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Enrolled patients were randomly divided into 2 groups. One group will be treated with resective surgery and with the insertion of HAM patch (Group A), while the second group had been treated exclusively with resective surgery (Group B).The patients underwent MRONJ surgical treatment with the placement of amniotic membrane patches at the wound site. Data regarding the long-term complications\/functions were evaluated at 3, 6, 12, and 24\u00a0months after surgery. Pain measurements were performed before the intervention (T0), 7(T1) and 30(T2) days after surgery. 49 patients were included in the study. 2 patients of GROUP A after 30\u00a0days since they were surgically treated showed persistent bone exposure. 5 patients of group B demonstrated a lack of healing of the surgical wound with the persistence of bone exposed to 30\u00a0days after surgery. Statistical analysis ruled out any difference in OUTCOME (relapse) between GROUP A and B (<jats:italic>p<\/jats:italic>\u2009=\u20090.23). However, the Fisher test highlighted a significant difference between the use of HAM and only surgical treatment in pain at rest (<jats:italic>p<\/jats:italic>\u2009=\u20090.032). The use of amniotic membrane implement the patient's quality of life and reduce pain perception. has a learning curve that is fast enough to justify its routine use.<\/jats:p>","DOI":"10.1007\/s10561-021-09922-y","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T14:38:42Z","timestamp":1618497522000},"page":"129-141","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Human amniotic membrane: an improvement in the treatment of Medication-related osteonecrosis of the jaw (MRONJ)? 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