{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:32:01Z","timestamp":1785439921601,"version":"3.56.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","doi-asserted-by":"publisher","award":["No. 451-03-65\/2024-03\/200111"],"award-info":[{"award-number":["No. 451-03-65\/2024-03\/200111"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010301","name":"Fakultet Medicinskih Nauka, Univerziteta U Kragujevcu","doi-asserted-by":"publisher","award":["JP 01\/24"],"award-info":[{"award-number":["JP 01\/24"]}],"id":[{"id":"10.13039\/501100010301","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Drugs Ther"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s10557-025-07675-4","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T04:57:36Z","timestamp":1738817856000},"page":"81-95","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Combined Empagliflozin and Sacubitril\/Valsartan Therapy Attenuates Isoproterenol-Induced Heart Failure in Rats: Functional, Molecular, and Structural Insights"],"prefix":"10.1007","volume":"40","author":[{"given":"Maja","family":"Muric","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3835-1856","authenticated-orcid":false,"given":"Ivan","family":"Srejovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovana","family":"Novakovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Zivkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovana Joksimovic","family":"Jovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmina","family":"Sretenovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Nikolic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevena","family":"Lazarevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijana","family":"Andjic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Kocovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovana Jakovljevic","family":"Uzelac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Bolevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Jakovljevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"issue":"19","key":"7675_CR1","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1001\/jama.2023.5942","volume":"329","author":"M Rasmussen","year":"2023","unstructured":"Rasmussen M, Prado A, Hominal MA, Zaidman CJ, Cursack G, MacKinnon I, Zapata G, Rojas DG, Duran RG, Vilamajo OG, Dutra OP. Global variations in heart failure etiology, management, and outcomes. JAMA. 2023;329(19):1650\u201361. https:\/\/doi.org\/10.1001\/jama.2023.5942.","journal-title":"JAMA"},{"issue":"1","key":"7675_CR2","doi-asserted-by":"publisher","first-page":"242","DOI":"10.3390\/cells9010242","volume":"9","author":"SJ Simmonds","year":"2020","unstructured":"Simmonds SJ, Cuijpers I, Heymans S, Jones EAV. Cellular and molecular differences between HFpEF and HFrEF: a step ahead in an improved pathological understanding. Cells. 2020;9(1):242. https:\/\/doi.org\/10.3390\/cells9010242.","journal-title":"Cells"},{"issue":"5","key":"7675_CR3","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1177\/2047487319870344","volume":"27","author":"A Aimo","year":"2020","unstructured":"Aimo A, Castiglione V, Borrelli C, et al. Oxidative stress and inflammation in the evolution of heart failure: from pathophysiology to therapeutic strategies. Eur J Prev Cardiol. 2020;27(5):494\u2013510. https:\/\/doi.org\/10.1177\/2047487319870344.","journal-title":"Eur J Prev Cardiol"},{"key":"7675_CR4","doi-asserted-by":"publisher","first-page":"3753","DOI":"10.1113\/JP273609","volume":"595","author":"M Kohlhaas","year":"2017","unstructured":"Kohlhaas M, Nickel AG, Maack C. Mitochondrial energetics and calcium coupling in the heart. J Physiol. 