{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T03:43:45Z","timestamp":1773805425198,"version":"3.50.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T00:00:00Z","timestamp":1550448000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Drugs Ther"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s10557-019-06866-0","type":"journal-article","created":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T05:37:48Z","timestamp":1550468268000},"page":"353-361","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association of Elevated Plasma Homocysteine Level with Restenosis and Clinical Outcomes After Percutaneous Coronary Interventions: a Systemic Review and Meta-analysis"],"prefix":"10.1007","volume":"33","author":[{"given":"Zhipeng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changqiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runyu","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianjin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9359-7023","authenticated-orcid":false,"given":"Xiaoping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,2,18]]},"reference":[{"issue":"4","key":"6866_CR1","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1007\/s12272-018-1016-4","volume":"41","author":"J Kim","year":"2018","unstructured":"Kim J, Kim H, Roh H, Kwon Y. Causes of hyperhomocysteinemia and its pathological significance. Arch Pharm Res. 2018;41(4):372\u201383.","journal-title":"Arch Pharm Res"},{"key":"6866_CR2","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12986-017-0233-z","volume":"14","author":"A Kumar","year":"2017","unstructured":"Kumar A, Palfrey HA, Pathak R, Kadowitz PJ, Gettys TW, Murthy SN. The metabolism and significance of homocysteine in nutrition and health. Nutr Metab (Lond). 2017;14:78.","journal-title":"Nutr Metab (Lond)"},{"key":"6866_CR3","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.ijcard.2018.04.083","volume":"266","author":"I Dhar","year":"2018","unstructured":"Dhar I, Svingen GFT, Pedersen ER, DeRatt B, Ulvik A, Strand E, et al. Plasma cystathionine and risk of acute myocardial infarction among patients with coronary heart disease: results from two independent cohorts. Int J Cardiol. 2018;266:24\u201330.","journal-title":"Int J Cardiol"},{"key":"6866_CR4","doi-asserted-by":"crossref","unstructured":"Kubota Y., Alonso A., Heckbert S. R., Norby F. L., Folsom A. R., Homocysteine and incident atrial fibrillation: the atherosclerosis risk in communities study and the multi-ethnic study of atherosclerosis. Heart Lung Circ, 2018.","DOI":"10.1016\/j.hlc.2018.03.007"},{"issue":"16","key":"6866_CR5","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1001\/jama.288.16.2015","volume":"288","author":"C Homocysteine Studies","year":"2002","unstructured":"Homocysteine Studies C. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA. 2002;288(16):2015\u201322.","journal-title":"JAMA"},{"issue":"4","key":"6866_CR6","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1111\/jch.13246","volume":"20","author":"L Chen","year":"2018","unstructured":"Chen L, Wang B, Wang J, Ban Q, Wu H, Song Y, et al. Association between serum total homocysteine and arterial stiffness in adults: a community-based study. J Clin Hypertens (Greenwich). 2018;20(4):686\u201393.","journal-title":"J Clin Hypertens (Greenwich)"},{"issue":"10","key":"6866_CR7","doi-asserted-by":"publisher","first-page":"E1150","DOI":"10.21037\/jtd.2016.10.93","volume":"8","author":"D Buccheri","year":"2016","unstructured":"Buccheri D, Piraino D, Andolina G, Cortese B. Understanding and managing in-stent restenosis: a review of clinical data, from pathogenesis to treatment. J Thorac Dis. 2016;8(10):E1150\u2013e1162.","journal-title":"J Thorac Dis"},{"issue":"3","key":"6866_CR8","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1172\/JCI108520","volume":"58","author":"LA Harker","year":"1976","unstructured":"Harker LA, Ross R, Slichter SJ, Scott CR. Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis. J Clin Invest. 