{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T10:06:22Z","timestamp":1768557982310,"version":"3.49.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300249"],"award-info":[{"award-number":["81300249"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Drugs Ther"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1007\/s10557-017-6742-1","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T02:50:26Z","timestamp":1501815026000},"page":"367-379","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Erythropoietin Attenuates Cardiac Dysfunction in Rats by Inhibiting Endoplasmic Reticulum Stress-Induced Diabetic Cardiomyopathy"],"prefix":"10.1007","volume":"31","author":[{"given":"Jing","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi-ming","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen-shan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue-hong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-yu","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,8,4]]},"reference":[{"key":"6742_CR1","doi-asserted-by":"publisher","first-page":"R1787","DOI":"10.1152\/ajpregu.00059.2007","volume":"293","author":"VA Lacombe","year":"2007","unstructured":"Lacombe VA, Viatchenko-Karpinski S, Terentyev D, et al. Mechanisms of impaired calcium handling underlying subclinical diastolic dysfunction in diabetes. Am J Physiol Regul Integr Comp Physiol. 2007;293:R1787\u201397.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"6742_CR2","doi-asserted-by":"publisher","first-page":"H2096","DOI":"10.1152\/ajpheart.00452.2009","volume":"297","author":"R Basu","year":"2009","unstructured":"Basu R, Oudit GY, Wang X, et al. Type 1 diabetic cardiomyopathy in the Akita (Ins2WT\/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function. Am J Physiol Heart Circ Physiol. 2009;297:H2096\u2013108.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"6742_CR3","doi-asserted-by":"publisher","first-page":"292","DOI":"10.3389\/fphys.2012.00292","volume":"3","author":"AL Kranstuber","year":"2012","unstructured":"Kranstuber AL, Del Rio C, Biesiadecki BJ, et al. Advanced glycation end product cross-link breaker attenuates diabetes-induced cardiac dysfunction by improving sarcoplasmic reticulum calcium handling. Front Physiol. 2012;3:292.","journal-title":"Front Physiol"},{"key":"6742_CR4","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s10741-012-9313-3","volume":"18","author":"T Miki","year":"2013","unstructured":"Miki T, Yuda S, Kouzu H, Miura T. Diabetic cardiomyopathy: pathophysiology and clinical features. Heart Fail Rev. 2013;18:149\u201366.","journal-title":"Heart Fail Rev"},{"key":"6742_CR5","doi-asserted-by":"publisher","first-page":"e39893","DOI":"10.1371\/journal.pone.0039893","volume":"7","author":"A Takada","year":"2012","unstructured":"Takada A, Miki T, Kuno A, et al. Role of ER stress in ventricular contractile dysfunction in type 2 diabetes. PLoS One. 2012;7:e39893.","journal-title":"PLoS One"},{"key":"6742_CR6","doi-asserted-by":"publisher","first-page":"833","DOI":"10.3892\/etm.2011.280","volume":"2","author":"S Weng","year":"2011","unstructured":"Weng S, Zhu X, Jin Y, Wang T, Huang H. Protective effect of erythropoietin on myocardial infarction in rats by inhibition of caspase-12 expression. Exp Ther Med. 2011;2:833\u20136.","journal-title":"Exp Ther Med"},{"key":"6742_CR7","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s11481-014-9571-z","volume":"10","author":"H Zhao","year":"2015","unstructured":"Zhao H, Wang R, Wu X, et al. Erythropoietin delivered via intra-arterial infusion reduces endoplasmic reticulum stress in brain microvessels of rats following cerebral ischemia and reperfusion. J NeuroImmune Pharmacol. 2015;10:153\u201361.","journal-title":"J NeuroImmune Pharmacol"},{"key":"6742_CR8","doi-asserted-by":"publisher","first-page":"219","DOI":"10.5301\/jn.5000177","volume":"26","author":"D Kong","year":"2013","unstructured":"Kong D, Zhuo L, Gao C, et al. Erythropoietin protects against cisplatin-induced nephrotoxicity by attenuating endoplasmic reticulum stress-induced apoptosis. J Nephrol. 2013;26:219\u201327.","journal-title":"J Nephrol"},{"key":"6742_CR9","doi-asserted-by":"publisher","first-page":"e1000412","DOI":"10.1371\/journal.pbio.1000412","volume":"8","author":"C Kilkenny","year":"2010","unstructured":"Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol. 2010;8:e1000412.","journal-title":"PLoS Biol"},{"key":"6742_CR10","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/1475-2840-10-85","volume":"10","author":"M Yin","year":"2011","unstructured":"Yin M, Sillje HH, Meissner M, van Gilst WH, de Boer RA. Early and late effects of the DPP-4 inhibitor vildagliptin in a rat model of post-myocardial infarction heart failure. Cardiovasc Diabetol. 2011;10:85.","journal-title":"Cardiovasc Diabetol"},{"key":"6742_CR11","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/0076-6879(94)30026-7","volume":"230","author":"VC Hascall","year":"1994","unstructured":"Hascall VC, Calabro A, Midura RJ, Yanagishita M. Isolation and characterization of proteoglycans. Methods Enzymol. 