{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T08:17:25Z","timestamp":1787991445172,"version":"build-2784847793"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["grant no. 82070321"],"award-info":[{"award-number":["grant no. 82070321"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Drugs Ther"],"DOI":"10.1007\/s10557-026-07947-7","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T08:14:33Z","timestamp":1787991273000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Berberine Attenuates Hypertrophic Phenotype in RAF1-Mutant Induced Pluripotent Stem Cell-Derived Cardiomyocytes through Suppression of ERK5-Cyclin D1 Signaling"],"prefix":"10.1007","author":[{"given":"Hongfei","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yule","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shushui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"7947_CR1","doi-asserted-by":"publisher","first-page":"915129","DOI":"10.3389\/fgene.2022.915129","volume":"13","author":"L Sun","year":"2022","unstructured":"Sun L, Xie YM, Wang SS, Zhang ZW. Cardiovascular Abnormalities and Gene Mutations in Children With Noonan Syndrome. Front Genet. 2022;13:915129.","journal-title":"Front Genet"},{"issue":"9863","key":"7947_CR2","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/S0140-6736(12)61023-X","volume":"381","author":"AE Roberts","year":"2013","unstructured":"Roberts AE, Allanson JE, Tartaglia M, Gelb BD. Noonan syndrome. Lancet. 2013;381(9863):333\u201342.","journal-title":"Lancet"},{"key":"7947_CR3","doi-asserted-by":"publisher","first-page":"e37","DOI":"10.1017\/S1462399408000902","volume":"10","author":"WE Tidyman","year":"2008","unstructured":"Tidyman WE, Rauen KA. Noonan, Costello and cardio-facio-cutaneous syndromes: dysregulation of the Ras-MAPK pathway. Expert Rev Mol Med. 2008;10:e37.","journal-title":"Expert Rev Mol Med"},{"issue":"8","key":"7947_CR4","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1002\/humu.20748","volume":"29","author":"Y Aoki","year":"2008","unstructured":"Aoki Y, Niihori T, Narumi Y, Kure S, Matsubara Y. The RAS\/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders. Hum Mutat. 2008;29(8):992\u20131006.","journal-title":"Hum Mutat"},{"issue":"11","key":"7947_CR5","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/nrm1498","volume":"5","author":"C Wellbrock","year":"2004","unstructured":"Wellbrock C, Karasarides M, Marais R. The RAF proteins take centre stage. Nat Rev Mol Cell Biol. 2004;5(11):875\u201385.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"3","key":"7947_CR6","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1161\/CIRCULATIONAHA.118.037227","volume":"140","author":"F Jaffr\u00e9","year":"2019","unstructured":"Jaffr\u00e9 F, Miller CL, Sch\u00e4nzer A, Evans T, Roberts AE, Hahn A, Kontaridis MI. Inducible Pluripotent Stem Cell-Derived Cardiomyocytes Reveal Aberrant Extracellular Regulated Kinase 5 and Mitogen-Activated Protein Kinase Kinase 1\/2 Signaling Concomitantly Promote Hypertrophic Cardiomyopathy in RAF1-Associated Noonan Syndrome. Circulation. 2019;140(3):207\u201324.","journal-title":"Circulation"},{"issue":"8","key":"7947_CR7","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/ng2078","volume":"39","author":"MA Razzaque","year":"2007","unstructured":"Razzaque MA, Nishizawa T, Komoike Y, Yagi H, Furutani M, Amo R, Kamisago M, Momma K, Katayama H, Nakagawa M, et al. Germline gain-of-function mutations in RAF1 cause Noonan syndrome. Nat Genet. 2007;39(8):1013\u20137.","journal-title":"Nat Genet"},{"issue":"1","key":"7947_CR8","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.beem.2010.09.002","volume":"25","author":"M Tartaglia","year":"2011","unstructured":"Tartaglia M, Gelb BD, Zenker M. Noonan syndrome and clinically related disorders. Best Pract Res Clin Endocrinol Metab. 