{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T18:08:47Z","timestamp":1785262127991,"version":"3.55.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T00:00:00Z","timestamp":1757116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T00:00:00Z","timestamp":1757116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2023ZD0504100"],"award-info":[{"award-number":["2023ZD0504100"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170332"],"award-info":[{"award-number":["82170332"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2024C03095"],"award-info":[{"award-number":["2024C03095"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Transvascular Implantation Devices Research Institute","award":["KY012024002"],"award-info":[{"award-number":["KY012024002"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Drugs Ther"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s10557-025-07768-0","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T05:43:01Z","timestamp":1757137381000},"page":"987-999","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Thorough Physiological Assessment in Non-Culprit Vessels of Patients with Acute Myocardial Infarction: Is It a Required Action?"],"prefix":"10.1007","volume":"40","author":[{"given":"Zining","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyue","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abuduwufuer","family":"Yidilisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiniu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2019an","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6926-9516","authenticated-orcid":false,"given":"Jun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,6]]},"reference":[{"issue":"10159","key":"7768_CR1","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1016\/S0140-6736(18)32335-3","volume":"392","author":"GBD 2017 DALYs and HALE Collaborators","year":"2018","unstructured":"GBD 2017 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990\u20132017: a systematic analysis for the global burden of disease study 2017. Lancet. 2018;392(10159):1859\u2013922. https:\/\/doi.org\/10.1016\/S0140-6736(18)32335-3.","journal-title":"Lancet"},{"key":"7768_CR2","doi-asserted-by":"publisher","unstructured":"The WCOTROCHADIC. Report on Cardiovascular Health and Diseases in China 2022: an Updated Summary. Biomed Environ Sci. 2023;36(8):669\u2013701. https:\/\/doi.org\/10.3967\/bes2023.106","DOI":"10.3967\/bes2023.106"},{"issue":"20","key":"7768_CR3","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1097\/CM9.0000000000002741","volume":"136","author":"H Wang","year":"2023","unstructured":"Wang H, Zhang H, Zou Z. Changing profiles of cardiovascular disease and risk factors in China: a secondary analysis for the Global Burden of Disease Study 2019. Chin Med J Engl. 2023;136(20):2431\u201341. https:\/\/doi.org\/10.1097\/CM9.0000000000002741.","journal-title":"Chin Med J Engl"},{"issue":"3","key":"7768_CR4","doi-asserted-by":"publisher","first-page":"137","DOI":"10.4103\/hm.HM-D-23-00029","volume":"7","author":"AC Jackson","year":"2023","unstructured":"Jackson AC, Rogerson MC, Murphy BM. An integrated perspective for understanding the psychosocial impact of acute cardiovascular events: a scoping review. Heart Mind. 2023;7(3):137. https:\/\/doi.org\/10.4103\/hm.HM-D-23-00029.","journal-title":"Heart Mind"},{"issue":"21","key":"7768_CR5","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1056\/NEJMra1606915","volume":"376","author":"JL Anderson","year":"2017","unstructured":"Anderson JL, Morrow DA. Acute myocardial infarction. N Engl J Med. 2017;376(21):2053\u201364. https:\/\/doi.org\/10.1056\/NEJMra1606915.","journal-title":"N Engl J Med"},{"issue":"19","key":"7768_CR6","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1001\/jama.2014.15095","volume":"312","author":"DW