{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:48:51Z","timestamp":1792615731201,"version":"4.5.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["No. 278453"],"award-info":[{"award-number":["No. 278453"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medizinische Hochschule Hannover (MHH)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Bank"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>For decades, bovine jugular vein conduits (BJV) and classic cryopreserved homografts have been the two most widely used options for pulmonary valve replacement (PVR) in congenital heart disease. More recently, decellularized pulmonary homografts (DPH) have provided an alternative avenue for PVR. Matched comparison of patients who received DPH for PVR with patients who received bovine jugular vein conduits (BJV) considering patient age group, type of heart defect, and previous procedures. 319 DPH patients were matched to 319 BJV patients; the mean age of BJV patients was 15.3 (SD 9.5) years versus 19.1 (12.4) years in DPH patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). The mean conduit diameter was 24.5 (3.5) mm for DPH and 20.3 (2.5) mm for BJV (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). There was no difference in survival rates between the two groups after 10\u00a0years (97.0 vs. 98.1%, <jats:italic>p<\/jats:italic>\u2009=\u20090.45). The rate of freedom from endocarditis was significantly lower for BJV patients (87.1 vs. 96.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.006). Freedom from explantation was significantly lower for BJV at 10\u00a0years (81.7 vs. 95.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) as well as freedom from any significant degeneration at 10\u00a0years (39.6 vs. 65.4%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). 140 Patients, matched for age, heart defect type, prior procedures, and conduit sizes of 20\u201322\u00a0mm (\u00b1\u20092\u00a0mm), were compared separately; mean age BJV 8.7 (4.9) and DPH 9.5 (7.3) years (<jats:italic>p<\/jats:italic>\u2009=\u2009n.s.). DPH showed 20% higher freedom from explantation and degeneration in this subgroup (<jats:italic>p<\/jats:italic>\u2009=\u20090.232). Decellularized pulmonary homografts exhibit superior 10-year results to bovine jugular vein conduits in PVR.<\/jats:p>","DOI":"10.1007\/s10561-023-10082-4","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T13:03:23Z","timestamp":1678799003000},"page":"55-66","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Matched comparison of decellularized homografts and bovine jugular vein conduits for pulmonary valve replacement in congenital heart disease"],"prefix":"10.1007","volume":"25","author":[{"given":"Dmitry","family":"Bobylev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Horke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Avsar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomislav","family":"Cvitkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Boethig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Hazekamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Meyns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Rega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitendu","family":"Dave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schmiady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatol","family":"Ciubotaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Cheptanaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimiro","family":"Vida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Padalino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramadan","family":"Jashari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnther","family":"Laufer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Andreas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Andreeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Tudorache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serghei","family":"Cebotari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Haverich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7277-7597","authenticated-orcid":false,"given":"Samir","family":"Sarikouch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,14]]},"reference":[{"key":"10082_CR1","doi-asserted-by":"publisher","first-page":"e008163","DOI":"10.1161\/JAHA.117.008163","volume":"7","author":"M Abdelghani","year":"2018","unstructured":"Abdelghani M, Nassif M, Blom NA, Van Mourik MS, Straver B, Koolbergen DR et al (2018) Infective endocarditis after melody valve implantation in the pulmonary position: a systematic review. J Am Heart Assoc 7:e008163","journal-title":"J Am Heart Assoc"},{"issue":"5","key":"10082_CR2","doi-asserted-by":"publisher","first-page":"ezac219","DOI":"10.1093\/ejcts\/ezac219","volume":"62","author":"D Bobylev","year":"2022","unstructured":"Bobylev D, Horke A, Boethig D, Hazekamp M, Meyns B, Rega F et al (2022) 5-Year results from the prospective European multi-centre study on decellularized homografts for pulmonary valve replacement