2011;25(1):161\u201379.","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"1","key":"7947_CR9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13023-019-1010-z","volume":"14","author":"H Chen","year":"2019","unstructured":"Chen H, Li X, Liu X, Wang J, Zhang Z, Wu J, Huang M, Guo Y, Li F, Wang X, et al. Clinical and mutation profile of pediatric patients with RASopathy-associated hypertrophic cardiomyopathy: results from a Chinese cohort. Orphanet J Rare Dis. 2019;14(1):29.","journal-title":"Orphanet J Rare Dis"},{"issue":"8","key":"7947_CR10","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1038\/s41431-024-01643-6","volume":"32","author":"A Gazzin","year":"2024","unstructured":"Gazzin A, Fornari F, Niceta M, Leoni C, Dentici ML, Carli D, Villar AM, Calcagni G, Banaudi E, Massuras S, et al. Defining the variant-phenotype correlation in patients affected by Noonan syndrome with the RAF1:c.770C\u2009>\u2009T p.(Ser257Leu) variant. Eur J Hum Genet. 2024;32(8):964\u201371.","journal-title":"Eur J Hum Genet"},{"issue":"1","key":"7947_CR11","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s40659-021-00342-6","volume":"54","author":"M Ramos-Kuri","year":"2021","unstructured":"Ramos-Kuri M, Meka SH, Salamanca-Buentello F, Hajjar RJ, Lipskaia L, Chemaly ER. Molecules linked to Ras signaling as therapeutic targets in cardiac pathologies. Biol Res. 2021;54(1):23.","journal-title":"Biol Res"},{"issue":"6","key":"7947_CR12","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1007\/s10637-010-9452-0","volume":"29","author":"V Beljanski","year":"2011","unstructured":"Beljanski V, Knaak C, Zhuang Y, Smith CD. Combined anticancer effects of sphingosine kinase inhibitors and sorafenib. Invest New Drugs. 2011;29(6):1132\u201342.","journal-title":"Invest New Drugs"},{"issue":"1","key":"7947_CR13","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ccell.2015.11.011","volume":"29","author":"TK Hayes","year":"2016","unstructured":"Hayes TK, Neel NF, Hu C, Gautam P, Chenard M, Long B, Aziz M, Kassner M, Bryant KL, Pierobon M, et al. Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression. Cancer Cell. 2016;29(1):75\u201389.","journal-title":"Cancer Cell"},{"key":"7947_CR14","doi-asserted-by":"publisher","first-page":"106481","DOI":"10.1016\/j.phrs.2022.106481","volume":"185","author":"S Hu","year":"2022","unstructured":"Hu S, Wang J, Liu E, Zhang X, Xiang J, Li W, Wei P, Zeng J, Zhang Y, Ma X. Protective effect of berberine in diabetic nephropathy: A systematic review and meta-analysis revealing the mechanism of action. Pharmacol Res. 2022;185:106481.","journal-title":"Pharmacol Res"},{"issue":"3","key":"7947_CR15","doi-asserted-by":"publisher","first-page":"978","DOI":"10.3892\/etm.2016.3018","volume":"11","author":"Z Qin-Wei","year":"2016","unstructured":"Qin-Wei Z, Yong-Guang LI. Berberine attenuates myocardial ischemia reperfusion injury by suppressing the activation of PI3K\/AKT signaling. Exp Ther Med. 2016;11(3):978\u201384.","journal-title":"Exp Ther Med"},{"issue":"7","key":"7947_CR16","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.7150\/thno.30787","volume":"9","author":"X Feng","year":"2019","unstructured":"Feng X, Sureda A, Jafari S, Memariani Z, Tewari D, Annunziata G, Barrea L, Hassan STS, \u0160mejkal K, Malan\u00edk M, et al. Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics. Theranostics. 2019;9(7):1923\u201351.","journal-title":"Theranostics"},{"issue":"4","key":"7947_CR17","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1142\/S0192415X02000612","volume":"30","author":"Y Hong","year":"2002","unstructured":"Hong Y, Hui SC, Chan TY, Hou JY. Effect of berberine on regression of pressure-overload induced cardiac hypertrophy in rats. Am J Chin Med. 2002;30(4):589\u201399.","journal-title":"Am J Chin Med"},{"issue":"6","key":"7947_CR18","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1161\/HYPERTENSIONAHA.115.06068","volume":"66","author":"H Tsui","year":"2015","unstructured":"Tsui H, Zi M, Wang S, Chowdhury SK, Prehar S, Liang Q, Cartwright EJ, Lei M, Liu W, Wang X. Smad3 Couples Pak1 With the Antihypertrophic Pathway Through the E3 Ubiquitin Ligase, Fbxo32. Hypertension. 