{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:28:19Z","timestamp":1761845299758,"version":"3.37.3"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Department of Veterans Affairs Health Services Research & Development Service Investigator Initiated Grant","award":["IIR 16\u2013072"],"award-info":[{"award-number":["IIR 16\u2013072"]}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","award":["14BGIA20460366"],"award-info":[{"award-number":["14BGIA20460366"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]},{"name":"American Diabetes Association Clinical Science and Epidemiology award","award":["1-14- CE-44"],"award-info":[{"award-number":["1-14- CE-44"]}]},{"name":"Houston VA Health Services Research & Development Center for Innovations grant","award":["CIN13-413"],"award-info":[{"award-number":["CIN13-413"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Drugs Ther"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s10557-021-07148-4","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T05:02:41Z","timestamp":1612155761000},"page":"295-300","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Facility-Level Variation in Reported Statin-Associated Side Effects Among Patients with Atherosclerotic Cardiovascular Disease\u2014Perspective from the Veterans Affair Healthcare System"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7949-6173","authenticated-orcid":false,"given":"Xiaoming","family":"Jia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle T.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Ramsey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Al Rifai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhruv","family":"Mahtta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chayakrit","family":"Krittanawong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia M.","family":"Akeroyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Matheny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn","family":"Gobbel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil J.","family":"Stone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christie M.","family":"Ballantyne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura A.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salim S.","family":"Virani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"issue":"9976","key":"7148_CR1","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1016\/S0140-6736(14)61368-4","volume":"385","author":"C Cholesterol Treatment Trialists","year":"2015","unstructured":"Cholesterol Treatment Trialists C, Fulcher J, O'Connell R, Voysey M, Emberson J, Blackwell L, et al. Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174,000 participants in 27 randomised trials. Lancet. 2015;385(9976):1397\u2013405.","journal-title":"Lancet."},{"issue":"4","key":"7148_CR2","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.ahj.2011.07.013","volume":"162","author":"SS Virani","year":"2011","unstructured":"Virani SS, Woodard LD, Chitwood SS, Landrum CR, Urech TH, Wang D, et al. Frequency and correlates of treatment intensification for elevated cholesterol levels in patients with cardiovascular disease. Am Heart J. 2011;162(4):725\u201332. e1.","journal-title":"Am Heart J"},{"key":"7148_CR3","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.ahj.2016.09.007","volume":"182","author":"F Rodriguez","year":"2016","unstructured":"Rodriguez F, Lin S, Maron DJ, Knowles JW, Virani SS, Heidenreich PA. Use of high-intensity statins for patients with atherosclerotic cardiovascular disease in the Veterans Affairs Health System: practice impact of the new cholesterol guidelines. Am Heart J. 2016;182:97\u2013102.","journal-title":"Am Heart J"},{"issue":"4","key":"7148_CR4","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1001\/jamacardio.2016.5922","volume":"2","author":"Y Pokharel","year":"2017","unstructured":"Pokharel Y, Tang F, Jones PG, Nambi V, Bittner VA, Hira RS, et al. Adoption of the 2013 American College of Cardiology\/American Heart Association cholesterol management guideline in cardiology practices Nationwide. JAMA Cardiol. 