{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:30:09Z","timestamp":1789119009495,"version":"build-2803163510"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Metastasis Rev"],"DOI":"10.1007\/s10555-026-10376-5","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T08:07:59Z","timestamp":1789114079000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reframing early gastric carcinogenesis through lineage, niche, and evolution"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6469-2320","authenticated-orcid":false,"given":"Xuyu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"10376_CR1","volume":"76","author":"RL Siegel","year":"2026","unstructured":"Siegel, R. L., Kratzer, T. B., Wagle, N. S., Sung, H., & Jemal, A. (2026). Cancer statistics, 2026. CA: A Cancer Journal for Clinicians, 76, Article e70043.","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"10376_CR2","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s10120-026-01717-y","volume":"29","author":"T Sano","year":"2026","unstructured":"Sano, T., Boku, N., & Lordick, F. (2026). Reconsidering the terminology of \u201cearly\u201d and \u201cadvanced\u201d gastric cancer: Toward a harmonized global lexicon. Gastric Cancer, 29, 321\u2013322.","journal-title":"Gastric Cancer"},{"key":"10376_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2025.101979","volume":"75","author":"N Gon\u00e7alves","year":"2025","unstructured":"Gon\u00e7alves, N., Chaves, J., Marques-S\u00e1, I., Dinis-Ribeiro, M., & Lib\u00e2nio, D. (2025). Early diagnosis of gastric cancer: Endoscopy and artificial intelligence. Best Practice & Research. Clinical Gastroenterology, 75, Article 101979.","journal-title":"Best Practice & Research. Clinical Gastroenterology"},{"key":"10376_CR4","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1136\/gutjnl-2024-332705","volume":"73","author":"M Leja","year":"2024","unstructured":"Leja, M. (2024). Where are we with gastric cancer screening in Europe in 2024? Gut, 73, 2074\u20132082.","journal-title":"Gut"},{"key":"10376_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2024.101075","volume":"15","author":"W Liao","year":"2024","unstructured":"Liao, W., Wang, J., & Li, Y. (2024). Natural products based on Correa\u2019s cascade for the treatment of gastric cancer trilogy: Current status and future perspective. Journal of Pharmaceutical Analysis, 15, Article 101075.","journal-title":"Journal of Pharmaceutical Analysis"},{"key":"10376_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.215764","volume":"542","author":"J He","year":"2022","unstructured":"He, J., Hu, W., Ouyang, Q., Zhang, S., He, L., Chen, W., Li, X., & Hu, C. (2022). Helicobacter pylori infection induces stem cell-like properties in Correa cascade of gastric cancer. Cancer Letters, 542, Article 215764.","journal-title":"Cancer Letters"},{"key":"10376_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106440","volume":"184","author":"Q Liu","year":"2022","unstructured":"Liu, Q., Tang, J., Chen, S., Hu, S., Shen, C., Xiang, J., Chen, N., Wang, J., Ma, X., Zhang, Y., & Zeng, J. (2022). Berberine for gastric cancer prevention and treatment: Multi-step actions on the Correa\u2019s cascade underlie its therapeutic effects. Pharmacological Research, 184, Article 106440.","journal-title":"Pharmacological Research"},{"key":"10376_CR8","first-page":"6735","volume":"52","author":"P Correa","year":"1992","unstructured":"Correa, P. (1992). Human gastric carcinogenesis: A multistep and multifactorial process\u2013First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Research, 52, 6735\u20136740.","journal-title":"Cancer Research"},{"key":"10376_CR9","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.08.028","author":"K