{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T12:15:59Z","timestamp":1771935359659,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100010211","name":"Education Department of Jilin Province","doi-asserted-by":"publisher","award":["JJKH20190009KJ"],"award-info":[{"award-number":["JJKH20190009KJ"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health and Family Planning Commission of Jilin Province","award":["2017J055"],"award-info":[{"award-number":["2017J055"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Drugs Ther"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s10557-019-06930-9","type":"journal-article","created":{"date-parts":[[2020,2,15]],"date-time":"2020-02-15T10:02:28Z","timestamp":1581760948000},"page":"15-23","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Pharmacodynamic Study of CN-218, a Novel Antiplatelet and Antithrombotic Agent Primarily Targeting the P2Y12 Receptor"],"prefix":"10.1007","volume":"34","author":[{"given":"Xiaohua","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingkai","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujia","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jujin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2668-9374","authenticated-orcid":false,"given":"Xia","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,2,15]]},"reference":[{"issue":"3","key":"6930_CR1","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1124\/pr.117.014530","volume":"70","author":"J Yeung","year":"2018","unstructured":"Yeung J, Li W, Holinstat M. Platelet signaling and disease: targeted therapy for thrombosis and other related diseases. Pharmacol Rev. 2018;70(3):526\u201348.","journal-title":"Pharmacol Rev"},{"issue":"7","key":"6930_CR2","doi-asserted-by":"publisher","first-page":"2102","DOI":"10.1182\/blood-2010-08-263111","volume":"117","author":"M Cattaneo","year":"2011","unstructured":"Cattaneo M. The platelet P2Y(1)(2) receptor for adenosine diphosphate: congenital and drug-induced defects. Blood. 2011;117(7):2102\u201312.","journal-title":"Blood"},{"issue":"4","key":"6930_CR3","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1161\/01.CIR.72.4.741","volume":"72","author":"GV Born","year":"1985","unstructured":"Born GV. Adenosine diphosphate as a mediator of platelet aggregation in vivo: an editorial view. Circulation. 1985;72(4):741\u20136.","journal-title":"Circulation."},{"key":"6930_CR4","doi-asserted-by":"crossref","unstructured":"Murugappa S, Kunapuli SP. The role of ADP receptors in platelet function.\u00a0Front Biosci. 2006;11:1977\u201386.","DOI":"10.2741\/1939"},{"key":"6930_CR5","first-page":"33","volume":"3","author":"J Yeung","year":"2012","unstructured":"Yeung J, Holinstat M. Newer agents in antiplatelet therapy: a review. J blood med. 2012;3:33\u201342.","journal-title":"J blood med"},{"issue":"15","key":"6930_CR6","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1161\/01.CIR.100.15.1667","volume":"100","author":"MJ Quinn","year":"1999","unstructured":"Quinn MJ, Fitzgerald DJ. Ticlopidine and clopidogrel. Circulation. 1999;100(15):1667\u201372.","journal-title":"Circulation"},{"issue":"21","key":"6930_CR7","first-page":"2250","volume":"360","author":"J Miao","year":"2009","unstructured":"Miao J, Liu R, Li Z. Cytochrome P-450 polymorphisms and response to clopidogrel. N Engl J Med. 2009;360(21):2250\u20131.","journal-title":"N Engl J Med"},{"issue":"2","key":"6930_CR8","first-page":"211","volume":"106","author":"T Gremmel","year":"2011","unstructured":"Gremmel T, Panzer S. Clinical, genetic and confounding factors determine the dynamics of the in vitro response\/non response to clopidogrel. Thromb Haemost. 2011;106(2):211\u20138.","journal-title":"Thromb Haemost"},{"issue":"3","key":"6930_CR9","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1007\/s11302-012-9303-x","volume":"8","author":"C Gachet","year":"2012","unstructured":"Gachet C. P2Y(12) receptors in platelets and other hematopoietic and non-hematopoietic cells. Purinergic Signal. 