{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:57:40Z","timestamp":1784825860622,"version":"3.55.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570268"],"award-info":[{"award-number":["81570268"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Drugs Ther"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s10557-025-07721-1","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T06:09:38Z","timestamp":1749622178000},"page":"461-473","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pericardial Administration of Extracellular Vesicles Derived from Bone Marrow Stem Cells Improved Doxorubicin-induced Heart Failure with Mid Range Ejection Fraction (HFmrEF) in Rats"],"prefix":"10.1007","volume":"40","author":[{"given":"Jintao","family":"Dou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9214-405X","authenticated-orcid":false,"given":"Zhikun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,11]]},"reference":[{"issue":"5","key":"7721_CR1","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1111\/j.1582-4934.2010.01255.x","volume":"15","author":"Z Wen","year":"2011","unstructured":"Wen Z, Zheng S, Zhou C, et al. Repair mechanisms of bone marrow mesenchymal stem cells in myocardial infarction. J Cell Mol Med. 2011;15(5):1032\u201343. https:\/\/doi.org\/10.1111\/j.1582-4934.2010.01255.x.","journal-title":"J Cell Mol Med"},{"issue":"1","key":"7721_CR2","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1186\/s13287-020-01881-7","volume":"11","author":"J Sun","year":"2020","unstructured":"Sun J, Shen H, Shao L, et al. HIF-1\u03b1 overexpression in mesenchymal stem cell-derived exosomes mediates cardioprotection in myocardial infarction by enhanced angiogenesis. Stem Cell Res Ther. 2020;11(1):373. https:\/\/doi.org\/10.1186\/s13287-020-01881-7.","journal-title":"Stem Cell Res Ther"},{"issue":"18","key":"7721_CR3","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1016\/j.jacc.2015.08.879","volume":"66","author":"V Karantalis","year":"2015","unstructured":"Karantalis V, Suncion-Loescher VY, Bagno L, et al. Synergistic effects of combined cell therapy for chronic ischemic cardiomyopathy. J Am Coll Cardiol. 2015;66(18):1990\u20139. https:\/\/doi.org\/10.1016\/j.jacc.2015.08.879.","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"7721_CR4","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.exphem.2008.01.005","volume":"36","author":"S Charwat","year":"2008","unstructured":"Charwat S, Gy\u00f6ngy\u00f6si M, Lang I, et al. Role of adult bone marrow stem cells in the repair of ischemic myocardium: current state of the art. Exp Hematol. 2008;36(6):672\u201380. https:\/\/doi.org\/10.1016\/j.exphem.2008.01.005.","journal-title":"Exp Hematol"},{"issue":"3","key":"7721_CR5","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1002\/stem.269","volume":"28","author":"HK Salem","year":"2010","unstructured":"Salem HK, Thiemermann C. Mesenchymal stromal cells: current understanding and clinical status. Stem Cells (Dayton, Ohio). 2010;28(3):585\u201396. https:\/\/doi.org\/10.1002\/stem.269.","journal-title":"Stem Cells (Dayton, Ohio)"},{"key":"7721_CR6","doi-asserted-by":"publisher","first-page":"26316","DOI":"10.3402\/jev.v4.26316","volume":"4","author":"OPB Wiklander","year":"2015","unstructured":"Wiklander OPB, Nordin JZ, O\u2019Loughlin A, et al. Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting. J Extracellular Vesicles. 2015;4:26316. https:\/\/doi.org\/10.3402\/jev.v4.26316.","journal-title":"J Extracellular Vesicles"},{"issue":"5","key":"7721_CR7","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nrd3978","volume":"12","author":"S El Andaloussi","year":"2013","unstructured":"El Andaloussi S, M\u00e4ger I, Breakefield XO, et al. Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov. 2013;12(5):347\u201357. https:\/\/doi.org\/10.1038\/nrd3978.","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"7721_CR8","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1161\/CIRCRESAHA.117.305990","volume":"117","author":"M Khan","year":"2015","unstructured":"Khan M, Nickoloff E, Abramova T, et al. Embryonic stem cell-derived exosomes promote endogenous repair mechanisms and enhance cardiac function following myocardial infarction. Circ Res. 2015;117(1):52\u201364. https:\/\/doi.org\/10.1161\/CIRCRESAHA.117.305990.","journal-title":"Circ Res"},{"issue":"3","key":"7721_CR9","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.scr.2011.01.001","volume":"6","author":"L Timmers","year":"2011","unstructured":"Timmers L, Lim SK, Hoefer IE, et al. Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction. Stem Cell Research. 2011;6(3):206\u201314. https:\/\/doi.org\/10.1016\/j.scr.2011.01.001.","journal-title":"Stem Cell Research"},{"issue":"15","key":"7721_CR10","doi-asserted-by":"publisher","first-page":"e008737","DOI":"10.1161\/JAHA.118.008737","volume":"7","author":"X Wang","year":"2018","unstructured":"Wang X, Chen Y, Zhao Z, et al. Engineered exosomes with ischemic myocardium-targeting peptide for targeted therapy in myocardial infarction. J Am Heart Assoc. 