Sugano","year":"2023","unstructured":"Sugano, K., Moss, S. F., & Kuipers, E. J. (2023). Gastric intestinal metaplasia: Real culprit or innocent bystander as a precancerous condition for gastric cancer? Gastroenterology. https:\/\/doi.org\/10.1053\/j.gastro.2023.08.028","journal-title":"Gastroenterology"},{"key":"10376_CR10","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41698-022-00251-1","volume":"6","author":"J Kim","year":"2022","unstructured":"Kim, J., Park, C., Kim, K. H., Kim, E. H., Kim, H., Woo, J. K., Seong, J. K., Nam, K. T., Lee, Y. C., & Cho, S. Y. (2022). Single-cell analysis of gastric pre-cancerous and cancer lesions reveals cell lineage diversity and intratumoral heterogeneity. NPJ Precis Oncol, 6, 9.","journal-title":"NPJ Precis Oncol"},{"issue":"8","key":"10376_CR11","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1136\/gutjnl-2025-336182","volume":"75","author":"L Decourtye-Espiard","year":"2026","unstructured":"Decourtye-Espiard, L., Schulpen, E., McElroy, K., Charlton, A., van der Post, R. S., Godwin, T., Bougen-Zhukov, N., Garcia-Pelaez, J., Chen, A., Zou, D., Vaessen, C., Black, M., Humar, B., & Guilford, P. (2026). E-cadherin loss in Cd44-positive gastric cells initiates diffuse gastric cancer in a murine model. Gut, 75(8), 1466\u20131479.","journal-title":"Gut"},{"key":"10376_CR12","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1158\/2159-8290.CD-21-0683","volume":"12","author":"V Kumar","year":"2022","unstructured":"Kumar, V., Ramnarayanan, K., Sundar, R., Padmanabhan, N., Srivastava, S., Koiwa, M., Yasuda, T., Koh, V., Huang, K. K., Tay, S. T., Ho, S. W. T., Tan, A. L. K., Ishimoto, T., Kim, G., Shabbir, A., Chen, Q., Zhang, B., Xu, S., Lam, K.-P., \u2026 Tan, P. (2022). Single-cell atlas of lineage states, tumor microenvironment, and subtype-specific expression programs in gastric cancer. Cancer Discovery, 12, 670\u2013691.","journal-title":"Cancer Discovery"},{"key":"10376_CR13","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1136\/gutjnl-2024-332901","volume":"74","author":"SH Lee","year":"2025","unstructured":"Lee, S. H., Lee, D., Choi, J., Oh, H. J., Ham, I.-H., Ryu, D., Lee, S.-Y., Han, D.-J., Kim, S., Moon, Y., Song, I.-H., Song, K. Y., Lee, H., Lee, S., Hur, H., & Kim, T.-M. (2025). Spatial dissection of tumour microenvironments in gastric cancers reveals the immunosuppressive crosstalk between CCL2+ fibroblasts and STAT3-activated macrophages. Gut, 74, 714\u2013727.","journal-title":"Gut"},{"key":"10376_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1712830","volume":"17","author":"X Chen","year":"2026","unstructured":"Chen, X., Jiang, X., Wang, S., Xia, J., Wang, W., Fu, X., Yukun, P., Liu, Z., Li, Y., Zhang, M., & Ding, Y. (2026). Integrated single-cell and spatial transcriptomics reveal the differentiation drivers of gastric epithelial lineage progression. Frontiers in Immunology, 17, Article 1712830.","journal-title":"Frontiers in Immunology"},{"key":"10376_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-024-03598-6","volume":"24","author":"X Chen","year":"2024","unstructured":"Chen, X., Zhou, B., Wang, S., Jiang, X., Ping, Y., Xia, J., Yu, F., Li, Y., Zhang, M., & Ding, Y. (2024). Intestinal metaplasia key molecules and UPP1 activation via Helicobacter pylori \/NF-kB: Drivers of malignant progression in gastric cancer. Cancer Cell International, 24, Article Article 399.","journal-title":"Cancer Cell International"},{"key":"10376_CR16","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.canlet.2013.08.016","volume":"345","author":"F Wang","year":"2013","unstructured":"Wang, F., Meng, W., Wang, B., & Qiao, L. (2013). Helicobacter pylori-induced gastric inflammation and gastric cancer. Cancer Letters, 345, 