{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:51:13Z","timestamp":1792000273363,"version":"4.4.0"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ60022"],"award-info":[{"award-number":["2023JJ60022"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Bank"],"DOI":"10.1007\/s10561-026-10255-x","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:23:55Z","timestamp":1791998635000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Research hotspots and emerging trends of 3D printing in bone defects: a bibliometric analysis based on Web of Science core collection from 2006 to March 2026"],"prefix":"10.1007","volume":"27","author":[{"given":"Xiongjie","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"10255_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2024.213900","volume":"161","author":"M Babaei","year":"2024","unstructured":"Babaei M, Ebrahim-Najafabadi N, Mirzadeh M et al (2024) A comprehensive bench-to-bed look into the application of gamma-sterilized 3D-printed polycaprolactone\/hydroxyapatite implants for craniomaxillofacial defects, an in vitro, in vivo, and clinical study. Biomater Adv 161:213900. https:\/\/doi.org\/10.1016\/j.bioadv.2024.213900","journal-title":"Biomater Adv"},{"key":"10255_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102351","volume":"35","author":"Y Bai","year":"2025","unstructured":"Bai Y, Wu N, Li X (2025) Recent progress of 3D printed responsive scaffolds for bone repair: a review. Mater Today Bio 35:102351. https:\/\/doi.org\/10.1016\/j.mtbio.2025.102351","journal-title":"Mater Today Bio"},{"issue":"12","key":"10255_CR3","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.mattod.2013.11.017","volume":"16","author":"S Bose","year":"2013","unstructured":"Bose S, Vahabzadeh S, Bandyopadhyay A (2013) Bone tissue engineering using 3D printing. Mater Today 16(12):496\u2013504. https:\/\/doi.org\/10.1016\/j.mattod.2013.11.017","journal-title":"Mater Today"},{"issue":"7","key":"10255_CR4","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1002\/hed.27660","volume":"46","author":"CF Chen","year":"2024","unstructured":"Chen CF, Chen CM, Huang WC et al (2024) The use of customized 3D-printed mandibular prostheses with pressure-reducing device: a clinical trial. Head Neck 46(7):1614\u20131624. https:\/\/doi.org\/10.1002\/hed.27660","journal-title":"Head Neck"},{"issue":"1","key":"10255_CR5","doi-asserted-by":"publisher","DOI":"10.1186\/s13036-015-0001-4","volume":"9","author":"HN Chia","year":"2015","unstructured":"Chia HN, Wu BM (2015) Recent advances in 3D printing of biomaterials. J Biol Eng 9(1):4. https:\/\/doi.org\/10.1186\/s13036-015-0001-4","journal-title":"J Biol Eng"},{"issue":"21","key":"10255_CR6","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202010609","volume":"31","author":"MN Collins","year":"2021","unstructured":"Collins MN, Ren G, Young K, Pina S, Reis RL, Oliveira JM (2021) Scaffold fabrication technologies and structure\/function properties in bone tissue engineering. Adv Funct Mater 31(21):2010609. https:\/\/doi.org\/10.1002\/adfm.202010609","journal-title":"Adv Funct Mater"},{"issue":"23-24","key":"10255_CR7","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1089\/ten.tea.2020.0191","volume":"26","author":"A Conev","year":"2020","unstructured":"Conev A, Litsa EE, Perez MR, Diba M, Mikos AG, Kavraki LE (2020) Machine learning-guided three-dimensional printing of tissue engineering scaffolds. Tissue Eng Part A 26(23\u201324):1359\u20131368. https:\/\/doi.org\/10.1089\/ten.tea.2020.0191","journal-title":"Tissue Eng Part A"},{"issue":"2","key":"10255_CR8","first-page":"129","volume":"15","author":"A