2018;7(15):e008737. https:\/\/doi.org\/10.1161\/JAHA.118.008737.","journal-title":"J Am Heart Assoc"},{"issue":"6","key":"7721_CR11","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.3892\/ijmm.2019.4150","volume":"43","author":"J-Y Kang","year":"2019","unstructured":"Kang J-Y, Park H, Kim H, et al. Human peripheral blood-derived exosomes for microRNA delivery. Int J Mol Med. 2019;43(6):2319\u201328. https:\/\/doi.org\/10.3892\/ijmm.2019.4150.","journal-title":"Int J Mol Med"},{"issue":"561","key":"7721_CR12","doi-asserted-by":"publisher","first-page":"eaay1318","DOI":"10.1126\/scitranslmed.aay1318","volume":"12","author":"L Gao","year":"2020","unstructured":"Gao L, Wang L, Wei Y, et al. Exosomes secreted by hiPSC-derived cardiac cells improve recovery from myocardial infarction in swine. Sci Transl Med. 2020;12(561):eaay1318. https:\/\/doi.org\/10.1126\/scitranslmed.aay1318.","journal-title":"Sci Transl Med"},{"issue":"6","key":"7721_CR13","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1097\/00005344-200012000-00006","volume":"36","author":"R Moreno","year":"2000","unstructured":"Moreno R, Waxman S, Rowe K, et al. Intrapericardial beta-adrenergic blockade with esmolol exerts a potent antitachycardic effect without depressing contractility. J Cardiovasc Pharmacol. 2000;36(6):722\u20137.","journal-title":"J Cardiovasc Pharmacol"},{"issue":"2\u20133","key":"7721_CR14","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0167-5273(00)00462-9","volume":"77","author":"M Fujita","year":"2001","unstructured":"Fujita M, Komeda M, Hasegawa K, et al. Pericardial fluid as a new material for clinical heart research. Int J Cardiol. 2001;77(2\u20133):113\u20138.","journal-title":"Int J Cardiol"},{"issue":"4","key":"7721_CR15","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1136\/heartjnl-2021-320273","volume":"108","author":"L Nedkoff","year":"2022","unstructured":"Nedkoff L, Weber C. Heart failure: not just a disease of the elderly. Heart (British Cardiac Society). 2022;108(4):249\u201350. https:\/\/doi.org\/10.1136\/heartjnl-2021-320273.","journal-title":"Heart (British Cardiac Society)"},{"issue":"7","key":"7721_CR16","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/s41569-018-0027-7","volume":"15","author":"A Le Bras","year":"2018","unstructured":"Le Bras A. Exosome-based therapy to repair the injured heart. Nat Rev Cardiol. 2018;15(7):382. https:\/\/doi.org\/10.1038\/s41569-018-0027-7.","journal-title":"Nat Rev Cardiol"},{"issue":"2","key":"7721_CR17","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1161\/CIRCRESAHA.114.300639","volume":"114","author":"S Sahoo","year":"2014","unstructured":"Sahoo S, Losordo DW. Exosomes and cardiac repair after myocardial infarction. Circ Res. 2014;114(2):333\u201344. https:\/\/doi.org\/10.1161\/CIRCRESAHA.114.300639.","journal-title":"Circ Res"},{"key":"7721_CR18","doi-asserted-by":"publisher","first-page":"737512","DOI":"10.3389\/fcvm.2021.737512","volume":"8","author":"T Pant","year":"2021","unstructured":"Pant T, Juric M, Bosnjak ZJ, et al. Recent insight on the non-coding rnas in mesenchymal stem cell-derived exosomes: Regulatory and therapeutic role in regenerative medicine and tissue engineering. Front Cardiovasc Med. 2021;8:737512. https:\/\/doi.org\/10.3389\/fcvm.2021.737512.","journal-title":"Front Cardiovasc Med"},{"issue":"7","key":"7721_CR19","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1093\/cvr\/cvz040","volume":"115","author":"J Zhao","year":"2019","unstructured":"Zhao J, Li X, Hu J, et al. Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization. Cardiovasc Res. 2019;115(7):1205\u201316. https:\/\/doi.org\/10.1093\/cvr\/cvz040.","journal-title":"Cardiovasc Res"},{"issue":"1","key":"7721_CR20","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/s13287-020-01737-0","volume":"11","author":"H Cheng","year":"2020","unstructured":"Cheng H, Chang S, Xu R, et al. Hypoxia-challenged MSC-derived exosomes deliver miR-210 to attenuate post-infarction cardiac apoptosis. Stem Cell Res Ther. 2020;11(1):224. https:\/\/doi.org\/10.1186\/s13287-020-01737-0.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"7721_CR21","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1002\/hep.31658","volume":"74","author":"X Hou","year":"2021","unstructured":"Hou X, Yin S, Ren R, et al. Myeloid-Cell-Specific IL-6 signaling promotes MicroRNA-223-enriched exosome production to attenuate NAFLD-associated fibrosis. Hepatology (Baltimore, Md). 2021;74(1):116\u201332. https:\/\/doi.org\/10.1002\/hep.31658.","journal-title":"Hepatology (Baltimore, Md.)"}],"container-title":["Cardiovascular Drugs and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-025-07721-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10557-025-07721-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-025-07721-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T22:02:10Z","timestamp":1773698530000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10557-025-07721-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,11]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["7721"],"URL":"https:\/\/doi.org\/10.1007\/s10557-025-07721-1","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5615328\/v1","asserted-by":"object"}]},"ISSN":["0920-3206","1573-7241"],"issn-type":[{"value":"0920-3206","type":"print"},{"value":"1573-7241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,11]]},"assertion":[{"value":"14 May 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were performed following the Guide for the Care and Use of Laboratory Animals and approved by the Animal Care Committee of Xinxiang Medical University (Approval No. 030032).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"The authors declare that they have no conflict of interest.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}