196\u2013202.","journal-title":"Cancer Letters"},{"key":"10376_CR17","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/s41575-022-00591-0","volume":"19","author":"Y Zavros","year":"2022","unstructured":"Zavros, Y., & Merchant, J. L. (2022). The immune microenvironment in gastric adenocarcinoma. Nature Reviews Gastroenterology & Hepatology, 19, 451\u2013467.","journal-title":"Nature Reviews Gastroenterology & Hepatology"},{"key":"10376_CR18","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1038\/s41586-025-08708-6","volume":"640","author":"THH Coorens","year":"2025","unstructured":"Coorens, T. H. H., Collord, G., Jung, H., Wang, Y., Moore, L., Hooks, Y., Mahbubani, K., Law, S. Y. K., Yan, H. H. N., Yuen, S. T., Saeb-Parsy, K., Campbell, P. J., Martincorena, I., Leung, S. Y., & Stratton, M. R. (2025). The somatic mutation landscape of normal gastric epithelium. Nature, 640, 418\u2013426.","journal-title":"Nature"},{"issue":"12","key":"10376_CR19","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1016\/j.ccell.2023.10.004","volume":"41","author":"KK Huang","year":"2023","unstructured":"Huang, K. K., Ma, H., Chong, R. H. H., Uchihara, T., Lian, B. S. X., Zhu, F., Sheng, T., Srivastava, S., Tay, S. T., Sundar, R., Tan, A. L. K., Ong, X., Lee, M., Ho, S. W. T., Lesluyes, T., Ashktorab, H., Smoot, D., Van Loo, P., Chua, J. S., \u2026 Tan, P. (2023). Spatiotemporal genomic profiling of intestinal metaplasia reveals clonal dynamics of gastric cancer progression. Cancer Cell, 41(12), 2019\u20132037.","journal-title":"Cancer Cell"},{"key":"10376_CR20","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1053\/j.gastro.2023.04.038","volume":"165","author":"S-H Lee","year":"2023","unstructured":"Lee, S.-H., Contreras Panta, E. W., Gibbs, D., Won, Y., Min, J., Zhang, C., Roland, J. T., Hong, S.-H., Sohn, Y., Krystofiak, E., Jang, B., Ferri, L., Sangwan, V., Ragoussis, J., Camilleri-Bro\u00ebt, S., Caruso, J., Chen-Tanyolac, C., Strasser, M., Gascard, P., \u2026 Goldenring, J. R. (2023). Apposition of fibroblasts with metaplastic gastric cells promotes dysplastic transition. Gastroenterology, 165, 374\u2013390.","journal-title":"Gastroenterology"},{"issue":"8113","key":"10376_CR21","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/s41586-026-10157-8","volume":"653","author":"G Skrupskelyte","year":"2026","unstructured":"Skrupskelyte, G., Rojo Arias, J. E., Ajith, H., Dang, Y., Rossetti, D., Han, S., Tang, M. K. S., Bejar, M. T., Colom, B., Fowler, J. C., Murai, K., Knight, W., Aust, D., Schmidt, M. H. H., J\u00e1szai, J., Zeki, S., Noorani, A., Jones, P. H., Rulands, S., \u2026 Alcolea, M. P. (2026). Precancerous niche remodelling dictates nascent tumour persistence. Nature, 653(8113), 242\u2013253.","journal-title":"Nature"},{"key":"10376_CR22","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1136\/gutjnl-2025-335793","volume":"75","author":"H Kim","year":"2025","unstructured":"Kim, H., Kim, J., Jeong, I. H., Park, E., Yoo, M., Yoon, S., Lee, D., Myung, J., Choi, E., Goldenring, J. R., & Jang, B. (2025). Hybrid identity and distinct methylation profiles of incomplete intestinal metaplasia in the stomach. Gut, 75, 10\u201323.","journal-title":"Gut"},{"issue":"4","key":"10376_CR23","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20230561","volume":"221","author":"G Zou","year":"2024","unstructured":"Zou, G., Huang, Y., Zhang, S., Ko, K.-P., Kim, B., Zhang, J., Venkatesan, V., Pizzi, M. P., Fan, Y., Jun, S., Niu, N., Wang, H., Song, S., Ajani, J. A., & Park, J.