{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T07:40:53Z","timestamp":1771832453601,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T00:00:00Z","timestamp":1476662400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T00:00:00Z","timestamp":1476662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL123647 and R15 HL122922"],"award-info":[{"award-number":["R01 HL123647 and R15 HL122922"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Drugs Ther"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1007\/s10557-016-6695-9","type":"journal-article","created":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T03:00:32Z","timestamp":1476673232000},"page":"559-566","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Cardioprotective Effects of Mitochondria-Targeted Peptide SBT-20 in two Different Models of Rat Ischemia\/Reperfusion"],"prefix":"10.1007","volume":"30","author":[{"given":"Wangde","family":"Dai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elissa","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rick J.","family":"Alleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin B.","family":"Perry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell E.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Kloner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,10,17]]},"reference":[{"issue":"4","key":"6695_CR1","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1177\/1074248415616187","volume":"21","author":"RA Kloner","year":"2016","unstructured":"Kloner RA, Dai W, Hale SL, Shi J. Approaches to improving cardiac structure and function during and after an acute myocardial infarction: acute and chronic phases. J Cardiovasc Pharmacol Ther. 2016;21(4):363\u20137.","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"21","key":"6695_CR2","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1161\/CIRCULATIONAHA.108.814640","volume":"120","author":"A Prasad","year":"2009","unstructured":"Prasad A, Stone GW, Holmes DR, Gersh B. Reperfusion injury, microvascular dysfunction, and cardioprotection: the \"dark side\" of reperfusion. Circulation. 2009;120(21):2105\u201312.","journal-title":"Circulation"},{"key":"6695_CR3","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1161\/01.HYP.20.1.118","volume":"20","author":"JI Goldhaber","year":"1992","unstructured":"Goldhaber JI, Weis JN. Oxygen free radicals and cardiac reperfusion abnormalities. Hypertension. 1992;20:118\u201327.","journal-title":"Hypertension"},{"key":"6695_CR4","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1096\/fj.05-4692com","volume":"20","author":"G Petrosillo","year":"2006","unstructured":"Petrosillo G, Venosa ND, Pistolese M, et al. Protective effect of melatonin against mitochondrial dysfunction associated with cardiac ischemia\u2013reperfusion: role of cardiolipin. FASEB J. 2006;20:269\u201376.","journal-title":"FASEB J"},{"issue":"3","key":"6695_CR5","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1089\/ars.2007.1892","volume":"10","author":"HH Szeto","year":"2008","unstructured":"Szeto HH. Mitochondria-targeted cytoprotective peptides for ischemia-reperfusion injury. Antioxid Redox Signal. 2008;10(3):601\u201319.","journal-title":"Antioxid Redox Signal"},{"issue":"3","key":"6695_CR6","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1097\/01.mca.0000236285.71683.b6","volume":"18","author":"J Cho","year":"2007","unstructured":"Cho J, Won K, Wu D, et al. Potent mitochondria-targeted peptides reduce myocardial infarction in rats. Coron Artery Dis. 2007;18(3):215\u201320.","journal-title":"Coron Artery Dis"},{"issue":"1","key":"6695_CR7","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1093\/cvr\/cvt009","volume":"98","author":"CR Frasier","year":"2013","unstructured":"Frasier CR, Moukdar F, Patel HD, et al. Redox-dependent increases in glutathione reductase and exercise preconditioning: role of NADPH oxidase and mitochondria. Cardiovasc Res. 2013;98(1):47\u201355.","journal-title":"Cardiovasc Res"},{"issue":"1","key":"6695_CR8","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1177\/1074248413508003","volume":"19","author":"DA Brown","year":"2014","unstructured":"Brown DA, Hale SL, Baines CP, et al. Reduction of early reperfusion injury with the mitochondria-targeting peptide bendavia. J Cardiovasc Pharmacol Ther. 2014;19(1):121\u201332.","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"3","key":"6695_CR9","doi-asserted-by":"publisher","first-page":"e001644","DOI":"10.1161\/JAHA.112.001644","volume":"1","author":"RA Kloner","year":"2012","unstructured":"Kloner RA, Hale SL, Dai W, et al. Reduction of ischemia\/reperfusion injury with bendavia, a mitochondria-targeting cytoprotective peptide. J Am Heart Assoc. 2012;1(3):e001644.","journal-title":"J Am Heart Assoc"},{"issue":"5","key":"6695_CR10","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/j.yjmcc.2012.02.009","volume":"52","author":"RC Sloan","year":"2012","unstructured":"Sloan RC, Moukdar F, Frasier CR, et al. Mitochondrial permeability transition in the diabetic heart: contributions of thiol redox state and mitochondrial calcium to augmented reperfusion injury. J Mol Cell Cardiol. 2012;52(5):1009\u201318.","journal-title":"J Mol Cell Cardiol"},{"issue":"2","key":"6695_CR11","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1042\/BJ20110162","volume":"435","author":"MD Brand","year":"2011","unstructured":"Brand MD, Nicholls DG. Assessing mitochondrial dysfunction in cells. Biochem J. 2011;435(2):297\u2013312.","journal-title":"Biochem J"},{"issue":"10","key":"6695_CR12","doi-asserted-by":"publisher","first-page":"H1360","DOI":"10.1152\/ajpheart.00858.2015","volume":"310","author":"RJ Alleman","year":"2016","unstructured":"Alleman RJ, Tsang AM, Ryan TE, et al. Exercise-induced protection against reperfusion arrhythmia involves stabilization of mitochondrial energetics. Am J Physiol Heart Circ Physiol. 