1976;58(3):731\u201341.","journal-title":"J Clin Invest"},{"issue":"1","key":"6866_CR9","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1161\/01.RES.57.1.105","volume":"57","author":"PM Steele","year":"1985","unstructured":"Steele PM, Chesebro JH, Stanson AW, Holmes DR Jr, Dewanjee MK, Badimon L, et al. Balloon angioplasty. Natural history of the pathophysiological response to injury in a pig model. Circ Res. 1985;57(1):105\u201312.","journal-title":"Circ Res"},{"issue":"10","key":"6866_CR10","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1161\/01.ATV.17.10.2074","volume":"17","author":"A Majors","year":"1997","unstructured":"Majors A, Ehrhart LA, Pezacka EH. Homocysteine as a risk factor for vascular disease. Enhanced collagen production and accumulation by smooth muscle cells. Arterioscler Thromb Vasc Biol. 1997;17(10):2074\u201381.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"6866_CR11","doi-asserted-by":"publisher","first-page":"b2535","DOI":"10.1136\/bmj.b2535","volume":"339","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG. Prisma Group, Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535.","journal-title":"BMJ"},{"issue":"9","key":"6866_CR12","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","volume":"25","author":"A Stang","year":"2010","unstructured":"Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25(9):603\u20135.","journal-title":"Eur J Epidemiol"},{"issue":"4","key":"6866_CR13","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.3892\/etm.2013.927","volume":"5","author":"Y Ma","year":"2013","unstructured":"Ma Y, Li L, Shang XM, Tan Z, Geng XB, Zhao BQ, et al. Analysis of factors related to short-term prognosis in patients undergoing percutaneous coronary intervention for acute myocardial infarction. Exp Ther Med. 2013;5(4):1206\u201310.","journal-title":"Exp Ther Med"},{"issue":"10","key":"6866_CR14","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1016\/S0735-1097(02)02481-6","volume":"40","author":"G Schnyder","year":"2002","unstructured":"Schnyder G, Flammer Y, Roffi M, Pin R, Hess OM. Plasma homocysteine levels and late outcome after coronary angioplasty. J Am Coll Cardiol. 2002;40(10):1769\u201376.","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"6866_CR15","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1053\/euhj.2001.2962","volume":"23","author":"G Schnyder","year":"2002","unstructured":"Schnyder G, Roffi M, Flammer Y, Pin R, Hess OM. Association of plasma homocysteine with restenosis after percutaneous coronary angioplasty. Eur Heart J. 2002;23(9):726\u201333.","journal-title":"Eur Heart J"},{"issue":"3","key":"6866_CR16","first-page":"189","volume":"5","author":"P Ortolani","year":"2004","unstructured":"Ortolani P, Marzocchi A, Marrozzini C, Palmerini T, Aquilina M, Corliano L, et al. Clinical relevance of homocysteine levels in patients receiving coronary stenting for unstable angina. Ital Heart J. 2004;5(3):189\u201396.","journal-title":"Ital Heart J"},{"issue":"4","key":"6866_CR17","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1159\/000063113","volume":"97","author":"I Hodish","year":"2002","unstructured":"Hodish I, Matetzky S, Selah BA, Guetta V, Goldenberg I, Doolman R, et al. Effect of elevated homocysteine levels on clinical restenosis following percutaneous coronary intervention. Cardiology. 2002;97(4):214\u20137.","journal-title":"Cardiology"},{"issue":"1","key":"6866_CR18","first-page":"27","volume":"84","author":"H Morita","year":"2000","unstructured":"Morita H, Kurihara H, Kuwaki T, Hamada C, Kitaoka M, Suzuki S, et al. Homocysteine as a risk factor for restenosis after coronary angioplasty. Thromb Haemost. 2000;84(1):27\u201331.","journal-title":"Thromb Haemost"},{"issue":"Suppl 3","key":"6866_CR19","first-page":"S636","volume":"84","author":"N Mahanonda","year":"2001","unstructured":"Mahanonda N, Leowattana W, Kangkagate C, Lolekha P, Pokum S. Homocysteine and restenosis after percutaneous coronary intervention. J Med Assoc Thai. 2001;84(Suppl 3):S636\u201344.","journal-title":"J Med Assoc Thai"},{"issue":"3","key":"6866_CR20","first-page":"137","volume":"13","author":"O Sirikci","year":"2000","unstructured":"Sirikci O, Aytekin V, Topcu G, Aytekin S, Demiroglu ICC, Demiroglu C. Homocysteine is not an indicator of restenosis risk after percutaneous transluminal coronary angioplasty. Marmara Med J. 2000;13(3):137\u201342.","journal-title":"Marmara Med J"},{"issue":"12","key":"6866_CR21","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.1161\/01.ATV.0000105055.68038.29","volume":"23","author":"W Koch","year":"2003","unstructured":"Koch W, Ndrepepa G, Mehilli J, Braun S, Burghartz M, Lengnick H, et al. Homocysteine status and polymorphisms of methylenetetrahydrofolate reductase are not associated with restenosis after stenting in coronary arteries. Arterioscler Thromb Vasc Biol. 2003;23(12):2229\u201334.