{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:09:07Z","timestamp":1778652547000,"version":"3.51.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Science and Technology Program of Traditional Chinese Medicine in Zhejiang Province","award":["2024ZL667"],"award-info":[{"award-number":["2024ZL667"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Drugs Ther"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s10557-025-07817-8","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T06:59:36Z","timestamp":1763621976000},"page":"897-910","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Paeoniflorin Alleviates Coronary Artery Lesions in Kawasaki Disease by Activating NRF2 Pathway and Inhibiting CYP2E1 Expression"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7173-5001","authenticated-orcid":false,"given":"Hangli","family":"Pan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huahong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"issue":"14","key":"7817_CR1","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1016\/j.jacc.2015.12.073","volume":"67","author":"JW Newburger","year":"2016","unstructured":"Newburger JW, Takahashi M, Burns JC. Kawasaki disease. J Am Coll Cardiol. 2016;67(14):1738\u201349.","journal-title":"J Am Coll Cardiol"},{"key":"7817_CR2","doi-asserted-by":"publisher","first-page":"153208","DOI":"10.1016\/j.phymed.2020.153208","volume":"70","author":"B Tang","year":"2020","unstructured":"Tang B, et al. Adjuvant herbal therapy for targeting susceptibility genes to Kawasaki disease: an overview of epidemiology, pathogenesis, diagnosis and pharmacological treatment of Kawasaki disease. Phytomedicine. 2020;70:153208.","journal-title":"Phytomedicine"},{"issue":"7","key":"7817_CR3","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1038\/s41584-020-0426-0","volume":"16","author":"RM Noval","year":"2020","unstructured":"Noval RM, Arditi M. Kawasaki disease: pathophysiology and insights from mouse models. Nat Rev Rheumatol. 2020;16(7):391\u2013405.","journal-title":"Nat Rev Rheumatol"},{"issue":"10","key":"7817_CR4","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s11926-020-00941-4","volume":"22","author":"E Rife","year":"2020","unstructured":"Rife E, Gedalia A. Kawasaki disease: an update. Curr Rheumatol Rep. 2020;22(10):75.","journal-title":"Curr Rheumatol Rep"},{"key":"7817_CR5","doi-asserted-by":"crossref","unstructured":"Kuo HC. Diagnosis, Progress, and treatment update of Kawasaki disease. Int J Mol Sci, 2023. 24(18).","DOI":"10.3390\/ijms241813948"},{"key":"7817_CR6","doi-asserted-by":"crossref","unstructured":"Solis-Jimenez F, et al. Anticoagulant versus antiplatelet therapy after acute coronary syndromes in patients with coronary artery ectasia: A retrospective cohort study. Cardiovasc Drugs Ther; 2025.","DOI":"10.1007\/s10557-025-07784-0"},{"issue":"6","key":"7817_CR7","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1007\/s10557-023-07479-4","volume":"38","author":"Y Chen","year":"2024","unstructured":"Chen Y, et al. Rivaroxaban combined with Atorvastatin inhibits acute pulmonary embolism by promoting the expression of NRF2\/NQO1. Cardiovasc Drugs Ther. 2024;38(6):1271\u201387.","journal-title":"Cardiovasc Drugs Ther"},{"key":"7817_CR8","doi-asserted-by":"crossref","unstructured":"Chen C, et al. Early management of blood lipid levels with Non-Statin lipid-Lowering drugs in acute coronary syndrome: A mini review. Cardiovasc Drugs Ther; 2024.","DOI":"10.1007\/s10557-024-07587-9"},{"issue":"11","key":"7817_CR9","doi-asserted-by":"publisher","first-page":"e2343801","DOI":"10.1001\/jamanetworkopen.2023.43801","volume":"6","author":"KB Dummer","year":"2023","unstructured":"Dummer KB, et al. DOACs in patients with giant coronary artery aneurysms after Kawasaki disease. JAMA Netw Open. 2023;6(11):e2343801.","journal-title":"JAMA Netw Open"},{"issue":"4","key":"7817_CR10","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1007\/s10557-024-07595-9","volume":"39","author":"A