1994;230:390\u2013417.","journal-title":"Methods Enzymol"},{"key":"6742_CR12","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.brainresbull.2014.12.006","volume":"111","author":"Y Zhao","year":"2015","unstructured":"Zhao Y, Yan Y, Zhao Z, Li S, Yin J. The dynamic changes of endoplasmic reticulum stress pathway markers GRP78 and CHOP in the hippocampus of diabetic mice. Brain Res Bull. 2015;111:27\u201335.","journal-title":"Brain Res Bull"},{"key":"6742_CR13","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1111\/jcmm.12739","volume":"20","author":"H Yu","year":"2016","unstructured":"Yu H, Zhen J, Yang Y, Gu J, Wu S, Liu Q. Ginsenoside Rg1 ameliorates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress-induced apoptosis in a streptozotocin-induced diabetes rat model. J Cell Mol Med. 2016;20:623\u201331.","journal-title":"J Cell Mol Med"},{"key":"6742_CR14","doi-asserted-by":"publisher","first-page":"827971","DOI":"10.1155\/2012\/827971","volume":"2012","author":"J Xu","year":"2012","unstructured":"Xu J, Zhou Q, Xu W, Cai L. Endoplasmic reticulum stress and diabetic cardiomyopathy. Exp Diabetes Res. 2012;2012:827971.","journal-title":"Exp Diabetes Res"},{"key":"6742_CR15","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/s00210-013-0852-5","volume":"386","author":"FH Shi","year":"2013","unstructured":"Shi FH, Cheng YS, Dai DZ, Peng HJ, Cong XD, Dai Y. Depressed calcium-handling proteins due to endoplasmic reticulum stress and apoptosis in the diabetic heart are attenuated by argirein. Naunyn Schmiedeberg's Arch Pharmacol. 2013;386:521\u201331.","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"6742_CR16","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/1475-2840-10-97","volume":"10","author":"V Kain","year":"2011","unstructured":"Kain V, Kumar S, Sitasawad SL. Azelnidipine prevents cardiac dysfunction in streptozotocin-diabetic rats by reducing intracellular calcium accumulation, oxidative stress and apoptosis. Cardiovasc Diabetol. 2011;10:97.","journal-title":"Cardiovasc Diabetol"},{"key":"6742_CR17","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/1475-2840-11-105","volume":"11","author":"J Lu","year":"2012","unstructured":"Lu J, Yao YY, Dai QM, et al. Erythropoietin attenuates cardiac dysfunction by increasing myocardial angiogenesis and inhibiting interstitial fibrosis in diabetic rats. Cardiovasc Diabetol. 2012;11:105.","journal-title":"Cardiovasc Diabetol"},{"key":"6742_CR18","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1179\/1743132811Y.0000000026","volume":"34","author":"Z Hong","year":"2012","unstructured":"Hong Z, Hong H, Chen H, Wang Z, Hong D. Protective effects of erythropoietin in experimental spinal cord injury by reducing the C\/EBP-homologous protein expression. Neurol Res. 2012;34:85\u201390.","journal-title":"Neurol Res"},{"key":"6742_CR19","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.biopha.2011.04.019","volume":"65","author":"JR Cha","year":"2011","unstructured":"Cha JR, Kim SJ, Heo TH. Protective effect of recombinant human erythropoietin in type II Gaucher disease patient cells by scavenging endoplasmic reticulum stress. Biomed Pharmacother. 2011;65:364\u20138.","journal-title":"Biomed Pharmacother"},{"key":"6742_CR20","doi-asserted-by":"publisher","first-page":"2903","DOI":"10.1161\/CIRCULATIONAHA.111.030411","volume":"124","author":"H Skali","year":"2011","unstructured":"Skali H, Parving HH, Parfrey PS, et al. Stroke in patients with type 2 diabetes mellitus, chronic kidney disease, and anemia treated with Darbepoetin Alfa: the trial to reduce cardiovascular events with Aranesp therapy (TREAT) experience. Circulation. 2011;124:2903\u20138.","journal-title":"Circulation"},{"key":"6742_CR21","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/sj.jcbfm.9600360","volume":"27","author":"T Frietsch","year":"2007","unstructured":"Frietsch T, Maurer MH, Vogel J, Gassmann M, Kuschinsky W, Waschke KF. Reduced cerebral blood flow but elevated cerebral glucose metabolic rate in erythropoietin overexpressing transgenic mice with excessive erythrocytosis. J Cereb Blood Flow Metab. 2007;27:469\u201376.","journal-title":"J Cereb Blood Flow Metab"}],"container-title":["Cardiovascular Drugs and Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10557-017-6742-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-017-6742-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-017-6742-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,22]],"date-time":"2019-09-22T07:47:11Z","timestamp":1569138431000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10557-017-6742-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["6742"],"URL":"https:\/\/doi.org\/10.1007\/s10557-017-6742-1","relation":{},"ISSN":["0920-3206","1573-7241"],"issn-type":[{"value":"0920-3206","type":"print"},{"value":"1573-7241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"4 August 2017","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"Forty male Sprague,Dawley rats were utilized in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research Involving Human Participants and\/or Animals"}},{"value":"None.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"This study was supported by a grant from the National Natural Science Foundation of China (81300249 to Jing Lu, 81470401 to Yuyu Yao).","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"All procedures described in the present study were conducted in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals and approved by the Care of Experimental Animals Committee of Southeast University (approval ID: SYXK-2014.1923).","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}