2015;66(6):1176\u201383.","journal-title":"Hypertension"},{"issue":"22","key":"7947_CR19","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1016\/S0024-3205(03)00144-9","volume":"72","author":"Y Hong","year":"2003","unstructured":"Hong Y, Hui SS, Chan BT, Hou J. Effect of berberine on catecholamine levels in rats with experimental cardiac hypertrophy. Life Sci. 2003;72(22):2499\u2013507.","journal-title":"Life Sci"},{"key":"7947_CR20","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.ejphar.2014.01.061","volume":"728","author":"MH Li","year":"2014","unstructured":"Li MH, Zhang YJ, Yu YH, Yang SH, Iqbal J, Mi QY, Li B, Wang ZM, Mao WX, Xie HG, et al. Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy. Eur J Pharmacol. 2014;728:67\u201376.","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"7947_CR21","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1002\/humu.21187","volume":"31","author":"T Kobayashi","year":"2010","unstructured":"Kobayashi T, Aoki Y, Niihori T, Cav\u00e9 H, Verloes A, Okamoto N, Kawame H, Fujiwara I, Takada F, Ohata T, et al. Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation. Hum Mutat. 2010;31(3):284\u201394.","journal-title":"Hum Mutat"},{"issue":"8","key":"7947_CR22","doi-asserted-by":"publisher","first-page":"e42137","DOI":"10.1371\/journal.pone.0042137","volume":"7","author":"Y Takaoka","year":"2012","unstructured":"Takaoka Y, Shimizu Y, Hasegawa H, Ouchi Y, Qiao S, Nagahara M, Ichihara M, Lee JD, Adachi K, Hamaguchi M, et al. Forced expression of miR-143 represses ERK5\/c-Myc and p68\/p72 signaling in concert with miR-145 in gut tumors of Apc(Min) mice. PLoS ONE. 2012;7(8):e42137.","journal-title":"PLoS ONE"},{"issue":"3","key":"7947_CR23","doi-asserted-by":"publisher","first-page":"e12410","DOI":"10.1111\/cpr.12410","volume":"51","author":"C Chen","year":"2018","unstructured":"Chen C, Wu S, Lin X, Wu D, Fischbach S, Xiao X. ERK5 plays an essential role in gestational beta-cell proliferation. Cell Prolif. 2018;51(3):e12410.","journal-title":"Cell Prolif"},{"issue":"2","key":"7947_CR24","doi-asserted-by":"publisher","first-page":"227","DOI":"10.15283\/ijsc18053","volume":"11","author":"C Kang","year":"2018","unstructured":"Kang C, Kim JS, Kim CY, Kim EY, Chung HM. The Pharmacological Inhibition of ERK5 Enhances Apoptosis in Acute Myeloid Leukemia Cells. Int J Stem Cells. 2018;11(2):227\u201334.","journal-title":"Int J Stem Cells"},{"issue":"1","key":"7947_CR25","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.18632\/oncotarget.23392","volume":"9","author":"Q Zhao","year":"2018","unstructured":"Zhao Q, Wang L, Sun Y, Wang XX. Molecular regulation of ERK5 in development of diabetic retinopathy. Oncotarget. 2018;9(1):1229\u201336.","journal-title":"Oncotarget"},{"key":"7947_CR26","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.3389\/fonc.2020.01164","volume":"10","author":"VT Hoang","year":"2020","unstructured":"Hoang VT, Matossian MD, Ucar DA, Elliott S, La J, Wright MK, Burks HE, Perles A, Hossain F, King CT, et al. ERK5 Is Required for Tumor Growth and Maintenance Through Regulation of the Extracellular Matrix in Triple Negative Breast Cancer. Front Oncol. 