800910791859489","journal-title":"Current Cancer Drug Targets"},{"issue":"1","key":"10297_CR126","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s13402-019-00473-9","volume":"43","author":"M Momeny","year":"2020","unstructured":"Momeny, M., et al. (2020). Anti-tumor activity of cediranib, a pan-vascular endothelial growth factor receptor inhibitor, in pancreatic ductal adenocarcinoma cells. Cellular Oncology, 43(1), 81\u201393. https:\/\/doi.org\/10.1007\/s13402-019-00473-9","journal-title":"Cellular Oncology"},{"issue":"7","key":"10297_CR127","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13758","volume":"26","author":"JW Kim","year":"2021","unstructured":"Kim, J. W., et al. (2021). Clinical activity and safety of cediranib and olaparib combination in patients with metastatic pancreatic ductal adenocarcinoma without BRCA mutation. The Oncologist, 26(7), Article e1104. https:\/\/doi.org\/10.1002\/onco.13758","journal-title":"The Oncologist"},{"issue":"4","key":"10297_CR128","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/S1470-2045(17)30084-0","volume":"18","author":"G Middleton","year":"2017","unstructured":"Middleton, G., et al. (2017). Vandetanib plus gemcitabine versus placebo plus gemcitabine in locally advanced or metastatic pancreatic carcinoma (ViP): A prospective, randomised, double-blind, multicentre phase 2 trial. The Lancet Oncology, 18(4), 486\u2013499. https:\/\/doi.org\/10.1016\/S1470-2045(17)30084-0","journal-title":"The Lancet Oncology"},{"key":"10297_CR129","doi-asserted-by":"publisher","unstructured":"Meadows, Kellen, L., and Herbert I Hurwitz. (2012) Anti-VEGF therapies in the clinic.\u00a0Cold Spring Harbor Perspectives in Medicine, 2(10). a006577.\u00a0https:\/\/doi.org\/10.1101\/cshperspect.a006577","DOI":"10.1101\/cshperspect.a006577"},{"issue":"4","key":"10297_CR130","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.cell.2010.01.045","volume":"140","author":"T Tammela","year":"2010","unstructured":"Tammela, T., & Alitalo, K. (2010). Lymphangiogenesis: Molecular mechanisms and future promise. Cell, 140(4), 460\u2013476. https:\/\/doi.org\/10.1016\/j.cell.2010.01.045","journal-title":"Cell"},{"issue":"4","key":"10297_CR131","doi-asserted-by":"publisher","first-page":"E371","DOI":"10.1002\/ijc.26502","volume":"131","author":"J Sperveslage","year":"2012","unstructured":"Sperveslage, J., et al. (2012). Lack of CCR7 expression is rate limiting for lymphatic spread of pancreatic ductal adenocarcinoma. International Journal of Cancer, 131(4), E371\u2013E381. https:\/\/doi.org\/10.1002\/ijc.26502","journal-title":"International Journal of Cancer"},{"issue":"21","key":"10297_CR132","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1093\/jnci\/93.21.1638","volume":"93","author":"HE Wiley","year":"2001","unstructured":"Wiley, H. E., et al. (2001). Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma. Journal of the National Cancer Institute, 93(21), 1638\u20131643. https:\/\/doi.org\/10.1093\/jnci\/93.21.1638","journal-title":"Journal of the National Cancer Institute"},{"key":"10297_CR133","doi-asserted-by":"publisher","unstructured":"Yu, Shuyi et al. (2008). A critical role of CCR7 in invasiveness and metastasis of SW620 colon cancer cell in vitro and in vivo.\u00a0Cancer biology & therapy, 7(7):1037\u201343. https:\/\/doi.org\/10.4161\/cbt.7.7.6065","DOI":"10.4161\/cbt.7.7.6065"},{"key":"10297_CR134","unstructured":"Chi, Bao-Jin et al. (2015). Silencing of CCR7 inhibits the growth, invasion and migration of prostate cancer cells induced by VEGFC.\u00a0International journal of clinical and experimental pathology, 8(10):12533\u201340.\u00a0"},{"key":"10297_CR135","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2023.171111","volume":"175","author":"MN Sagini","year":"2024","unstructured":"Sagini, M. N., et al. (2024). EPI-X4, a CXCR4 antagonist inhibits tumor growth in pancreatic cancer and lymphoma models. Peptides, 175, Article 171111. https:\/\/doi.org\/10.1016\/j.peptides.2023.171111","journal-title":"Peptides"},{"issue":"50","key":"10297_CR136","doi-asserted-by":"publisher","first-page":"20212","DOI":"10.1073\/pnas.1320318110","volume":"110","author":"C Feig","year":"2013","unstructured":"Feig, C., et al. (2013). Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America, 110(50), 20212\u201320217. https:\/\/doi.org\/10.1073\/pnas.1320318110","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6","key":"10297_CR137","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1038\/s41591-020-0880-x","volume":"26","author":"B Bockorny","year":"2020","unstructured":"Bockorny, B., et al. (2020). BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: The COMBAT trial. Nature Medicine, 26(6), 878\u2013885. https:\/\/doi.org\/10.1038\/s41591-020-0880-x","journal-title":"Nature Medicine"},{"issue":"11","key":"10297_CR138","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1038\/nrd4608","volume":"14","author":"NL Trevaskis","year":"2015","unstructured":"Trevaskis, N. L., et al. (2015). From sewer to saviour - Targeting the lymphatic system to promote drug exposure and activity. Nature reviews. Drug discovery, 14(11), 781\u2013803. https:\/\/doi.org\/10.1038\/nrd4608","journal-title":"Nature reviews. Drug discovery"},{"issue":"1","key":"10297_CR139","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01576-4","volume":"8","author":"H Ji","year":"2023","unstructured":"Ji, H., Hu, C., Yang, X., Liu, Y., Ji, G., Ge, S., Wang, X., & Wang, M. (2023). Lymph node metastasis in cancer progression: Molecular mechanisms, clinical significance and therapeutic interventions. Signal Transduction and Targeted Therapy, 8(1), Article 367. https:\/\/doi.org\/10.1038\/s41392-023-01576-4","journal-title":"Signal Transduction and Targeted Therapy"},{"issue":"2","key":"10297_CR140","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1021\/acsbiomaterials.6b00438","volume":"3","author":"NA Rohner","year":"2017","unstructured":"Rohner, N. A., & Thomas, S. N. (2017). Flexible macromolecule versus rigid particle retention in the injected skin and accumulation in draining lymph nodes are differentially influenced by hydrodynamic size. ACS Biomaterials Science & Engineering, 3(2), 153\u2013159. https:\/\/doi.org\/10.1021\/acsbiomaterials.6b00438","journal-title":"ACS Biomaterials Science & Engineering"},{"issue":"2","key":"10297_CR141","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1023\/a:1015880819328","volume":"7","author":"A Supersaxo","year":"1990","unstructured":"Supersaxo, A., et al. (1990). Effect of molecular weight on the lymphatic absorption of water-soluble compounds following subcutaneous administration. Pharmaceutical Research, 7(2), 167\u2013169. https:\/\/doi.org\/10.1023\/a:1015880819328","journal-title":"Pharmaceutical Research"},{"issue":"3","key":"10297_CR142","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1021\/acs.molpharmaceut.9b01182","volume":"17","author":"T Nakamura","year":"2020","unstructured":"Nakamura, T., et al. (2020). The effect of size and charge of lipid nanoparticles prepared by microfluidic mixing on their lymph node transitivity and distribution. Molecular Pharmaceutics, 17(3), 944\u2013953. https:\/\/doi.org\/10.1021\/acs.molpharmaceut.9b01182","journal-title":"Molecular Pharmaceutics"},{"key":"10297_CR143","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.122101","volume":"625","author":"S Shah","year":"2022","unstructured":"Shah, S., et al. (2022). Nanotechnology based drug delivery systems: Does shape really matter? International Journal of Pharmaceutics, 625, Article 122101. https:\/\/doi.org\/10.1016\/j.ijpharm.2022.122101","journal-title":"International Journal of Pharmaceutics"},{"key":"10297_CR144","doi-asserted-by":"publisher","first-page":"6771","DOI":"10.2147\/IJN.S131295","volume":"12","author":"X Yu","year":"2017","unstructured":"Yu, X., et al. (2017). Triple-functional albumin-based nanoparticles for combined chemotherapy and photodynamic therapy of pancreatic cancer with lymphatic metastases. International Journal of Nanomedicine, 12, 6771\u20136785. https:\/\/doi.org\/10.2147\/IJN.S131295","journal-title":"International Journal of Nanomedicine"},{"issue":"5","key":"10297_CR145","doi-asserted-by":"publisher","first-page":"4957","DOI":"10.1021\/nn5070259","volume":"9","author":"H Cabral","year":"2015","unstructured":"Cabral, H., et al. (2015). Systemic targeting of lymph node metastasis through the blood vascular system by using size-controlled nanocarriers. ACS Nano, 9(5), 4957\u20134967. https:\/\/doi.org\/10.1021\/nn5070259","journal-title":"ACS Nano"},{"issue":"7","key":"10297_CR146","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/nm720","volume":"8","author":"P Laakkonen","year":"2002","unstructured":"Laakkonen, P., et al. (2002). A tumor-homing peptide with a targeting specificity related to lymphatic vessels. Nature Medicine, 8(7), 751\u2013755. https:\/\/doi.org\/10.1038\/nm720","journal-title":"Nature Medicine"},{"issue":"1\u20132","key":"10297_CR147","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.ijpharm.2009.10.014","volume":"385","author":"G Luo","year":"2010","unstructured":"Luo, G., et al. (2010). LyP-1-conjugated nanoparticles for targeting drug delivery to lymphatic metastatic tumors. International Journal of Pharmaceutics, 385(1\u20132), 150\u2013156. https:\/\/doi.org\/10.1016\/j.ijpharm.2009.10.014","journal-title":"International Journal of Pharmaceutics"},{"issue":"5","key":"10297_CR148","doi-asserted-by":"publisher","first-page":"2891","DOI":"10.1111\/jcmm.14864","volume":"24","author":"Q-J Lin","year":"2020","unstructured":"Lin, Q.