{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:02:37Z","timestamp":1789524157431,"version":"build-2803163510"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Drugs Ther"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s10557-026-07879-2","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:39:55Z","timestamp":1777865995000},"page":"1729-1746","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["NR1D2 Knockdown Alleviates Myocardial Infarction through Nrf2 Signaling Pathway Activation"],"prefix":"10.1007","volume":"40","author":[{"given":"Ting","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"issue":"11","key":"7879_CR1","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1016\/j.jcmg.2024.03.012","volume":"17","author":"MC Gissler","year":"2024","unstructured":"Gissler MC, Antiochos P, Ge Y, Heydari B, Gr\u00e4ni C, Kwong RY. Cardiac Magnetic Resonance Evaluation of LV Remodeling Post-Myocardial Infarction: Prognosis, Monitoring and Trial Endpoints. JACC Cardiovasc imaging. 2024;17(11):1366\u201380.","journal-title":"JACC Cardiovasc imaging"},{"issue":"5","key":"7879_CR2","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1007\/s10557-024-07564-2","volume":"39","author":"X Zhang","year":"2025","unstructured":"Zhang X, Zhao Y, Guo D, Luo M, Zhang Q, Zhang L, Zhang D. Exercise Improves Heart Function after Myocardial Infarction: The Merits of AMPK. Cardiovasc Drugs Ther. 2025;39(5):1153\u201361.","journal-title":"Cardiovasc Drugs Ther"},{"issue":"4","key":"7879_CR3","doi-asserted-by":"publisher","first-page":"200367","DOI":"10.1098\/rsob.200367","volume":"11","author":"XD Wang","year":"2021","unstructured":"Wang XD, Kang S. Ferroptosis in myocardial infarction: not a marker but a maker. Open biology. 2021;11(4):200367.","journal-title":"Open biology"},{"issue":"1\u20132","key":"7879_CR4","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s10495-022-01785-2","volume":"28","author":"X Han","year":"2023","unstructured":"Han X, Zhang J, Liu J, Wang H, Du F, Zeng X, Guo C. Targeting ferroptosis: a novel insight against myocardial infarction and ischemia-reperfusion injuries. Apoptosis: Int J Program cell death. 2023;28(1\u20132):108\u201323.","journal-title":"Apoptosis: Int J Program cell death"},{"issue":"1","key":"7879_CR5","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s40779-025-00610-6","volume":"12","author":"KJ Chen","year":"2025","unstructured":"Chen KJ, Zhang Y, Zhu XY, Yu S, Xie Y, Jin CJ, Shen YM, Zhou SY, Dai XC, Su SA, et al. GSTM1 suppresses cardiac fibrosis post-myocardial infarction through inhibiting lipid peroxidation and ferroptosis. Military Med Res. 2025;12(1):26.","journal-title":"Military Med Res"},{"issue":"2","key":"7879_CR6","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1097\/FJC.0000000000001590","volume":"84","author":"C Jiang","year":"2024","unstructured":"Jiang C, Wang S, Wang C, Chen G, Xu J, You C. Mesenchymal Stem Cells Alleviate Mouse Sepsis-Induced Cardiomyopathy by Inhibiting the NR1D2\/LCN2 Pathway. J Cardiovasc Pharmacol. 