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The purpose of this study was to constuct the rat bone marrow derived-endothelial progenitor cell (BM-EPCs) sheet and investigate invest the role of stromal cell-derived factor-1\u03b1 (SDF-1\u03b1)\/CXCR4 axis in the biological function of BM-EPCs sheet. BM-EPC cells were identified by the cell-surface markers-CD34\/CD133\/VE-cadherin\/KDR using flow cytometry and dual affinity for acLDL and UEA-1. After 7\u00a0days of incubation, the BM-EPC single-cell suspensions were seeded on thermo-sensitive plate to harvest the BM-EPC cell sheets. The expression levels of SDF-1\u03b1\/CXCR4 axis-associated genes and proteins were examined using RT-qPCR and western blot analysis, and enzyme-linked immunosorbent assay (ELISA) was applied to determine the concentration of vascular endothelial growth factor (VEGF), epidermal growth factor (EGF) and SDF-1\u03b1 in the cell culture medium. The BM-EPC cell sheets were successfully harvested. Moreover, BM-EPC cell sheets have superior migration and tube formation activity when compared with single cell suspension. When capillary-like tube were formed from EPCs sheets, the releasing of paracrine factors such as VEGF, EGF and SDF-1\u03b1 were increased. To reveal the mechanism of tube formation of BM-EPCs sheets, our research showed that the activation of PI3K\/AKT\/eNOS pathway was involved in the process, because the phosphorylation of CXCR, PI3K, AKT and eNOS were increased. BM-EPC cell sheets have superior paracrine and tube formation activity than the BM-EPC single-cell. The strong ability to secrete paracrine factors was be potentially related to the SDF-1\u03b1\/CXCR4 axis through PI3K\/AKT\/eNOS pathway.<\/jats:p>","DOI":"10.1007\/s10561-021-09932-w","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T09:03:10Z","timestamp":1625562190000},"page":"185-197","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Construction and a preliminary study of paracrine effect of bone marrow-derived endothelial progenitor cell sheet"],"prefix":"10.1007","volume":"23","author":[{"given":"Fenlong","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianshi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitao","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,30]]},"reference":[{"issue":"12","key":"9932_CR1","doi-asserted-by":"publisher","first-page":"e82085","DOI":"10.1371\/journal.pone.0082085","volume":"8","author":"Y Abe","year":"2013","unstructured":"Abe Y, Ozaki Y, Kasuya J, Yamamoto K, Ando J, Sudo R, Ikeda M, Tanishita K (2013) Endothelial progenitor cells promote directional three-dimensional endothelial network formation by secreting vascular endothelial growth factor. 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