-J., et al. (2020). LyP-1-fMWNTs enhanced targeted delivery of MBD1siRNA to pancreatic cancer cells. Journal of Cellular and Molecular Medicine, 24(5), 2891\u20132900. https:\/\/doi.org\/10.1111\/jcmm.14864","journal-title":"Journal of Cellular and Molecular Medicine"},{"issue":"41","key":"10297_CR149","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/22\/41\/415103","volume":"22","author":"Z Yan","year":"2011","unstructured":"Yan, Z., et al. (2011). LyP-1-conjugated doxorubicin-loaded liposomes suppress lymphatic metastasis by inhibiting lymph node metastases and destroying tumor lymphatics. Nanotechnology, 22(41), Article 415103. https:\/\/doi.org\/10.1088\/0957-4484\/22\/41\/415103","journal-title":"Nanotechnology"},{"key":"10297_CR150","doi-asserted-by":"publisher","unstructured":"Ma, Tao et al. (2022) A novel delivery system of RGD-HSA loaded GEM\/CUR nanoparticles for the treatment of pancreatic cancer therapy. Drug design, development and therapy, 16:2395\u20132406. https:\/\/doi.org\/10.2147\/DDDT.S366558","DOI":"10.2147\/DDDT.S366558"},{"issue":"27","key":"10297_CR151","doi-asserted-by":"publisher","first-page":"9343","DOI":"10.1073\/pnas.0803728105","volume":"105","author":"EA Murphy","year":"2008","unstructured":"Murphy, E. A., et al. (2008). Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis. Proceedings of the National Academy of Sciences of the United States of America, 105(27), 9343\u20139348. https:\/\/doi.org\/10.1073\/pnas.0803728105","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6","key":"10297_CR152","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.ccell.2020.08.004","volume":"38","author":"AS Bear","year":"2020","unstructured":"Bear, A. S., Vonderheide, R. H., & O\u2019Hara, M. H. (2020). Challenges and opportunities for pancreatic cancer immunotherapy. Cancer Cell, 38(6), 788\u2013802. https:\/\/doi.org\/10.1016\/j.ccell.2020.08.004","journal-title":"Cancer Cell"},{"issue":"6024","key":"10297_CR153","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1126\/science.1198443","volume":"331","author":"GL Beatty","year":"2011","unstructured":"Beatty, G. L., Chiorean, E. G., Fishman, M. P., Saboury, B., Teitelbaum, U. R., Sun, W., Huhn, R. D., Song, W., Li, D., Sharp, L. L., Torigian, D. A., O\u2019Dwyer, P. J., & Vonderheide, R. H. (2011). CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science, 331(6024), 1612\u20131616. https:\/\/doi.org\/10.1126\/science.1198443","journal-title":"Science"},{"key":"10297_CR154","unstructured":"Therapeutics, P.\u00a0A Phase I, first-in-human, open-label, dose escalation and expansion study of PT886 in adult patients with advanced gastric, gastroesophageal junction and pancreatic adenocarcinomas. Report No. NCT05482893 (clinicaltrials.gov, 2022)."},{"issue":"594","key":"10297_CR155","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abf5058","volume":"13","author":"K Roehle","year":"2021","unstructured":"Roehle, K., Qiang, L., Ventre, K. S., Heid, D., Ali, L. R., Lenehan, P., Heckler, M., Crowley, S. J., Stump, C. T., Ro, G., Godicelj, A., Bhuiyan, A. M., Yang, A., Quiles Del Rey, M., Biary, T., Luoma, A. M., Bruck, P. T., Tegethoff, J. F., Nopper, S. L., & Dougan, S. K. (2021). CIAP1\/2 antagonism eliminates MHC class I-negative tumors through T cell-dependent reprogramming of mononuclear phagocytes. Science Translational Medicine, 13(594), Article eabf5058. https:\/\/doi.org\/10.1126\/scitranslmed.abf5058","journal-title":"Science Translational Medicine"},{"key":"10297_CR156","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.semcancer.2022.08.009","volume":"86","author":"X Li","year":"2022","unstructured":"Li, X., Gulati, M., Larson, A. C., Solheim, J. C., Jain, M., Kumar, S., & Batra, S. K. (2022). Immune checkpoint blockade in pancreatic cancer: Trudging through the immune desert. Seminars In Cancer Biology, 86, 14\u201327. https:\/\/doi.org\/10.1016\/j.semcancer.2022.08.009","journal-title":"Seminars In Cancer Biology"},{"issue":"6","key":"10297_CR157","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.ccell.2020.08.004","volume":"14","author":"AS