Cucchi","year":"2022","unstructured":"Cucchi A, Bettini S, Corinaldesi G (2022) A novel technique for digitalisation and customisation of reinforced polytetrafluoroethylene meshes: preliminary results of a clinical trial. Int J Oral Implantol 15(2):129\u2013146","journal-title":"Int J Oral Implantol"},{"issue":"1","key":"10255_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-022-06843-3","volume":"23","author":"CM de Almeida Malzoni","year":"2022","unstructured":"de Almeida Malzoni CM, Gon\u00e7alves V, Possari J, Junior EM (2022) The use of 3D ceramic block graft compared with autogenous block graft for rehabilitation of the atrophic maxilla: a randomized controlled clinical trial. Trials 23(1):903. https:\/\/doi.org\/10.1186\/s13063-022-06843-3","journal-title":"Trials"},{"issue":"2","key":"10255_CR10","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.bioactmat.2017.11.008","volume":"3","author":"S Derakhshanfar","year":"2018","unstructured":"Derakhshanfar S, Mbeleck R, Xu K, Zhang X, Zhong W, Xing M (2018) 3D bioprinting for biomedical devices and tissue engineering: a review of recent trends and advances. Bioact Mater 3(2):144\u2013156. https:\/\/doi.org\/10.1016\/j.bioactmat.2017.11.008","journal-title":"Bioact Mater"},{"issue":"20","key":"10255_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28207039","volume":"28","author":"Q Ding","year":"2023","unstructured":"Ding Q, Zhang S, Liu X et al (2023) Hydrogel tissue bioengineered scaffolds in bone repair: a review. Molecules 28(20):7039. https:\/\/doi.org\/10.3390\/molecules28207039","journal-title":"Molecules"},{"issue":"12","key":"10255_CR12","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1002\/adhm.201500168","volume":"4","author":"AV Do","year":"2015","unstructured":"Do AV, Khorsand B, Geary SM, Salem AK (2015) 3D printing of scaffolds for tissue regeneration applications. Adv Healthc Mater 4(12):1742\u20131762. https:\/\/doi.org\/10.1002\/adhm.201500168","journal-title":"Adv Healthc Mater"},{"issue":"4","key":"10255_CR13","doi-asserted-by":"publisher","first-page":"505","DOI":"10.3897\/folmed.66.e123766","volume":"66","author":"K Giragosyan","year":"2024","unstructured":"Giragosyan K, Chenchev I, Ivanova V (2024) Linear bone gain and healing complication rate comparative outcomes following ridge augmentation with custom 3D printed titanium mesh vs Ti-reinforced dPTFE. A randomized clinical trial. Folia Med 66(4):505\u2013514. https:\/\/doi.org\/10.3897\/folmed.66.e123766","journal-title":"Folia Med"},{"key":"10255_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123751","volume":"327","author":"M Gong","year":"2026","unstructured":"Gong M, Zha Y, Lu S et al (2026) Efficacy and safety of the low-temperature-derived 3D printed biodegradable Mg-containing composite porous scaffold for bone defect repair: a prospective and multi-center randomized controlled trial. Biomaterials 327:123751. https:\/\/doi.org\/10.1016\/j.biomaterials.2025.123751","journal-title":"Biomaterials"},{"issue":"8","key":"10255_CR15","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-020-06406-5","volume":"31","author":"G Hou","year":"2020","unstructured":"Hou G, Liu B, Tian Y et al (2020) An innovative strategy to treat large metaphyseal segmental femoral bone defect using customized design and 3D printed micro-porous prosthesis: a prospective clinical study. J Mater Sci Mater Med 31(8):66. https:\/\/doi.org\/10.1007\/s10856-020-06406-5","journal-title":"J Mater Sci Mater Med"},{"issue":"6","key":"10255_CR16","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1097\/SCS.0000000000011829","volume":"36","author":"J Hu","year":"2025","unstructured":"Hu J, Yang