2012;8(3):609\u201319.","journal-title":"Purinergic Signal"},{"issue":"11","key":"6930_CR10","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1056\/NEJMoa0904327","volume":"361","author":"L Wallentin","year":"2009","unstructured":"Wallentin L, Becker RC, Budaj A, Cannon CP, Emanuelsson H, Held C, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009;361(11):1045\u201357.","journal-title":"N Engl J Med"},{"issue":"24","key":"6930_CR11","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1056\/NEJMoa0908629","volume":"361","author":"DL Bhatt","year":"2009","unstructured":"Bhatt DL, Lincoff AM, Gibson CM, Stone GW, McNulty S, Montalescot G, et al. Intravenous platelet blockade with cangrelor during PCI. N Engl J Med. 2009;361(24):2330\u201341.","journal-title":"N Engl J Med"},{"issue":"7","key":"6930_CR12","doi-asserted-by":"publisher","first-page":"3342","DOI":"10.1021\/jm300038c","volume":"55","author":"J Shan","year":"2012","unstructured":"Shan J, Zhang B, Zhu Y, Jiao B, Zheng W, Qi X, et al. Overcoming clopidogrel resistance: discovery of vicagrel as a highly potent and orally bioavailable antiplatelet agent. J Med Chem. 2012;55(7):3342\u201352.","journal-title":"J Med Chem"},{"key":"6930_CR13","doi-asserted-by":"crossref","unstructured":"Lu N, Li L, Zheng X, Zhang S, Li Y, Yuan J et al. Synthesis of a Novel Series of Amino Acid Prodrugs Based on Thienopyridine Scaffolds and Evaluation of Their Antiplatelet Activity. Molecules (Basel, Switzerland). 2018;23(5).","DOI":"10.3390\/molecules23051041"},{"issue":"1, Supplement","key":"6930_CR14","doi-asserted-by":"publisher","first-page":"S8","DOI":"10.1016\/j.dmpk.2018.09.041","volume":"34","author":"EH Margaret Bradbury","year":"2018","unstructured":"Margaret Bradbury EH, Marantz Y, Baillie T, Stamler D. Site-specific deuterium substitution: A viable approach in drug discovery and development. Drug Met Pharmacokinet. 2018;34(1, Supplement):S8\u20139.","journal-title":"Drug Met Pharmacokinet"},{"key":"6930_CR15","doi-asserted-by":"crossref","unstructured":"Xu X, Zhao X, Yang Z, Wang H, Meng X, Su C et al. Significant Improvement of Metabolic Characteristics and Bioactivities of Clopidogrel and Analogs by Selective Deuteration. Molecules (Basel, Switzerland). 2016;21(6).","DOI":"10.3390\/molecules21060704"},{"key":"6930_CR16","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.thromres.2018.08.022","volume":"170","author":"Z Xu","year":"2018","unstructured":"Xu Z, Gu J, Gao M, Du N, Liu P, Xu X, et al. Study on antiplatelet effect of a new thiophenopyridine platelets P2Y12 receptor antagonist DV-127. Thromb Res. 2018;170:192\u20139.","journal-title":"Thromb Res"},{"issue":"13","key":"6930_CR17","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.2174\/1389201019666181112102702","volume":"19","author":"E Pontiki","year":"2018","unstructured":"Pontiki E, Peperidou A, Fotopoulos I, Hadjipavlou-Litina D. Cinnamate hybrids: a unique family of compounds with multiple biological activities. Curr Pharm Biotechnol. 2018;19(13):1019\u201348.","journal-title":"Curr Pharm Biotechnol"},{"key":"6930_CR18","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1038\/194927b0","volume":"194","author":"GV Born","year":"1962","unstructured":"Born GV. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature. 1962;194:927\u20139.","journal-title":"Nature"},{"issue":"5","key":"6930_CR19","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1007\/BF01982887","volume":"16","author":"H Bekemeier","year":"1985","unstructured":"Bekemeier H, Hirschelmann R, Giessler AJ. Carrageenin-induced thrombosis in rats and mice: a model for testing antithrombotic substances? Agents actions. 1985;16(5):446\u201351.","journal-title":"Agents actions"},{"issue":"7236","key":"6930_CR20","first-page":"269","volume":"458","author":"K Sanderson","year":"2009","unstructured":"Sanderson K. Big interest in heavy drugs. Nature. 2009;458(7236):269.","journal-title":"Nature"},{"key":"6930_CR21","doi-asserted-by":"crossref","unstructured":"Hagihara K, Kazui M, Ikenaga H, Nanba T, Fusegawa K, Takahashi M, et al. Comparison of formation of thiolactones and active metabolites of prasugrel and clopidogrel in rats and dogs. Xenobiotica. 2009;39(3):218\u201326.","DOI":"10.1080\/00498250802650077"},{"issue":"2","key":"6930_CR22","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1002\/jps.23394","volume":"102","author":"Z Qiu","year":"2013","unstructured":"Qiu Z, Li N, Wang X, Tian F, Liu Q, Song L, et al. Pharmacokinetics of vicagrel, a promising analog of clopidogrel, in rats and beagle dogs. J Pharm Sci. 2013;102(2):741\u20139.","journal-title":"J Pharm Sci"},{"issue":"7","key":"6930_CR23","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1038\/sj.bjp.0703237","volume":"129","author":"A Sugidachi","year":"2000","unstructured":"Sugidachi A, Asai F, Ogawa T, Inoue T, Koike H. The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties. Br J Pharmacol. 