{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:36:25Z","timestamp":1781796985514,"version":"3.54.5"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100008958","name":"Sanad Children's Cancer Support Association","doi-asserted-by":"publisher","award":["RGP-2013-05"],"award-info":[{"award-number":["RGP-2013-05"]}],"id":[{"id":"10.13039\/501100008958","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Bank"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s10561-020-09855-y","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T18:03:33Z","timestamp":1597773813000},"page":"625-630","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Screening for pre-leukemia TEL-AML1 chromosomal translocation in banked cord blood units: cord blood bank perspective"],"prefix":"10.1007","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3615-2909","authenticated-orcid":false,"given":"Dunia","family":"Jawdat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4145-1890","authenticated-orcid":false,"given":"Walid","family":"Almashaqbeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman","family":"Sumaily","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Albaloushi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Jammah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman","family":"Alsultan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,18]]},"reference":[{"issue":"17","key":"9855_CR1","doi-asserted-by":"publisher","first-page":"7523","DOI":"10.7314\/APJCP.2015.16.17.7523","volume":"16","author":"K Aljamaan","year":"2015","unstructured":"Aljamaan K, Aljumah TK, Aloraibi S et al (2015) Low frequency of ETV6-RUNX1 (t 12; 21) in Saudi Arabian pediatric acute lymphoblastic leukemia patients: association with clinical parameters and early remission. Asian Pac J Cancer Prev 16(17):7523\u20137527","journal-title":"Asian Pac J Cancer Prev"},{"issue":"1","key":"9855_CR2","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1002\/pbc.24584","volume":"61","author":"R Al-Sudairy","year":"2014","unstructured":"Al-Sudairy R, Al-Nasser A, Alsultan A et al (2014) Clinical characteristics and treatment outcome of childhood acute lymphoblastic leukemia in Saudi Arabia: a multi-institutional retrospective national collaborative study. Pediatr Blood Cancer 61(1):74\u201380","journal-title":"Pediatr Blood Cancer"},{"issue":"4","key":"9855_CR3","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1080\/00313029800169666","volume":"30","author":"DJ Amor","year":"1998","unstructured":"Amor DJ, Algar EM, Slater HR, Smith PJ (1998) High frequency of t(12;21) in childhood acute lymphoblastic leukemia detected by RT-PCR. Pathology 30(4):381\u2013385","journal-title":"Pathology"},{"issue":"4","key":"9855_CR4","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1182\/blood-2013-02-453175","volume":"122","author":"KK Ballen","year":"2013","unstructured":"Ballen KK, Gluckman E, Broxmeyer HE (2013) Umbilical cord blood transplantation: the first 25 years and beyond. Blood 122(4):491\u2013498","journal-title":"Blood"},{"issue":"1","key":"9855_CR5","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1182\/blood-2010-09-304337","volume":"117","author":"P Brown","year":"2011","unstructured":"Brown P (2011) TEL-AML1 in cord blood: 1% or 0.01%? Blood 117(1):2\u20134","journal-title":"Blood"},{"issue":"4","key":"9855_CR6","doi-asserted-by":"publisher","first-page":"99","DOI":"10.5500\/wjt.v3.i4.99","volume":"3","author":"DKL Cheuk","year":"2013","unstructured":"Cheuk DKL (2013) Optimal stem cell source for allogeneic stem cell transplantation for hematological malignancies. World J Transplant 3(4):99\u2013112","journal-title":"World J Transplant"},{"issue":"4","key":"9855_CR7","doi-asserted-by":"publisher","first-page":"530","DOI":"10.2353\/jmoldx.2010.090215","volume":"12","author":"J Crow","year":"2010","unstructured":"Crow J, Youens K, Michalowski S et al (2010) Donor cell leukemia in umbilical cord blood transplant patients. A case study and literature review highlighting the importance of molecular engraftment analysis. J Mol Diagn 12(4):530\u2013553","journal-title":"J Mol Diagn"},{"key":"9855_CR8","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/363358a0","volume":"363","author":"AM Ford","year":"1993","unstructured":"Ford AM, Ridge SA, Cabrera ME et al (1993) In