{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:37:18Z","timestamp":1740123438712,"version":"3.37.3"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T00:00:00Z","timestamp":1619222400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T00:00:00Z","timestamp":1619222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"the National Natural Science Foundation of China Youth Program","award":["81900314"],"award-info":[{"award-number":["81900314"]}]},{"DOI":"10.13039\/501100010041","name":"Tianjin Science and Technology Committee","doi-asserted-by":"publisher","award":["17JCYBJC27800"],"award-info":[{"award-number":["17JCYBJC27800"]}],"id":[{"id":"10.13039\/501100010041","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Tianjin Health and Family Planning Commission Foundation","award":["16KG120"],"award-info":[{"award-number":["16KG120"]}]},{"name":"the Tianjin Graduate Scientific Research Innovation Program","award":["2019YJS181"],"award-info":[{"award-number":["2019YJS181"]}]},{"name":"the Key Laboratory Fund of the Second Hospital of Tianjin Medical University","award":["2018ZDSYS10"],"award-info":[{"award-number":["2018ZDSYS10"]}]},{"name":"the Science & Technology Development Fund of Tianjin Education Commission for Higher Education","award":["2017KJ205"],"award-info":[{"award-number":["2017KJ205"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Drugs Ther"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s10557-021-07184-0","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T06:35:20Z","timestamp":1619332520000},"page":"455-465","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CD36+\/CD61+ Microparticles Correlate with the Risk of Percutaneous Cardiac Interventions in Coronary Artery Disease Patients and the Effects of Ticagrelor"],"prefix":"10.1007","volume":"36","author":[{"given":"Xue","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Dou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangyin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiding","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuewen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7305-6297","authenticated-orcid":false,"given":"Jingjin","family":"Che","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,24]]},"reference":[{"key":"7184_CR1","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1093\/cvr\/cvx211","volume":"114","author":"J Sluijter","year":"2018","unstructured":"Sluijter J, Davidson S, Boulanger C, et al. Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology. Cardiovasc Res. 2018;114:19\u201334.","journal-title":"Cardiovasc Res"},{"key":"7184_CR2","doi-asserted-by":"publisher","first-page":"2358","DOI":"10.1111\/j.1538-7836.2010.04007.x","volume":"8","author":"E Shantsila","year":"2010","unstructured":"Shantsila E, Kamphuisen P, Lip G. Circulating microparticles in cardiovascular disease: implications for atherogenesis and atherothrombosis. J Thromb Haemostasis. 2010;8:2358\u201368.","journal-title":"J Thromb Haemostasis"},{"key":"7184_CR3","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1080\/07853890.2019.1609076","volume":"51","author":"C Voukalis","year":"2019","unstructured":"Voukalis C, Shantsila E, Lip G. Microparticles and cardiovascular diseases. Ann Med. 2019;51:193\u2013223.","journal-title":"Ann Med"},{"key":"7184_CR4","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1160\/TH06-06-0313","volume":"97","author":"E Sinauridze","year":"2007","unstructured":"Sinauridze E, Kireev D, Popenko N, Pichugin AV, Panteleev MA, Krymskaya OV, et al. Platelet microparticle membranes have 50- to 100-fold higher specific procoagulant activity than activated platelets. Thromb Haemost. 2007;97:425\u201334.","journal-title":"Thromb Haemost"},{"key":"7184_CR5","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1080\/07853890410018943","volume":"37","author":"K Tan","year":"2005","unstructured":"Tan K, Tayebjee M, Lynd C, Blann A, Lip G. Platelet microparticles and soluble P selectin in peripheral artery disease: relationship to extent of disease and platelet activation markers. Ann Med. 2005;37:61\u20136.","journal-title":"Ann Med"},{"key":"7184_CR6","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.psym.2013.09.004","volume":"55","author":"M Williams","year":"2014","unstructured":"Williams M, Rogers H, Wang N, Ziegelstein R. Do platelet-derived microparticles play a role in depression, inflammation, and acute coronary syndrome? Psychosomatics. 2014;55:252\u201360.","journal-title":"Psychosomatics."