Bear","year":"2020","unstructured":"Bear, A. S., Vonderheide, R. H., & O\u2019Hara, M. H. (2020). Challenges and opportunities for pancreatic cancer immunotherapy. Cancer Cell, 14(6), 788\u2013802. https:\/\/doi.org\/10.1016\/j.ccell.2020.08.004","journal-title":"Cancer Cell"},{"key":"10297_CR158","doi-asserted-by":"publisher","unstructured":"Pant, S., Wainberg, ZA., Weekes, CD., Furqan, M., Kasi, PM., Devoe, CE., Leal, AD., Chung, V., Basturk, O., VanWyk, H., Tavares, AM., Seenappa, LM., Perry, JR., Kheoh, T., McNeil LK., Welkowsky, E., DeMuth, PC., Haqq, CM., O'Reilly, EM. ( 2024) Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: The phase 1 AMPLIFY-201 trial. Nat Med, 30(2):531\u2013542. https:\/\/doi.org\/10.1038\/s41591-023-02760-3. Epub 2024 Jan 9. PMID: 38195752; PMCID: PMC10878978.","DOI":"10.1038\/s41591-023-02760-3"},{"issue":"7","key":"10297_CR159","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1080\/08820139.2020.1765795","volume":"49","author":"BJ Han","year":"2020","unstructured":"Han, B. J., Murphy, J. D., Qin, S., Ye, J., Uccello, T. P., Garrett-Larsen, J., Belt, B. A., Prieto, P. A., Egilmez, N. K., Lord, E. M., Linehan, D. C., Mills, B. N., & Gerber, S. A. (2020). Microspheres encapsulating immunotherapy agents target the tumor-draining lymph node in pancreatic ductal adenocarcinoma. Immunological Investigations, 49(7), 808\u2013823. https:\/\/doi.org\/10.1080\/08820139.2020.1765795","journal-title":"Immunological Investigations"},{"issue":"6","key":"10297_CR160","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1097\/MPA.0b013e3182148342","volume":"40","author":"M Kanda","year":"2011","unstructured":"Kanda, M., et al. (2011). Pattern of lymph node metastasis spread in pancreatic cancer. Pancreas, 40(6), 951\u2013955. https:\/\/doi.org\/10.1097\/MPA.0b013e3182148342","journal-title":"Pancreas"},{"issue":"5","key":"10297_CR161","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1002\/bjs.9444","volume":"101","author":"L Schwarz","year":"2014","unstructured":"Schwarz, L., et al. (2014). Para-aortic lymph node sampling in pancreatic head adenocarcinoma. British Journal of Surgery, 101(5), 530\u2013538. https:\/\/doi.org\/10.1002\/bjs.9444","journal-title":"British Journal of Surgery"},{"issue":"1","key":"10297_CR162","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s00268-005-0730-5","volume":"31","author":"R Doi","year":"2007","unstructured":"Doi, R., et al. (2007). Prognostic implication of para-aortic lymph node metastasis in resectable pancreatic cancer. World Journal of Surgery, 31(1), 147\u2013154. https:\/\/doi.org\/10.1007\/s00268-005-0730-5","journal-title":"World Journal of Surgery"},{"issue":"5","key":"10297_CR163","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.ejso.2016.02.003","volume":"42","author":"S Paiella","year":"2016","unstructured":"Paiella, S., et al. (2016). The prognostic impact of para-aortic lymph node metastasis in pancreatic cancer: A systematic review and meta-analysis. European Journal of Surgical Oncology, 42(5), 616\u2013624. https:\/\/doi.org\/10.1016\/j.ejso.2016.02.003","journal-title":"European Journal of Surgical Oncology"},{"issue":"2","key":"10297_CR164","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.jviscsurg.2018.06.014","volume":"156","author":"U Marchese","year":"2019","unstructured":"Marchese, U., et al. (2019). Outcomes of pancreatic adenocarcinoma that was not resected because of isolated para-aortic lymph node involvement. Journal of Visceral Surgery, 156(2), 97\u2013101. https:\/\/doi.org\/10.1016\/j.jviscsurg.2018.06.014","journal-title":"Journal of Visceral Surgery"},{"issue":"3","key":"10297_CR165","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1245\/s10434-022-12700-z","volume":"30","author":"Z Shen","year":"2023","unstructured":"Shen, Z., et al. (2023). The impact of additional para-aortic dissection during pancreaticoduodenectomy for resectable pancreatic cancer. Annals of Surgical Oncology, 30(3), 1474\u20131482. https:\/\/doi.org\/10.1245\/s10434-022-12700-z","journal-title":"Annals of Surgical Oncology"},{"issue":"12","key":"10297_CR166","doi-asserted-by":"publisher","first-page":"2789","DOI":"10.1007\/s11605-019-04483-8","volume":"24","author":"JS Kim","year":"2020","unstructured":"Kim, J. S., et al. (2020). Unexpected para-aortic lymph node metastasis in pancreatic ductal adenocarcinoma: A contraindication to resection? Journal of Gastrointestinal Surgery, 24(12), 2789\u20132799. https:\/\/doi.org\/10.1007\/s11605-019-04483-8","journal-title":"Journal of Gastrointestinal Surgery"},{"issue":"5","key":"10297_CR167","doi-asserted-by":"publisher","first-page":"429","DOI":"10.4240\/wjgs.v14.i5.429","volume":"14","author":"R Pande","year":"2022","unstructured":"Pande, R., et al. (2022). Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma. World Journal of Gastrointestinal Surgery, 14(5), 429\u2013441. https:\/\/doi.org\/10.4240\/wjgs.v14.i5.429","journal-title":"World Journal of Gastrointestinal Surgery"},{"issue":"1","key":"10297_CR168","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-023-02123-2","volume":"23","author":"Martin Sillesen","year":"2023","unstructured":"Sillesen, Martin, et al. (2023). Impact of para aortic lymph node removal on survival following resection for pancreatic adenocarcinoma. BMC Surgery, 23(1), Article 214. https:\/\/doi.org\/10.1186\/s12893-023-02123-2","journal-title":"BMC Surgery"},{"issue":"9","key":"10297_CR169","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1002\/jhbp.1159","volume":"29","author":"SK Min","year":"2022","unstructured":"Min, S. K., et al. (2022). Prognosis of pancreatic head cancer with different patterns of lymph node metastasis. Journal of Hepato-Biliary-Pancreatic Sciences, 29(9), 1004\u20131013. https:\/\/doi.org\/10.1002\/jhbp.1159","journal-title":"Journal of Hepato-Biliary-Pancreatic Sciences"},{"key":"10297_CR170","doi-asserted-by":"publisher","unstructured":"Aysal, Anil et al. (2022). The site of lymph node metastasis: A significant prognostic factor in pancreatic ductal adenocarcinoma. The Site of Lymph Node Metastasis: A Significant Prognostic Factor in Pancreatic Ductal Adenocarcinoma. Turk patoloji dergisi 38(3): 284\u2013291. https:\/\/doi.org\/10.5146\/tjpath.2022.01583","DOI":"10.5146\/tjpath.2022.01583"},{"issue":"6","key":"10297_CR171","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1007\/s11605-012-2071-7","volume":"17","author":"J LaFemina","year":"2013","unstructured":"LaFemina, J., et al. (2013). Hepatic arterial nodal metastases in pancreatic cancer: Is this the node of importance? Journal of Gastrointestinal Surgery, 17(6), 1092\u20131097. https:\/\/doi.org\/10.1007\/s11605-012-2071-7","journal-title":"Journal of Gastrointestinal Surgery"},{"issue":"7","key":"10297_CR172","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.hpb.2016.05.001","volume":"18","author":"LB van Rijssen","year":"2016","unstructured":"van Rijssen, L. B., et al. (2016). Prognostic value of lymph node metastases detected during surgical exploration for pancreatic or periampullary cancer: A systematic review and meta-analysis. HPB, 18(7), 559\u2013566. https:\/\/doi.org\/10.1016\/j.hpb.2016.05.001","journal-title":"HPB"},{"issue":"12","key":"10297_CR173","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1111\/hpb.12306","volume":"16","author":"P Philips","year":"2014","unstructured":"Philips, P., et al. (2014). The role of hepatic artery lymph node in pancreatic adenocarcinoma: Prognostic factor or a selection criterion for surgery. HPB\u202f: official journal of the Hepato-Pancreato-Biliary Association, 16(12), 1051\u20131055. https:\/\/doi.org\/10.1111\/hpb.12306","journal-title":"HPB : official journal of the Hepato-Pancreato-Biliary Association"},{"key":"10297_CR174","doi-asserted-by":"crossref","unstructured":"Rodrigues, Victor et al. (2020). Is the involvement of the hepatic artery lymph node a poor prognostic factor in pancreatic adenocarcinoma?. \u00bfEs realmente la afectaci\u00f3n del ganglio de la arteria hep\u00e1tica un factor de mal pron\u00f3stico en el adenocarcinoma de p\u00e1ncreas?. Cirugia espanola\u00a0vol. 98,4 (2020): 204\u2013211.https:\/\/doi.org\/10.1016\/j.ciresp.2019.09.015","DOI":"10.1016\/j.ciresp.2019.09.015"},{"key":"10297_CR175","unstructured":"National Comprehensive Cancer Network. Pancreatic adenocarcinoma (Version 1.2024).\u00a0http:\/\/www.nccnchina.org.cn\/guide\/detail\/664. Accessed December 13, 2013."},{"issue":"6","key":"10297_CR176","doi-asserted-by":"publisher","first-page":"e554","DOI":"10.1097\/SLA.0000000000003558","volume":"274","author":"L Huang","year":"2021","unstructured":"Huang, L., et al. (2021). Significance of examined lymph node number in accurate staging and long-term survival in resected stage I-II pancreatic cancer-more is better? A large international population-based cohort study. Annals Of Surgery, 274(6), e554\u2013e563. https:\/\/doi.org\/10.1097\/SLA.0000000000003558","journal-title":"Annals Of Surgery"},{"issue":"3","key":"10297_CR177","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s00268-021-06410-y","volume":"46","author":"AA Javed","year":"2022","unstructured":"Javed, A. A., et al. (2022). Accurate nodal staging in pancreatic cancer in the era of neoadjuvant therapy. World Journal of Surgery, 46(3), 667\u2013677. https:\/\/doi.org\/10.1007\/s00268-021-06410-y","journal-title":"World Journal of Surgery"},{"issue":"4","key":"10297_CR178","doi-asserted-by":"publisher","first-page":"644","DOI":"10.21037\/jgo-20-158","volume":"11","author":"Y-F Li","year":"2020","unstructured":"Li, Y.