-I. (2024). E-cadherin loss drives diffuse-type gastric tumorigenesis via EZH2-mediated reprogramming. Journal of Experimental Medicine, 221(4), Article e20230561.","journal-title":"Journal of Experimental Medicine"},{"key":"10376_CR24","first-page":"231","volume":"65","author":"N Matsukura","year":"1980","unstructured":"Matsukura, N., Suzuki, K., Kawachi, T., Aoyagi, M., Sugimura, T., Kitaoka, H., Numajiri, H., Shirota, A., Itabashi, M., & Hirota, T. (1980). Distribution of marker enzymes and mucin in intestinal metaplasia in human stomach and relation to complete and incomplete types of intestinal metaplasia to minute gastric carcinomas. Journal of the National Cancer Institute, 65, 231\u2013240.","journal-title":"Journal of the National Cancer Institute"},{"key":"10376_CR25","first-page":"639","volume":"79","author":"PH Schmidt","year":"1999","unstructured":"Schmidt, P. H., Lee, J. R., Joshi, V., Playford, R. J., Poulsom, R., Wright, N. A., & Goldenring, J. R. (1999). Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma. Laboratory Investigation, 79, 639\u2013646.","journal-title":"Laboratory Investigation"},{"issue":"6","key":"10376_CR26","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1053\/j.gastro.2010.09.005","volume":"139","author":"KT Nam","year":"2010","unstructured":"Nam, K. T., Lee, H.-J., Sousa, J. F., Weis, V. G., O\u2019Neal, R. L., Finke, P. E., Romero-Gallo, J., Shi, G., Mills, J. C., Peek, R. M., Konieczny, S. F., & Goldenring, J. R. (2010). Mature chief cells are cryptic progenitors for metaplasia in the stomach. Gastroenterology, 139(6), 2028\u20132037.","journal-title":"Gastroenterology"},{"key":"10376_CR27","doi-asserted-by":"publisher","DOI":"10.1111\/hel.13119","volume":"29","author":"Z Liu","year":"2024","unstructured":"Liu, Z., Li, H., Huang, X., & Liu, Q. (2024). Animal models of Helicobacter pylori infection and vaccines: Current status and future prospects. Helicobacter, 29, Article e13119.","journal-title":"Helicobacter"},{"key":"10376_CR28","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1080\/01926230701420632","volume":"35","author":"T Tsukamoto","year":"2007","unstructured":"Tsukamoto, T., Mizoshita, T., & Tatematsu, M. (2007). Animal models of stomach carcinogenesis. Toxicologic Pathology, 35, 636\u2013648.","journal-title":"Toxicologic Pathology"},{"key":"10376_CR29","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1158\/2159-8290.CD-20-1109","volume":"11","author":"Y-H Lo","year":"2021","unstructured":"Lo, Y.-H., Kolahi, K. S., Du, Y., Chang, C.-Y., Krokhotin, A., Nair, A., Sobba, W. D., Karlsson, K., Jones, S. J., Longacre, T. A., Mah, A. T., Tercan, B., Sockell, A., Xu, H., Seoane, J. A., Chen, J., Shmulevich, I., Weissman, J. S., Curtis, C., \u2026 Kuo, C. J. (2021). A CRISPR\/Cas9-engineered ARID1A-deficient human gastric cancer organoid model reveals essential and nonessential modes of oncogenic transformation. Cancer Discovery, 11, 1562\u20131581.","journal-title":"Cancer Discovery"},{"key":"10376_CR30","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/s41588-019-0574-9","volume":"52","author":"NS Sethi","year":"2020","unstructured":"Sethi, N. S., Kikuchi, O., Duronio, G. N., Stachler, M. D., McFarland, J. M., Ferrer-Luna, R., Zhang, Y., Bao, C., Bronson, R., Patil, D., Sanchez-Vega, F., Liu, J.-B., Sicinska, E., Lazaro, J.-B., Ligon, K. L., Beroukhim, R., & Bass, A. J. (2020). Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model. Nature Genetics, 52, 219\u2013230.","journal-title":"Nature Genetics"},{"issue":"7","key":"10376_CR31","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjae030","volume":"16","author":"Y Li","year":"2024","unstructured":"Li, Y., Chen, J., Li, T., Lin, J., Zheng, H., Johnson, N., Yao, X., & Ding, X. (2024). Modeling gastric intestinal metaplasia in 3D organoids using nitrosoguanidine. Journal of Molecular Cell Biology, 16(7), Article mjae030.","journal-title":"Journal of Molecular Cell