},{"key":"7184_CR7","doi-asserted-by":"publisher","first-page":"2174","DOI":"10.1253\/circj.CJ-12-0068","volume":"76","author":"L Biasucci","year":"2012","unstructured":"Biasucci L, Porto I, Di Vito L, et al. Differences in microparticle release in patients with acute coronary syndrome and stable angina. Circ J. 2012;76:2174\u201382.","journal-title":"Circ J"},{"key":"7184_CR8","doi-asserted-by":"publisher","first-page":"247","DOI":"10.5551\/jat.26658","volume":"22","author":"Y Chen","year":"2015","unstructured":"Chen Y, Chen C, Wallace C, et al. Levels of circulating microparticles in patients with chronic cardiorenal disease. J Atheroscler Thromb. 2015;22:247\u201356.","journal-title":"J Atheroscler Thromb"},{"key":"7184_CR9","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.06.018","volume":"24","author":"Y Chen","year":"2015","unstructured":"Chen Y, Xiao Y, Lin Z, Xiao X, He C, Bihl JC, et al. The role of circulating platelets microparticles and platelet parameters in acute ischemic stroke patients. J Stroke Cerebrovasc Dis. 2015;24:2313\u201320.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"7184_CR10","doi-asserted-by":"publisher","first-page":"e0148176","DOI":"10.1371\/journal.pone.0148176","volume":"11","author":"G Chiva-Blanch","year":"2016","unstructured":"Chiva-Blanch G, Suades R, Crespo J, Pe\u00f1a E, Padr\u00f3 T, Jim\u00e9nez-Xarri\u00e9 E, et al. Microparticle shedding from neural progenitor cells and vascular compartment cells is increased in ischemic stroke. PLoS One. 2016;11:e0148176.","journal-title":"PLoS One"},{"key":"7184_CR11","first-page":"481","volume":"41","author":"Y Yang","year":"2019","unstructured":"Yang Y, Luo H, Liu S, et al. Platelet microparticles-containing miR-4306 inhibits human monocyte-derived macrophages migration through VEGFA\/ERK1\/2\/NF-\u03baB signaling pathways. Clin Exp Hypertens (New York, NY : 1993). 2019;41:481\u201391.","journal-title":"Clin Exp Hypertens (New York, NY : 1993)"},{"key":"7184_CR12","doi-asserted-by":"publisher","first-page":"529","DOI":"10.5114\/aoms.2016.59926","volume":"12","author":"AB Hartopo","year":"2016","unstructured":"Hartopo AB, Puspitawati I, Gharini PP, Setianto BY. Platelet microparticle number is associated with the extent of myocardial damage in acute myocardial infarction. Arch Med Sci. 2016;12:529\u201337.","journal-title":"Arch Med Sci"},{"key":"7184_CR13","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.3892\/etm.2016.3060","volume":"11","author":"B Zhou","year":"2016","unstructured":"Zhou B, Li J, Chen S, et al. Time course of various cell origin circulating microparticles in ST-segment elevation myocardial infarction patients undergoing percutaneous transluminal coronary intervention. Exp Ther Med. 2016;11:1481\u20136.","journal-title":"Exp Ther Med"},{"key":"7184_CR14","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1161\/CIRCRESAHA.108.172064","volume":"102","author":"K Chen","year":"2008","unstructured":"Chen K, Febbraio M, Li W, Silverstein R. A specific CD36-dependent signaling pathway is required for platelet activation by oxidized low-density lipoprotein. Circ Res. 2008;102:1512\u20139.","journal-title":"Circ Res"},{"key":"7184_CR15","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.freeradbiomed.2019.02.021","volume":"136","author":"M Yang","year":"2019","unstructured":"Yang M, Silverstein R. CD36 signaling in vascular redox stress. Free Radic Biol Med. 2019;136:159\u201371.","journal-title":"Free Radic Biol Med"},{"key":"7184_CR16","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.3949\/ccjm.76.s2.06","volume":"76","author":"R Silverstein","year":"2009","unstructured":"Silverstein R. Inflammation, atherosclerosis, and arterial thrombosis: role of the scavenger receptor CD36. Cleve Clin J Med. 2009;76:S27\u201330.","journal-title":"Cleve Clin J Med"},{"key":"7184_CR17","first-page":"1934","volume":"118","author":"A Ghosh","year":"2008","unstructured":"Ghosh A, Li W, Febbraio M, Espinola RG, McCrae K, Cockrell E, et al. Platelet CD36 mediates interactions with endothelial cell-derived microparticles and contributes to thrombosis in mice. J Clin Invest. 2008;118:1934\u201343.","journal-title":"J Clin Invest"},{"key":"7184_CR18","doi-asserted-by":"publisher","first-page":"183","DOI":"10.14712\/18059694.2019.31","volume":"46","author":"M Loudov\u00e1","year":"2003","unstructured":"Loudov\u00e1 M, Krejsek J. Platelets activation in patients undergoing PTCA and their responsiveness after in vitro stimulation. Acta Med (Hradec Kralove). 2003;46:183\u20138.","journal-title":"Acta Med (Hradec Kralove)"},{"key":"7184_CR19","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3109\/13813455.2013.808671","volume":"119","author":"P Wilhelmsen","year":"2013","unstructured":"Wilhelmsen P, Kj\u00e6r J, Thomsen K, et al. Elevated platelet expression of CD36 may contribute to increased risk of thrombo-embolism in active inflammatory bowel disease. Arch Physiol Biochem. 