2020;10:1164.","journal-title":"Front Oncol"},{"issue":"5","key":"7947_CR27","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1161\/CIRCRESAHA.109.209320","volume":"106","author":"TE Kimura","year":"2010","unstructured":"Kimura TE, Jin J, Zi M, Prehar S, Liu W, Oceandy D, Abe J, Neyses L, Weston AH, Cartwright EJ, et al. Targeted deletion of the extracellular signal-regulated protein kinase 5 attenuates hypertrophic response and promotes pressure overload-induced apoptosis in the heart. Circ Res. 2010;106(5):961\u201370.","journal-title":"Circ Res"},{"issue":"1","key":"7947_CR28","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1002\/jcp.10457","volume":"199","author":"K Kesavan","year":"2004","unstructured":"Kesavan K, Lobel-Rice K, Sun W, Lapadat R, Webb S, Johnson GL, Garrington TP. MEKK2 regulates the coordinate activation of ERK5 and JNK in response to FGF-2 in fibroblasts. J Cell Physiol. 2004;199(1):140\u20138.","journal-title":"J Cell Physiol"},{"key":"7947_CR29","doi-asserted-by":"crossref","unstructured":"Bhatt AB, Patel S, Matossian MD, Ucar DA, Miele L, Burow ME, Flaherty PT, Cavanaugh JE. Molecular mechanisms of epithelial to mesenchymal transition regulated by ERK5 signaling. Biomolecules 2021;11(2):183.","DOI":"10.3390\/biom11020183"},{"issue":"1","key":"7947_CR30","doi-asserted-by":"publisher","first-page":"27737","DOI":"10.1038\/s41598-024-78676-w","volume":"14","author":"J Zhao","year":"2024","unstructured":"Zhao J, Xia Y, He J. Low fluid shear stress promotes chondrocyte proliferation and extracellular matrix secretion by downregulating mir-143-3p and activating the ERK5\/KLF4 signaling pathway. Sci Rep. 2024;14(1):27737.","journal-title":"Sci Rep"},{"issue":"1","key":"7947_CR31","doi-asserted-by":"publisher","first-page":"103596","DOI":"10.1016\/j.isci.2021.103596","volume":"25","author":"AB Meier","year":"2022","unstructured":"Meier AB, Raj Murthi S, Rawat H, Toepfer CN, Santamaria G, Schmid M, Mastantuono E, Schwarzmayr T, Berutti R, Cleuziou J, et al. Cell cycle defects underlie childhood-onset cardiomyopathy associated with Noonan syndrome. iScience. 2022;25(1):103596.","journal-title":"iScience"},{"issue":"1","key":"7947_CR32","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/s42003-023-05013-8","volume":"6","author":"S Nakhaei-Rad","year":"2023","unstructured":"Nakhaei-Rad S, Haghighi F, Bazgir F, Dahlmann J, Busley AV, Buchholzer M, Kleemann K, Sch\u00e4nzer A, Borchardt A, Hahn A, et al. Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues. Commun Biol. 2023;6(1):657.","journal-title":"Commun Biol"},{"issue":"3","key":"7947_CR33","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1002\/ehf2.15173","volume":"12","author":"J Hamers","year":"2025","unstructured":"Hamers J, Sen P, Murthi SR, Papanakli L, von Stumm M, Baessato F, Cleuziou J, Meierhofer C, Ewert P, Dendorfer A, et al. Trametinib alters contractility of paediatric Noonan syndrome-associated hypertrophic myocardial tissue slices. ESC Heart Fail. 2025;12(3):2321\u201334.","journal-title":"ESC Heart Fail"},{"key":"7947_CR34","doi-asserted-by":"crossref","unstructured":"Mussa A, Carli D, Giorgio E, Villar AM, Cardaropoli S, Carbonara C, Campagnoli MF, Galletto P, Palumbo M, Olivieri S et al. MEK inhibition in a newborn with RAF1-associated noonan syndrome ameliorates hypertrophic cardiomyopathy but is insufficient to revert pulmonary vascular disease. Genes (Basel). 2021;13(1):6.","DOI":"10.3390\/genes13010006"},{"issue":"3","key":"7947_CR35","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1007\/s00431-023-05263-y","volume":"183","author":"C Saint-Laurent","year":"2024","unstructured":"Saint-Laurent C, Mazeyrie L, Yart A, Edouard T. Novel therapeutic perspectives in Noonan syndrome and RASopathies. Eur J Pediatr. 2024;183(3):1011\u20139.","journal-title":"Eur J Pediatr"},{"key":"7947_CR36","doi-asserted-by":"publisher","first-page":"1475143","DOI":"10.3389\/fped.2025.1475143","volume":"13","author":"I De Brouchoven","year":"2025","unstructured":"De Brouchoven I, Lorand J, Bofferding L, Sorlin A, Van Damme A, Danhaive O. Trametinib as a targeted treatment in cardiac and lymphatic presentations of Noonan syndrome. Front Pediatr. 