2024;84(2):199\u2013209.","journal-title":"J Cardiovasc Pharmacol"},{"issue":"1","key":"7879_CR7","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s44161-021-00001-9","volume":"1","author":"P Dierickx","year":"2022","unstructured":"Dierickx P, Zhu K, Carpenter BJ, Jiang C, Vermunt MW, Xiao Y, Luongo TS, Yamamoto T, Mart\u00ed-P\u00e0mies \u00cd, Mia S, et al. Circadian REV-ERBs repress E4bp4 to activate NAMPT-dependent NAD(+) biosynthesis and sustain cardiac function. Nat Cardiovasc Res. 2022;1(1):45\u201358.","journal-title":"Nat Cardiovasc Res"},{"issue":"6","key":"7879_CR8","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1007\/s10557-024-07642-5","volume":"39","author":"X Zhou","year":"2025","unstructured":"Zhou X, Wang H, Yan B, Nie X, Chen Q, Yang X, Lei M, Guo X, Ouyang C, Ren Z. Ferroptosis in Cardiovascular Diseases and Ferroptosis-Related Intervention Approaches. Cardiovasc Drugs Ther. 2025;39(6):1521\u201348.","journal-title":"Cardiovasc Drugs Ther"},{"key":"7879_CR9","doi-asserted-by":"crossref","unstructured":"Yao D, Bao L, Wang S, Tan M, Xu Y, Wu T, Zhang Z, Gong K. Isoliquiritigenin alleviates myocardial ischemia-reperfusion injury by regulating the Nrf2\/HO-1\/SLC7a11\/GPX4 axis in mice. Free Radic Biol Med. 2024;221:1-12.","DOI":"10.1016\/j.freeradbiomed.2024.05.012"},{"issue":"5","key":"7879_CR10","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.bbamcr.2018.02.010","volume":"1865","author":"I Bellezza","year":"2018","unstructured":"Bellezza I, Giambanco I, Minelli A, Donato R. Nrf2-Keap1 signaling in oxidative and reductive stress. Biochim et Biophys acta Mol cell Res. 2018;1865(5):721\u201333.","journal-title":"Biochim et Biophys acta Mol cell Res"},{"issue":"3","key":"7879_CR11","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/s00204-023-03660-8","volume":"98","author":"Y Xiang","year":"2024","unstructured":"Xiang Y, Song X, Long D. Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseases. Arch Toxicol. 2024;98(3):579\u2013615.","journal-title":"Arch Toxicol"},{"issue":"4","key":"7879_CR12","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1007\/s10557-024-07595-9","volume":"39","author":"A Kandpal","year":"2025","unstructured":"Kandpal A, Kumar K, Singh S, Yadav HN, Jaggi AS, Singh D, Chopra DS, Maslov L, Singh N. Amplification of Cardioprotective Response of Remote Ischemic Preconditioning in Rats by Quercetin: Potential Role of Activation of mTOR-dependent Autophagy and Nrf2. Cardiovasc Drugs Ther. 2025;39(4):721\u201336.","journal-title":"Cardiovasc Drugs Ther"},{"issue":"6","key":"7879_CR13","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1093\/bib\/bby067","volume":"20","author":"A McDermaid","year":"2019","unstructured":"McDermaid A, Monier B, Zhao J, Liu B, Ma Q. Interpretation of differential gene expression results of RNA-seq data: review and integration. Brief Bioinform. 2019;20(6):2044\u201354.","journal-title":"Brief Bioinform"},{"issue":"9","key":"7879_CR14","doi-asserted-by":"publisher","first-page":"e0184129","DOI":"10.1371\/journal.pone.0184129","volume":"12","author":"L Chen","year":"2017","unstructured":"Chen L, Zhang YH, Wang S, Zhang Y, Huang T, Cai YD. Prediction and analysis of essential genes using the enrichments of gene ontology and KEGG pathways. PLoS ONE. 2017;12(9):e0184129.","journal-title":"PLoS ONE"},{"key":"7879_CR15","doi-asserted-by":"publisher","first-page":"177568","DOI":"10.1016\/j.ejphar.2025.177568","volume":"996","author":"HY Wu","year":"2025","unstructured":"Wu HY, Wang L, Yao BQ, Hou SX, Zheng XB. Tangeretin alleviates myocardial ischemia-reperfusion injury by inhibiting ferroptosis via targeting nicotinamide phosphoribosyltransferase (NAMPT). Eur J Pharmacol. 2025;996:177568.","journal-title":"Eur J Pharmacol"},{"issue":"12","key":"7879_CR16","doi-asserted-by":"publisher","first-page":"100141","DOI":"10.1016\/j.mocell.2024.100141","volume":"47","author":"D Bong","year":"2024","unstructured":"Bong D, Sohn J, Lee SV. Brief guide to RT-qPCR. Mol Cells. 