Kandpal","year":"2025","unstructured":"Kandpal A, et al. Amplification of cardioprotective response of remote ischemic preconditioning in rats by quercetin: potential role of activation of mTOR-dependent autophagy and Nrf2. Cardiovasc Drugs Ther. 2025;39(4):721\u201336.","journal-title":"Cardiovasc Drugs Ther"},{"key":"7817_CR11","doi-asserted-by":"publisher","first-page":"531","DOI":"10.3389\/fphar.2020.00531","volume":"11","author":"X Ma","year":"2020","unstructured":"Ma X, et al. Paeoniflorin, a natural product with multiple targets in liver diseases-a mini review. Front Pharmacol. 2020;11:531.","journal-title":"Front Pharmacol"},{"key":"7817_CR12","doi-asserted-by":"publisher","first-page":"107452","DOI":"10.1016\/j.pharmthera.2019.107452","volume":"207","author":"L Zhang","year":"2020","unstructured":"Zhang L, Wei W. Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony. Pharmacol Ther. 2020;207:107452.","journal-title":"Pharmacol Ther"},{"key":"7817_CR13","doi-asserted-by":"publisher","first-page":"112800","DOI":"10.1016\/j.biopha.2022.112800","volume":"149","author":"XZ Wang","year":"2022","unstructured":"Wang XZ, et al. The multifaceted mechanisms of Paeoniflorin in the treatment of tumors: State-of-the-Art. Biomed Pharmacother. 2022;149:112800.","journal-title":"Biomed Pharmacother"},{"key":"7817_CR14","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.neuroscience.2014.11.008","volume":"285","author":"H Dong","year":"2015","unstructured":"Dong H, et al. Paeoniflorin inhibition of 6-hydroxydopamine-induced apoptosis in PC12 cells via suppressing reactive oxygen species-mediated PKC\u03b4\/NF-\u03baB pathway. Neuroscience. 2015;285:70\u201380.","journal-title":"Neuroscience"},{"issue":"1","key":"7817_CR15","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s11658-024-00631-4","volume":"29","author":"X Deng","year":"2024","unstructured":"Deng X, et al. Paeoniflorin protects hepatocytes from APAP-induced damage through launching autophagy via the MAPK\/mTOR signaling pathway. Cell Mol Biol Lett. 2024;29(1):119.","journal-title":"Cell Mol Biol Lett"},{"issue":"6","key":"7817_CR16","doi-asserted-by":"publisher","first-page":"100940","DOI":"10.1016\/j.jpha.2024.01.008","volume":"14","author":"S Huang","year":"2024","unstructured":"Huang S, et al. Paeoniflorin ameliorates chronic colitis via the DR3 signaling pathway in group 3 innate lymphoid cells. J Pharm Anal. 2024;14(6):100940.","journal-title":"J Pharm Anal"},{"key":"7817_CR17","doi-asserted-by":"publisher","first-page":"1122969","DOI":"10.3389\/fphar.2023.1122969","volume":"14","author":"X Li","year":"2023","unstructured":"Li X, et al. Protective effects of paeoniflorin on cardiovascular diseases: a pharmacological and mechanistic overview. Front Pharmacol. 2023;14:1122969.","journal-title":"Front Pharmacol"},{"key":"7817_CR18","doi-asserted-by":"publisher","first-page":"1072007","DOI":"10.3389\/fimmu.2022.1072007","volume":"13","author":"W Yu","year":"2022","unstructured":"Yu W, et al. Therapeutic potential of paeoniflorin in atherosclerosis: a cellular action and mechanism-based perspective. Front Immunol. 2022;13:1072007.","journal-title":"Front Immunol"},{"issue":"6","key":"7817_CR19","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1097\/FJC.0000000000001021","volume":"77","author":"F Jiao","year":"2021","unstructured":"Jiao F, et al. Recent insights into the protective mechanisms of paeoniflorin in neurological, cardiovascular, and renal diseases. J Cardiovasc Pharmacol. 