Biology"},{"key":"10376_CR32","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1053\/j.gastro.2024.08.032","volume":"168","author":"SG Hoft","year":"2024","unstructured":"Hoft, S. G., Brennan, M., Carrero, J. A., Jackson, N. M., Pretorius, C. A., Bigley, T. M., S\u00e1enz, J. B., & DiPaolo, R. J. (2024). Unveiling cancer-related metaplastic cells in both Helicobacter pylori infection and autoimmune gastritis. Gastroenterology, 168, 53\u201367.","journal-title":"Gastroenterology"},{"key":"10376_CR33","first-page":"433","volume":"14","author":"J Dong","year":"2023","unstructured":"Dong, J., Wu, X., Zhou, X., Gao, Y., Wang, C., Wang, W., He, W., Li, J., Deng, W., Liao, J., Wu, X., Lu, Y., Chen, A. K., Wen, L., Fu, W., & Tang, F. (2023). Spatially resolved expression landscape and gene-regulatory network of human gastric corpus epithelium, Protein. Cell, 14, 433\u2013447.","journal-title":"Cell"},{"key":"10376_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108819","volume":"34","author":"GA Busslinger","year":"2021","unstructured":"Busslinger, G. A., Weusten, B. L. A., Bogte, A., Begthel, H., Brosens, L. A. A., & Clevers, H. (2021). Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution. Cell Reports, 34, Article 108819.","journal-title":"Cell Reports"},{"key":"10376_CR35","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2025.2463581","volume":"17","author":"X Xu","year":"2025","unstructured":"Xu, X., Fei, X., Wang, H., Wu, X., Zhan, Y., Li, X., Zhou, Y., Shu, C., He, C., Hu, Y., Liu, J., Lv, N., Li, N., & Zhu, Y. (2025). Helicobacter pylori infection induces DNA double-strand breaks through the ACVR1\/IRF3\/POLD1 signaling axis to drive gastric tumorigenesis. Gut Microbes, 17, Article 2463581.","journal-title":"Gut Microbes"},{"key":"10376_CR36","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-334234","author":"K Togasaki","year":"2025","unstructured":"Togasaki, K., & Sato, T. (2025). Decoding intestinal metaplasia: A step towards understanding gastric tumourigenesis. Gut. https:\/\/doi.org\/10.1136\/gutjnl-2024-334234","journal-title":"Gut"},{"key":"10376_CR37","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1136\/gutjnl-2024-332594","volume":"74","author":"SSK Yue","year":"2025","unstructured":"Yue, S. S. K., Tong, Y., Siu, H. C., Ho, S. L., Law, S. Y. K., Tsui, W. Y., Chan, D., Huang, Y., Chan, A. S. Y., Yun, S. W., Hui, H. S., Choi, J.-E., Hsu, M. S. S., Lai, F. P. L., Chan, A. S., Yuen, S. T., Clevers, H., Leung, S. Y., & Yan, H. H. N. (2025). Divergent lineage trajectories and genetic landscapes in human gastric intestinal metaplasia organoids associated with early neoplastic progression. Gut, 74, 522\u2013538.","journal-title":"Gut"},{"key":"10376_CR38","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s13045-024-01654-2","volume":"18","author":"Y Duan","year":"2025","unstructured":"Duan, Y., Xu, Y., Dou, Y., & Xu, D. (2025). Helicobacter pylori and gastric cancer: Mechanisms and new perspectives. Journal of Hematology & Oncology, 18, 10.","journal-title":"Journal of Hematology & Oncology"},{"issue":"8","key":"10376_CR39","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1016\/j.chom.2023.06.016","volume":"31","author":"I Sharafutdinov","year":"2023","unstructured":"Sharafutdinov, I., Tegtmeyer, N., Linz, B., Rohde, M., Vieth, M., Tay, A.C.