Park","year":"2014","unstructured":"Park DW, Clare RM, Schulte PJ, et al. Extent, location, and clinical significance of non\u2013infarct-related coronary artery disease among patients with ST-elevation myocardial infarction. JAMA. 2014;312(19):2019\u201327. https:\/\/doi.org\/10.1001\/jama.2014.15095.","journal-title":"JAMA"},{"issue":"3","key":"7768_CR7","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.jacc.2024.04.051","volume":"84","author":"Percutaneous coronary revascularization strategies after myocardial infarction","year":"2024","unstructured":"Percutaneous coronary revascularization strategies after myocardial infarction. a systematic review and network meta-analysis. J Am Coll Cardiol. 2024;84(3):276\u201394. https:\/\/doi.org\/10.1016\/j.jacc.2024.04.051.","journal-title":"J Am Coll Cardiol"},{"key":"7768_CR8","doi-asserted-by":"publisher","unstructured":"Complete percutaneous coronary revascularization in acute coronary syndromes with multivessel coronary disease: a systematic review. JACC: Cardiovascular Interventions. 2023;16(19):2347\u20132364. https:\/\/doi.org\/10.1016\/j.jcin.2023.07.043","DOI":"10.1016\/j.jcin.2023.07.043"},{"key":"7768_CR9","doi-asserted-by":"publisher","unstructured":"Singh S, Tantry US, Bliden K, et al. Meta-analysis of physiology-guided complete or culprit lesion-only percutaneous coronary interventions in myocardial infarction. Am J Cardiol. Published online September 17, 2024:S0002\u20139149(24)00691-X. https:\/\/doi.org\/10.1016\/j.amjcard.2024.09.013","DOI":"10.1016\/j.amjcard.2024.09.013"},{"key":"7768_CR10","doi-asserted-by":"publisher","first-page":"1181803","DOI":"10.3389\/fcvm.2023.1181803","volume":"10","author":"M Dobri\u0107","year":"2023","unstructured":"Dobri\u0107 M, Furtula M, Te\u0161i\u0107 M, et al. Current status and future perspectives of fractional flow reserve derived from invasive coronary angiography. Front Cardiovasc Med. 2023;10: 1181803. https:\/\/doi.org\/10.3389\/fcvm.2023.1181803.","journal-title":"Front Cardiovasc Med"},{"issue":"5","key":"7768_CR11","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.jacasi.2023.07.003","volume":"3","author":"BK Koo","year":"2023","unstructured":"Koo BK, Lee JM, Hwang D, et al. Practical application of coronary physiologic assessment. JACC Asia. 2023;3(5):689\u2013706. https:\/\/doi.org\/10.1016\/j.jacasi.2023.07.003.","journal-title":"JACC Asia"},{"issue":"6","key":"7768_CR12","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1093\/eurheartj\/ehac763","volume":"44","author":"JM Lee","year":"2023","unstructured":"Lee JM, Kim HK, Park KH, et al. Fractional flow reserve versus angiography-guided strategy in acute myocardial infarction with multivessel disease: a randomized trial. Eur Heart J. 2023;44(6):473\u201384. https:\/\/doi.org\/10.1093\/eurheartj\/ehac763.","journal-title":"Eur Heart J"},{"issue":"2","key":"7768_CR13","doi-asserted-by":"publisher","first-page":"94958","DOI":"10.21037\/qims-21-463","volume":"12","author":"J Jiang","year":"2022","unstructured":"Jiang J, Tang L, Du C, et al. Diagnostic performance of AccuFFRangio in the functional assessment of coronary stenosis compared with pressure wire-derived fractional flow reserve. Quant Imaging Med Surg. 2022;12(2):94958\u201394958. https:\/\/doi.org\/10.21037\/qims-21-463.","journal-title":"Quant Imaging Med Surg"},{"issue":"36","key":"7768_CR14","doi-asserted-by":"publisher","first-page":"3415","DOI":"10.1093\/eurheartj\/ehae177","volume":"45","author":"C Vrints","year":"2024","unstructured":"Vrints C, Andreotti F, Koskinas KC, et al. 2024 ESC Guidelines for the management of chronic coronary syndromes: developed by the task force for the management of chronic coronary