utero rearrangements in the trithorax-related oncogene in infant leukaemias. Nature 363:358\u2013360","journal-title":"Nature"},{"issue":"3","key":"9855_CR9","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1182\/blood.V83.3.641.641","volume":"83","author":"HJ Gill Super","year":"1994","unstructured":"Gill Super HJ, Rothberg PG, Kobayashi H et al (1994) Clonal, nonconstitutional rearrangements of the MLL gene in infant twins with acute lymphoblastic leukemia: in utero chromosome rearrangement of 11q23. Blood 83(3):641\u2013644","journal-title":"Blood"},{"issue":"7","key":"9855_CR10","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1182\/blood-2002-12-3817","volume":"102","author":"MF Greaves","year":"2003","unstructured":"Greaves MF, Maia AT, Wiemels JL, Ford AM (2003) Leukemia in twins: lessons in natural history. Blood 102(7):2321\u20132333","journal-title":"Blood"},{"issue":"12","key":"9855_CR11","doi-asserted-by":"publisher","first-page":"4933","DOI":"10.1182\/blood.V90.12.4933","volume":"90","author":"J Harbott","year":"1997","unstructured":"Harbott J, Viehmann S, Borkhardt A et al (1997) Incidence of TEL\/AML1 fusion gene analyzed consecutively in children with acute lymphoblastic leukemia in relapse. Blood 90(12):4933\u20134937","journal-title":"Blood"},{"issue":"7","key":"9855_CR12","first-page":"969","volume":"90","author":"B Hertenstein","year":"2005","unstructured":"Hertenstein B, Hambach L, Bacigalupo A et al (2005) Development of leukemia in donor cells after allogeneic stem cell transplantation-a survey of the European Group for Blood and Marrow Transplantation (EBMT). Haematologica 90(7):969\u2013975","journal-title":"Haematologica"},{"issue":"9","key":"9855_CR13","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1038\/sj.bjc.6600601","volume":"87","author":"LL Hjalgrim","year":"2002","unstructured":"Hjalgrim LL, Madsen HO, Melbye M et al (2002) Presence of clone-specific markers at birth in children with acute lymphoblastic leukemia. Br J Cancer 87(9):994\u2013999","journal-title":"Br J Cancer"},{"key":"9855_CR14","volume-title":"SEER cancer statistics review 1975\u20132006","author":"MJ Horner","year":"2008","unstructured":"Horner MJ, Ries LAG, Krapcho M et al (2008) SEER cancer statistics review 1975\u20132006. National Cancer Institute, Bethesda"},{"key":"9855_CR15","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/978-3-319-33270-3_8","volume-title":"Recent advances in stem cells, from basic research to clinical applications. Stem cell biology and regenerative medicine book","author":"D Jawdat","year":"2016","unstructured":"Jawdat D (2016) Banking of human umbilical cord blood stem cells and their clinical applications. In: Abdelalim E (ed) Recent advances in stem cells, from basic research to clinical applications. Stem cell biology and regenerative medicine book. Humana Press, Cham, pp 159\u2013178. (Chapter 8)"},{"issue":"1\u20132","key":"9855_CR16","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3109\/10428199709058329","volume":"28","author":"H Kobayashi","year":"1997","unstructured":"Kobayashi H, Satake N, Kaneko Y (1997) Detection of the Der (21) t(12;21) chromosome forming the TEL-AML1 fusion gene in childhood acute lymphoblastic leukemia. Leuk Lymphoma 28(1\u20132):43\u201350","journal-title":"Leuk Lymphoma"},{"issue":"1","key":"9855_CR17","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1182\/blood-2010-05-282764","volume":"117","author":"U Lausten-Thomsen","year":"2011","unstructured":"Lausten-Thomsen U, Madsen HO, Vestergaard TR et al (2011) Prevalence of t(12;21) [ETV6-RUNX1]-positive cells in healthy neonates. Blood 117(1):186\u2013189","journal-title":"Blood"},{"issue":"9","key":"9855_CR18","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1182\/blood-2014-03-562918","volume":"124","author":"AV Moorman","year":"2014","unstructured":"Moorman AV, Enshaei A, Schwab C et al (2014) A novel integrated cytogenetic and genomic classification refines risk stratification in pediatric acute lymphoblastic leukemia. Blood 124(9):1434\u20131444","journal-title":"Blood"},{"issue":"12","key":"9855_CR19","doi-asserted-by":"publisher","first-page":"8242","DOI":"10.1073\/pnas.112218799","volume":"99","author":"H Mori","year":"2002","unstructured":"Mori H, Colman SM, Xiao Z et al (2002) Chromosome translocations