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Morita reports grants from LSI Medience, AMNOS Company, UNITIKA, and TED Pharmaceutical Co. M. Asakura reports grants from the government during the conduct of the study, personal fees and non-financial support from Pfizer, and personal fees from Boehringer-Ingerheim, Mitsubishi-Tanabe, Kowa, and Takeda. M. Kitakaze reports grants from the Japanese government;grants from Japan Heart Foundation; grants from Japan Cardiovascular Research Foundation; grants and personal fees from Takeda, Asteras, Sanofi, Pfizer, Novartis, Boehringer-Ingerheim, Mitsubishi-Tanabe, Kyowa-Hakko-Kirin, Abott, and Otsuka; personal fees from Daiichi-Sankyo, Ono, Bayer, from Kowa, Dainihon-Sumitomo, Sawai, MSD, Calpis, Shionogi, AstraZeneca, Asahikasei, Novo Nordisk, Fuji-film RI, and Japan Medical Data; and grants from Nihon Kohden.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed. All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted. 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