X, Yang X, Xu H (2025) Clinical trial of 3D-printed PCL\/\u03b2-TCP composite scaffold for craniofacial reconstruction in China. J Craniofac Surg 36(6):2158\u20132160. https:\/\/doi.org\/10.1097\/SCS.0000000000011829","journal-title":"J Craniofac Surg"},{"key":"10255_CR17","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.bioactmat.2023.10.031","volume":"33","author":"X Huang","year":"2024","unstructured":"Huang X, Lou Y, Duan Y et al (2024) Biomaterial scaffolds in maxillofacial bone tissue engineering: a review of recent advances. Bioact Mater 33:129\u2013156. https:\/\/doi.org\/10.1016\/j.bioactmat.2023.10.031","journal-title":"Bioact Mater"},{"issue":"13","key":"10255_CR18","doi-asserted-by":"publisher","first-page":"4026","DOI":"10.1016\/j.biomaterials.2014.01.064","volume":"35","author":"JA Inzana","year":"2014","unstructured":"Inzana JA, Olvera D, Fuller SM et al (2014) 3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration. Biomaterials 35(13):4026\u20134034. https:\/\/doi.org\/10.1016\/j.biomaterials.2014.01.064","journal-title":"Biomaterials"},{"issue":"358","key":"10255_CR19","doi-asserted-by":"publisher","first-page":"358ra127","DOI":"10.1126\/scitranslmed.aaf7704","volume":"8","author":"AE Jakus","year":"2016","unstructured":"Jakus AE, Rutz AL, Jordan SW et al (2016) Hyperelastic \u201cbone\u201d: a highly versatile, growth factor\u2013free, osteoregenerative, scalable, and surgically friendly biomaterial. Sci Transl Med 8(358):358ra127-358ra127. https:\/\/doi.org\/10.1126\/scitranslmed.aaf7704","journal-title":"Sci Transl Med"},{"issue":"3","key":"10255_CR20","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1038\/nbt.3413","volume":"34","author":"HW Kang","year":"2016","unstructured":"Kang HW, Lee SJ, Ko IK, Kengla C, Yoo JJ, Atala A (2016) A 3D bioprinting system to produce human-scale tissue constructs with structural integrity. Nat Biotechnol 34(3):312\u2013319. https:\/\/doi.org\/10.1038\/nbt.3413","journal-title":"Nat Biotechnol"},{"key":"10255_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00842","volume":"11","author":"L Ke","year":"2020","unstructured":"Ke L, Lu C, Shen R, Lu T, Ma B, Hua Y (2020) Knowledge mapping of drug-induced liver injury: a scientometric investigation (2010-2019). Front Pharmacol 11:842. https:\/\/doi.org\/10.3389\/fphar.2020.00842","journal-title":"Front Pharmacol"},{"issue":"1","key":"10255_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-53686-w","volume":"14","author":"NH Kim","year":"2024","unstructured":"Kim NH, Yang BE, On SW et al (2024) Customized three-dimensional printed ceramic bone grafts for osseous defects: a prospective randomized study. Sci Rep 14(1):3397. https:\/\/doi.org\/10.1038\/s41598-024-53686-w","journal-title":"Sci Rep"},{"issue":"8","key":"10255_CR23","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/s41578-020-0204-2","volume":"5","author":"GL Koons","year":"2020","unstructured":"Koons GL, Diba M, Mikos AG (2020) Materials design for bone-tissue engineering. Nat Rev Mater 5(8):584\u2013603. https:\/\/doi.org\/10.1038\/s41578-020-0204-2","journal-title":"Nat Rev Mater"},{"issue":"9","key":"10255_CR24","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202202766","volume":"12","author":"TM Koushik","year":"2023","unstructured":"Koushik TM, Miller CM, Antunes E (2023) Bone tissue engineering scaffolds: function of multi-material hierarchically structured scaffolds. Adv Healthc Mater 12(9):2202766. https:\/\/doi.org\/10.1002\/adhm.202202766","journal-title":"Adv Healthc Mater"},{"key":"10255_CR25","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.biomaterials.2019.01.013","volume":"197","author":"Y