2000;129(7):1439\u201346.","journal-title":"Br J Pharmacol"},{"issue":"7","key":"6930_CR24","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1111\/j.1538-7836.2007.02598.x","volume":"5","author":"A Sugidachi","year":"2007","unstructured":"Sugidachi A, Ogawa T, Kurihara A, Hagihara K, Jakubowski JA, Hashimoto M, et al. The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metabolite. J Thromb Haemost. 2007;5(7):1545\u201351.","journal-title":"J Thromb Haemost"},{"key":"6930_CR25","doi-asserted-by":"crossref","unstructured":"Wang KH, Li SF, Zhao Y, Li HX, Zhang LW. In Vitro Anticoagulant Activity and Active Components of Safflower Injection. Molecules (Basel, Switzerland). 2018;23(1).","DOI":"10.3390\/molecules23010170"},{"issue":"13","key":"6930_CR26","doi-asserted-by":"publisher","first-page":"2715","DOI":"10.1002\/jsfa.5695","volume":"92","author":"D Arrieta-Baez","year":"2012","unstructured":"Arrieta-Baez D, Dorantes-Alvarez L, Martinez-Torres R, Zepeda-Vallejo G, Jaramillo-Flores ME, Ortiz-Moreno A, et al. Effect of thermal sterilization on ferulic, coumaric and cinnamic acids: dimerization and antioxidant activity. J Sci Food Agric. 2012;92(13):2715\u201320.","journal-title":"J Sci Food Agric"},{"key":"6930_CR27","doi-asserted-by":"crossref","unstructured":"Hadjipavlou-Litina D, Pontiki E. Aryl-acetic and cinnamic acids as lipoxygenase inhibitors with antioxidant, anti-inflammatory, and anticancer activity. Methods mol biology (Clifton, NJ). 2015;1208:361\u201377.","DOI":"10.1007\/978-1-4939-1441-8_26"},{"key":"6930_CR28","doi-asserted-by":"crossref","unstructured":"Guzman JD. Natural cinnamic acids, synthetic derivatives and hybrids with antimicrobial activity. Molecules (Basel, Switzerland). 2014;19(12):19292\u2013349.","DOI":"10.3390\/molecules191219292"},{"issue":"26","key":"6930_CR29","doi-asserted-by":"publisher","first-page":"8115","DOI":"10.1021\/jm050454c","volume":"48","author":"C Lapeyre","year":"2005","unstructured":"Lapeyre C, Delomenede M, Bedos-Belval F, Duran H, Negre-Salvayre A, Baltas M. Design, synthesis, and evaluation of pharmacological properties of cinnamic derivatives as antiatherogenic agents. J Med Chem. 2005;48(26):8115\u201324.","journal-title":"J Med Chem"},{"issue":"12","key":"6930_CR30","first-page":"870","volume":"44","author":"A Kurup","year":"1989","unstructured":"Kurup A, Kumar AV, Rao MN. Anti-inflammatory activity of cinnamic acids. Die Pharmazie. 1989;44(12):870.","journal-title":"Die Pharmazie"},{"issue":"1","key":"6930_CR31","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jep.2013.08.019","volume":"150","author":"F Song","year":"2013","unstructured":"Song F, Li H, Sun J, Wang S. Protective effects of cinnamic acid and cinnamic aldehyde on isoproterenol-induced acute myocardial ischemia in rats. J Ethnopharmacol. 2013;150(1):125\u201330.","journal-title":"J Ethnopharmacol"},{"issue":"4","key":"6930_CR32","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.phrs.2009.04.010","volume":"60","author":"M Hagimori","year":"2009","unstructured":"Hagimori M, Kamiya S, Yamaguchi Y, Arakawa M. Improving frequency of thrombosis by altering blood flow in the carrageenan-induced rat tail thrombosis model. Pharmacol Res. 2009;60(4):320\u20133.","journal-title":"Pharmacol Res"}],"container-title":["Cardiovascular Drugs and Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-019-06930-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10557-019-06930-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-019-06930-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T09:51:12Z","timestamp":1613296272000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10557-019-06930-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["6930"],"URL":"https:\/\/doi.org\/10.1007\/s10557-019-06930-9","relation":{},"ISSN":["0920-3206","1573-7241"],"issn-type":[{"value":"0920-3206","type":"print"},{"value":"1573-7241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"15 February 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This study was approved by the Animal Experiment Committee of Jilin University. Experimental mice and rats were housed with 12\/12\u00a0h dark\/light cycles and standard food and water under specific sterile (SPF) conditions. All mice and rats were provided with anesthesia and postoperative care.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}