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"6866_CR22","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1067\/mhj.2000.107546","volume":"140","author":"SES Miner","year":"2000","unstructured":"Miner SES, Hegele RA, Sparkes J, Teitel JM, Bowman KA, Connelly PW, et al. Homocysteine, lipoprotein(a), and restenosis after percutaneous transluminal coronary angioplasty: a prospective study. Am Heart J. 2000;140(2):272\u20138.","journal-title":"Am Heart J"},{"issue":"2\u20133","key":"6866_CR23","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S0167-5273(00)00380-6","volume":"76","author":"K Stangl","year":"2000","unstructured":"Stangl K, Cascorbi I, Stangl V, Laule M, Dschietzig T, Richter C, et al. Hyperhomocysteinaemia and adverse events complicating coronary catheter interventions. Int J Cardiol. 2000;76(2\u20133):211\u20137.","journal-title":"Int J Cardiol"},{"issue":"1","key":"6866_CR24","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1097\/00043798-200102000-00002","volume":"8","author":"SD Kumbasar","year":"2001","unstructured":"Kumbasar SD, Din\u00e7er I, Ertas F, G\u00fcle\u00e7 S, Erol C, Aky\u00fcrek O, et al. Hyperhomocysteinemia and restenosis. J Cardiovasc Risk. 2001;8(1):9\u201313.","journal-title":"J Cardiovasc Risk"},{"issue":"7","key":"6866_CR25","doi-asserted-by":"publisher","first-page":"696","DOI":"10.5551\/jat.36434","volume":"24","author":"JK Yeh","year":"2017","unstructured":"Yeh JK, Chen CC, Hsieh MJ, Tsai ML, Yang CH, Chen DY, et al. Impact of homocysteine level on long-term cardiovascular outcomes in patients after coronary artery stenting. J Atheroscler Thromb. 2017;24(7):696\u2013705.","journal-title":"J Atheroscler Thromb"},{"issue":"8","key":"6866_CR26","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1016\/S0735-1097(02)02267-2","volume":"40","author":"MN Zairis","year":"2002","unstructured":"Zairis MN, Ambrose JA, Manousakis SJ, Stefanidis AS, Papadaki OA, Bilianou HI, et al. The impact of plasma levels of C-reactive protein, lipoprotein (a) and homocysteine on the long-term prognosis after successful coronary stenting\u2014the global evaluation of new events and restenosis after stent implantation study. J Am Coll Cardiol. 2002;40(8):1375\u201382.","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"6866_CR27","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1136\/hrt.2003.020701","volume":"90","author":"CK Wong","year":"2004","unstructured":"Wong CK, Hammett CJK, The R, French JK, Gao W, Webber BJ, et al. Lack of association between baseline plasma homocysteine concentrations and restenosis rates after a first elective percutaneous coronary intervention without stenting. Heart. 2004;90(11):1299\u2013302.","journal-title":"Heart"},{"issue":"1","key":"6866_CR28","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.ijcard.2005.03.059","volume":"108","author":"F Breuckmann","year":"2006","unstructured":"Breuckmann F, Naber C, Beckert J, Schmermund A, Haude M, Baumgart D, et al. Postinterventional homocysteine levels: failure as a predictive biomarker of in-stent restenosis. Int J Cardiol. 2006;108(1):20\u20135.","journal-title":"Int J Cardiol"},{"issue":"8","key":"6866_CR29","doi-asserted-by":"publisher","first-page":"373","DOI":"10.4070\/kcj.2007.37.8.373","volume":"37","author":"KimIhnsue","year":"2007","unstructured":"KimIhnsue. Predictive factors after percutaneous coronary intervention in young patients with acute myocardial infarction. Korean Circ J. 2007;37(8):373\u20139.","journal-title":"Korean Circ J"},{"issue":"6","key":"6866_CR30","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.jjcc.2016.08.013","volume":"69","author":"A Hassan","year":"2017","unstructured":"Hassan A, Dohi T, Miyauchi K, Ogita M, Kurano M, Ohkawa R, et al. Prognostic impact of homocysteine levels and homocysteine thiolactonase activity on long-term clinical outcomes in patients undergoing percutaneous coronary intervention. J Cardiol. 