2024;47(12):100141.","journal-title":"Mol Cells"},{"key":"7879_CR17","doi-asserted-by":"publisher","first-page":"102852","DOI":"10.1016\/j.redox.2023.102852","volume":"66","author":"YY Sun","year":"2023","unstructured":"Sun YY, Zhu HJ, Zhao RY, Zhou SY, Wang MQ, Yang Y, Guo ZN. Remote ischemic conditioning attenuates oxidative stress and inflammation via the Nrf2\/HO-1 pathway in MCAO mice. Redox Biol. 2023;66:102852.","journal-title":"Redox Biol"},{"issue":"1","key":"7879_CR18","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1007\/s12672-025-02411-8","volume":"16","author":"HG Zhang","year":"2025","unstructured":"Zhang HG, Yao WR, Zhou ZY, Liu L. The immunosuppressive role of VSIG4 in colorectal cancer and its interaction with the tumor microenvironment. Discover Oncol. 2025;16(1):664.","journal-title":"Discover Oncol"},{"key":"7879_CR19","doi-asserted-by":"publisher","first-page":"1672667","DOI":"10.3389\/fimmu.2025.1672667","volume":"16","author":"M Mastrangelo","year":"2025","unstructured":"Mastrangelo M, Ruscitti P, Bruni M, Lucantonio E, De Berardinis A, Barile A, Fargnoli MC, Cipriani P, Esposito M, Pellegrini C. Assessment of gene signatures following the inhibition of IL-23: a study to evaluate the mechanistic effects behind the clinical efficacy of guselkumab in patients with psoriatic arthritis. Front Immunol. 2025;16:1672667.","journal-title":"Front Immunol"},{"key":"7879_CR20","doi-asserted-by":"publisher","first-page":"1533111","DOI":"10.3389\/fimmu.2025.1533111","volume":"16","author":"J Ding","year":"2025","unstructured":"Ding J, Teng Y, Cui R, Liu J, Xiao K, Dong Z, Zhang Y, Xu X. LncRNAs in serum-derived extracellular vesicles are potential biomarker and correlated with immune infiltration in gastric cancer. Front Immunol. 2025;16:1533111.","journal-title":"Front Immunol"},{"key":"7879_CR21","doi-asserted-by":"crossref","unstructured":"Rochette L, Dogon G, Rigal E, Zeller M, Cottin Y, Vergely C. Lipid peroxidation and iron metabolism: Two corner stones in the homeostasis control of ferroptosis. Int J Mol Sci. 2022;24(1):449.","DOI":"10.3390\/ijms24010449"},{"issue":"8","key":"7879_CR22","doi-asserted-by":"publisher","first-page":"112945","DOI":"10.1016\/j.celrep.2023.112945","volume":"42","author":"Z Yang","year":"2023","unstructured":"Yang Z, Su W, Wei X, Qu S, Zhao D, Zhou J, Wang Y, Guan Q, Qin C, Xiang J, et al. HIF-1\u03b1 drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1. Cell Rep. 2023;42(8):112945.","journal-title":"Cell Rep"},{"issue":"7","key":"7879_CR23","doi-asserted-by":"publisher","first-page":"3052","DOI":"10.7150\/thno.54113","volume":"11","author":"X Wu","year":"2021","unstructured":"Wu X, Li Y, Zhang S, Zhou X. Ferroptosis as a novel therapeutic target for cardiovascular disease. Theranostics. 2021;11(7):3052\u20139.","journal-title":"Theranostics"},{"key":"7879_CR24","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.bbrc.2022.03.043","volume":"606","author":"DI Bromage","year":"2022","unstructured":"Bromage DI, Trevelin SC, Huntington J, Yang VX, Muthukumar A, Mackie SJ, Sawyer G, Zhang X, Santos CXC, Safinia N, et al. Nrf2 attenuates the innate immune response after experimental myocardial infarction. Biochem Biophys Res Commun. 2022;606:10\u20136.","journal-title":"Biochem Biophys Res Commun"},{"key":"7879_CR25","doi-asserted-by":"publisher","first-page":"113572","DOI":"10.1016\/j.biopha.2022.113572","volume":"154","author":"Z Wang","year":"2022","unstructured":"Wang Z, Yao M, Jiang L, Wang L, Yang Y, Wang Q, Qian X, Zhao Y, Qian J. Dexmedetomidine attenuates myocardial ischemia\/reperfusion-induced ferroptosis via AMPK\/GSK-3\u03b2\/Nrf2 axis. Biomed pharmacotherapy = Biomedecine pharmacotherapie. 