2017;2(4):361\u20139.","journal-title":"JAMA Cardiol"},{"issue":"6","key":"7148_CR5","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s10557-020-07057-y","volume":"34","author":"D Mahtta","year":"2020","unstructured":"Mahtta D, Ahmed ST, Ramsey DJ, Akeroyd JM, Lee MT, Rodriguez F, et al. Statin prescription rates, adherence, and associated clinical outcomes among women with PAD and ICVD. Cardiovasc Drugs Ther. 2020;34(6):745\u201354.","journal-title":"Cardiovasc Drugs Ther"},{"issue":"8","key":"7148_CR6","doi-asserted-by":"publisher","first-page":"e2011051","DOI":"10.1001\/jamanetworkopen.2020.11051","volume":"3","author":"D Mahtta","year":"2020","unstructured":"Mahtta D, Ramsey DJ, Al Rifai M, Nasir K, Samad Z, Aguilar D, et al. Evaluation of aspirin and statin therapy use and adherence in patients with premature atherosclerotic cardiovascular disease. JAMA Netw Open. 2020;3(8):e2011051.","journal-title":"JAMA Netw Open"},{"issue":"7","key":"7148_CR7","doi-asserted-by":"publisher","first-page":"526","DOI":"10.7326\/0003-4819-158-7-201304020-00004","volume":"158","author":"H Zhang","year":"2013","unstructured":"Zhang H, Plutzky J, Skentzos S, Morrison F, Mar P, Shubina M, et al. Discontinuation of statins in routine care settings: a cohort study. Ann Intern Med. 2013;158(7):526\u201334.","journal-title":"Ann Intern Med"},{"issue":"20","key":"7148_CR8","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1016\/j.jacc.2016.02.071","volume":"67","author":"PD Thompson","year":"2016","unstructured":"Thompson PD, Panza G, Zaleski A, Taylor B. Statin-associated side effects. J Am Coll Cardiol. 2016;67(20):2395\u2013410.","journal-title":"J Am Coll Cardiol"},{"issue":"25","key":"7148_CR9","first-page":"e1082","volume":"139","author":"SM Grundy","year":"2019","unstructured":"Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, et al. 2018 AHA\/ACC\/AACVPR\/AAPA\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA guideline on the management of blood cholesterol: a report of the American College of Cardiology\/American Heart Association task force on clinical practice guidelines. Circulation. 2019;139(25):e1082\u2013e143.","journal-title":"Circulation."},{"issue":"5","key":"7148_CR10","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.jacl.2013.03.001","volume":"7","author":"MY Wei","year":"2013","unstructured":"Wei MY, Ito MK, Cohen JD, Brinton EA, Jacobson TA. Predictors of statin adherence, switching, and discontinuation in the USAGE survey: understanding the use of statins in America and gaps in patient education. J Clin Lipidol. 2013;7(5):472\u201383.","journal-title":"J Clin Lipidol"},{"key":"7148_CR11","unstructured":"Statin therapy for the prevention and treatment of cardiovascular disease. In: Program QP, editor. 2020."},{"key":"7148_CR12","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.ahj.2016.07.020","volume":"181","author":"SS Virani","year":"2016","unstructured":"Virani SS, Akeroyd JM, Ramsey DJ, Chan WJ, Frazier L, Nasir K, et al. Comparative effectiveness of outpatient cardiovascular disease and diabetes care delivery between advanced practice providers and physician providers in primary care: implications for care under the Affordable Care Act. Am Heart J. 2016;181:74\u201382.","journal-title":"Am Heart J"},{"issue":"5","key":"7148_CR13","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.jacl.2019.08.002","volume":"13","author":"SS Virani","year":"2019","unstructured":"Virani SS, Akeroyd JM, Ahmed ST, Krittanawong C, Martin LA, Slagle J, et al. The use of structured data elements to identify ASCVD patients with statin-associated side effects: insights from the Department of Veterans Affairs. J Clin Lipidol. 2019;13(5):797\u2013803. e1.","journal-title":"J Clin Lipidol"},{"issue":"11","key":"7148_CR14","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1002\/clc.22769","volume":"40","author":"H Rehman","year":"2017","unstructured":"Rehman H, Akeroyd JM, Ramsey D, Ahmed ST, Merchant AT, Navaneethan SD, et al. Facility-level variation in diabetes and blood pressure control in patients with diabetes: findings from the Veterans Affairs national database. Clin Cardiol. 2017;40(11):1055\u201360.","journal-title":"Clin Cardiol"},{"issue":"5","key":"7148_CR15","doi-asserted-by":"publisher","first-page":"e58","DOI":"10.2337\/dc19-2160","volume":"43","author":"D Mahtta","year":"2020","unstructured":"Mahtta D, Ahmed ST, Shah NR, Ramsey DJ, Akeroyd JM, Nasir K, et al. Facility-level variation in cardiac stress test use among patients with diabetes: findings from the Veterans Affairs National Database. Diabetes Care. 2020;43(5):e58\u201360.","journal-title":"Diabetes Care"},{"issue":"1","key":"7148_CR16","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.amjcard.2014.09.041","volume":"115","author":"SS Virani","year":"2015","unstructured":"Virani SS, Woodard LD, Ramsey DJ, Urech TH, Akeroyd JM, Shah T, et al. Gender disparities in evidence-based statin therapy in patients with cardiovascular disease. Am J Cardiol. 2015;115(1):21\u20136.","journal-title":"Am J Cardiol"},{"issue":"3","key":"7148_CR17","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.jacl.2012.03.003","volume":"6","author":"JD Cohen","year":"2012","unstructured":"Cohen JD, Brinton EA, Ito MK, Jacobson TA. Understanding Statin Use in America and Gaps in Patient Education (USAGE): an internet-based survey of 10,138 current and former statin users. J Clin Lipidol. 