-F., et al. (2020). Impact of examined lymph node count on prognosis in patients with lymph node-negative pancreatic body\/tail ductal adenocarcinoma. Journal of Gastrointestinal Oncology, 11(4), 644\u2013653. https:\/\/doi.org\/10.21037\/jgo-20-158","journal-title":"Journal of Gastrointestinal Oncology"},{"key":"10297_CR179","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jss.2017.06.076","volume":"220","author":"KA Mirkin","year":"2017","unstructured":"Mirkin, K. A., et al. (2017). Greater lymph node retrieval and lymph node ratio impacts survival in resected pancreatic cancer. Journal of Surgical Research, 220, 12\u201324. https:\/\/doi.org\/10.1016\/j.jss.2017.06.076","journal-title":"Journal of Surgical Research"},{"issue":"1","key":"10297_CR180","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1245\/s10434-007-9587-1","volume":"15","author":"MB Slidell","year":"2008","unstructured":"Slidell, M. B., et al. (2008). Impact of total lymph node count and lymph node ratio on staging and survival after pancreatectomy for pancreatic adenocarcinoma: A large, population-based analysis. Annals of Surgical Oncology, 15(1), 165\u2013174. https:\/\/doi.org\/10.1245\/s10434-007-9587-1","journal-title":"Annals of Surgical Oncology"},{"issue":"1","key":"10297_CR181","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1245\/s10434-007-9587-1","volume":"15","author":"MB Slidell","year":"2008","unstructured":"Slidell, M. B., et al. (2008). Impact of total lymph node count and lymph node ratio on staging and survival after pancreatectomy for pancreatic adenocarcinoma: A large, population-based analysis. Annals of Surgical Oncology, 15(1), 165\u2013174. https:\/\/doi.org\/10.1245\/s10434-007-9587-1","journal-title":"Annals of Surgical Oncology"},{"issue":"6","key":"10297_CR182","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1002\/jso.22013","volume":"104","author":"M La Torre","year":"2011","unstructured":"La Torre, M., et al. (2011). Role of the lymph node ratio in pancreatic ductal adenocarcinoma. Impact on patient stratification and prognosis. Journal of Surgical Oncology, 104(6), 629\u2013633. https:\/\/doi.org\/10.1002\/jso.22013","journal-title":"Journal of Surgical Oncology"},{"key":"10297_CR183","unstructured":"He, Chengzhi et al. (2019). Prognostic value of the metastatic lymph node ratio in patients with pancreatic cancer. International journal of clinical and experimental pathology\u00a0vol. 12,12 4329\u20134337.\u00a0"},{"issue":"6","key":"10297_CR184","doi-asserted-by":"publisher","first-page":"822","DOI":"10.21037\/hbsn-21-99","volume":"11","author":"G-R Joliat","year":"2022","unstructured":"Joliat, G.-R., et al. (2022). International assessment and validation of the prognostic role of lymph node ratio in patients with resected pancreatic head ductal adenocarcinoma. Hepatobiliary Surgery and Nutrition, 11(6), 822\u2013833. https:\/\/doi.org\/10.21037\/hbsn-21-99","journal-title":"Hepatobiliary Surgery and Nutrition"},{"issue":"10","key":"10297_CR185","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1007\/s11605-016-3200-5","volume":"20","author":"H Riediger","year":"2016","unstructured":"Riediger, H., et al. (2016). Prognostic role of log odds of lymph nodes after resection of pancreatic head cancer. Journal of Gastrointestinal Surgery, 20(10), 1707\u20131715. https:\/\/doi.org\/10.1007\/s11605-016-3200-5","journal-title":"Journal of Gastrointestinal Surgery"},{"issue":"7","key":"10297_CR186","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14071834","volume":"14","author":"Dimitrios Prassas","year":"2022","unstructured":"Prassas, Dimitrios, et al. (2022). N, LNR or LODDS: Which is the most appropriate lymph node classification scheme for patients with radically resected pancreatic cancer? Cancers, 14(7), Article 1834. https:\/\/doi.org\/10.3390\/cancers14071834","journal-title":"Cancers"},{"issue":"2","key":"10297_CR187","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1308\/rcsann.2016.0340","volume":"99","author":"M Elshaer","year":"2017","unstructured":"Elshaer, M., et al. (2017). A systematic review of the prognostic value of lymph node ratio, number of positive nodes and total nodes examined in pancreatic ductal adenocarcinoma. The Annals of the Royal College of Surgeons of England, 99(2), 101\u2013106. https:\/\/doi.org\/10.1308\/rcsann.2016.0340","journal-title":"The Annals of the Royal College of Surgeons of England"},{"issue":"6","key":"10297_CR188","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/s1499-3872(14)60264-2","volume":"13","author":"Z-Q Liu","year":"2014","unstructured":"Liu, Z.