{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T16:33:42Z","timestamp":1773938022539,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Bank"],"DOI":"10.1007\/s10561-026-10209-3","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:11:27Z","timestamp":1770718287000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dimethyl fumarate as an immunomodulatory enhancer of adipose-derived mesenchymal stem cells: therapeutic implications"],"prefix":"10.1007","volume":"27","author":[{"given":"Leila","family":"Abdullahi-Keivani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"Montazeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Rahavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Taher","family":"Tahoori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"issue":"4","key":"10209_CR1","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","volume":"8","author":"M Dominici","year":"2006","unstructured":"Dominici M et al (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8(4):315\u2013317","journal-title":"Cytotherapy"},{"issue":"5","key":"10209_CR2","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1002\/path.5357","volume":"250","author":"S Galland","year":"2020","unstructured":"Galland S, Stamenkovic I (2020) Mesenchymal stromal cells in cancer: a review of their immunomodulatory functions and dual effects on tumor progression. J Pathol 250(5):555\u2013572","journal-title":"J Pathol"},{"key":"10209_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.809952","volume":"9","author":"W Gao","year":"2021","unstructured":"Gao W et al (2021) Dissecting the crosstalk between Nrf2 and NF-\u03baB response pathways in drug-induced toxicity. Front Cell Dev Biol 9:809952","journal-title":"Front Cell Dev Biol"},{"issue":"11","key":"10209_CR4","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1084\/jem.20100977","volume":"208","author":"K Ghoreschi","year":"2011","unstructured":"Ghoreschi K et al (2011) Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells. J Exp Med 208(11):2291\u20132303","journal-title":"J Exp Med"},{"issue":"1","key":"10209_CR5","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1358-y","volume":"10","author":"P Hong","year":"2019","unstructured":"Hong P et al (2019) The functions and clinical application potential of exosomes derived from adipose mesenchymal stem cells: a comprehensive review. Stem Cell Res Ther 10(1):242","journal-title":"Stem Cell Res Ther"},{"key":"10209_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108698","volume":"107","author":"H Huldani","year":"2022","unstructured":"Huldani H et al (2022) Immunotherapy of inflammatory bowel disease (IBD) through mesenchymal stem cells. Int Immunopharmacol 107:108698","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"10209_CR7","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1093\/toxres\/tfad016","volume":"12","author":"V Jamshidi","year":"2023","unstructured":"Jamshidi V et al (2023) Accelerating synergistic effects of preconditioned mesenchymal stem cells with Crocin and dexamethasone in pulmonary epithelial cells injury. Toxicol Res 12(3):369\u2013380","journal-title":"Toxicol Res"},{"issue":"7","key":"10209_CR8","doi-asserted-by":"publisher","first-page":"4177","DOI":"10.1007\/s12010-023-04324-0","volume":"195","author":"MA Khan","year":"2023","unstructured":"Khan MA et al (2023) Divulging the intricacies of crosstalk between NF-kB and Nrf-2\/Keap1 pathway in the treatment of arthritis by dimethyl fumarate. Appl Biochem Biotechnol 195(7):4177\u20134195","journal-title":"Appl Biochem Biotechnol"},{"issue":"2","key":"10209_CR9","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1634\/stemcells.2005-0008","volume":"24","author":"M Krampera","year":"2006","unstructured":"Krampera M et al (2006) Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells. Stem Cells 24(2):386\u2013398","journal-title":"Stem Cells"},{"issue":"13","key":"10209_CR10","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1007\/s00018-017-2473-5","volume":"74","author":"N Li","year":"2017","unstructured":"Li N, Hua J (2017a) Interactions between mesenchymal stem cells and the immune system. Cell Mol Life Sci 74(13):2345\u20132360","journal-title":"Cell Mol Life Sci"},{"key":"10209_CR11","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1007\/s00018-017-2473-5","volume":"74","author":"N Li","year":"2017","unstructured":"Li N, Hua J (2017b) Interactions between mesenchymal stem cells and the immune system. Cell Mol Life Sci 74:2345\u20132360","journal-title":"Cell Mol Life Sci"},{"key":"10209_CR12","doi-asserted-by":"publisher","first-page":"1074863","DOI":"10.3389\/fimmu.2023.1074863","volume":"14","author":"W Li","year":"2023","unstructured":"Li W et al (2023) The role of TNF-alpha in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment. Front Immunol 14:1074863","journal-title":"Front Immunol"},{"issue":"11","key":"10209_CR13","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-013-0394-8","volume":"13","author":"RA Linker","year":"2013","unstructured":"Linker RA, Gold R (2013) Dimethyl fumarate for treatment of multiple sclerosis: mechanism of action, effectiveness, and side effects. Curr Neurol Neurosci Rep 13(11):394","journal-title":"Curr Neurol Neurosci Rep"},{"key":"10209_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179531","author":"L L\u00f3pez-Garc\u00eda","year":"2021","unstructured":"L\u00f3pez-Garc\u00eda L, Castro-Manrreza ME (2021) TNF-\u03b1 and IFN-\u03b3 participate in improving the immunoregulatory capacity of mesenchymal stem\/stromal cells: importance of cell-cell contact and extracellular vesicles. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms22179531","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10209_CR15","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/cdd.2013.158","volume":"21","author":"S Ma","year":"2014","unstructured":"Ma S et al (2014) Immunobiology of mesenchymal stem cells. Cell Death Differ 21(2):216\u2013225","journal-title":"Cell Death Differ"},{"key":"10209_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-213X-10-47","volume":"10","author":"S-W Qian","year":"2010","unstructured":"Qian S-W et al (2010) Characterization of adipocyte differentiation from human mesenchymal stem cells in bone marrow. BMC Dev Biol 10:1\u201311","journal-title":"BMC Dev Biol"},{"key":"10209_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12861-021-00246-4","volume":"21","author":"S Rawat","year":"2021","unstructured":"Rawat S, Dadhwal V, Mohanty S (2021) Dexamethasone priming enhances stemness and immunomodulatory property of tissue-specific human mesenchymal stem cells. BMC Dev Biol 21:1\u201318","journal-title":"BMC Dev Biol"},{"issue":"2","key":"10209_CR18","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.stem.2007.11.014","volume":"2","author":"G Ren","year":"2008","unstructured":"Ren G et al (2008) Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell 2(2):141\u2013150","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10209_CR19","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1124\/jpet.111.190132","volume":"341","author":"RH Scannevin","year":"2012","unstructured":"Scannevin RH et al (2012) Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway. J Pharmacol Exp Ther 341(1):274\u2013284","journal-title":"J Pharmacol Exp Ther"},{"issue":"10","key":"10209_CR20","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1182\/blood.2020009404","volume":"138","author":"A Schmitt","year":"2021","unstructured":"Schmitt A et al (2021) Dimethyl fumarate induces ferroptosis and impairs NF-\u03baB\/STAT3 signaling in DLBCL. Blood 138(10):871\u2013884","journal-title":"Blood"},{"issue":"9","key":"10209_CR21","doi-asserted-by":"publisher","first-page":"6375","DOI":"10.1007\/s11033-021-06638-w","volume":"48","author":"S Shekarchi","year":"2021","unstructured":"Shekarchi S et al (2021) Dimethyl fumarate prevents cytotoxicity and apoptosis mediated by oxidative stress in human adipose-derived mesenchymal stem cells. Mol Biol Rep 48(9):6375\u20136385","journal-title":"Mol Biol Rep"},{"issue":"4","key":"10209_CR22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010088","volume":"5","author":"RS Waterman","year":"2010","unstructured":"Waterman RS et al (2010) A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an immunosuppressive MSC2 phenotype. PLoS ONE 5(4):e10088","journal-title":"PLoS ONE"},{"issue":"2","key":"10209_CR23","doi-asserted-by":"publisher","first-page":"677","DOI":"10.3892\/ijmm.2020.4830","volume":"47","author":"X Wei","year":"2021","unstructured":"Wei X et al (2021) Ultrasound-targeted microbubble destruction-mediated Galectin-7-siRNA promotes the homing of bone marrow mesenchymal stem cells to alleviate acute myocardial infarction in rats. Int J Mol Med 47(2):677\u2013687","journal-title":"Int J Mol Med"},{"key":"10209_CR24","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/3602962","volume":"2023","author":"X-w Yao","year":"2023","unstructured":"Yao X-w et al (2023) Exosomes from adipose-derived stem cells alleviate dexamethasone-induced bone loss by regulating the Nrf2\/HO-1 axis. Oxid Med Cell Longev 2023:3602962","journal-title":"Oxid Med Cell Longev"},{"key":"10209_CR25","unstructured":"Zamini A, et al (2008) Osteogenic differentiation of rat mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells: melatonin as a differentiation factor"}],"container-title":["Cell and Tissue Banking"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10561-026-10209-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10561-026-10209-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10561-026-10209-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T15:02:30Z","timestamp":1773932550000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10561-026-10209-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,10]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["10209"],"URL":"https:\/\/doi.org\/10.1007\/s10561-026-10209-3","relation":{},"ISSN":["1573-6814"],"issn-type":[{"value":"1573-6814","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,10]]},"assertion":[{"value":"19 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All experimental protocols in this study were evaluated and approved by the Ethics Committee of Shahid Sadoughi University of Medical Sciences, Yazd, Iran (Approval No.: IR.SSU.MEDICINE.REC.1396.102).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"8"}}