ESPOIR Trial and ESPOIR Registry data. Eur J Cardiothorac Surg 62(5):ezac219","journal-title":"Eur J Cardiothorac Surg"},{"key":"10082_CR3","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1055\/s-0029-1185394","volume":"57","author":"D Boethig","year":"2009","unstructured":"Boethig D, Westhoff-Bleck M, Hecker H, Ono M, Goerler A, Sarikouch S et al (2009) Bovine jugular veins in the pulmonary position in adults \u2013 5 years\u2019 experience with 64 implantations. Thorac Cardiovasc Surg 57:196\u2013201","journal-title":"Thorac Cardiovasc Surg"},{"key":"10082_CR4","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1055\/s-0031-1298062","volume":"60","author":"D Boethig","year":"2012","unstructured":"Boethig D, Schreiber C, Hazekamp M, Blanz U, Pretre R, Asfour B et al (2012) Risk factors for distal Contegra stenosis: results of a prospective European multicentre study. Thorac Cardiovasc Surg 60:195\u2013204","journal-title":"Thorac Cardiovasc Surg"},{"key":"10082_CR5","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1136\/heartjnl-2015-307754","volume":"101","author":"JP Bokma","year":"2015","unstructured":"Bokma JP, Winter MM, Oosterhof T, Vliegen HW, van Dijk AP, Hazekamp MG et al (2015) Individualised prediction of pulmonary homograft durability in tetralogy of Fallot. Heart 101:1717\u20131723","journal-title":"Heart"},{"key":"10082_CR6","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1055\/s-0029-1185513","volume":"57","author":"T Breymann","year":"2009","unstructured":"Breymann T, Blanz U, Wojtalik MA, Daenen W, Hetzer R, Sarris G et al (2009) European Contegra multicentre study: 7-year results after 165 valved bovine jugular vein graft implantations. Thorac Cardiovasc Surg 57:257\u2013269","journal-title":"Thorac Cardiovasc Surg"},{"key":"10082_CR7","unstructured":"Contegra pulmonary valved conduit FDA executive summary. 2020 FDA Pediatric advisory committee meeting. Last accessed 05.07.2022"},{"issue":"4","key":"10082_CR8","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1093\/ejcts\/ezaa393","volume":"59","author":"JMN Ebken","year":"2021","unstructured":"Ebken JMN, Smart I, Ramm R, Goecke T, Jashari R, B\u00f6thig D, Horke A, Cebotari S, Tudorache I, Avsar M, Bobylev D, Haverich A, Sarikouch S, Hilfiker A (2021) Residual immune response towards decellularized homografts may be highly individual. Eur J Cardiothorac Surg 59(4):773\u2013782","journal-title":"Eur J Cardiothorac Surg"},{"key":"10082_CR9","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.ejcts.2010.01.063","volume":"38","author":"AC Fiore","year":"2010","unstructured":"Fiore AC, Ruzmetov M, Huynh D, Hanley S, Rodefeld MD, Turrentine MW et al (2010) Comparison of bovine jugular vein with pulmonary homograft conduits in children less than 2 years of age. Eur J Cardio-Thorac 38:318\u2013325","journal-title":"Eur J Cardio-Thorac"},{"issue":"4","key":"10082_CR10","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1093\/ejcts\/ezaa119","volume":"58","author":"A Horke","year":"2020","unstructured":"Horke A, Bobylev D, Avsar M, Meyns B, Rega F, Hazekamp M et al (2020) Paediatric aortic valve replacement using decellularized allografts. Eur J Cardiothorac Surg 58(4):817\u2013824","journal-title":"Eur J Cardiothorac Surg"},{"issue":"4","key":"10082_CR11","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1007\/s10561-021-09902-2","volume":"22","author":"R Jashari","year":"2021","unstructured":"Jashari R (2021) Transplantation of cryopreserved human heart valves in Europe: 30 years of banking in Brussels and future perspectives. Cell Tissue Bank 22(4):519\u2013537","journal-title":"Cell Tissue Bank"},{"key":"10082_CR12","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.athoracsur.2015.03.025","volume":"100","author":"AD Khanna","year":"2015","unstructured":"Khanna AD, Hill KD, Pasquali SK, Wallace AS, Masoudi FA, Jacobs ML et al (2015) Benchmark outcomes for pulmonary valve replacement using the society of thoracic surgeons databases. Ann Thorac Surg 100:138\u2013145","journal-title":"Ann Thorac Surg"},{"key":"10082_CR13","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.jtcvs.2021.11.087","volume":"164","author":"SP Marathe","year":"2021","unstructured":"Marathe SP, Hussein N, Wallace FRO, Bell D, Yong M, Betts KS et al (2021) Comparison of homografts and bovine jugular vein conduits in the pulmonary position in patients <20 years of age. J Thorac Cardiovasc Surg 164:752\u2013762","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10082_CR14","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1093\/icvts\/ivy242","volume":"28","author":"FMM Meijer","year":"2019","unstructured":"Meijer FMM, Kies P, Jongbloed MRM, Hazekamp MG, Koolbergen DR, Blom NA et al (2019) Excellent durability of homografts in pulmonary position analysed in a predefined adult group with tetralogy of Fallot. Interact Cardiovasc Thorac Surg 28:279\u2013283","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10082_CR15","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1017\/S1047951119003007","volume":"30","author":"PM