{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:38:11Z","timestamp":1788212291451,"version":"build-2803163510"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Bank"],"DOI":"10.1007\/s10561-025-10187-y","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T08:45:05Z","timestamp":1756197905000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of Platelet and Leukocyte Rich Fibrin (L-PRF) in the healing process and bone repair in maxillary sinus lift surgeries: a systematic review"],"prefix":"10.1007","volume":"26","author":[{"given":"\u00c9lio Hitoshi","family":"Shinohara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan Hudson Gomes","family":"de Santana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayara Rebeca Martins","family":"Viana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmundo Junio Rodrigues","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson Jara","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Marcos Pereira","family":"J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur Felipe","family":"de Brito Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Kendi","family":"Horikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Dias","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"issue":"1","key":"10187_CR1","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s40729-021-00393-0.PMID:34923613;PMCID:PMC8684569","volume":"7","author":"S Al-Maawi","year":"2021","unstructured":"Al-Maawi S, Becker K, Schwarz F, Sader R, Ghanaati S (2021) Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review. Int J Implant Dent 7(1):117. https:\/\/doi.org\/10.1186\/s40729-021-00393-0.PMID:34923613;PMCID:PMC8684569","journal-title":"Int J Implant Dent"},{"issue":"1","key":"10187_CR2","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.cden.2020.09.013","volume":"65","author":"N Bhalla","year":"2021","unstructured":"Bhalla N, Dym H (2021) Update on maxillary sinus augmentation. Dent Clin North Am 65(1):197\u2013210. https:\/\/doi.org\/10.1016\/j.cden.2020.09.013","journal-title":"Dent Clin North Am"},{"issue":"9","key":"10187_CR3","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1007\/s00784-016-1747-x","volume":"20","author":"J Caball\u00e9-Serrano","year":"2016","unstructured":"Caball\u00e9-Serrano J, Fujioka-Kobayashi M, Bosshardt DD, Gruber R, Buser D, Miron RJ (2016) Pre-coating deproteinized bovine bone mineral (DBBM) with bone-conditioned medium (BCM) improves osteoblast migration, adhesion, and differentiation in vitro. Clin Oral Investig 20(9):2507\u20132513. https:\/\/doi.org\/10.1007\/s00784-016-1747-x","journal-title":"Clin Oral Investig"},{"issue":"2","key":"10187_CR4","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1055\/s-0039-1696585","volume":"13","author":"A Caruana","year":"2019","unstructured":"Caruana A, Savina D, Macedo JP, Soares SC (2019) From platelet-rich plasma to advanced platelet-rich fibrin: biological achievements and clinical advances in modern surgery. Eur J Dent 13(2):280\u2013286. https:\/\/doi.org\/10.1055\/s-0039-1696585","journal-title":"Eur J Dent"},{"issue":"4","key":"10187_CR5","doi-asserted-by":"publisher","first-page":"855","DOI":"10.11607\/jomi.7275","volume":"34","author":"AB Castro","year":"2019","unstructured":"Castro AB, Cortellini S, Temmerman A, Li X, Pinto N, Teughels W, Quirynen M (2019) Characterization of the leukocyte- and platelet-rich fibrin block: release of growth factors, cellular content, and structure. Int J Oral Maxillofac Implants 34(4):855\u2013864. https:\/\/doi.org\/10.11607\/jomi.7275","journal-title":"Int J Oral Maxillofac Implants"},{"issue":"3","key":"10187_CR6","doi-asserted-by":"publisher","first-page":"433","DOI":"10.4103\/ccd.ccd_715_18","volume":"10","author":"RV Chandra","year":"2019","unstructured":"Chandra RV, Vaishnavi VS, Chakravarthy YSH (2019) Regenerative capacity of leukocyte-rich and platelet-rich fibrin in indirect sinus elevation procedure may be dependent on model-specific modification of the centrifugation cycle. Contemp Clin Dent. 10(3):433\u2013439. https:\/\/doi.org\/10.4103\/ccd.ccd_715_18","journal-title":"Contemp Clin Dent."