2017;595:3753\u201363. https:\/\/doi.org\/10.1113\/JP273609.","journal-title":"J Physiol"},{"issue":"3","key":"7675_CR5","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1530\/JOE-16-0146","volume":"230","author":"SK Mahata","year":"2016","unstructured":"Mahata SK, Zheng H, Mahata S, Liu X, Patel KP. Effect of heart failure on catecholamine granule morphology and storage in chromaffin cells. J Endocrinol. 2016;230(3):309\u201323. https:\/\/doi.org\/10.1530\/JOE-16-0146.","journal-title":"J Endocrinol"},{"issue":"13","key":"7675_CR6","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1093\/cvr\/cvz161","volume":"115","author":"C Riehle","year":"2019","unstructured":"Riehle C, Bauersachs J. Small animal models of heart failure. Cardiovasc Res. 2019;115(13):1838\u201349. https:\/\/doi.org\/10.1093\/cvr\/cvz161.","journal-title":"Cardiovasc Res"},{"issue":"18","key":"7675_CR7","doi-asserted-by":"publisher","first-page":"e895","DOI":"10.1161\/CIR.0000000000001063","volume":"145","author":"PA Heidenreich","year":"2022","unstructured":"Heidenreich PA, Bozkurt B, Aguilar D, et al. AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on clinical practice guidelines. Circulation. 2022;145(18):e895-1032. https:\/\/doi.org\/10.1161\/CIR.0000000000001063.","journal-title":"Circulation"},{"issue":"6","key":"7675_CR8","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1093\/eurheartj\/ehaa968","volume":"42","author":"M Packer","year":"2021","unstructured":"Packer M, Anker SD, Butler J, et al. Influence of neprilysin inhibition on the efficacy and safety of empagliflozin in patients with chronic heart failure and a reduced ejection fraction: the EMPEROR-Reduced trial. Eur Heart J. 2021;42(6):671\u201380. https:\/\/doi.org\/10.1093\/eurheartj\/ehaa968.","journal-title":"Eur Heart J"},{"key":"7675_CR9","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.jchf.2020.04.008","volume":"8","author":"SD Solomon","year":"2020","unstructured":"Solomon SD, Jhund PS, Claggett BL, et al. Effect of dapagliflozin in patients with HFrEF treated with sacubitril\/valsartan: the DAPA-HF trial. JACC Heart Failure. 2020;8:811\u20138. https:\/\/doi.org\/10.1016\/j.jchf.2020.04.008.","journal-title":"JACC Heart Failure"},{"issue":"1","key":"7675_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s40261-021-01098-3","volume":"42","author":"YN Teo","year":"2022","unstructured":"Teo YN, Teo YH, Syn NL, et al. Comparing sacubitril\/valsartan against sodium-glucose cotransporter 2 inhibitors in heart failure: a systematic review and network meta-analysis. Clin Drug Investig. 2022;42(1):1\u201316. https:\/\/doi.org\/10.1007\/s40261-021-01098-3.","journal-title":"Clin Drug Investig"},{"issue":"4","key":"7675_CR11","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1177\/00033197211047329","volume":"73","author":"U Karabulut","year":"2022","unstructured":"Karabulut U, Keskin K, Karabulut D, Yi\u011fit E, Yi\u011fit Z. Effect of sacubitril\/valsartan combined with dapagliflozin on long-term cardiac mortality in heart failure with reduced ejection fraction. Angiology. 2022;73(4):350\u20136. https:\/\/doi.org\/10.1177\/00033197211047329.","journal-title":"Angiology"},{"key":"7675_CR12","doi-asserted-by":"publisher","first-page":"1097066","DOI":"10.3389\/fcvm.2023.1097066","volume":"10","author":"J Jiang","year":"2023","unstructured":"Jiang J, Gao J, Zhang X, et al. Combined treatment with sacubitril\/valsartan plus dapagliflozin in patients affected by heart failure with reduced ejection fraction. Front Cardiovasc Med. 2023;10:1097066. https:\/\/doi.org\/10.3389\/fcvm.2023.1097066.","journal-title":"Front Cardiovasc Med"},{"issue":"3","key":"7675_CR13","doi-asserted-by":"publisher","first-page":"100546","DOI":"10.1016\/j.bj.2022.06.002","volume":"46","author":"SF Ko","year":"2023","unstructured":"Ko SF, Sung PH, Yang CC, Chiang JY, Yip HK. Combined therapy with dapagliflozin and entresto offers an additional benefit on improving