syndromes of the European Society of Cardiology (ESC) Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2024;45(36):3415\u2013537. https:\/\/doi.org\/10.1093\/eurheartj\/ehae177.","journal-title":"Eur Heart J"},{"key":"7768_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.735743","author":"N Dai","year":"2021","unstructured":"Dai N, Che W, Liu L, et al. Diagnostic value of angiography-derived IMR for coronary microcirculation and its prognostic implication after PCI. Front Cardiovasc Med. 2021. https:\/\/doi.org\/10.3389\/fcvm.2021.735743.","journal-title":"Front Cardiovasc Med"},{"issue":"9","key":"7768_CR16","doi-asserted-by":"publisher","first-page":"6215","DOI":"10.21037\/qims-23-72","volume":"13","author":"C Li","year":"2023","unstructured":"Li C, Hu Y, Wang J, et al. Are baseline conditions of coronary arteries sufficient for calculating angio-based index of microcirculatory resistance and fractional flow reserve? Quant Imaging Med Surg. 2023;13(9):6215\u201327. https:\/\/doi.org\/10.21037\/qims-23-72.","journal-title":"Quant Imaging Med Surg"},{"issue":"4","key":"7768_CR17","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.jcin.2021.11.039","volume":"15","author":"G Witberg","year":"2022","unstructured":"Witberg G, Bental T, Levi A, et al. Clinical outcomes of FFRangio-guided treatment for coronary artery disease. JACC Cardiovasc Interv. 2022;15(4):468\u201370. https:\/\/doi.org\/10.1016\/j.jcin.2021.11.039.","journal-title":"JACC Cardiovasc Interv"},{"issue":"12","key":"7768_CR18","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1016\/j.jcin.2024.04.022","volume":"17","author":"A Erriquez","year":"2024","unstructured":"Erriquez A, Campo G, Guiducci V, et al. QFR for the revascularization of nonculprit vessels in MI patients: insights from the FIRE Trial. JACC Cardiovasc Interv. 2024;17(12):1425\u201336. https:\/\/doi.org\/10.1016\/j.jcin.2024.04.022.","journal-title":"JACC Cardiovasc Interv"},{"issue":"15","key":"7768_CR19","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1016\/j.jcin.2021.05.027","volume":"14","author":"KH Choi","year":"2021","unstructured":"Choi KH, Dai N, Li Y, et al. Functional coronary angiography-derived index of microcirculatory resistance in patients with ST-segment elevation myocardial infarction. JACC Cardiovasc Interv. 2021;14(15):1670\u201384. https:\/\/doi.org\/10.1016\/j.jcin.2021.05.027.","journal-title":"JACC Cardiovasc Interv"},{"issue":"22","key":"7768_CR20","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1016\/j.jacc.2022.09.007","volume":"80","author":"L Song","year":"2022","unstructured":"Song L, Xu B, Tu S, et al. 2-year outcomes of angiographic quantitative flow ratio-guided coronary interventions. J Am Coll Cardiol. 2022;80(22):2089\u2013101. https:\/\/doi.org\/10.1016\/j.jacc.2022.09.007.","journal-title":"J Am Coll Cardiol"},{"issue":"18","key":"7768_CR21","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1016\/j.jcin.2018.06.045","volume":"11","author":"KH Choi","year":"2018","unstructured":"Choi KH, Lee JM, Kim HK, et al. Fractional flow reserve and instantaneous wave-free ratio for nonculprit stenosis in patients with acute myocardial infarction. JACC Cardiovasc Interv. 2018;11(18):1848\u201358. https:\/\/doi.org\/10.1016\/j.jcin.2018.06.045.","journal-title":"JACC Cardiovasc Interv"},{"issue":"0","key":"7768_CR22","doi-asserted-by":"publisher","first-page":"e035672","DOI":"10.1161\/JAHA.124.035672","volume":"0","author":"J Jiang","year":"2025","unstructured":"Jiang J, Hu Y, Li C, et al. Diagnostic accuracy of computational fluid dynamics-based fractional flow reserve derived from coronary angiography: the ACCURATE study. J Am Heart Assoc. 