{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:15:41Z","timestamp":1788322541763,"version":"build-2803163510"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003358","name":"Gedeon Richter","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003358","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009232","name":"University of Debrecen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009232","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Bank"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Human brain tissues obtained from autopsies, as well as muscle and nerve samples derived from biopsies, constitute indispensable resources for translational research investigating the pathomechanisms of neuropsychiatric disorders. In this study, we introduce the Nervous System Tissue Bank of University of Debrecen, which contains formalin-preserved and formalin-fixed paraffin-embedded (FFPE) brain samples, as well as frozen nerve and muscle biopsy specimens. Database was established containing clinical and pathological parameters. For autopsy cases, the following variables were recorded: sex, age, number of hospitalization days, admission diagnosis, comorbidities, cause of death, post-mortem interval, general autopsy findings, and macro- and microscopic brain pathology diagnoses. For biopsy samples, we recorded: sex, age, biopsy site, and microscopic and molecular genetic diagnoses. Based on the recorded parameters and their temporal changes, retrospective statistical analyses were performed. Formalin-fixed brain samples and FFPE blocks were available from 2425 deceased individuals, and nerve\/muscle samples from 257 patients. The brain samples originate from the period between 1990 and 2012. The most frequent admission diagnoses included ischemic stroke (n\u2009=\u20091070), hemorrhagic stroke (n\u2009=\u2009462), subarachnoid hemorrhage (n\u2009=\u2009102), epilepsy (n\u2009=\u2009103), brain metastasis (n\u2009=\u200970), primary brain tumor (n\u2009=\u200960), parkinsonism (n\u2009=\u200928), dementia (n\u2009=\u200921), and amyotrophic lateral sclerosis (n\u2009=\u200921). Prevalence of hypertension (67.6%) and diabetes mellitus (20.1%) showed a significant increase over time (\n                    <jats:italic>p\u2009&lt;\u2009<\/jats:italic>\n                    0.001), whereas the prevalence of malignancies, dementia, parkinsonism, and psychiatric disorders remained stable. Our tissue bank represents the largest nervous system collection in Hungary, providing well-characterized brain, muscle, and nerve samples linked to nearly three decades of clinical data. Samples are made available to researchers.\n                  <\/jats:p>","DOI":"10.1007\/s10561-026-10249-9","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:36:22Z","timestamp":1788320182000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Establishment of a novel human nervous system tissue bank: University of Debrecen tissue bank\u2014introduction and retrospective data analysis"],"prefix":"10.1007","volume":"27","author":[{"given":"Viktor","family":"Bencs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"Hortob\u00e1gyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila Csaba","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rk","family":"Koz\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"M\u00e9hes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Ol\u00e1h","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Csiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"10249_CR1","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.5858\/arpa.2013-0691-RA","volume":"138","author":"BP Bass","year":"2014","unstructured":"Bass BP, Engel KB, Greytak SR, Moore HM (2014) A review of preanalytical factors affecting molecular, protein, and morphological analysis of formalin-fixed, paraffin-embedded (FFPE) tissue: how well do you know your FFPE specimen? Arch Pathol Lab Med 138:1520\u20131530. https:\/\/doi.org\/10.5858\/arpa.2013-0691-RA","journal-title":"Arch Pathol Lab Med"},{"key":"10249_CR2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-066404","volume":"13","author":"M Bennett","year":"2023","unstructured":"Bennett M, Pistillo A, Recalde M et al (2023) Time trends in the incidence of cardiovascular disease, hypertension and diabetes by sex and socioeconomic status in Catalonia, Spain: a population-based cohort study. BMJ Open 13:e066404. https:\/\/doi.org\/10.1136\/bmjopen-2022-066404","journal-title":"BMJ Open"},{"key":"10249_CR3","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H et al (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74:229\u2013263. https:\/\/doi.org\/10.3322\/caac.21834","journal-title":"CA Cancer J Clin"},{"key":"10249_CR4","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S1474-4422(19)30411-9","volume":"19","author":"VL Feigin","year":"2020","unstructured":"Feigin VL, Vos T, Nichols E et al (2020) The global burden of neurological disorders: translating evidence into policy. Lancet Neurol 19:255\u2013265. https:\/\/doi.org\/10.1016\/S1474-4422(19)30411-9","journal-title":"Lancet Neurol"},{"key":"10249_CR5","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/j.1750-3639.2007.00073.x","volume":"17","author":"I Ferrer","year":"2007","unstructured":"Ferrer I, Armstrong J, Capellari S et al (2007) Effects of formalin fixation, paraffin embedding, and time of storage on DNA preservation in brain tissue: a BrainNet Europe study. Brain Pathol 17:297\u2013303. https:\/\/doi.org\/10.1111\/j.1750-3639.2007.00073.x","journal-title":"Brain Pathol"},{"key":"10249_CR6","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.prp.2012.07.001","volume":"208","author":"KS Funabashi","year":"2012","unstructured":"Funabashi KS, Barcelos D, Vison\u00e1 I et al (2012) DNA extraction and molecular analysis of non-tumoral liver, spleen, and brain from autopsy samples: the effect of formalin fixation and paraffin embedding. Pathol Res Pract 208:584\u2013591. https:\/\/doi.org\/10.1016\/j.prp.2012.07.001","journal-title":"Pathol Res Pract"},{"key":"10249_CR7","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/S1474-4422(17)30299-5","volume":"16","author":"GBD 2015 Neurological Disorders Collaborator Group","year":"2017","unstructured":"GBD 2015 Neurological Disorders Collaborator Group (2017) Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Neurol 16:877\u2013897. https:\/\/doi.org\/10.1016\/S1474-4422(17)30299-5","journal-title":"Lancet Neurol"},{"key":"10249_CR8","doi-asserted-by":"publisher","first-page":"2686","DOI":"10.1161\/CIRCULATIONAHA.118.033236","volume":"137","author":"L Goldman","year":"2018","unstructured":"Goldman L (2018) Autopsy 2018: still necessary, even if occasionally not sufficient. Circulation 137:2686\u20132688. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.118.033236","journal-title":"Circulation"},{"key":"10249_CR9","unstructured":"(2016) Hatvanezer mint\u00e1t t\u00e1rolnak a vil\u00e1gszinten is egyed\u00fcl\u00e1ll\u00f3 Hum\u00e1n Agysz\u00f6vet Bank \u00e9s Laborat\u00f3riumban. https:\/\/semmelweis.hu\/hirek\/2016\/12\/29\/hatvanezer-mintat-tarolnak-a-vilagszinten-is-egyedulallo-human-agyszovet-bank-es-laboratoriumban\/. Accessed 2 July 2025"},{"key":"10249_CR10","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1136\/svn-2021-001030","volume":"7","author":"L Hud\u00e1k","year":"2022","unstructured":"Hud\u00e1k L, Nagy AC, Moln\u00e1r S et al (2022) Discrepancies between clinical and autopsy findings in patients who had an acute stroke. 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As this was a retrospective study and all individuals from whom the data were derived were deceased, obtaining informed consent was not possible and was not required in accordance with the relevant ethical guidelines and applicable Hungarian laws and regulations.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"47"}}