Patel","year":"2020","unstructured":"Patel PM, Herrmann JL, Rodefeld MD, Turrentine MW, Brown JW (2020) Bovine jugular vein conduit versus pulmonary homograft in the ross operation. Cardiol Young 30:323\u2013327","journal-title":"Cardiol Young"},{"key":"10082_CR16","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s13019-018-0698-5","volume":"13","author":"N Poinot","year":"2018","unstructured":"Poinot N, Fils JF, Demanet H, Dessy H, Biarent D, Wauthy P (2018) Pulmonary valve replacement after right ventricular outflow tract reconstruction with homograft vs Contegra(R): a case control comparison of mortality and morbidity. J Cardiothorac Surg 13:8","journal-title":"J Cardiothorac Surg"},{"key":"10082_CR17","doi-asserted-by":"publisher","first-page":"036","DOI":"10.1093\/rb\/rbab036","volume":"8","author":"R Ramm","year":"2021","unstructured":"Ramm R, Goecke T, K\u00f6hler P, Tudorache I, Cebotari S, Ciubotaru A, Sarikouch S, H\u00f6ffler K, Bothe F, Petersen B, Haverich A, Niemann H, Hilfiker A (2021) Immunological and functional features of decellularized xenogenic heart valves after transplantation into GGTA1-KO pigs. Regen Biomat 8:036","journal-title":"Regen Biomat"},{"key":"10082_CR18","first-page":"25","volume":"64","author":"E Sandica","year":"2016","unstructured":"Sandica E, Boethig D, Blanz U, Goerg R, Haas NA, Laser KT et al (2016) bovine jugular veins versus homografts in the pulmonary position: an analysis across two centers and 711 patients-conventional comparisons and time status graphs as a new approach. Thorac Cardiovasc Surg 64:25\u201335","journal-title":"Thorac Cardiovasc Surg"},{"key":"10082_CR19","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1016\/S1010-7940(03)00094-0","volume":"23","author":"P Simon","year":"2003","unstructured":"Simon P, Kasimir MT, Seebacher G, Weigel G, Ullrich R, Salzer-Muhar U et al (2003) Early failure of the tissue engineered porcine heart valve SYNERGRAFT in pediatric patients. Eur J Cardiothorac Surg 23:1002\u20131006","journal-title":"Eur J Cardiothorac Surg"},{"key":"10082_CR20","doi-asserted-by":"publisher","first-page":"e022231","DOI":"10.1161\/JAHA.121.022231","volume":"11","author":"C Stammnitz","year":"2022","unstructured":"Stammnitz C, Huscher D, Bauer UMM, Urban A, Nordmeyer J, Schubert S et al (2022) Nationwide registry-based analysis of infective endocarditis risk after pulmonary valve replacement. J Am Heart Assoc 11:e022231","journal-title":"J Am Heart Assoc"},{"key":"10082_CR21","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1186\/s13019-020-01292-y","volume":"15","author":"S Waqanivavalagi","year":"2020","unstructured":"Waqanivavalagi S, Bhat S, Ground MB, Milsom PF, Cornish J (2020) Clinical performance of decellularized heart valves versus standard tissue conduits: a systematic review and meta-analysis. J Cardiothorac Surg 15:260","journal-title":"J Cardiothorac Surg"},{"key":"10082_CR22","doi-asserted-by":"publisher","first-page":"728577","DOI":"10.3389\/fcvm.2021.728577","volume":"8","author":"DF Williams","year":"2021","unstructured":"Williams DF, Bezuidenhout D, de Villiers J, Human P, Zilla P (2021) Long-term stability and biocompatibility of pericardial bioprosthetic heart valves. Front Cardiovasc Med 8:728577","journal-title":"Front Cardiovasc Med"},{"key":"10082_CR23","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1111\/ans.13018","volume":"85","author":"MS Yong","year":"2015","unstructured":"Yong MS, Yim D, d\u2019Udekem Y, Brizard CP, Robertson T, Galati JC et al (2015) Medium-term outcomes of bovine jugular vein graft and homograft conduits in children. ANZ J Surg 85:381\u2013385","journal-title":"ANZ J Surg"}],"container-title":["Cell and Tissue Banking"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10561-023-10082-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10561-023-10082-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10561-023-10082-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T10:25:56Z","timestamp":1709115956000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10561-023-10082-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,14]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10082"],"URL":"https:\/\/doi.org\/10.1007\/s10561-023-10082-4","relation":{},"ISSN":["1389-9333","1573-6814"],"issn-type":[{"value":"1389-9333","type":"print"},{"value":"1573-6814","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,14]]},"assertion":[{"value":"13 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"AH holds shares in corlife oHG, the company providing the service of processing decellularized allografts used in this study. RJ is Director of the European Homograft Bank. Martin Andreas has received institutional research funding (Edwards, Abbott, Medtronic, LSI), and has served as a proctor\/speaker\/consultant (Edwards, Abbott, Medtronic, Boston, Zoll). Guenther Laufer has received consulting fees from Edwards Lifesciences.\u00a0All other authors declare that there are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}