2025;0(0): e035672. https:\/\/doi.org\/10.1161\/JAHA.124.035672.","journal-title":"J Am Heart Assoc"},{"key":"7768_CR23","doi-asserted-by":"publisher","first-page":"106897","DOI":"10.1016\/j.cmpb.2022.106897","volume":"221","author":"J Jiang","year":"2022","unstructured":"Jiang J, Li C, Hu Y, et al. A novel CFD-based computed index of microcirculatory resistance (IMR) derived from coronary angiography to assess coronary microcirculation. Comput Methods Programs Biomed. 2022;221: 106897. https:\/\/doi.org\/10.1016\/j.cmpb.2022.106897.","journal-title":"Comput Methods Programs Biomed"},{"issue":"16","key":"7768_CR24","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1016\/j.jcin.2024.04.048","volume":"17","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Pu J, Niu T, et al. Prognostic value of coronary angiography\u2013derived index of microcirculatory resistance in non\u2013ST-segment elevation myocardial infarction patients. JACC Cardiovasc Interv. 2024;17(16):1874\u201386. https:\/\/doi.org\/10.1016\/j.jcin.2024.04.048.","journal-title":"JACC Cardiovasc Interv"},{"issue":"17","key":"7768_CR25","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1161\/CIRCULATIONAHA.106.685313","volume":"115","author":"DE Cutlip","year":"2007","unstructured":"Cutlip DE, Windecker S, Mehran R, et al. Clinical end points in coronary stent trials. Circulation. 2007;115(17):2344\u201351. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.106.685313.","journal-title":"Circulation"},{"issue":"12","key":"7768_CR26","doi-asserted-by":"publisher","first-page":"e074349","DOI":"10.1136\/bmjopen-2023-074349","volume":"13","author":"J Zhang","year":"2023","unstructured":"Zhang J, Hu X, Jiang J, et al. Rationale and design of a comparison of angiography-derived fractional flow reserve-guided and intravascular ultrasound-guided intervention strategy for clinical outcomes in patients with coronary artery disease: a randomised controlled trial (FLAVOUR II). BMJ Open. 2023;13(12): e074349. https:\/\/doi.org\/10.1136\/bmjopen-2023-074349.","journal-title":"BMJ Open"},{"issue":"26","key":"7768_CR27","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1056\/NEJM199606273342604","volume":"334","author":"NHJ Pijls","year":"1996","unstructured":"Pijls NHJ, de Bruyne B, Peels K, et al. Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses. N Engl J Med. 1996;334(26):1703\u20138. https:\/\/doi.org\/10.1056\/NEJM199606273342604.","journal-title":"N Engl J Med"},{"issue":"2","key":"7768_CR28","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1093\/eurheartj\/ehy394","volume":"40","author":"FJ Neumann","year":"2019","unstructured":"Neumann FJ, Sousa-Uva M, Ahlsson A, et al. 2018 ESC\/EACTS guidelines on myocardial revascularization. Eur Heart J. 2019;40(2):87\u2013165. https:\/\/doi.org\/10.1093\/eurheartj\/ehy394.","journal-title":"Eur Heart J"},{"key":"7768_CR29","doi-asserted-by":"publisher","unstructured":"Lawton JS, Tamis-Holland JE, Bangalore S, et al. 2021 ACC\/AHA\/SCAI guideline for coronary artery revascularization: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. Published online January 18, 2022. https:\/\/doi.org\/10.1161\/CIR.0000000000001038","DOI":"10.1161\/CIR.0000000000001038"},{"issue":"16","key":"7768_CR30","doi-asserted-by":"publisher","first-page":"e1358","DOI":"10.4244\/EIJ-D-21-00214","volume":"18","author":"BK Andersen","year":"2023","unstructured":"Andersen BK, Sejr-Hansen M, Westra J, et al. Quantitative flow ratio versus fractional flow reserve for guiding percutaneous coronary intervention: design and rationale of the randomised FAVOR III Europe Japan trial. EuroIntervention. 2023;18(16):e1358\u201364. https:\/\/doi.org\/10.4244\/EIJ-D-21-00214.","journal-title":"EuroIntervention"},{"key":"7768_CR31","doi-asserted-by":"publisher","unstructured":"Angiographic quantitative flow ratio-guided coronary intervention (FAVOR III China): a multicentre, randomised, sham-controlled trial. The Lancet. 