-Y., Lamichhane, B., Tuan, V. P., Fauzia, K. A., Sticht, H., Yamaoka, Y., Marshall, B. J., & Backert, S. (2023). A single-nucleotide polymorphism in Helicobacter pylori promotes gastric cancer development. Cell Host & Microbe, 31(8), 1345\u20131358.","journal-title":"Cell Host & Microbe"},{"key":"10376_CR40","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1080\/19490976.2020.1762520","volume":"11","author":"OA Stewart","year":"2020","unstructured":"Stewart, O. A., Wu, F., & Chen, Y. (2020). The role of gastric microbiota in gastric cancer. Gut Microbes, 11, 1220\u20131230.","journal-title":"Gut Microbes"},{"key":"10376_CR41","doi-asserted-by":"publisher","first-page":"4007","DOI":"10.7150\/ijbs.96425","volume":"20","author":"Z Zhang","year":"2024","unstructured":"Zhang, Z., Huang, H., Chen, Z., Yan, M., Lu, C., Xu, Z., & Li, Z. (2024). Helicobacter pylori promotes gastric cancer through CagA-mediated mitochondrial cholesterol accumulation by targeting CYP11A1 redistribution. International Journal of Biological Sciences, 20, 4007\u20134028.","journal-title":"International Journal of Biological Sciences"},{"key":"10376_CR42","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1053\/j.gastro.2023.09.047","volume":"166","author":"SF Moss","year":"2023","unstructured":"Moss, S. F., Shah, S. C., Tan, M. C., & El-Serag, H. B. (2023). Evolving concepts in Helicobacter pylori management. Gastroenterology, 166, 267\u2013283.","journal-title":"Gastroenterology"},{"key":"10376_CR43","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2024-010354","author":"J Li","year":"2024","unstructured":"Li, J., Wu, Z., & Lin, R. (2024). Impact of Helicobacter pylori on immunotherapy in gastric cancer. Journal for ImmunoTherapy of Cancer. https:\/\/doi.org\/10.1136\/jitc-2024-010354","journal-title":"Journal for ImmunoTherapy of Cancer"},{"key":"10376_CR44","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1111\/j.1572-0241.2000.02074.x","volume":"95","author":"M Cassaro","year":"2000","unstructured":"Cassaro, M., Rugge, M., Gutierrez, O., Leandro, G., Graham, D. Y., & Genta, R. M. (2000). Topographic patterns of intestinal metaplasia and gastric cancer. American Journal of Gastroenterology, 95, 1431\u20131438.","journal-title":"American Journal of Gastroenterology"},{"key":"10376_CR45","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.molmed.2012.07.006","volume":"18","author":"R Barros","year":"2012","unstructured":"Barros, R., Freund, J.-N., David, L., & Almeida, R. (2012). Gastric intestinal metaplasia revisited: Function and regulation of CDX2. Trends in Molecular Medicine, 18, 555\u2013563.","journal-title":"Trends in Molecular Medicine"},{"key":"10376_CR46","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1136\/gutjnl-2019-319002","volume":"69","author":"V Krishnan","year":"2020","unstructured":"Krishnan, V., Lim, D. X. E., Hoang, P. M., Srivastava, S., Matsuo, J., Huang, K. K., Zhu, F., Ho, K. Y., So, J. B. Y., Khor, C., Tsao, S., Teh, M., Fock, K. M., Ang, T. L., Jeyasekharan, A. D., Tan, P., Yeoh, K.-G., & Ito, Y. (2020). DNA damage signalling as an anti-cancer barrier in gastric intestinal metaplasia. Gut, 69, 1738\u20131749.","journal-title":"Gut"},{"key":"10376_CR47","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1186\/s13046-024-03245-y","volume":"43","author":"Y He","year":"2024","unstructured":"He, Y., Wang, J., Deng, Z., Feng, H., Du, M., Zhang, D., Zhang, G., Shi, T., & Chen, W. (2024). FOLR2+ macrophage depletion from intestinal metaplasia to early gastric cancer: Single-cell sequencing insight into gastric cancer progression. Journal of Experimental & Clinical Cancer Research, 43, 326.","journal-title":"Journal of Experimental & Clinical Cancer Research"},{"key":"10376_CR48","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57465-7","volume":"16","author":"J Song","year":"2025","unstructured":"Song, J., Wei, R., Liu, C., Zhao, Z., Liu, X., Wang, Y., Liu, F., & Liu, X. (2025). Antigen-presenting cancer associated fibroblasts enhance antitumor immunity and predict immunotherapy response. Nature Communications, 16, Article 2175.","journal-title":"Nature