2017;69(6):830\u20135.","journal-title":"J Cardiol"},{"issue":"5","key":"6866_CR31","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/S0002-9149(01)02286-X","volume":"89","author":"D Genser","year":"2002","unstructured":"Genser D, Prachar H, Hauer R, Halbmayer WM, Mlczoch J, Elmadfa I. Relation of homocysteine, vitamin B-12, and folate to coronary in-stent restenosis. Am J Cardiol. 2002;89(5):495\u20139.","journal-title":"Am J Cardiol"},{"issue":"6","key":"6866_CR32","doi-asserted-by":"publisher","first-page":"e1464","DOI":"10.1097\/MJT.0000000000000130","volume":"23","author":"Y Ma","year":"2016","unstructured":"Ma Y, Li L, Geng XB, Hong Y, Shang XM, Tan Z, et al. Correlation between hyperhomocysteinemia and outcomes of patients with acute myocardial infarction. Am J Ther. 2016;23(6):e1464\u20138.","journal-title":"Am J Ther"},{"issue":"4","key":"6866_CR33","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1111\/jdi.12460","volume":"7","author":"T Gong","year":"2016","unstructured":"Gong T, Wang J, Yang M, Shao Y, Liu J, Wu Q, et al. Serum homocysteine level and gestational diabetes mellitus: a meta-analysis. J Diabetes Investig. 2016;7(4):622\u20138.","journal-title":"J Diabetes Investig"},{"issue":"8","key":"6866_CR34","first-page":"12529","volume":"8","author":"Y Feng","year":"2015","unstructured":"Feng Y, Shan MQ, Bo L, Zhang XY, Hu J. Association of homocysteine with type 1 diabetes mellitus: a meta-analysis. Int J Clin Exp Med. 2015;8(8):12529\u201338.","journal-title":"Int J Clin Exp Med"},{"key":"6866_CR35","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1186\/1471-2164-14-867","volume":"14","author":"T Huang","year":"2013","unstructured":"Huang T, Ren J, Huang J, Li D. Association of homocysteine with type 2 diabetes: a meta-analysis implementing Mendelian randomization approach. BMC Genomics. 2013;14:867.","journal-title":"BMC Genomics"},{"issue":"22","key":"6866_CR36","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.1161\/01.CIR.103.22.2717","volume":"103","author":"R Poddar","year":"2001","unstructured":"Poddar R, Sivasubramanian N, Dibello PM, Robinson K, Jacobsen DW. Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cells: implications for vascular disease. Circulation. 2001;103(22):2717\u201323.","journal-title":"Circulation"},{"issue":"1","key":"6866_CR37","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/j.1745-7254.2005.00005.x","volume":"26","author":"X Zeng","year":"2010","unstructured":"Zeng X, Guan Y, Remick DG, Wang X. Signal pathways underlying homocysteine-induced production of mcp-1 and il-8in cultured human whole blood. Acta Pharmacol Sin. 2010;26(1):85\u201391.","journal-title":"Acta Pharmacol Sin"},{"key":"6866_CR38","doi-asserted-by":"crossref","unstructured":"Dionisio N., Jardin I., Salido G. M., Rosado J. A, Homocysteine, intracellular signaling and thrombotic disorders. Curr Med Chem, 2010. 17(27): p. 3109\u20133119.","DOI":"10.2174\/092986710791959783"},{"issue":"6","key":"6866_CR39","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1161\/01.CIR.94.6.1247","volume":"94","author":"R Hoffmann","year":"1996","unstructured":"Hoffmann R, Mintz GS, Dussaillant GR, Popma JJ, Pichard AD, Satler LF, et al. Patterns and mechanisms of in-stent restenosis. A serial intravascular ultrasound study. Circulation. 1996;94(6):1247\u201354.","journal-title":"Circulation"},{"issue":"1","key":"6866_CR40","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/S1054-8807(02)00135-7","volume":"12","author":"M Nakatani","year":"2003","unstructured":"Nakatani M, Takeyama Y, Shibata M, Yorozuya M, Suzuki H, Koba S, et al. Mechanisms of restenosis after coronary intervention\u2014difference between plain old balloon angioplasty and stenting. Cardiovasc Pathol. 