2021;398(10317):2149\u20132159. https:\/\/doi.org\/10.1016\/S0140-6736(21)02248-0","DOI":"10.1016\/S0140-6736(21)02248-0"},{"issue":"2","key":"7768_CR32","doi-asserted-by":"publisher","first-page":"e001691","DOI":"10.1136\/openhrt-2021-001691","volume":"8","author":"CC Chang","year":"2021","unstructured":"Chang CC, Chuang MJ, Lee YH, et al. Vessel fractional flow reserve in assessment of non-culprit lesions in ST elevation myocardial infarction. Open Heart. 2021;8(2): e001691. https:\/\/doi.org\/10.1136\/openhrt-2021-001691.","journal-title":"Open Heart"},{"key":"7768_CR33","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015507","author":"YS Jo","year":"2020","unstructured":"Jo YS, Moon H, Park K. Different microcirculation response between culprit and non-culprit vessels in patients with acute coronary syndrome. J Am Heart Assoc. 2020. https:\/\/doi.org\/10.1161\/JAHA.119.015507.","journal-title":"J Am Heart Assoc"},{"issue":"12","key":"7768_CR34","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1016\/j.jcin.2010.08.025","volume":"3","author":"A Ntalianis","year":"2010","unstructured":"Ntalianis A, Sels JW, Davidavicius G, et al. Fractional flow reserve for the assessment of nonculprit coronary artery stenoses in patients with acute myocardial infarction. JACC Cardiovasc Interv. 2010;3(12):1274\u201381. https:\/\/doi.org\/10.1016\/j.jcin.2010.08.025.","journal-title":"JACC Cardiovasc Interv"},{"issue":"2","key":"7768_CR35","doi-asserted-by":"publisher","first-page":"e007257","DOI":"10.1161\/CIRCINTERVENTIONS.118.007257","volume":"12","author":"F D\u00edez-Delhoyo","year":"2019","unstructured":"D\u00edez-Delhoyo F, Guti\u00e9rrez-Iba\u00f1es E, Sanz-Ruiz R, et al. Prevalence of microvascular and endothelial dysfunction in the nonculprit territory in patients with acute myocardial infarction: the FISIOIAM study. Circ: Cardiovascular Interventions. 2019;12(2): e007257. https:\/\/doi.org\/10.1161\/CIRCINTERVENTIONS.118.007257.","journal-title":"Circ: Cardiovascular Interventions"},{"key":"7768_CR36","doi-asserted-by":"publisher","first-page":"100997","DOI":"10.1016\/j.ijcha.2022.100997","volume":"39","author":"CH Flores","year":"2022","unstructured":"Flores CH. Microvascular dysfunction of the non-culprit circulation predicts poor prognosis in patients with ST-segment elevation myocardial infarction. IJC Heart Vasc. 2022;39: 100997. https:\/\/doi.org\/10.1016\/j.ijcha.2022.100997.","journal-title":"IJC Heart Vasc"},{"issue":"8","key":"7768_CR37","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1001\/jamacardio.2019.2138","volume":"4","author":"NW Van Der Hoeven","year":"2019","unstructured":"Van Der Hoeven NW, Janssens GN, De Waard GA, et al. Temporal changes in coronary hyperemic and resting hemodynamic indices in nonculprit vessels of patients with ST-segment elevation myocardial infarction. JAMA Cardiol. 2019;4(8):736. https:\/\/doi.org\/10.1001\/jamacardio.2019.2138.","journal-title":"JAMA Cardiol"},{"key":"7768_CR38","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.ijcard.2018.09.097","volume":"273","author":"J Sanchis","year":"2018","unstructured":"Sanchis J, Avanzas P. Microvascular obstruction in non-STEMI related areas: an uninvited guest in STEMI? Int J Cardiol. 2018;273:54\u20135. https:\/\/doi.org\/10.1016\/j.ijcard.2018.09.097.","journal-title":"Int J Cardiol"},{"key":"7768_CR39","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.ijcard.2018.08.020","volume":"273","author":"R Khorramirouz","year":"2018","unstructured":"Khorramirouz R, Corban MT, Yang SW, et al. Microvascular obstruction in non-infarct related coronary arteries is an independent predictor of major adverse cardiovascular events in patients with ST segment-elevation myocardial infarction. Int J Cardiol. 