2013;119:202\u20138.","journal-title":"Arch Physiol Biochem"},{"key":"7184_CR20","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.1182\/blood-2016-10-743930","volume":"128","author":"W Parker","year":"2016","unstructured":"Parker W, Storey R. Ticagrelor: agonising over its mechanisms of action. Blood. 2016;128:2595\u20137.","journal-title":"Blood."},{"key":"7184_CR21","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.1182\/blood-2016-03-707844","volume":"128","author":"R Aungraheeta","year":"2016","unstructured":"Aungraheeta R, Conibear A, Butler M, Kelly E, Nylander S, Mumford A, et al. Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor. Blood. 2016;128:2717\u201328.","journal-title":"Blood."},{"key":"7184_CR22","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1080\/09537104.2017.1356453","volume":"29","author":"V Rabani","year":"2018","unstructured":"Rabani V, Montange D, Meneveau N, Davani S. Impact of ticagrelor on P2Y1 and P2Y12 localization and on cholesterol levels in platelet plasma membrane. Platelets. 2018;29:709\u201315.","journal-title":"Platelets."},{"key":"7184_CR23","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1253\/circj.CJ-11-1145","volume":"76","author":"C Fran\u00e7a","year":"2012","unstructured":"Fran\u00e7a C, Pinheiro L, Izar M, et al. Endothelial progenitor cell mobilization and platelet microparticle release are influenced by clopidogrel plasma levels in stable coronary artery disease. Circ J. 2012;76:729\u201336.","journal-title":"Circ J"},{"key":"7184_CR24","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1161\/CIRCULATIONAHA.111.068833","volume":"125","author":"S Dasgupta","year":"2012","unstructured":"Dasgupta S, Le A, Chavakis T, Rumbaut R, Thiagarajan P. Developmental endothelial locus-1 (Del-1) mediates clearance of platelet microparticles by the endothelium. Circulation. 2012;125:1664\u201372.","journal-title":"Circulation."},{"key":"7184_CR25","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/S0002-9149(83)80105-2","volume":"51","author":"G Gensini","year":"1983","unstructured":"Gensini G. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol. 1983;51:606.","journal-title":"Am J Cardiol"},{"key":"7184_CR26","doi-asserted-by":"publisher","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","volume":"7","author":"C Th\u00e9ry","year":"2018","unstructured":"Th\u00e9ry C, Witwer K, Aikawa E, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracellular vesicles. 2018;7:1535750.","journal-title":"J Extracellular vesicles"},{"key":"7184_CR27","doi-asserted-by":"crossref","unstructured":"R. Lacroix, C. Judicone, M. Mooberry, M. Boucekine, N. S. Key, F. Dignat-George, (2013) Standardization of pre-analytical variables in plasma microparticle determination: results of the International Society on Thrombosis and Haemostasis SSC Collaborative workshop. Journal of Thrombosis and Haemostasis 11 (6):1190-1193","DOI":"10.1111\/jth.12207"},{"key":"7184_CR28","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1160\/TH12-08-0550","volume":"108","author":"P Ferroni","year":"2012","unstructured":"Ferroni P, Riondino S, Vazzana N, Santoro N, Guadagni F, Dav\u00ec G. Biomarkers of platelet activation in acute coronary syndromes. Thromb Haemost. 2012;108:1109\u201323.","journal-title":"Thromb Haemost"},{"key":"7184_CR29","doi-asserted-by":"publisher","first-page":"911","DOI":"10.3324\/haematol.13774","volume":"94","author":"M Trappenburg","year":"2009","unstructured":"Trappenburg M, van Schilfgaarde M, Marchetti M, et al. Elevated procoagulant microparticles expressing endothelial and platelet markers in essential thrombocythemia. Haematologica. 2009;94:911\u20138.","journal-title":"Haematologica."},{"key":"7184_CR30","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1111\/j.1538-7836.2011.04220.x","volume":"9","author":"M Alkhatatbeh","year":"2011","unstructured":"Alkhatatbeh M, Mhaidat N, Enjeti A, Lincz L, Thorne R. The putative diabetic plasma marker, soluble CD36, is non-cleaved, non-soluble and entirely associated with microparticles. J Thromb Haemostasis. 