2016;310(10):H1360\u201370.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"6695_CR13","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/978-1-4939-2257-4_22","volume":"1264","author":"G Krumschnabel","year":"2015","unstructured":"Krumschnabel G, Fontana-Ayoub M, Sumbalova Z, et al. Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production. Methods Mol Biol. 2015;1264:245\u201361.","journal-title":"Methods Mol Biol"},{"issue":"7527","key":"6695_CR14","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nature13909","volume":"515","author":"ET Chouchani","year":"2014","unstructured":"Chouchani ET, Pell VR, Gaude E, et al. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature. 2014;515(7527):431\u20135.","journal-title":"Nature"},{"issue":"6","key":"6695_CR15","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/clpt.2014.174","volume":"96","author":"HH Szeto","year":"2014","unstructured":"Szeto HH, Birk AV. Serendipity and the discovery of novel compounds that restore mitochondrial plasticity. Clin Pharmacol Ther. 2014;96(6):672\u201383.","journal-title":"Clin Pharmacol Ther"},{"issue":"3","key":"6695_CR16","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.pharmthera.2013.07.005","volume":"140","author":"DA Brown","year":"2013","unstructured":"Brown DA, Sabbah HN, Shaikh SR. Mitochondrial inner membrane lipids and proteins as targets for decreasing cardiac ischemia\/reperfusion injury. Pharmacol Ther. 2013;140(3):258\u201366.","journal-title":"Pharmacol Ther"},{"issue":"33","key":"6695_CR17","doi-asserted-by":"publisher","first-page":"34682","DOI":"10.1074\/jbc.M402999200","volume":"279","author":"K Zhao","year":"2004","unstructured":"Zhao K et al. Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury. J Biol Chem. 2004;279(33):34682\u201390.","journal-title":"J Biol Chem"},{"key":"6695_CR18","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1124\/jpet.102.040147","volume":"304","author":"K Zhao","year":"2003","unstructured":"Zhao K, Luo G, Zhao GM, Schiller PW, Szeto HHJ. Pharmacol Exp Ther. 2003;304:425\u201332.","journal-title":"Pharmacol Exp Ther"},{"issue":"8","key":"6695_CR19","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1681\/ASN.2012121216","volume":"24","author":"AV Birk","year":"2013","unstructured":"Birk AV et al. The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin. J Am Soc Nephrol. 2013;24(8):1250\u201361.","journal-title":"J Am Soc Nephrol"},{"issue":"10","key":"6695_CR20","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/j.bbabio.2015.06.006","volume":"1847","author":"AV Birk","year":"2015","unstructured":"Birk AV, Chao WM, Liu S, Soong Y, Szeto HH. Disruption of cytochrome c heme coordination is responsible for mitochondrial injury during ischemia. Biochim Biophys Acta. 2015;1847(10):1075\u201384.","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"6695_CR21","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1124\/jpet.108.145557","volume":"329","author":"Z Han","year":"2009","unstructured":"Han Z, Varadharaj S, Giedt RJ, Zweier JL, Szeto HH, Alevriadou BR. Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells. J Pharmacol Exp Ther. 2009;329(1):94\u2013101.","journal-title":"J Pharmacol Exp Ther"},{"issue":"3\u20134","key":"6695_CR22","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1177\/1074248411405990","volume":"16","author":"RA Kloner","year":"2011","unstructured":"Kloner RA. No-reflow phenomenon: maintaining vascular integrity. J Cardiovasc Pharmacol Ther. 2011;16(3\u20134):244\u201350.","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"16","key":"6695_CR23","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1093\/eurheartj\/ehv597","volume":"37","author":"CM Gibson","year":"2016","unstructured":"Gibson CM, Giugliano RP, Kloner RA, et al. EMBRACE STEMI study: a Phase 2a trial to evaluate the safety, tolerability, and efficacy of intravenous MTP-131 on reperfusion injury in patients undergoing primary percutaneous coronary intervention. Eur Heart J. 2016;37(16):1296\u2013303.","journal-title":"Eur Heart J"}],"container-title":["Cardiovascular Drugs and Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-016-6695-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10557-016-6695-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-016-6695-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T10:29:53Z","timestamp":1589711393000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10557-016-6695-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,17]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["6695"],"URL":"https:\/\/doi.org\/10.1007\/s10557-016-6695-9","relation":{},"ISSN":["0920-3206","1573-7241"],"issn-type":[{"value":"0920-3206","type":"print"},{"value":"1573-7241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,17]]},"assertion":[{"value":"17 October 2016","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"These studies were supported by grants from NIH (R01 HL123647 and R15 HL122922 to David A. Brown) and Stealth BioTherapeutics (to David A. Brown, and Robert A. Kloner).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Authors David A. Brown and Robert A. Kloner have received research grants from Company Stealth BioTherapeutics, and have received consulting income from Stealth BioTherapeutics. Authors Wangde Dai, Elissa Cheung, Justin B. Perry, Mitchell E. Allen, Rick J. Alleman declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed. This article does not contain any studies with human participants performed by any of the authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}