},{"issue":"8","key":"10187_CR7","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1080\/09537104.2022.2071851","volume":"33","author":"LMP da Silva","year":"2022","unstructured":"da Silva LMP, S\u00e1vio DSF, de \u00c1vila FC, Vicente RM, Reis GGD, Denardi RJ, da Costa NMM, Silva PHF, Mour\u00e3o CFAB, Miron RJ, Messora MR (2022) Comparison of the effects of platelet concentrates produced by high and low-speed centrifugation protocols on the healing of critical-size defects in rat calvaria: a microtomographic and histomorphometric study. Platelets 33(8):1175\u20131184. https:\/\/doi.org\/10.1080\/09537104.2022.2071851","journal-title":"Platelets"},{"key":"10187_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2020.537138","volume":"7","author":"M Damsaz","year":"2020","unstructured":"Damsaz M, Castagnoli CZ, Eshghpour M, Alamdari DH, Alamdari AH, Noujeim ZEF, Haidar ZS (2020) Evidence-based clinical efficacy of leukocyte and platelet-rich fibrin in maxillary sinus floor lift, graft and surgical augmentation procedures. Front Surg 7:537138. https:\/\/doi.org\/10.3389\/fsurg.2020.537138","journal-title":"Front Surg"},{"issue":"9","key":"10187_CR9","doi-asserted-by":"publisher","first-page":"5485","DOI":"10.1007\/s00784-023-05167-z","volume":"27","author":"CM de Almeida Malzoni","year":"2023","unstructured":"de Almeida Malzoni CM, Pichotano EC, Freitas de Paula LG, de Souza RV, Okamoto R, Austin RS, Zandim-Barcelos DL (2023) Combination of leukocyte and platelet\u2013rich fibrin and demineralized bovine bone graft enhanced bone formation and healing after maxillary sinus augmentation: a randomized clinical trial. Clin Oral Investig 27(9):5485\u20135498. https:\/\/doi.org\/10.1007\/s00784-023-05167-z","journal-title":"Clin Oral Investig"},{"issue":"2","key":"10187_CR10","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.ijom.2018.06.003","volume":"48","author":"P Dragonas","year":"2019","unstructured":"Dragonas P, Katsaros T, Avila-Ortiz G, Chambrone L, Schiavo JH, Palaiologou A (2019) Effects of leukocyte-platelet-rich fibrin (L-PRF) in different intraoral bone grafting procedures: a systematic review. Int J Oral Maxillofac Surg 48(2):250\u2013262. https:\/\/doi.org\/10.1016\/j.ijom.2018.06.003","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"3","key":"10187_CR11","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/s00068-017-0785-7","volume":"45","author":"K El Bagdadi","year":"2019","unstructured":"El Bagdadi K, Kubesch A, Yu X, Al-Maawi S, Orlowska A, Dias A, Booms P, Dohle E, Sader R, Kirkpatrick CJ, Choukroun J, Ghanaati S (2019) Reduction of relative centrifugal forces increases growth factor release within solid platelet-rich-fibrin (PRF)-based matrices: a proof of concept of LSCC (low speed centrifugation concept). Eur J Trauma Emerg Surg 45(3):467\u2013479. https:\/\/doi.org\/10.1007\/s00068-017-0785-7","journal-title":"Eur J Trauma Emerg Surg"},{"issue":"2","key":"10187_CR12","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.cden.2019.12.012","volume":"64","author":"Y Fan","year":"2020","unstructured":"Fan Y, Perez K, Dym H (2020) Clinical uses of platelet-rich fibrin in oral and maxillofacial surgery. Dent Clin North Am 64(2):291\u2013303. https:\/\/doi.org\/10.1016\/j.cden.2019.12.012","journal-title":"Dent Clin North Am"},{"issue":"4","key":"10187_CR13","first-page":"207","volume":"65","author":"G Gurler","year":"2016","unstructured":"Gurler G, Delilbasi C (2016) Effects of leukocyte-platelet rich fibrin on postoperative complications of direct sinus lifting. Minerva Stomatol 65(4):207\u2013212","journal-title":"Minerva Stomatol"},{"key":"10187_CR14","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.108807","author":"N Hadziabdic","year":"2023","unstructured":"Hadziabdic N (2023) PRF and sticky bone as regenerative materials in oral surgery