2021;77(6):728\u201334.","journal-title":"J Cardiovasc Pharmacol"},{"issue":"1","key":"7817_CR20","doi-asserted-by":"publisher","first-page":"e2024052","DOI":"10.4084\/MJHID.2024.052","volume":"16","author":"Y Li","year":"2024","unstructured":"Li Y, Lan S, Zhang H. Expression of oxidative stress and inflammatory indicators for coronary artery disease in Kawasaki disease. Mediterr J Hematol Infect Dis. 2024;16(1):e2024052.","journal-title":"Mediterr J Hematol Infect Dis"},{"issue":"3","key":"7817_CR21","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1161\/ATVBAHA.119.313863","volume":"40","author":"RA Porritt","year":"2020","unstructured":"Porritt RA, et al. Interleukin-1 beta-mediated sex differences in Kawasaki disease vasculitis development and response to treatment. Arterioscler Thromb Vasc Biol. 2020;40(3):802\u201318.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"7817_CR22","doi-asserted-by":"crossref","unstructured":"Marek-Iannucci S et al. Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis. JCI Insight, 2021. 6(18).","DOI":"10.1172\/jci.insight.151981"},{"key":"7817_CR23","doi-asserted-by":"publisher","first-page":"204062232095642","DOI":"10.1177\/2040622320956429","volume":"11","author":"C Zhang","year":"2020","unstructured":"Zhang C, et al. Extracellular HMGB-1 activates inflammatory signaling in tendon cells and tissues. Ther Adv Chronic Dis. 2020;11:2040622320956429.","journal-title":"Ther Adv Chronic Dis"},{"issue":"1","key":"7817_CR24","doi-asserted-by":"publisher","first-page":"2756","DOI":"10.1038\/s41467-023-38430-8","volume":"14","author":"H Yan","year":"2023","unstructured":"Yan H, et al. Regorafenib inhibits EphA2 phosphorylation and leads to liver damage via the ERK\/MDM2\/p53 axis. Nat Commun. 2023;14(1):2756.","journal-title":"Nat Commun"},{"key":"7817_CR25","doi-asserted-by":"publisher","first-page":"407","DOI":"10.2147\/VHRM.S291762","volume":"18","author":"M Seki","year":"2022","unstructured":"Seki M, Minami T. Pathology, risks, and management. Vasc Health Risk Manag. 2022;18:407\u201316.","journal-title":"Vasc Health Risk Manag"},{"key":"7817_CR26","doi-asserted-by":"crossref","unstructured":"Tsuge M et al. Roles of oxidative injury and nitric oxide system derangements in Kawasaki disease pathogenesis: A systematic review. Int J Mol Sci, 2023. 24(20).","DOI":"10.3390\/ijms242015450"},{"issue":"9","key":"7817_CR27","doi-asserted-by":"publisher","first-page":"e30555","DOI":"10.1016\/j.heliyon.2024.e30555","volume":"10","author":"J Yang","year":"2024","unstructured":"Yang J, et al. Paeoniflorin inhibits the inflammation of rheumatoid arthritis fibroblast-like synoviocytes by downregulating hsa_circ_009012. Heliyon. 2024;10(9):e30555.","journal-title":"Heliyon"},{"key":"7817_CR28","doi-asserted-by":"publisher","first-page":"536","DOI":"10.3389\/fphar.2020.00536","volume":"11","author":"J Yuan","year":"2020","unstructured":"Yuan J, et al. Paeoniflorin resists H(2)O(2)-Induced oxidative stress in melanocytes by JNK\/Nrf2\/HO-1 pathway. Front Pharmacol. 2020;11:536.","journal-title":"Front Pharmacol"},{"key":"7817_CR29","doi-asserted-by":"publisher","first-page":"115253","DOI":"10.1016\/j.biopha.2023.115253","volume":"165","author":"S Ren","year":"2023","unstructured":"Ren S, et al. Paeoniflorin alleviates AngII-induced cardiac hypertrophy in H9c2 cells by regulating oxidative stress and Nrf2 signaling pathway. Biomed Pharmacother. 2023;165:115253.","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"7817_CR30","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1080\/13880209.2023.2220360","volume":"61","author":"S Liu","year":"2023","unstructured":"Liu S, Li Y, Wu C. Paeoniflorin suppresses the apoptosis and inflammation of human coronary artery endothelial cells induced by oxidized low-density lipoprotein by regulating the Wnt\/beta-catenin pathway. Pharm Biol. 2023;61(1):1454\u201361.","journal-title":"Pharm Biol"},{"key":"7817_CR31","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.redox.2014.11.004","volume":"3","author":"S Sutti","year":"2014","unstructured":"Sutti S, et al. CYP2E1 autoantibodies in liver diseases. Redox Biol. 2014;3:72\u20138.","journal-title":"Redox Biol"},{"issue":"2","key":"7817_CR32","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.jhep.2012.08.018","volume":"58","author":"TM Leung","year":"2013","unstructured":"Leung TM, Nieto N. CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease. J Hepatol. 