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Each group consisted of a 6\u00a0h non-survival subgroup (n\u2009=\u20096) and a 48\u00a0h survival subgroup (n\u2009=\u20096). Ventricular fibrillation (VF) was induced and untreated for 6\u00a0min. CPR was initiated and continued for 8\u00a0min. Resuscitation was attempted with a 4\u00a0J defibrillation. MCC950 (10\u00a0mg\/kg) or vehicle was administered via intraperitoneal injection immediately after the return of spontaneous circulation (ROSC). Myocardial function and sublingual microcirculation were measured after ROSC in the non-survival subgroups. Plasma levels of interleukin I\u03b2 (IL-1\u03b2) and cardiac troponin I (cTnI) were measured at baseline and 6\u00a0h in the non-survival subgroups. Heart tissue was harvested to measure the NLRP3 inflammasome constituents, including NLRP3, apoptosis-associated speck-like protein (ASC), Caspase-1, and IL-1\u03b2. Survival duration and neurologic deficit score (NDS) were recorded and evaluated among survival groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Post-resuscitation myocardial function and sublingual microcirculation were improved in MCC950 compared with control (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). IL-1\u03b2 and cTnI were decreased in MCC950 compared to control (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The MCC950 treated groups showed significantly reduced ASC, caspase-1, and IL-1\u03b2 compared with the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Survival at 48\u00a0h after ROSC was greater in MCC950 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) with improved NDS (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Administration of MCC950 following ROSC mitigates post-resuscitation myocardial dysfunction and improves survival.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10557-021-07282-z","type":"journal-article","created":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T07:16:29Z","timestamp":1641021389000},"page":"423-433","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Selective NLRP3-inflammasome inhibitor MCC950 Mitigates Post-resuscitation Myocardial Dysfunction and Improves Survival in a Rat Model of Cardiac Arrest and Resuscitation"],"prefix":"10.1007","volume":"37","author":[{"given":"Guanghui","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenglian","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianfei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changsheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Ann","family":"Peberdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"Ornato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longyuan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Toldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3940-6369","authenticated-orcid":false,"given":"Wanchun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,1]]},"reference":[{"key":"7282_CR1","doi-asserted-by":"publisher","first-page":"e67","DOI":"10.1161\/CIR.0000000000000558","volume":"137","author":"EJ Benjamin","year":"2018","unstructured":"Benjamin EJ, Virani SS, Callaway CW, et al. 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