and covert leukemic clones are generated during normal fetal development. Proc Natl Acad Sci USA 99(12):8242\u20138247","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"9855_CR20","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1080\/14653240701466339","volume":"9","author":"T Nagamura-Inoue","year":"2007","unstructured":"Nagamura-Inoue T, Kodo H, Takahashi TA et al (2007) Four cases of donor cell-derived AML following unrelated cord blood transplantation for adult patients: experiences of the Tokyo Cord Blood Bank. Cytotherapy 9(8):727\u2013728","journal-title":"Cytotherapy"},{"issue":"4","key":"9855_CR21","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1097\/MPH.0b013e3182332268","volume":"34","author":"M Olsen","year":"2012","unstructured":"Olsen M, Hjalgrim H, Melbye M et al (2012) RTPCR screening for ETV6-RUNX1-positive clones in cord blood from newborns in the Danish National Birth Cohort. J Pediatr Hematol Oncol 34(4):301\u2013303","journal-title":"J Pediatr Hematol Oncol"},{"issue":"9","key":"9855_CR22","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1080\/10428190600693099","volume":"47","author":"GJ Ruiz-Arg\u00fcelles","year":"2006","unstructured":"Ruiz-Arg\u00fcelles GJ, Ruiz-Delgado GJ, Garces-Eisele J et al (2006) Donor cell leukemia after non-myeloablative allogeneic stem cell transplantation: a single institution experience. Leuk Lymphoma 47(9):1952\u20131955","journal-title":"Leuk Lymphoma"},{"issue":"7","key":"9855_CR23","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1182\/blood-2017-09-808402","volume":"131","author":"D Sch\u00e4fer","year":"2018","unstructured":"Sch\u00e4fer D, Olsen M, L\u00e4hnemann D et al (2018) Five percent of healthy newborns have an ETV6-RUNX1 fusion as revealed by DNA-based GIPFEL screening. Blood 131(7):821\u2013826","journal-title":"Blood"},{"issue":"12","key":"9855_CR24","first-page":"1985","volume":"9","author":"SA Shurtleff","year":"1995","unstructured":"Shurtleff SA, Buijs A, Behm FG et al (1995) TEL\/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis. Leukemia 9(12):1985\u20131989","journal-title":"Leukemia"},{"issue":"3","key":"9855_CR25","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1182\/blood.V93.3.1106","volume":"93","author":"J Trka","year":"1999","unstructured":"Trka J, Zuna J, Hrus\u00e1k O et al (1999) No evidence for MLL\/AF4 expression in normal cord blood samples. Blood 93(3):1106\u20131107","journal-title":"Blood"},{"issue":"3","key":"9855_CR26","first-page":"810","volume":"92","author":"FM Uckun","year":"1998","unstructured":"Uckun FM, Herman-Hatten K, Crotty ML et al (1998) Clinical significance of MLL-AF4 fusion transcript expression in the absence of a cytogenetically detectable t(4;11)(q21;q23) chromosomal translocation. Blood 92(3):810\u2013821","journal-title":"Blood"},{"issue":"1","key":"9855_CR27","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1182\/blood-2010-09-309070","volume":"117","author":"J Zuna","year":"2011","unstructured":"Zuna J, Madzo J, Krejci O et al (2011) ETV6\/ RUNX1 (TEL\/AML1) is a frequent prenatal first hit in childhood leukemia. Blood 117(1):368\u2013369","journal-title":"Blood"}],"container-title":["Cell and Tissue Banking"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10561-020-09855-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10561-020-09855-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10561-020-09855-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T23:30:08Z","timestamp":1629243008000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10561-020-09855-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,18]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["9855"],"URL":"https:\/\/doi.org\/10.1007\/s10561-020-09855-y","relation":{},"ISSN":["1389-9333","1573-6814"],"issn-type":[{"value":"1389-9333","type":"print"},{"value":"1573-6814","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,18]]},"assertion":[{"value":"20 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there is no conflict of interest regarding the publication of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All participants were consented prior sample collection.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The study received ethical approval.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}