Lai","year":"2019","unstructured":"Lai Y, Li Y, Cao H et al (2019) Osteogenic magnesium incorporated into PLGA\/TCP porous scaffold by 3D printing for repairing challenging bone defect. Biomaterials 197:207\u2013219. https:\/\/doi.org\/10.1016\/j.biomaterials.2019.01.013","journal-title":"Biomaterials"},{"issue":"9","key":"10255_CR26","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.1016\/j.matt.2022.06.003","volume":"5","author":"SS Lee","year":"2022","unstructured":"Lee SS, Du X, Kim I, Ferguson SJ (2022) Scaffolds for bone-tissue engineering. Matter 5(9):2722\u20132759. https:\/\/doi.org\/10.1016\/j.matt.2022.06.003","journal-title":"Matter"},{"key":"10255_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-025-01370-z","volume":"24","author":"H Li","year":"2025","unstructured":"Li H, Zhang Z, Liu J, Wang H (2025) Antioxidant scaffolds for enhanced bone regeneration: recent advances and challenges. Biomed Eng Online 24:41. https:\/\/doi.org\/10.1186\/s12938-025-01370-z","journal-title":"Biomed Eng Online"},{"key":"10255_CR28","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S583425","volume":"21","author":"G Li","year":"2026","unstructured":"Li G, Wang Y, Wang D, Cui H, Qin M, Ma J (2026) GelMA-based nanocomposites for bone defect regeneration: design, performance, and clinical translation potential. Int J Nanomed 21:583425. https:\/\/doi.org\/10.2147\/IJN.S583425","journal-title":"Int J Nanomed"},{"key":"10255_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbusres.2024.114760","volume":"182","author":"WM Lim","year":"2024","unstructured":"Lim WM, Kumar S, Donthu N (2024) How to combine and clean bibliometric data and use bibliometric tools synergistically: guidelines using metaverse research. J Bus Res 182:114760. https:\/\/doi.org\/10.1016\/j.jbusres.2024.114760","journal-title":"J Bus Res"},{"issue":"8","key":"10255_CR30","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1016\/j.bioactmat.2021.01.015","volume":"6","author":"T Liu","year":"2021","unstructured":"Liu T, Xu J, Pan X et al (2021) Advances of adipose-derived mesenchymal stem cells-based biomaterial scaffolds for oral and maxillofacial tissue engineering. Bioact Mater 6(8):2467\u20132478. https:\/\/doi.org\/10.1016\/j.bioactmat.2021.01.015","journal-title":"Bioact Mater"},{"issue":"2","key":"10255_CR31","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1021\/acsbiomaterials.3c01368","volume":"10","author":"A Logeshwaran","year":"2024","unstructured":"Logeshwaran A, Elsen R, Nayak S (2024) Artificial intelligence-based 3D printing strategies for bone scaffold fabrication and its application in preclinical and clinical investigations. ACS Biomater Sci Eng 10(2):677\u2013696. https:\/\/doi.org\/10.1021\/acsbiomaterials.3c01368","journal-title":"ACS Biomater Sci Eng"},{"issue":"10","key":"10255_CR32","doi-asserted-by":"publisher","first-page":"4308","DOI":"10.1111\/iwj.14333","volume":"20","author":"Y Lu","year":"2023","unstructured":"Lu Y, Sun N, Wu P, Zhou G, Peng L, Tang J (2023) The application of infrared thermography technology in flap: a perspective from bibliometric and visual analysis. Int Wound J 20(10):4308\u20134327. https:\/\/doi.org\/10.1111\/iwj.14333","journal-title":"Int Wound J"},{"key":"10255_CR33","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1291969","volume":"11","author":"N Lv","year":"2023","unstructured":"Lv N, Zhou Z, Hou M et al (2023) Research progress of vascularization strategies of tissue-engineered bone. Front Bioeng Biotechnol 11:1291969. https:\/\/doi.org\/10.3389\/fbioe.2023.1291969","journal-title":"Front Bioeng