{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:19:17Z","timestamp":1708388357215},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Drugs Ther"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1007\/s10557-023-07510-8","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T07:02:16Z","timestamp":1697439736000},"page":"203-205","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Winding Down the Storm: Could Empagliflozin\u2019s Ion-Dependent Mechanisms Tackle the Ventricular Arrhythmia Burden in Chronic Chagas Cardiomyopathy?"],"prefix":"10.1007","volume":"38","author":[{"given":"Sergio Alejandro","family":"G\u00f3mez-Ochoa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyda Z.","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Eduardo","family":"Echeverr\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"7510_CR1","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s10557-021-07311-x","volume":"37","author":"X Peng","year":"2023","unstructured":"Peng X, Li L, Lin R, et al. Empagliflozin ameliorates ouabain-induced Na+ and Ca2+ dysregulations in ventricular myocytes in an Na+-dependent manner. Cardiovasc Drugs Ther. 2023;37:461\u20139.","journal-title":"Cardiovasc Drugs Ther"},{"key":"7510_CR2","doi-asserted-by":"publisher","first-page":"e169","DOI":"10.1161\/CIR.0000000000000599","volume":"138","author":"MCP Nunes","year":"2018","unstructured":"Nunes MCP, Beaton A, Acquatella H, et al. Chagas cardiomyopathy: an update of current clinical knowledge and management: a scientific statement from the American Heart Association. Circulation. 2018;138:e169\u2013209.","journal-title":"Circulation"},{"key":"7510_CR3","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/fcp.12404","volume":"33","author":"N B\u00f6geholz","year":"2019","unstructured":"B\u00f6geholz N, Pauls P, Bauer BK, et al. Overexpression of the Na+ \/Ca2+ exchanger influences ouabain-mediated spontaneous Ca2+ activity but not positive inotropy. Fundam Clin Pharmacol. 2019;33:43\u201351.","journal-title":"Fundam Clin Pharmacol"},{"key":"7510_CR4","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s12933-021-01293-8","volume":"20","author":"H-L Li","year":"2021","unstructured":"Li H-L, Lip GYH, Feng Q, et al. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and cardiac arrhythmias: a systematic review and meta-analysis. Cardiovasc Diabetol. 2021;20:100.","journal-title":"Cardiovasc Diabetol"},{"key":"7510_CR5","doi-asserted-by":"publisher","first-page":"e0009421","DOI":"10.1371\/journal.pntd.0009421","volume":"15","author":"A Santos-Miranda","year":"2021","unstructured":"Santos-Miranda A, Joviano-Santos JV, Sarmento JO, et al. A novel substrate for arrhythmias in Chagas disease. PLoS Negl Trop Dis. 2021;15:e0009421.","journal-title":"PLoS Negl Trop Dis"}],"container-title":["Cardiovascular Drugs and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-023-07510-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10557-023-07510-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-023-07510-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T10:33:17Z","timestamp":1708338797000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10557-023-07510-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,16]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["7510"],"URL":"https:\/\/doi.org\/10.1007\/s10557-023-07510-8","relation":{},"ISSN":["0920-3206","1573-7241"],"issn-type":[{"value":"0920-3206","type":"print"},{"value":"1573-7241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,16]]},"assertion":[{"value":"15 September 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The institutional Ethics Committee of the Fundaci\u00f3n Cardiovascular de Colombia approved the EMPA-Chagas study (CEI-2023\u201305269).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"All patients provided their written informed consent for participation.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"All authors agree to the publication of the manuscript in its present form.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"SAGO, LZR, and LEE received funding from Boehringer Ingelheim S.A. for the development of the EMPA-Chagas Study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}