2003;12(1):40\u20138.","journal-title":"Cardiovasc Pathol"},{"issue":"1","key":"6866_CR41","doi-asserted-by":"publisher","first-page":"4769","DOI":"10.1038\/s41598-017-05205-3","volume":"7","author":"R Fan","year":"2017","unstructured":"Fan R, Zhang A, Zhong F. Association between homocysteine levels and all-cause mortality: a dose-response meta-analysis of prospective studies. Sci Rep. 2017;7(1):4769.","journal-title":"Sci Rep"},{"issue":"9","key":"6866_CR42","first-page":"1137","volume":"61","author":"P Fournier","year":"2015","unstructured":"Fournier P, Fourcade J, Roncalli J, Salvayre R, Galinier M, Causse E. Homocysteine in chronic heart failure. Clin Lab. 2015;61(9):1137\u201345.","journal-title":"Clin Lab"},{"issue":"7","key":"6866_CR43","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1097\/JGP.0b013e3181f17eed","volume":"19","author":"RC Ho","year":"2011","unstructured":"Ho RC, Cheung MW, Fu E, Win HH, Zaw MH, Ng A, et al. Is high homocysteine level a risk factor for cognitive decline in elderly? A systematic review, meta-analysis, and meta-regression. Am J Geriatr Psychiatry. 2011;19(7):607\u201317.","journal-title":"Am J Geriatr Psychiatry"},{"key":"6866_CR44","doi-asserted-by":"crossref","unstructured":"Chen C.J., Yang T. C., Chang C., Lu S. C., Chang P. Y., Homocysteine is a bystander for ST-segment elevation myocardial infarction: a case-control study. 2018. 18(1): p. 33.","DOI":"10.1186\/s12872-018-0774-8"},{"issue":"2","key":"6866_CR45","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/j.1365-2796.2007.01810.x","volume":"262","author":"O Bleie","year":"2007","unstructured":"Bleie O, Semb AG, Grundt H, Nordrehaug JE, Vollset SE, Ueland PM, et al. Homocysteine-lowering therapy does not affect inflammatory markers of atherosclerosis in patients with stable coronary artery disease. J Intern Med. 2007;262(2):244\u201353.","journal-title":"J Intern Med"},{"issue":"22","key":"6866_CR46","doi-asserted-by":"publisher","first-page":"2720","DOI":"10.1001\/jama.296.22.2720","volume":"296","author":"LA Bazzano","year":"2006","unstructured":"Bazzano LA, Reynolds K, Holder KN, He J. Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials. JAMA. 2006;296(22):2720\u20136.","journal-title":"JAMA"},{"issue":"10","key":"6866_CR47","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/j.numecd.2010.10.020","volume":"22","author":"AO Akanji","year":"2012","unstructured":"Akanji AO, Thalib L, Allsa AN. Folate, vitamin B(1)(2) and total homocysteine levels in Arab adolescent subjects: reference ranges and potential determinants. Nutr Metab Cardiovasc Dis. 2012;22(10):900\u20136.","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"5","key":"6866_CR48","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.numecd.2011.10.001","volume":"23","author":"B Zappacosta","year":"2013","unstructured":"Zappacosta B, Persichilli S, Iacoviello L, Di Castelnuovo A, Graziano M, Gervasoni J, et al. Folate, vitamin B12 and homocysteine status in an Italian blood donor population. Nutr Metab Cardiovasc Dis. 2013;23(5):473\u201380.","journal-title":"Nutr Metab Cardiovasc Dis"}],"container-title":["Cardiovascular Drugs and Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10557-019-06866-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-019-06866-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-019-06866-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T10:53:10Z","timestamp":1582023190000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10557-019-06866-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,18]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["6866"],"URL":"https:\/\/doi.org\/10.1007\/s10557-019-06866-0","relation":{},"ISSN":["0920-3206","1573-7241"],"issn-type":[{"value":"0920-3206","type":"print"},{"value":"1573-7241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,18]]},"assertion":[{"value":"18 February 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that there is no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All procedures involving human participants were performed in accordance with ethical standards of local committee. This article does not contain any studies with human or animal subjects performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of Human and Animal Rights"}},{"value":"The informal consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}