the heart function in rat after ischemia-reperfusion injury. Biomed J. 2023;46(3):100546. https:\/\/doi.org\/10.1016\/j.bj.2022.06.002.","journal-title":"Biomed J"},{"key":"7675_CR14","doi-asserted-by":"publisher","first-page":"1181473","DOI":"10.3389\/fcvm.2023.1181473","volume":"10","author":"W Tao","year":"2023","unstructured":"Tao W, Yang X, Zhang Q, Bi S, Yao Z. Optimal treatment for post-MI heart failure in rats: dapagliflozin first, adding sacubitril-valsartan 2 weeks later. Front Cardiovasc Med. 2023;10:1181473. https:\/\/doi.org\/10.3389\/fcvm.2023.1181473.","journal-title":"Front Cardiovasc Med"},{"issue":"3","key":"7675_CR15","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1007\/s10741-021-10079-9","volume":"27","author":"M Nikolic","year":"2022","unstructured":"Nikolic M, Zivkovic V, Jovic JJ, et al. SGLT2 inhibitors: a focus on cardiac benefits and potential mechanisms. Heart fail rev. 2022;27(3):935\u201349. https:\/\/doi.org\/10.1007\/s10741-021-10079-9.","journal-title":"Heart fail rev"},{"issue":"7","key":"7675_CR16","doi-asserted-by":"publisher","first-page":"238","DOI":"10.31083\/j.rcm2307238","volume":"23","author":"M Nikolic","year":"2022","unstructured":"Nikolic M, Srejovic I, Joksimovic JJ, et al. Sacubitril\/valsartan in heart failure and beyond\u2014from molecular mechanisms to clinical relevance. Rev Cardiovasc Med. 2022;23(7):238.","journal-title":"Rev Cardiovasc Med"},{"issue":"2","key":"7675_CR17","doi-asserted-by":"publisher","first-page":"e12241","DOI":"10.1111\/1755-5922.12241","volume":"35","author":"R Zhou","year":"2017","unstructured":"Zhou R, Ma P, Xiong A, Xu Y, Wang Y, Xu Q. Protective effects of low-dose rosuvastatin on isoproterenol-induced chronic heart failure in rats by regulation of DDAH-ADMA-NO pathway. Cardiovasc Ther. 2017;35(2):e12241. https:\/\/doi.org\/10.1111\/1755-5922.12241.","journal-title":"Cardiovasc Ther"},{"key":"7675_CR18","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.3389\/fphar.2019.01329","volume":"10","author":"C Fan","year":"2019","unstructured":"Fan C, Tang X, Ye M, et al. Qi-Li-Qiang-Xin alleviates isoproterenol-induced myocardial injury by inhibiting excessive autophagy via activating AKT\/mTOR pathway. Front Pharmacol. 2019;10:1329. https:\/\/doi.org\/10.3389\/fphar.2019.01329.","journal-title":"Front Pharmacol"},{"issue":"7","key":"7675_CR19","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.3390\/ijms20071680","volume":"20","author":"TI Lee","year":"2019","unstructured":"Lee TI, Chen YC, Lin YK, et al. Empagliflozin attenuates myocardial sodium and calcium dysregulation and reverses cardiac remodeling in streptozotocin-induced diabetic rats. Int J Mol Sci. 2019;20(7):1680. https:\/\/doi.org\/10.3390\/ijms20071680.","journal-title":"Int J Mol Sci"},{"issue":"8","key":"7675_CR20","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.2337\/db18-0062","volume":"67","author":"EP Davidson","year":"2018","unstructured":"Davidson EP, Coppey LJ, Shevalye H, Obrosov A, Yorek MA. Vascular and neural complications in type 2 diabetic rats: improvement by sacubitril\/valsartan greater than valsartan alone. Diabetes. 2018;67(8):1616\u201326. https:\/\/doi.org\/10.2337\/db18-0062.","journal-title":"Diabetes"},{"issue":"1","key":"7675_CR21","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/cvr\/cvaa110","volume":"117","author":"S Zacchigna","year":"2021","unstructured":"Zacchigna S, Paldino A, Falc\u00e3o-Pires I, et al. Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function. Cardiovasc Res. 2021;117(1):43\u201359. https:\/\/doi.org\/10.1093\/cvr\/cvaa110.","journal-title":"Cardiovasc Res"},{"key":"7675_CR22","doi-asserted-by":"publisher","first-page":"112941","DOI":"10.1016\/j.biopha.2022.112941","volume":"150","author":"M Andji\u0107","year":"2022","unstructured":"Andji\u0107 M, Dragini\u0107 N, Ko\u010dovi\u0107 A, et al. Immortelle essential oil-based ointment improves wound healing in a diabetic rat model. Biomed Pharm. 