2011;9:844\u201351.","journal-title":"J Thromb Haemostasis"},{"key":"7184_CR31","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.thromres.2019.04.006","volume":"178","author":"B Lee","year":"2019","unstructured":"Lee B, Lin K, Hu C, Lo S. Thromboelastography characterized CD36 null subjects as slow clot formation and indicative of hypocoagulability. Thromb Res. 2019;178:79\u201384.","journal-title":"Thromb Res"},{"key":"7184_CR32","doi-asserted-by":"publisher","first-page":"9337","DOI":"10.1096\/fj.201903189R","volume":"34","author":"M D\u00f6hrmann","year":"2020","unstructured":"D\u00f6hrmann M, Makhoul S, Gross K, Krause M, Pillitteri D, Auer C, et al. CD36-fibrin interaction propagates FXI-dependent thrombin generation of human platelets. FASEB J. 2020;34:9337\u201357.","journal-title":"FASEB J"},{"key":"7184_CR33","doi-asserted-by":"publisher","first-page":"489","DOI":"10.2147\/VHRM.S236286","volume":"16","author":"S Signorelli","year":"2020","unstructured":"Signorelli S, Oliveri Conti G, Fiore M, et al. Platelet-derived microparticles (MPs) and thrombin generation velocity in deep vein thrombosis (DVT): results of a case-control study. Vasc Health Risk Manag. 2020;16:489\u201395.","journal-title":"Vasc Health Risk Manag"},{"key":"7184_CR34","doi-asserted-by":"publisher","first-page":"1325.e1321","DOI":"10.1016\/j.cjca.2016.02.052","volume":"32","author":"C Sun","year":"2016","unstructured":"Sun C, Zhao W, Chen Y, Hu H. Higher plasma concentrations of platelet microparticles in patients with acute coronary syndrome: a systematic review and meta-analysis. Can J Cardiol. 2016;32:1325.e1321\u201310.","journal-title":"Can J Cardiol"},{"key":"7184_CR35","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.ijcard.2015.09.011","volume":"202","author":"R Suades","year":"2016","unstructured":"Suades R, Padr\u00f3 T, Crespo J, Ramaiola I, Martin-Yuste V, Sabat\u00e9 M, et al. Circulating microparticle signature in coronary and peripheral blood of ST elevation myocardial infarction patients in relation to pain-to-PCI elapsed time. Int J Cardiol. 2016;202:378\u201387.","journal-title":"Int J Cardiol"},{"key":"7184_CR36","doi-asserted-by":"publisher","first-page":"4257875","DOI":"10.1155\/2017\/4257875","volume":"2017","author":"J Botha","year":"2017","unstructured":"Botha J, Velling Magnussen L, Nielsen M, et al. Microvesicles correlated with components of metabolic syndrome in men with type 2 diabetes mellitus and lowered testosterone levels but were unaltered by testosterone therapy. J Diabetes Res. 2017;2017:4257875.","journal-title":"J Diabetes Res"},{"key":"7184_CR37","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1160\/TH16-02-0130","volume":"116","author":"G Chiva-Blanch","year":"2016","unstructured":"Chiva-Blanch G, Crespo J, Suades R, Arderiu G, Padro T, Vilahur G, et al. CD142+\/CD61+, CD146+ and CD45+ microparticles predict cardiovascular events in high risk patients following a Mediterranean diet supplemented with nuts. Thromb Haemost. 2016;116:103\u201314.","journal-title":"Thromb Haemost"},{"key":"7184_CR38","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1055\/s-0037-1613209","volume":"88","author":"J Heemskerk","year":"2002","unstructured":"Heemskerk J, Bevers E, Lindhout T. Platelet activation and blood coagulation. Thromb Haemost. 2002;88:186\u201393.","journal-title":"Thromb Haemost"},{"key":"7184_CR39","doi-asserted-by":"publisher","first-page":"2754","DOI":"10.1111\/j.1538-7836.2005.01646.x","volume":"3","author":"E Bir\u00f3","year":"2005","unstructured":"Bir\u00f3 E, Akkerman J, Hoek F, et al. The phospholipid composition and cholesterol content of platelet-derived microparticles: a comparison with platelet membrane fractions. J Thromb Haemostasis. 2005;3:2754\u201363.","journal-title":"J Thromb Haemostasis"},{"key":"7184_CR40","doi-asserted-by":"crossref","unstructured":"Qi Z, Hu L, Zhang J, et al. PCSK9 enhances platelet activation, thrombosis, and myocardial infarct expansion by binding to platelet CD36. Circulation. 2020.","DOI":"10.1161\/CIRCULATIONAHA.120.046290"}],"container-title":["Cardiovascular Drugs and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-021-07184-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10557-021-07184-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-021-07184-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T07:17:00Z","timestamp":1652167020000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10557-021-07184-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,24]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["7184"],"URL":"https:\/\/doi.org\/10.1007\/s10557-021-07184-0","relation":{},"ISSN":["0920-3206","1573-7241"],"issn-type":[{"type":"print","value":"0920-3206"},{"type":"electronic","value":"1573-7241"}],"subject":[],"published":{"date-parts":[[2021,4,24]]},"assertion":[{"value":"5 April 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"All participants provided written informed consent before enrollment in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"Written informed consent was obtained from all study participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}