-Q., et al. (2014). Effect of the number of positive lymph nodes and lymph node ratio on prognosis of patients after resection of pancreatic adenocarcinoma. Hepatobiliary and Pancreatic Diseases International, 13(6), 634\u2013641. https:\/\/doi.org\/10.1016\/s1499-3872(14)60264-2","journal-title":"Hepatobiliary and Pancreatic Diseases International"},{"issue":"2","key":"10297_CR189","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1097\/PAS.0b013e318206c37a","volume":"35","author":"RK Pai","year":"2011","unstructured":"Pai, R. K., et al. (2011). Pattern of lymph node involvement and prognosis in pancreatic adenocarcinoma: Direct lymph node invasion has similar survival to node-negative disease. American Journal of Surgical Pathology, 35(2), 228\u2013234. https:\/\/doi.org\/10.1097\/PAS.0b013e318206c37a","journal-title":"American Journal of Surgical Pathology"},{"issue":"4","key":"10297_CR190","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1002\/jso.24011","volume":"112","author":"JL Williams","year":"2015","unstructured":"Williams, J. L., et al. (2015). Pancreatic cancer patients with lymph node involvement by direct tumor extension have similar survival to those with node-negative disease. Journal of Surgical Oncology, 112(4), 396\u2013402. https:\/\/doi.org\/10.1002\/jso.24011","journal-title":"Journal of Surgical Oncology"},{"issue":"10","key":"10297_CR191","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1002\/jhbp.940","volume":"28","author":"Y Byun","year":"2021","unstructured":"Byun, Y., et al. (2021). Peritumoral lymph nodes in pancreatic cancer revisited; is it truly equivalent to lymph node metastasis? Journal of Hepato-Biliary-Pancreatic Sciences, 28(10), 893\u2013901. https:\/\/doi.org\/10.1002\/jhbp.940","journal-title":"Journal of Hepato-Biliary-Pancreatic Sciences"},{"key":"10297_CR192","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2024.111510","volume":"176","author":"R Castellana","year":"2024","unstructured":"Castellana, R., et al. (2024). Radiomics and deep learning models for CT pre-operative lymph node staging in pancreatic ductal adenocarcinoma: A systematic review and meta-analysis. European Journal of Radiology, 176, Article 111510. https:\/\/doi.org\/10.1016\/j.ejrad.2024.111510","journal-title":"European Journal of Radiology"},{"key":"10297_CR193","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2023.102753","volume":"85","author":"X Chen","year":"2023","unstructured":"Chen, X., et al. (2023). A dual-transformation with contrastive learning framework for lymph node metastasis prediction in pancreatic cancer. Medical Image Analysis, 85, Article 102753. https:\/\/doi.org\/10.1016\/j.media.2023.102753","journal-title":"Medical Image Analysis"},{"issue":"1","key":"10297_CR194","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1148\/radiol.220329","volume":"306","author":"Y Bian","year":"2023","unstructured":"Bian, Y., et al. (2023). Artificial intelligence to predict lymph node metastasis at CT in pancreatic ductal adenocarcinoma. Radiology, 306(1), 160\u2013169. https:\/\/doi.org\/10.1148\/radiol.220329","journal-title":"Radiology"},{"issue":"1","key":"10297_CR195","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-023-00624-3","volume":"14","author":"Q Gu","year":"2023","unstructured":"Gu, Q., et al. (2023). CT-measured body composition radiomics predict lymph node metastasis in localized pancreatic ductal adenocarcinoma. Discover Oncology, 14(1), Article 16. https:\/\/doi.org\/10.1007\/s12672-023-00624-3","journal-title":"Discover Oncology"},{"issue":"4","key":"10297_CR196","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1007\/s00259-021-05573-z","volume":"49","author":"C An","year":"2022","unstructured":"An, C., et al. (2022). Deep learning radiomics of dual-energy computed tomography for predicting lymph node metastases of pancreatic ductal adenocarcinoma. European Journal of Nuclear Medicine and Molecular Imaging, 49(4), 1187\u20131199. https:\/\/doi.org\/10.1007\/s00259-021-05573-z","journal-title":"European Journal of Nuclear Medicine and Molecular