2022;150:112941. https:\/\/doi.org\/10.1016\/j.biopha.2022.112941.","journal-title":"Biomed Pharm"},{"key":"7675_CR23","doi-asserted-by":"publisher","first-page":"8862878","DOI":"10.1155\/2021\/8862878","volume":"2021","author":"J Joksimovic Jovic","year":"2021","unstructured":"Joksimovic Jovic J, Sretenovic J, Jovic N, et al. Cardiovascular properties of the androgen-induced PCOS model in rats: the role of oxidative stress. Oxid Med Cell Longev. 2021;2021:8862878. https:\/\/doi.org\/10.1155\/2021\/8862878.","journal-title":"Oxid Med Cell Longev"},{"key":"7675_CR24","doi-asserted-by":"publisher","unstructured":"Bradic J, Jeremic N, Petkovic A, et al. Cardioprotective effects of\u00a0Galium verum\u00a0L. extract against myocardial ischemia-reperfusion injury.\u00a0Arch Physiol Biochem.\u00a02020;126:408\u2013415. https:\/\/doi.org\/10.1080\/13813455.2018.1551904","DOI":"10.1080\/13813455.2018.1551904"},{"issue":"4","key":"7675_CR25","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402\u20138. https:\/\/doi.org\/10.1006\/meth.2001.1262.","journal-title":"Methods"},{"issue":"8","key":"7675_CR26","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.3390\/life12081242","volume":"12","author":"J Sretenovic","year":"2022","unstructured":"Sretenovic J, Zivkovic V, Srejovic I, et al. Nandrolone decanoate and swimming affects cardiodynamic and morphometric parameters in the isolated rat heart. Life (Basel). 2022;12(8):1242. https:\/\/doi.org\/10.3390\/life12081242.","journal-title":"Life (Basel)"},{"issue":"5","key":"7675_CR27","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1097\/HJH.0000000000003633","volume":"42","author":"EO Cruz-L\u00f3pez","year":"2024","unstructured":"Cruz-L\u00f3pez EO, Ye D, Stolk DG, et al. Combining renin-angiotensin system blockade and sodium-glucose cotransporter-2 inhibition in experimental diabetes results in synergistic beneficial effects. J Hypertens. 2024;42(5):883\u201392. https:\/\/doi.org\/10.1097\/HJH.0000000000003633.","journal-title":"J Hypertens"},{"issue":"8","key":"7675_CR28","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1038\/s41401-024-01265-0","volume":"45","author":"XY Ni","year":"2024","unstructured":"Ni XY, Feng XJ, Wang ZH, et al. Empagliflozin and liraglutide ameliorate HFpEF in mice via augmenting the Erbb4 signaling pathway. Acta Pharmacol Sin. 2024;45(8):1604\u201317. https:\/\/doi.org\/10.1038\/s41401-024-01265-0.","journal-title":"Acta Pharmacol Sin"},{"issue":"2","key":"7675_CR29","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1007\/s00210-023-02655-7","volume":"397","author":"Z Wang","year":"2024","unstructured":"Wang Z, Liu Q, Wang X, Wang P, Wang Z, Zhang F. Empagliflozin improves cardiac function in rats with chronic heart failure. Naunyn Schmiedebergs Arch Pharmacol. 2024;397(2):1037\u201344. https:\/\/doi.org\/10.1007\/s00210-023-02655-7.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"7675_CR30","doi-asserted-by":"publisher","unstructured":"Stanko P, Repova K, Baka T, et al. Sacubitril\/valsartan alleviates cardiac remodeling and dysfunction in L-NAME-induced hypertension and hypertensive heart disease. Biomedicines. 2024;25;12(4):733. https:\/\/doi.org\/10.3390\/biomedicines12040733","DOI":"10.3390\/biomedicines12040733"},{"issue":"1","key":"7675_CR31","doi-asserted-by":"publisher","first-page":"22342","DOI":"10.1038\/s41598-021-01759-5","volume":"11","author":"HM Kim","year":"2021","unstructured":"Kim HM, Hwang IC, Choi W, Yoon YE, Cho GY. Combined effects of ARNI and SGLT2 inhibitors in diabetic patients with heart failure with reduced ejection fraction. Sci Rep. 2021;11(1):22342. https:\/\/doi.org\/10.1038\/s41598-021-01759-5.","journal-title":"Sci Rep"},{"issue":"10","key":"7675_CR32","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1002\/clc.24085","volume":"46","author":"X Mo","year":"2023","unstructured":"Mo X, Lu P, Yang X. Efficacy of sacubitril-valsartan and SGLT2 inhibitors in heart failure with reduced ejection fraction: a systematic review and meta-analysis. Clin cardiol. 