2025;13:1475143.","journal-title":"Front Pediatr"},{"key":"7947_CR37","doi-asserted-by":"crossref","unstructured":"Gazzin A, Fornari F, Cardaropoli S, Carli D, Tartaglia M, Ferrero GB, Mussa A. Exploring new drug repurposing opportunities for MEK inhibitors in RASopathies: a comprehensive review of safety, efficacy, and future perspectives of trametinib and selumetinib. Life (Basel). 2024;14(6):731.","DOI":"10.3390\/life14060731"},{"issue":"10","key":"7947_CR38","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.33963\/v.phj.106589","volume":"83","author":"A Ro\u017cnowska-W\u00f3jtowicz","year":"2025","unstructured":"Ro\u017cnowska-W\u00f3jtowicz A, Janiec I, Pietrzak R, Szcza\u0142uba K, Werner B. Rapamycin treatment for progressive hypertrophic cardiomyopathy in an infant with Noonan syndrome with multiple lentigines. Kardiol Pol. 2025;83(10):1216\u20138.","journal-title":"Kardiol Pol"},{"key":"7947_CR39","doi-asserted-by":"publisher","first-page":"865353","DOI":"10.3389\/fphar.2022.865353","volume":"13","author":"N An","year":"2022","unstructured":"An N, Zhang G, Li Y, Yuan C, Yang F, Zhang L, Gao Y, Xing Y. Promising Antioxidative Effect of Berberine in Cardiovascular Diseases. Front Pharmacol. 2022;13:865353.","journal-title":"Front Pharmacol"},{"key":"7947_CR40","doi-asserted-by":"publisher","first-page":"115571","DOI":"10.1016\/j.biopha.2023.115571","volume":"167","author":"F Cao","year":"2023","unstructured":"Cao F, Xia W, Dai S, Wang C, Shi R, Yang Y, Guo C, Xu XL, Luo J. Berberine: An inspiring resource for the treatment of colorectal diseases. Biomed Pharmacother. 2023;167:115571.","journal-title":"Biomed Pharmacother"},{"issue":"1\u20133","key":"7947_CR41","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.ejphar.2008.06.034","volume":"590","author":"KW Liang","year":"2008","unstructured":"Liang KW, Yin SC, Ting CT, Lin SJ, Hsueh CM, Chen CY, Hsu SL. Berberine inhibits platelet-derived growth factor-induced growth and migration partly through an AMPK-dependent pathway in vascular smooth muscle cells. Eur J Pharmacol. 2008;590(1\u20133):343\u201354.","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"7947_CR42","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/j.bcp.2005.07.010","volume":"70","author":"H Tanabe","year":"2005","unstructured":"Tanabe H, Suzuki H, Mizukami H, Inoue M. Double blockade of cell cycle progression by coptisine in vascular smooth muscle cells. Biochem Pharmacol. 2005;70(8):1176\u201384.","journal-title":"Biochem Pharmacol"}],"container-title":["Cardiovascular Drugs and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-026-07947-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10557-026-07947-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10557-026-07947-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T08:14:35Z","timestamp":1787991275000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10557-026-07947-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,29]]},"references-count":42,"alternative-id":["7947"],"URL":"https:\/\/doi.org\/10.1007\/s10557-026-07947-7","relation":{},"ISSN":["0920-3206","1573-7241"],"issn-type":[{"value":"0920-3206","type":"print"},{"value":"1573-7241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,29]]},"assertion":[{"value":"15 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study protocol was approved by the Ethics Committee of Guangdong Provincial People\u2019s Hospital (Project No. KY2024-780). All experiments involving human participants were conducted in accordance with the principles of the Declaration of Helsinki.","order":1,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors agreed to publication in the journal.","order":2,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from all participants prior to sample collection, and for children under 16 years of age, consent was obtained from their parents or legal guardians.","order":3,"name":"Ethics","label":"Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}