craniofacial surgery\u2014recent advances new perspectives and applications. Intech Open Crossref. https:\/\/doi.org\/10.5772\/intechopen.108807","journal-title":"Intech Open Crossref"},{"issue":"1","key":"10187_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","volume":"17","author":"AR Jadad","year":"1996","unstructured":"Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJM, Gavaghan DJ et al (1996) Avaliando a qualidade dos relat\u00f3rios de ensaios cl\u00ednicos randomizados: o cegamento \u00e9 necess\u00e1rio? Ensaios Cl\u00ednicos De Controle 17(1):1\u201312. https:\/\/doi.org\/10.1016\/0197-2456(95)00134-4","journal-title":"Ensaios Cl\u00ednicos De Controle"},{"key":"10187_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1286035","volume":"12","author":"K Jia","year":"2024","unstructured":"Jia K, You J, Zhu Y, Li M, Chen S, Ren S, Chen S, Zhang J, Wang H, Zhou Y (2024) Platelet-rich fibrin as an autologous biomaterial for bone regeneration: mechanisms, applications, optimization. Front Bioeng Biotechnol 12:1286035. https:\/\/doi.org\/10.3389\/fbioe.2024.1286035","journal-title":"Front Bioeng Biotechnol"},{"issue":"10","key":"10187_CR17","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1002\/jbm.a.36734","volume":"107","author":"RJ Miron","year":"2019","unstructured":"Miron RJ, Chai J, Zheng S, Feng M, Sculean A, Zhang Y (2019) A novel method for evaluating and quantifying cell types in platelet rich fibrin and an introduction to horizontal centrifugation. J Biomed Mater Res A 107(10):2257\u20132271. https:\/\/doi.org\/10.1002\/jbm.a.36734","journal-title":"J Biomed Mater Res A"},{"key":"10187_CR18","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","volume":"5","author":"H Ouzzani","year":"2016","unstructured":"Ouzzani H, Hammady H, Fedorowicz Z, Elmagarmid A (2016) Rayyan \u2014 um aplicativo web e m\u00f3vel para revis\u00f5es sistem\u00e1ticas. Revis\u00f5es Do Sistema 5:210. https:\/\/doi.org\/10.1186\/s13643-016-0384-4","journal-title":"Revis\u00f5es Do Sistema"},{"issue":"160","key":"10187_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/bmj.n160","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, Moher D, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) Explica\u00e7\u00e3o e elabora\u00e7\u00e3o do PRISMA 2020: orienta\u00e7\u00e3o atualizada e exemplares para relatar revis\u00f5es sistem\u00e1ticas. BMJ 372(160):1\u201336. https:\/\/doi.org\/10.1136\/bmj.n160","journal-title":"BMJ"},{"issue":"2","key":"10187_CR20","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/cid.12713","volume":"21","author":"EC Pichotano","year":"2019","unstructured":"Pichotano EC, de Molon RS, de Souza RV, Austin RS, Marcantonio E, Zandim-Barcelos DL (2019) Evaluation of L-PRF combined with deproteinized bovine bone mineral for early implant placement after maxillary sinus augmentation: a randomized clinical trial. Clin Implant Dent Relat Res 21(2):253\u2013262. https:\/\/doi.org\/10.1111\/cid.12713","journal-title":"Clin Implant Dent Relat Res"},{"key":"10187_CR21","unstructured":"PROSPERO (n.d.) International prospective register of systematic reviews. In: About PROSPERO. Retrieved from https:\/\/www.crd.york.ac.uk\/prospero\/#aboutpage"},{"issue":"9","key":"10187_CR22","first-page":"127","volume":"7","author":"A Rahpeyma","year":"2015","unstructured":"Rahpeyma A, Khajehahmadi S (2015) Open sinus lift surgery and the importance of preoperative cone-beam computed tomography scan: a review. J Int Oral Health. 7(9):127\u2013133","journal-title":"J Int Oral Health."