Biotechnol"},{"key":"10255_CR34","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.actbio.2018.08.026","volume":"79","author":"H Ma","year":"2018","unstructured":"Ma H, Feng C, Chang J, Wu C (2018) 3D-printed bioceramic scaffolds: from bone tissue engineering to tumor therapy. Acta Biomater 79:37\u201359. https:\/\/doi.org\/10.1016\/j.actbio.2018.08.026","journal-title":"Acta Biomater"},{"issue":"2","key":"10255_CR35","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202307846","volume":"36","author":"L Ma","year":"2024","unstructured":"Ma L, Cheng Y, Feng X et al (2024) A Janus-ROS healing system promoting infectious bone regeneration via sono-epigenetic modulation. Adv Mater 36(2):e2307846. https:\/\/doi.org\/10.1002\/adma.202307846","journal-title":"Adv Mater"},{"issue":"4","key":"10255_CR36","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.biotechadv.2015.12.011","volume":"34","author":"C Mandrycky","year":"2016","unstructured":"Mandrycky C, Wang Z, Kim K, Kim DH (2016) 3D bioprinting for engineering complex tissues. Biotechnol Adv 34(4):422\u2013434. https:\/\/doi.org\/10.1016\/j.biotechadv.2015.12.011","journal-title":"Biotechnol Adv"},{"key":"10255_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119536","volume":"226","author":"I Matai","year":"2020","unstructured":"Matai I, Kaur G, Seyedsalehi A, McClinton A, Laurencin CT (2020) Progress in 3D bioprinting technology for tissue\/organ regenerative engineering. Biomaterials 226:119536. https:\/\/doi.org\/10.1016\/j.biomaterials.2019.119536","journal-title":"Biomaterials"},{"key":"10255_CR38","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.actbio.2022.04.014","volume":"156","author":"M Mirkhalaf","year":"2023","unstructured":"Mirkhalaf M, Men Y, Wang R, No Y, Zreiqat H (2023) Personalized 3D printed bone scaffolds: a review. Acta Biomater 156:110\u2013124. https:\/\/doi.org\/10.1016\/j.actbio.2022.04.014","journal-title":"Acta Biomater"},{"issue":"8","key":"10255_CR39","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/nbt.2958","volume":"32","author":"SV Murphy","year":"2014","unstructured":"Murphy SV, Atala A (2014) 3D bioprinting of tissues and organs. Nat Biotechnol 32(8):773\u2013785. https:\/\/doi.org\/10.1038\/nbt.2958","journal-title":"Nat Biotechnol"},{"key":"10255_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2023.102231","volume":"43","author":"N Nashi","year":"2023","unstructured":"Nashi N, Kagda FH (2023) Current concepts of bone grafting in trauma surgery. J Clin Orthop Trauma 43:102231. https:\/\/doi.org\/10.1016\/j.jcot.2023.102231","journal-title":"J Clin Orthop Trauma"},{"issue":"9","key":"10255_CR41","doi-asserted-by":"publisher","first-page":"5191","DOI":"10.1007\/s11192-025-05415-x","volume":"130","author":"M Nowakowska","year":"2025","unstructured":"Nowakowska M (2025) A comprehensive approach to preprocessing data for bibliometric analysis. Scientometrics 130(9):5191\u20135225. https:\/\/doi.org\/10.1007\/s11192-025-05415-x","journal-title":"Scientometrics"},{"key":"10255_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-024-00332-w","volume":"12","author":"L Qin","year":"2024","unstructured":"Qin L, Yang S, Zhao C (2024) Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections. Bone Res 12:28. https:\/\/doi.org\/10.1038\/s41413-024-00332-w","journal-title":"Bone Res"},{"issue":"1","key":"10255_CR43","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.1038\/s41467-025-57609-9","volume":"16","author":"Y Qin","year":"2025","unstructured":"Qin Y, Jing Z, Zou D et al (2025) A metamaterial scaffold beyond modulus limits: enhanced osteogenesis and angiogenesis of critical bone defects. Nat Commun 