2022;154:113572.","journal-title":"Biomed pharmacotherapy = Biomedecine pharmacotherapie"},{"issue":"14","key":"7879_CR26","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1177\/15353702231199076","volume":"248","author":"F Li","year":"2023","unstructured":"Li F, Zhu H, Chang Z, Li Y. Gentiopicroside alleviates acute myocardial infarction injury in rats by disrupting Nrf2\/NLRP3 signaling. Experimental biology Med (Maywood NJ). 2023;248(14):1254\u201366.","journal-title":"Experimental biology Med (Maywood NJ)"},{"issue":"1","key":"7879_CR27","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s12012-024-09950-6","volume":"25","author":"G Zhang","year":"2025","unstructured":"Zhang G, Ma Z, Ma Z, Liu P, Zhang L, Lian Z, Guo C. SUZ12-Increased NRF2 Alleviates Cardiac Ischemia\/Reperfusion Injury by Regulating Apoptosis, Inflammation, and Ferroptosis. Cardiovasc Toxicol. 2025;25(1):97\u2013109.","journal-title":"Cardiovasc Toxicol"},{"key":"7879_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2024.05.012","volume":"221","author":"D Yao","year":"2024","unstructured":"Yao D, Bao L, Wang S, Tan M, Xu Y, Wu T, Zhang Z, Gong K. Isoliquiritigenin alleviates myocardial ischemia-reperfusion injury by regulating the Nrf2\/HO-1\/SLC7a11\/GPX4 axis in mice. Free Radic Biol Med. 2024;221:1\u201312.","journal-title":"Free Radic Biol Med"},{"key":"7879_CR29","doi-asserted-by":"publisher","first-page":"7537210","DOI":"10.1155\/2022\/7537210","volume":"2022","author":"T Fedchenko","year":"2022","unstructured":"Fedchenko T, Izmailova O, Shynkevych V, Shlykova O, Kaidashev I. PPAR-\u03b3 Agonist pioglitazone restored mouse liver mrna expression of clock genes and inflammation-related genes disrupted by reversed feeding. PPAR Res. 2022;2022:7537210.","journal-title":"PPAR Res"},{"issue":"2","key":"7879_CR30","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1152\/physrev.00031.2024","volume":"105","author":"J Zheng","year":"2025","unstructured":"Zheng J, Conrad M. Ferroptosis: when metabolism meets cell death. Physiol Rev. 2025;105(2):651\u2013706.","journal-title":"Physiol Rev"},{"issue":"51","key":"7879_CR31","doi-asserted-by":"publisher","first-page":"e1904197","DOI":"10.1002\/adma.201904197","volume":"31","author":"C Liang","year":"2019","unstructured":"Liang C, Zhang X, Yang M, Dong X. Recent Progress in Ferroptosis Inducers for Cancer Therapy. Adv Mater (Deerfield Beach Fla). 2019;31(51):e1904197.","journal-title":"Adv Mater (Deerfield Beach Fla)"}],"container-title":["Cardiovascular Drugs and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-026-07879-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10557-026-07879-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-026-07879-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:29:02Z","timestamp":1789522142000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10557-026-07879-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,4]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["7879"],"URL":"https:\/\/doi.org\/10.1007\/s10557-026-07879-2","relation":{},"ISSN":["0920-3206","1573-7241"],"issn-type":[{"value":"0920-3206","type":"print"},{"value":"1573-7241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,4]]},"assertion":[{"value":"11 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Consent to Participate, and Consent to Publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Clinical Trial Number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}