2012;6(3):208\u201315.","journal-title":"J Clin Lipidol"},{"issue":"17","key":"7148_CR18","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1093\/eurheartj\/ehv043","volume":"36","author":"ES Stroes","year":"2015","unstructured":"Stroes ES, Thompson PD, Corsini A, Vladutiu GD, Raal FJ, Ray KK, et al. Statin-associated muscle symptoms: impact on statin therapy-European atherosclerosis society consensus panel statement on assessment, aetiology and management. Eur Heart J. 2015;36(17):1012\u201322.","journal-title":"Eur Heart J"},{"issue":"22","key":"7148_CR19","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.017915","volume":"9","author":"ST Ahmed","year":"2020","unstructured":"Ahmed ST, Akeroyd JM, Mahtta D, Street R, Slagle J, Navar AM, et al. Shared decisions: a qualitative study on clinician and patient perspectives on statin therapy and statin-associated side effects. J Am Heart Assoc. 2020;9(22):e017915.","journal-title":"J Am Heart Assoc"},{"key":"7148_CR20","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.1056\/NEJMc2031173","volume":"383","author":"FA Wood","year":"2020","unstructured":"Wood FA, Howard JP, Finegold JA, Nowbar AN, Thompson DM, Arnold AD, et al. N-of-1 trial of a statin, placebo, or no treatment to assess side effects. N Engl J Med. 2020;383:2182\u20134.","journal-title":"N Engl J Med"},{"issue":"4","key":"7148_CR21","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.jacc.2013.04.059","volume":"62","author":"FY Lin","year":"2013","unstructured":"Lin FY, Dunning AM, Narula J, Shaw LJ, Gransar H, Berman DS, et al. Impact of an automated multimodality point-of-order decision support tool on rates of appropriate testing and clinical decision making for individuals with suspected coronary artery disease: a prospective multicenter study. J Am Coll Cardiol. 2013;62(4):308\u201316.","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"7148_CR22","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s10557-017-6723-4","volume":"31","author":"RS Rosenson","year":"2017","unstructured":"Rosenson RS, Miller K, Bayliss M, Sanchez RJ, Baccara-Dinet MT, Chibedi-De-Roche D, et al. The statin-associated muscle symptom clinical index (SAMS-CI): revision for clinical use, content validation, and inter-rater reliability. Cardiovasc Drugs Ther. 2017;31(2):179\u201386.","journal-title":"Cardiovasc Drugs Ther"},{"issue":"6","key":"7148_CR23","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s10557-005-5686-z","volume":"19","author":"E Bruckert","year":"2005","unstructured":"Bruckert E, Hayem G, Dejager S, Yau C, Begaud B. Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients--the PRIMO study. Cardiovasc Drugs Ther. 2005;19(6):403\u201314.","journal-title":"Cardiovasc Drugs Ther"}],"container-title":["Cardiovascular Drugs and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-021-07148-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10557-021-07148-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-021-07148-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T10:17:42Z","timestamp":1647944262000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10557-021-07148-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,1]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["7148"],"URL":"https:\/\/doi.org\/10.1007\/s10557-021-07148-4","relation":{},"ISSN":["0920-3206","1573-7241"],"issn-type":[{"type":"print","value":"0920-3206"},{"type":"electronic","value":"1573-7241"}],"subject":[],"published":{"date-parts":[[2021,2,1]]},"assertion":[{"value":"19 January 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The institutional review boards at Baylor College of Medicine and the Michael E. DeBakey VA Medical Center approved the study protocol. An approval was also obtained for the informed consent waiver.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Xiaoming Jia, Michelle T. Lee, David J. Ramsey, Mahmoud Al Rifai, Dhruv Mahtta, Chayakrit Krittanawong, Julia M. Akeroyd, Michael E. Matheny, Glenn Gobbel, Neil J. Stone, Laura A. Petersen: none. Christie M. Ballantyne: grant\/research support\u2014all significant. (All paid to institution, not individual): Akcea, Amgen, Esperion, Novartis, Regeneron, Sanofi-Synthelabo, NIH, AHA, ADA. Consultant\u2014Abbott Diagnostics, Akcea, Amarin, Amgen, Arrowhead, Astra Zeneca, Corvidia, Denka Seiken, Esperion, Intercept, Matinas BioPharma Inc., Merck, Novartis, Regeneron, Sanofi-Synthelabo. Salim S. Virani: honorarium, American College of Cardiology (Associate Editor for Innovations, ); Steering Committee, Patient and Provider Assessment of Lipid Management (PALM registry) at the Duke Clinical Research Institute (no financial remuneration).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"The opinions expressed reflect those of the authors and not necessarily those of the Department of Veterans Affairs or the US government.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}}]}}