},{"issue":"3","key":"10187_CR23","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.jobcr.2020.05.001","volume":"10","author":"A Rezuc","year":"2020","unstructured":"Rezuc A, Saavedra C, Maass R, Poblete C, Nappe C (2020) Histological comparison of DBBM and platelet rich fibrin for guided bone regeneration in a rabbit model. J Oral Biol Craniofac Res 10(3):287\u2013293. https:\/\/doi.org\/10.1016\/j.jobcr.2020.05.001","journal-title":"J Oral Biol Craniofac Res"},{"issue":"2020","key":"10187_CR24","doi-asserted-by":"publisher","first-page":"5073519","DOI":"10.1155\/2020\/5073519","volume":"11","author":"G Serafini","year":"2020","unstructured":"Serafini G, Lollobrigida M, Fortunato L, Mazzucchi G, Lamazza L, Di Nardo D, Vozza I, Riminucci M, De Biase A (2020) Postextractive alveolar ridge preservation using L-PRF: clinical and histological evaluation. Case Rep Dent 11(2020):5073519. https:\/\/doi.org\/10.1155\/2020\/5073519","journal-title":"Case Rep Dent"},{"issue":"10","key":"10187_CR25","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1002\/JPER.21-0369","volume":"93","author":"M Serroni","year":"2022","unstructured":"Serroni M, Paolantonio M, Romano L, Santamaria P, Rexhepi I, Sinjari B, Paolantonio G, Secondi L, De Ninis P, Femminella B (2022) Added benefit of L-PRF to autogenous bone grafts in the treatment of degree II furcation involvement in mandibular molars. J Periodontol 93(10):1486\u20131499. https:\/\/doi.org\/10.1002\/JPER.21-0369","journal-title":"J Periodontol"},{"issue":"8","key":"10187_CR26","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.28072.PMID:36127983;PMCID:PMC9477433","volume":"14","author":"U Shirbhate","year":"2022","unstructured":"Shirbhate U, Bajaj P (2022) Third-generation platelet concentrates in periodontal regeneration: gaining ground in the field of regeneration. Cureus 14(8):e28072. https:\/\/doi.org\/10.7759\/cureus.28072.PMID:36127983;PMCID:PMC9477433","journal-title":"Cureus"},{"issue":"1","key":"10187_CR27","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.cden.2011.09.003","volume":"56","author":"A Stern","year":"2012","unstructured":"Stern A, Green J (2012) Sinus lift procedures: an overview of current techniques. Dent Clin North Am 56(1):219\u2013233. https:\/\/doi.org\/10.1016\/j.cden.2011.09.003","journal-title":"Dent Clin North Am"},{"issue":"12","key":"10187_CR29","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-017-5992-6","volume":"28","author":"S Wend","year":"2017","unstructured":"Wend S, Kubesch A, Orlowska A, Al-Maawi S, Zender N, Dias A, Miron RJ, Sader R, Booms P, Kirkpatrick CJ, Choukroun J, Ghanaati S (2017) Reduction of the relative centrifugal force influences cell number and growth factor release within injectable PRF-based matrices. J Mater Sci Mater Med 28(12):188. https:\/\/doi.org\/10.1007\/s10856-017-5992-6","journal-title":"J Mater Sci Mater Med"},{"issue":"2","key":"10187_CR30","doi-asserted-by":"publisher","first-page":"407","DOI":"10.11607\/jomi.9215","volume":"37","author":"T Y\u00fccesoy","year":"2022","unstructured":"Y\u00fccesoy T, G\u00f6kta\u015f TA (2022) Evaluation of sinus pneumatization and dental implant placement in atrophic maxillary premolar and molar regions. Int J Oral Maxillofac Implants 37(2):407\u2013415. https:\/\/doi.org\/10.11607\/jomi.9215","journal-title":"Int J Oral Maxillofac Implants"}],"container-title":["Cell and Tissue Banking"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10561-025-10187-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10561-025-10187-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10561-025-10187-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T21:02:30Z","timestamp":1759179750000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10561-025-10187-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,26]]},"references-count":29,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["10187"],"URL":"https:\/\/doi.org\/10.1007\/s10561-025-10187-y","relation":{},"ISSN":["1573-6814"],"issn-type":[{"value":"1573-6814","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,26]]},"assertion":[{"value":"19 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"As this was a systematic review, it was not necessary to obtain approval from the research ethics committee to carry out this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human ethics statements and consent to participate"}}],"article-number":"36"}}