2018;273:22\u20138. https:\/\/doi.org\/10.1016\/j.ijcard.2018.08.020.","journal-title":"Int J Cardiol"},{"key":"7768_CR40","doi-asserted-by":"publisher","unstructured":"Di Bella E v. r., Parker D l., Sinusas A j. On the dark rim artifact in dynamic contrast-enhanced MRI myocardial perfusion studies. Magnetic Resonance in Medicine. 2005;54(5):1295\u20131299. https:\/\/doi.org\/10.1002\/mrm.20666","DOI":"10.1002\/mrm.20666"},{"issue":"4","key":"7768_CR41","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1161\/01.CIR.87.4.1354","volume":"87","author":"NH Pijls","year":"1993","unstructured":"Pijls NH, Van Son JA, Kirkeeide RL, De Bruyne B, Gould KL. Experimental basis of determining maximum coronary, myocardial, and collateral blood flow by pressure measurements for assessing functional stenosis severity before and after percutaneous transluminal coronary angioplasty. Circulation. 1993;87(4):1354\u201367. https:\/\/doi.org\/10.1161\/01.CIR.87.4.1354.","journal-title":"Circulation"},{"key":"7768_CR42","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.ijcard.2022.11.043","volume":"373","author":"FTW Groenland","year":"2023","unstructured":"Groenland FTW, Huang J, Scoccia A, et al. Vessel fractional flow reserve-based non-culprit lesion reclassification in patients with ST-segment elevation myocardial infarction: impact on treatment strategy and clinical outcome (FAST STEMI I study). Int J Cardiol. 2023;373:33\u20138. https:\/\/doi.org\/10.1016\/j.ijcard.2022.11.043.","journal-title":"Int J Cardiol"},{"key":"7768_CR43","doi-asserted-by":"publisher","first-page":"178","DOI":"10.5603\/CJ.a2021.0111","volume":"30","author":"J Zhang","year":"2023","unstructured":"Zhang J, et al. The efficacy and safety of quantitative flow ratio-guided complete revascularization in patients with ST-segment elevation myocardial infarction and multivessel disease: a pilot randomized controlled trial. Cardiol J. 2023;30:178\u201387. https:\/\/doi.org\/10.5603\/CJ.a2021.0111.","journal-title":"Cardiol J"}],"container-title":["Cardiovascular Drugs and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-025-07768-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10557-025-07768-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-025-07768-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:21:19Z","timestamp":1778649679000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10557-025-07768-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,6]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["7768"],"URL":"https:\/\/doi.org\/10.1007\/s10557-025-07768-0","relation":{},"ISSN":["0920-3206","1573-7241"],"issn-type":[{"value":"0920-3206","type":"print"},{"value":"1573-7241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,6]]},"assertion":[{"value":"13 August 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from all individual participants for whom identifying information is included in this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"Informed consent for participation in the study was duly obtained from all the individual participants involved.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"The research protocol obtained approval from the Medical Ethics Committee of the Second Affiliated Hospital of Zhejiang University and aligned with the international standards for biomedical research involving human subjects, including the Declaration of Helsinki and ICH-GCP guidelines.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Dr. Jianping Xiang is the principal scientist of ArteryFlow Technology. Dr. Yumeng Hu is the head of cardiac research of ArteryFlow Technology. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}