2023;46(10):1137\u201345. https:\/\/doi.org\/10.1002\/clc.24085.","journal-title":"Clin cardiol"},{"issue":"6","key":"7675_CR33","doi-asserted-by":"publisher","first-page":"629","DOI":"10.2174\/1874467215666220919104526","volume":"16","author":"MS Akhtar","year":"2023","unstructured":"Akhtar MS, Hassan Q, Afzal O, et al. Comparative efficacy of levosimendan, ramipril, and sacubitril\/ valsartan in isoproterenol-induced experimental heart failure: a hemodynamic and molecular approach. Curr mol pharmacol. 2023;16(6):629\u201339. https:\/\/doi.org\/10.2174\/1874467215666220919104526.","journal-title":"Curr mol pharmacol"},{"key":"7675_CR34","doi-asserted-by":"publisher","unstructured":"Adamcova M, Baka T, Dolezelova E, et al. Relations between markers of cardiac remodelling and left ventricular collagen in an isoproterenol-induced heart damage model. J Physiol Pharmacol. 2019;70(1):https:\/\/doi.org\/10.26402\/jpp.2019.1.08. https:\/\/doi.org\/10.26402\/jpp.2019.1.08","DOI":"10.26402\/jpp.2019.1.08"},{"issue":"6","key":"7675_CR35","doi-asserted-by":"publisher","first-page":"H1552","DOI":"10.1152\/ajpheart.00182.2019","volume":"316","author":"QAJ Hagdorn","year":"2019","unstructured":"Hagdorn QAJ, Bossers GPL, Koop AC, et al. A novel method optimizing the normalization of cardiac parameters in small animal models: the importance of dimensional indexing. Am J Physiol Heart Circ Physiol. 2019;316(6):H1552\u20137. https:\/\/doi.org\/10.1152\/ajpheart.00182.2019.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"7675_CR36","doi-asserted-by":"publisher","unstructured":"Pellicori P, Kaur K, Clark AL. Fluid management in patients with chronic heart failure. Card fail rev. 2015;1(2):90\u201395. https:\/\/doi.org\/10.15420\/cfr.2015.1.2.90","DOI":"10.15420\/cfr.2015.1.2.90"},{"issue":"4","key":"7675_CR37","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/pin.13413","volume":"74","author":"M Ren","year":"2024","unstructured":"Ren M, Ye X, Ouyang C, Da Q, Xue W, Chen P. JMJD2A mediates transcriptional activation of SFRP4 and regulates oxidative stress and mitochondrial dysfunction in heart failure. Pathol int. 2024;74(4):210\u201321. https:\/\/doi.org\/10.1111\/pin.13413.","journal-title":"Pathol int"},{"key":"7675_CR38","doi-asserted-by":"publisher","unstructured":"Sharma S, Iqubal A, Khan V, Sharma K, Najmi AK, Haque SE. Icariin ameliorates oxidative stress-induced inflammation, apoptosis, and heart failure in isoproterenol-challenged Wistar rats. Iranian journal of basic medical sciences. 2023;26(5):517\u2013525. https:\/\/doi.org\/10.22038\/IJBMS.2023.66481.14589","DOI":"10.22038\/IJBMS.2023.66481.14589"},{"key":"7675_CR39","doi-asserted-by":"publisher","unstructured":"Dogan Z, Ergun DD, Durmus S, et al. Empagliflozin and sacubitril\/valsartan reverse methotrexate cardiotoxicity by repressing oxidative stress and hypoxia in heart embryonic H9c2 cardiomyocytes - the role of morphology of mitochondria observed on electron microscopy. Eur Rev Med Pharmacol Sci. 2023;27(9):3979\u20133992. https:\/\/doi.org\/10.26355\/eurrev_202305_32304","DOI":"10.26355\/eurrev_202305_32304"},{"issue":"1","key":"7675_CR40","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1007\/s11239-022-02719-0","volume":"55","author":"F Zhang","year":"2023","unstructured":"Zhang F, Cao X, Zhao C, Chen L, Chen X. Empagliflozin activates JAK2\/STAT3 signaling and protects cardiomyocytes from hypoxia\/reoxygenation injury under high glucose conditions. J Thromb Thrombolysis. 