Communications"},{"key":"10376_CR49","doi-asserted-by":"publisher","DOI":"10.1002\/imt2.70050","volume":"4","author":"L Zhou","year":"2025","unstructured":"Zhou, L., Yang, M., Deng, C., Hu, M., Wu, S., Lai, K., Zhang, L., Chen, Z., Tang, Q., Wang, Q., Chen, L., Zha, R., Chen, Y., Tan, Y., He, S., & Zhou, Z. (2025). Single-cell sequencing reveals the role of IL-33 + endothelial subsets in promoting early gastric cancer progression. Imeta, 4, Article e70050.","journal-title":"Imeta"},{"key":"10376_CR50","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10676-1","volume":"10","author":"MF Eissmann","year":"2019","unstructured":"Eissmann, M. F., Dijkstra, C., Jarnicki, A., Phesse, T., Brunnberg, J., Poh, A. R., Etemadi, N., Tsantikos, E., Thiem, S., Huntington, N. D., Hibbs, M. L., Boussioutas, A., Grimbaldeston, M. A., Buchert, M., O\u2019Donoghue, R. J. J., Masson, F., & Ernst, M. (2019). IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization. Nature Communications, 10, Article 2735.","journal-title":"Nature Communications"},{"key":"10376_CR51","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13081881","author":"C Yu","year":"2021","unstructured":"Yu, C., Wong, E. M., Joo, J. E., Hodge, A. M., Makalic, E., Schmidt, D., Buchanan, D. D., Severi, G., Hopper, J. L., English, D. R., Giles, G. G., Southey, M. C., & Dugu\u00e9, P.-A. (2021). Epigenetic drift association with cancer risk and survival, and modification by sex. Cancers. https:\/\/doi.org\/10.3390\/cancers13081881","journal-title":"Cancers"},{"key":"10376_CR52","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1136\/gutjnl-2023-329492","volume":"73","author":"C Takeuchi","year":"2024","unstructured":"Takeuchi, C., Yamashita, S., Liu, Y.-Y., Takeshima, H., Sasaki, A., Fukuda, M., Hashimoto, T., Naka, T., Ishizu, K., Sekine, S., Yoshikawa, T., Hamada, A., Yamamichi, N., Fujishiro, M., & Ushijima, T. (2024). Precancerous nature of intestinal metaplasia with increased chance of conversion and accelerated DNA methylation. Gut, 73, 255\u2013267.","journal-title":"Gut"},{"key":"10376_CR53","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1053\/j.gastro.2025.09.009","volume":"170","author":"J He","year":"2025","unstructured":"He, J., Papa, G., Azizi, F., Kirsche, L., Artola-Boran, M., Ferreira Cassio, R., Hotz, A. L., Geiger, G., Francas, B., Weber, A., Tzankov, A., Kontarakis, Z., Leary, P., & M\u00fcller, A. (2025). Gastric organoid-based ectopic and orthotopic in vivo CRISPR screening for tumor suppressors in gastric cancer. Gastroenterology, 170, 495\u2013510.","journal-title":"Gastroenterology"},{"key":"10376_CR54","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/s41586-023-06102-8","volume":"618","author":"K Karlsson","year":"2023","unstructured":"Karlsson, K., Przybilla, M. J., Kotler, E., Khan, A., Xu, H., Karagyozova, K., Sockell, A., Wong, W. H., Liu, K., Mah, A., Lo, Y.-H., Lu, B., Houlahan, K. E., Ma, Z., Suarez, C. J., Barnes, C. P., Kuo, C. J., & Curtis, C. (2023). Deterministic evolution and stringent selection during preneoplasia. Nature, 618, 383\u2013393.","journal-title":"Nature"},{"key":"10376_CR55","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1053\/j.gastro.2023.01.038","volume":"164","author":"L Decourtye-Espiard","year":"2023","unstructured":"Decourtye-Espiard, L., & Guilford, P. (2023). Hereditary diffuse gastric cancer. Gastroenterology, 164, 719\u2013735.","journal-title":"Gastroenterology"},{"key":"10376_CR56","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1001\/jamasurg.2020.6155","volume":"156","author":"LA Gamble","year":"2021","unstructured":"Gamble, L. A., Heller, T., & Davis, J. L. (2021). Hereditary diffuse gastric cancer syndrome and the role of CDH1: A review. JAMA Surgery, 156, 387\u2013392.","journal-title":"JAMA Surgery"},{"key":"10376_CR57","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/S1470-2045(23)00057-8","volume":"24","author":"B Asif","year":"2023","unstructured":"Asif, B., Sarvestani, A. L., Gamble, L. A., Samaranayake, S. G., Famiglietti, A. L., Fasaye, G.