Imaging"},{"issue":"1","key":"10297_CR197","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s40644-021-00443-1","volume":"22","author":"Yun Bian","year":"2022","unstructured":"Bian, Yun, et al. (2022). Radiomics nomogram for the preoperative prediction of lymph node metastasis in pancreatic ductal adenocarcinoma. Cancer imaging\u202f: the official publication of the International Cancer Imaging Society, 22(1), 4. https:\/\/doi.org\/10.1186\/s40644-021-00443-1","journal-title":"Cancer imaging : the official publication of the International Cancer Imaging Society"},{"issue":"6","key":"10297_CR198","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1021\/acsbiomaterials.2c00111","volume":"8","author":"M Han","year":"2022","unstructured":"Han, M., Kang, R., & Zhang, C. (2022). Lymph node mapping for tumor micrometastasis. ACS Biomaterials Science & Engineering, 8(6), 2307\u20132320. https:\/\/doi.org\/10.1021\/acsbiomaterials.2c00111","journal-title":"ACS Biomaterials Science & Engineering"},{"key":"10297_CR199","unstructured":"Fluorescence guided sentinel lymph node mapping: From current molecular probes to future multimodal nanoprobes"},{"issue":"7","key":"10297_CR200","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.ejso.2007.02.037","volume":"33","author":"HM Kocher","year":"2007","unstructured":"Kocher, H. M., Sohail, M., Benjamin, I. S., & Patel, A. G. (2007). Technical limitations of lymph node mapping in pancreatic cancer. European Journal of Surgical Oncology, 33(7), 887\u2013891. https:\/\/doi.org\/10.1016\/j.ejso.2007.02.037","journal-title":"European Journal of Surgical Oncology"},{"key":"10297_CR201","doi-asserted-by":"publisher","unstructured":"Hutteman, M., van der Vorst, JR., Mieog, JS., Bonsing, BA., Hartgrink, HH., Kuppen, PJ., L\u00f6wik, CW., Frangioni, JV., van de Velde, CJ., Vahrmeijer, AL. (2011) Near-infrared fluorescence imaging in patients undergoing pancreaticoduodenectomy. European Surgical Research, 47(2):90\u20137. https:\/\/doi.org\/10.1159\/000329411. Epub 2011 Jun 30. PMID: 21720166; PMCID: PMC3130979.","DOI":"10.1159\/000329411"},{"issue":"118","key":"10297_CR202","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.5754\/hge11836.PMID:22369743;PMCID:PMC4096574","volume":"59","author":"HS Tran Cao","year":"2012","unstructured":"Tran Cao, H. S., Kaushal, S., Metildi, C. A., Menen, R. S., Lee, C., Snyder, C. S., Messer, K., Pu, M., Luiken, G. A., Talamini, M. A., Hoffman, R. M., & Bouvet, M. (2012Sep). Tumor-specific fluorescence antibody imaging enables accurate staging laparoscopy in an orthotopic model of pancreatic cancer. Hepato-Gastroenterology, 59(118), 1994\u20131999. https:\/\/doi.org\/10.5754\/hge11836.PMID:22369743;PMCID:PMC4096574","journal-title":"Hepato-Gastroenterology"},{"issue":"2","key":"10297_CR203","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/php.12574","volume":"92","author":"X Yu","year":"2016","unstructured":"Yu, X., Yao, L., Di, Y., He, H., Li, X., Zhang, C., Fu, D., Jin, C., & Li, J. (2016). Application of deuteporfin in the metastatic lymph node mapping of pancreatic cancer: An in vivo study. Photochemistry and Photobiology, 92(2), 325\u2013330. https:\/\/doi.org\/10.1111\/php.12574","journal-title":"Photochemistry and Photobiology"},{"issue":"3","key":"10297_CR204","doi-asserted-by":"publisher","first-page":"277","DOI":"10.14701\/ahbps.2020.24.3.277","volume":"24","author":"R Sadeghi","year":"2020","unstructured":"Sadeghi, R., Aliakbarian, M., Shayegani, H., Memar, B., & Dabbagh, V. R. (2020). The accuracy of sentinel node biopsy by 99mTc-sodium phytate in patients with pancreatic cancer. Annals Of Hepato-Biliary-Pancreatic Surgery, 24(3), 277\u2013282. https:\/\/doi.org\/10.14701\/ahbps.2020.24.3.277","journal-title":"Annals Of Hepato-Biliary-Pancreatic Surgery"}],"container-title":["Cancer and Metastasis Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10555-025-10297-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10555-025-10297-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10555-025-10297-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T06:52:54Z","timestamp":1761375174000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10555-025-10297-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,25]]},"references-count":204,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["10297"],"URL":"https:\/\/doi.org\/10.1007\/s10555-025-10297-9","relation":{},"ISSN":["1573-7233"],"issn-type":[{"value":"1573-7233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,25]]},"assertion":[{"value":"25 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"79"}}