2023;55(1):116\u201325. https:\/\/doi.org\/10.1007\/s11239-022-02719-0.","journal-title":"J Thromb Thrombolysis"},{"key":"7675_CR41","doi-asserted-by":"publisher","unstructured":"Li N, Zhu QX, Li GZ, Wang T, Zhou H. Empagliflozin ameliorates diabetic cardiomyopathy probably via activating AMPK\/PGC-1\u03b1 and inhibiting the RhoA\/ROCK pathway. World journal of diabetes, 14(12), 1862\u20131876. https:\/\/doi.org\/10.4239\/wjd.v14.i12.1862","DOI":"10.4239\/wjd.v14.i12.1862"},{"key":"7675_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112244","volume":"144","author":"JN Yeh","year":"2021","unstructured":"Yeh JN, Yue Y, Chu YC, et al. Entresto protected the cardiomyocytes and preserved heart function in cardiorenal syndrome rat fed with high-protein diet through regulating the oxidative stress and Mfn2-mediated mitochondrial functional integrity. Biomed Pharmacother. 2021;144: 112244. https:\/\/doi.org\/10.1016\/j.biopha.2021.112244.","journal-title":"Biomed Pharmacother"},{"key":"7675_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116534","volume":"174","author":"L Flori","year":"2024","unstructured":"Flori L, Lazzarini G, Spezzini J, et al. The isoproterenol-induced myocardial fibrosis: a biochemical and histological investigation. Biomed Pharmacother. 2024;174: 116534. https:\/\/doi.org\/10.1016\/j.biopha.2024.116534.","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"7675_CR44","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s12933-023-01756-0","volume":"22","author":"CC Chung","year":"2023","unstructured":"Chung CC, Lin YK, Chen YC, et al. Empagliflozin suppressed cardiac fibrogenesis through sodium-hydrogen exchanger inhibition and modulation of the calcium homeostasis. Cardiovasc Diabetol. 2023;22(1):27. https:\/\/doi.org\/10.1186\/s12933-023-01756-0.","journal-title":"Cardiovasc Diabetol"},{"key":"7675_CR45","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.600953","volume":"11","author":"W Zhang","year":"2021","unstructured":"Zhang W, Liu J, Fu Y, et al. Sacubitril\/valsartan reduces fibrosis and alleviates high-salt diet-induced HFpEF in rats. Front pharmacol. 2021;11: 600953. https:\/\/doi.org\/10.3389\/fphar.2020.600953.","journal-title":"Front pharmacol"},{"key":"7675_CR46","doi-asserted-by":"publisher","unstructured":"Lee WC, Chang WT, Hong CS, et al. Sodium-glucose cotransporter 2 inhibitors first strategy improve decongestion in patients with symptomatic heart failure and reduced ejection fraction when compared to angiotensin receptor neprilysin inhibitor first strategy. Front Biosci. 2023;28(4):81. https:\/\/doi.org\/10.31083\/j.fbl2804081","DOI":"10.31083\/j.fbl2804081"}],"container-title":["Cardiovascular Drugs and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-025-07675-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10557-025-07675-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-025-07675-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T10:58:34Z","timestamp":1770202714000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10557-025-07675-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,6]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["7675"],"URL":"https:\/\/doi.org\/10.1007\/s10557-025-07675-4","relation":{},"ISSN":["0920-3206","1573-7241"],"issn-type":[{"value":"0920-3206","type":"print"},{"value":"1573-7241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,6]]},"assertion":[{"value":"17 January 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by the Ethical Committee for Laboratory Animal Welfare of the Faculty of Medical Sciences, University of Kragujevac, Serbia (approval no.: 01\u201312766, date: November 16, 2023).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}