-A., Quezado, M., Miettinen, M., Korman, L., Koh, C., Heller, T., & Davis, J. L. (2023). Cancer surveillance as an alternative to prophylactic total gastrectomy in hereditary diffuse gastric cancer: A prospective cohort study. Lancet Oncology, 24, 383\u2013391.","journal-title":"Lancet Oncology"},{"key":"10376_CR58","doi-asserted-by":"publisher","DOI":"10.1126\/science.adr2428","volume":"390","author":"HYG Lim","year":"2025","unstructured":"Lim, H. Y. G., Yada, S., Murakami, K., Lee, B. T. K., Sagiraju, S., Phuah, P., Chen, T.-Y., Alvina, F. B., Tan, S. H., Kaslikar, K. K., Ruhazat, N. S. B., Rajapakse, M. P., Murad, K. B. A., Kancheva, S., Tan, L. T., Mustafah, S., So, J. B. Y., & Barker, N. (2025). AQP5: A functional gastric cancer stem cell marker in mouse and human tumors. Science, 390, Article eadr2428.","journal-title":"Science"},{"key":"10376_CR59","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-025-01553-y","author":"BC Jones","year":"2026","unstructured":"Jones, B. C., Benedetti, G., Cal\u00e0, G., Amiri, R., Tullie, L., Lutman, R., Sufi, J., Holland, L., Jafree, D. J., Balys, M., Anderson, G., Simcock, I. C., Arthurs, O. J., Eaton, S., Elvassore, N., Li, V. S., Tape, C. J., Jones, K. D., Luni, C., \u2026 De Coppi, P. (2026). Human gastric multi-regional assembloids for functional parietal maturation and patient-specific modelling of antral foveolar hyperplasia. Nature Biomedical Engineering. https:\/\/doi.org\/10.1038\/s41551-025-01553-y","journal-title":"Nature Biomedical Engineering"},{"key":"10376_CR60","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1136\/gutjnl-2017-314549","volume":"68","author":"T Seidlitz","year":"2018","unstructured":"Seidlitz, T., Merker, S. R., Rothe, A., Zakrzewski, F., von Neubeck, C., Gr\u00fctzmann, K., Sommer, U., Schweitzer, C., Sch\u00f6lch, S., Uhlemann, H., Gaebler, A.-M., Werner, K., Krause, M., Baretton, G. B., Welsch, T., Koo, B.-K., Aust, D. E., Klink, B., Weitz, J., & Stange, D. E. (2018). Human gastric cancer modelling using organoids. Gut, 68, 207\u2013217.","journal-title":"Gut"},{"key":"10376_CR61","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.09.026","author":"T Seidlitz","year":"2019","unstructured":"Seidlitz, T., Chen, Y.-T., Uhlemann, H., Sch\u00f6lch, S., Kochall, S., Merker, S. R., Klimova, A., Hennig, A., Schweitzer, C., Pape, K., Baretton, G. B., Welsch, T., Aust, D. E., Weitz, J., Koo, B.-K., & Stange, D. E. (2019). Mouse models of human gastric cancer subtypes with stomach-specific CreERT2-mediated pathway alterations. Gastroenterology. https:\/\/doi.org\/10.1053\/j.gastro.2019.09.026","journal-title":"Gastroenterology"}],"container-title":["Cancer and Metastasis Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10555-026-10376-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10555-026-10376-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10555-026-10376-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:03:26Z","timestamp":1789117406000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10555-026-10376-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":61,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["10376"],"URL":"https:\/\/doi.org\/10.1007\/s10555-026-10376-5","relation":{},"ISSN":["1573-7233"],"issn-type":[{"value":"1573-7233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]},"assertion":[{"value":"23 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"67"}}