2013;58(2):395\u20138.","journal-title":"J Hepatol"},{"issue":"6","key":"7817_CR33","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.1002\/hep.30652","volume":"73","author":"YE Cho","year":"2021","unstructured":"Cho YE, et al. Fructose promotes leaky Gut, Endotoxemia, and liver fibrosis through Ethanol-Inducible cytochrome P450\u20102E1\u2013Mediated oxidative and nitrative stress. Hepatology (Baltimore MD). 2021;73(6):2180\u201395.","journal-title":"Hepatology (Baltimore MD)"},{"issue":"9","key":"7817_CR34","doi-asserted-by":"publisher","first-page":"3906","DOI":"10.1016\/j.apsb.2023.01.009","volume":"13","author":"Y Wang","year":"2023","unstructured":"Wang Y, et al. Amelioration of ethanol-induced oxidative stress and alcoholic liver disease by in vivo RNAi targeting Cyp2e1. Acta Pharm Sin B. 2023;13(9):3906\u201318.","journal-title":"Acta Pharm Sin B"},{"issue":"1","key":"7817_CR35","first-page":"199","volume":"70","author":"O Maksymchuk","year":"2023","unstructured":"Maksymchuk O, Shysh A, Kotliarova A. Quercetin inhibits the expression of MYC and CYP2E1 and reduces oxidative stress in the myocardium of spontaneously hypertensive rats. Acta Biochim Pol. 2023;70(1):199\u2013204.","journal-title":"Acta Biochim Pol"},{"issue":"3","key":"7817_CR36","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1152\/physrev.00023.2017","volume":"98","author":"M Yamamoto","year":"2018","unstructured":"Yamamoto M, Kensler TW, Motohashi H. The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis. Physiol Rev. 2018;98(3):1169\u2013203.","journal-title":"Physiol Rev"},{"key":"7817_CR37","doi-asserted-by":"crossref","unstructured":"Ngo V, Duennwald ML. Nrf2 and oxidative stress: A general overview of mechanisms and implications in human disease. Antioxid (Basel), 2022. 11(12).","DOI":"10.3390\/antiox11122345"},{"key":"7817_CR38","doi-asserted-by":"publisher","first-page":"102825","DOI":"10.1016\/j.redox.2023.102825","volume":"65","author":"B Wang","year":"2023","unstructured":"Wang B, et al. EP1 activation inhibits doxorubicin-cardiomyocyte ferroptosis via Nrf2. Redox Biol. 2023;65:102825.","journal-title":"Redox Biol"},{"key":"7817_CR39","doi-asserted-by":"crossref","unstructured":"Yue Z et al. Kaempferol alleviates myocardial ischemia injury by reducing oxidative stress via the HDAC3-mediated Nrf2 signaling pathway. J Adv Res, 2024.","DOI":"10.1016\/j.jare.2024.10.037"},{"key":"7817_CR40","doi-asserted-by":"crossref","unstructured":"Song J et al. Itaconate suppresses atherosclerosis by activating a Nrf2-dependent antiinflammatory response in macrophages in mice. J Clin Invest, 2023. 134(3).","DOI":"10.1172\/JCI173034"}],"container-title":["Cardiovascular Drugs and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-025-07817-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10557-025-07817-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-025-07817-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:21:15Z","timestamp":1778649675000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10557-025-07817-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,20]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["7817"],"URL":"https:\/\/doi.org\/10.1007\/s10557-025-07817-8","relation":{},"ISSN":["0920-3206","1573-7241"],"issn-type":[{"value":"0920-3206","type":"print"},{"value":"1573-7241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,20]]},"assertion":[{"value":"8 November 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The animal study was approved by the Experimental Animal Welfare Ethics Committee of Beijing MDKN. All animal experiments should comply with the ARRIVE guidelines. All methods were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"The authors declare that they have no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}