16(1):2180. https:\/\/doi.org\/10.1038\/s41467-025-57609-9","journal-title":"Nat Commun"},{"issue":"6","key":"10255_CR44","doi-asserted-by":"publisher","first-page":"327","DOI":"10.36922\/IJB025270257","volume":"11","author":"R Quan","year":"2025","unstructured":"Quan R, Liu F, Cantero-Chinchilla S (2025) Integrating machine learning and finite element simulation for interpretable prediction of 3D-printed bone scaffold mechanics. Int J Biopr 11(6):327\u2013348. https:\/\/doi.org\/10.36922\/IJB025270257","journal-title":"Int J Biopr"},{"issue":"15","key":"10255_CR45","doi-asserted-by":"publisher","DOI":"10.3390\/su14159455","volume":"14","author":"P Rita","year":"2022","unstructured":"Rita P, Ramos RF (2022) Global research trends in consumer behavior and sustainability in E-commerce: a bibliometric analysis of the knowledge structure. Sustainability 14(15):9455. https:\/\/doi.org\/10.3390\/su14159455","journal-title":"Sustainability"},{"key":"10255_CR46","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.msec.2017.05.017","volume":"78","author":"L Roseti","year":"2017","unstructured":"Roseti L, Parisi V, Petretta M et al (2017) Scaffolds for bone tissue engineering: state of the art and new perspectives. Mater Sci Eng C Mater Biol Appl 78:1246\u20131262. https:\/\/doi.org\/10.1016\/j.msec.2017.05.017","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"10255_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102685","volume":"36","author":"Z Sabouri","year":"2026","unstructured":"Sabouri Z, Dequeecker M, Anees H et al (2026) Recent advances in biomaterials for bone regeneration: Bridging innovation and clinical translation. Mater Today Bio 36:102685. https:\/\/doi.org\/10.1016\/j.mtbio.2025.102685","journal-title":"Mater Today Bio"},{"key":"10255_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100382","volume":"16","author":"M Shen","year":"2022","unstructured":"Shen M, Wang L, Gao Y et al (2022) 3D bioprinting of in situ vascularized tissue engineered bone for repairing large segmental bone defects. Mater Today Bio 16:100382. https:\/\/doi.org\/10.1016\/j.mtbio.2022.100382","journal-title":"Mater Today Bio"},{"key":"10255_CR49","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-15122-5","volume":"15","author":"A Shetty","year":"2025","unstructured":"Shetty A, Fathima A, Anika B (2025) Computational optimization of 3D printed bone scaffolds using orthogonal array-driven FEA and neural network modeling. Sci Rep 15:30515. https:\/\/doi.org\/10.1038\/s41598-025-15122-5","journal-title":"Sci Rep"},{"key":"10255_CR50","doi-asserted-by":"publisher","first-page":"1108942","DOI":"10.3389\/fsurg.2023.1108942","volume":"10","author":"N Sun","year":"2023","unstructured":"Sun N, Khan UZ, Zeng L et al (2023a) Successful management of a rare radius schwannoma mimicking malignant bone tumors: a case report and literature review. Front Surg 10:1108942. https:\/\/doi.org\/10.3389\/fsurg.2023.1108942","journal-title":"Front Surg"},{"issue":"10","key":"10255_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e20363","volume":"9","author":"N Sun","year":"2023","unstructured":"Sun N, Xing Y, Jiang J, Wu P, Qing L, Tang J (2023b) Knowledge mapping and emerging trends of ferroptosis in ischemia reperfusion injury research: a bibliometric analysis (2013-2022). Heliyon 9(10):e20363. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e20363","journal-title":"Heliyon"},{"issue":"3","key":"10255_CR52","first-page":"1569","volume":"15","author":"N Sun","year":"2023","unstructured":"Sun N, Ke L, Qing L et al (2023c) The research landscape on vascularized composite allografts: a bibliometric analysis (2002\u20132021). Am J Transl Res 15(3):1569\u20131589","journal-title":"Am J Transl Res"},{"issue":"2","key":"10255_CR53","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14587","volume":"21","author":"N Sun","year":"2024","unstructured":"Sun N, Sun Y, Xing Y et al (2024) Knowledge mapping and research trends of stem cell in wound healing: a bibliometric analysis. Int Wound J 21(2):e14587. https:\/\/doi.org\/10.1111\/iwj.14587","journal-title":"Int Wound J"},{"key":"10255_CR54","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-025-01381-w","volume":"24","author":"J Sun","year":"2025","unstructured":"Sun J, Chen C, Zhang B, Yao C, Zhang Y (2025) Advances in 3D-printed scaffold technologies for bone defect repair: materials, biomechanics, and clinical prospects. BioMed Eng Online 24:51. https:\/\/doi.org\/10.1186\/s12938-025-01381-w","journal-title":"BioMed Eng Online"},{"key":"10255_CR55","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2025.1707406","volume":"13","author":"X Tang","year":"2025","unstructured":"Tang X, Xu H, Liu X, Yang Y, Li Z (2025) Advances in 3D-printed scaffolds for bone defect repair: material strategies and synergistic functional performance. Front Bioeng Biotechnol 13:1707406. https:\/\/doi.org\/10.3389\/fbioe.2025.1707406","journal-title":"Front Bioeng Biotechnol"},{"issue":"5","key":"10255_CR56","doi-asserted-by":"publisher","DOI":"10.1002\/cre2.70237","volume":"11","author":"P Thammanoonkul","year":"2025","unstructured":"Thammanoonkul P, Limpattamapanee S, Thammarakcharoen F, Suwanprateeb J, Lim HC, Buranawat B (2025) Polycaprolactone impregnated 3D printed nanohydroxyapatite for sinus augmentation: a randomized controlled trial. Clin Exp Dent Res 11(5):e70237. https:\/\/doi.org\/10.1002\/cre2.70237","journal-title":"Clin Exp Dent Res"},{"issue":"4","key":"10255_CR57","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1007\/s12015-024-10696-5","volume":"20","author":"AM Theodosaki","year":"2024","unstructured":"Theodosaki AM, Tzemi M, Galanis N et al (2024) Bone regeneration with mesenchymal stem cells in scaffolds: systematic review of human clinical trials. Stem Cell Rev Rep 20(4):938\u2013966. https:\/\/doi.org\/10.1007\/s12015-024-10696-5","journal-title":"Stem Cell Rev Rep"},{"issue":"6","key":"10255_CR58","doi-asserted-by":"publisher","first-page":"3225","DOI":"10.1007\/s00590-024-04050-1","volume":"34","author":"STJ Tsang","year":"2024","unstructured":"Tsang STJ, van Rensburg AJ, van Heerden J, Epstein GZ, Venter R, Ferreira N (2024) The management of critical bone defects: outcomes of a systematic approach. Eur J Orthop Surg Traumatol 34(6):3225\u20133231. https:\/\/doi.org\/10.1007\/s00590-024-04050-1","journal-title":"Eur J Orthop Surg Traumatol"},{"issue":"3","key":"10255_CR59","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.bioactmat.2017.10.001","volume":"3","author":"G Turnbull","year":"2018","unstructured":"Turnbull G, Clarke J, Picard F et al (2018) 3D bioactive composite scaffolds for bone tissue engineering. Bioact Mater 3(3):278\u2013314. https:\/\/doi.org\/10.1016\/j.bioactmat.2017.10.001","journal-title":"Bioact Mater"},{"issue":"9","key":"10255_CR60","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1007\/s43465-025-01410-9","volume":"59","author":"S Wan","year":"2025","unstructured":"Wan S, Shen Y, Cai S, Hu Z, Ouyang F, Xu L (2025) Global research trends and hotspots in fracture nonunion and delayed union: a 2-decade bibliometric analysis. Indian J Orthop 59(9):1469\u20131486. https:\/\/doi.org\/10.1007\/s43465-025-01410-9","journal-title":"Indian J Orthop"},{"issue":"1","key":"10255_CR61","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.bioactmat.2020.01.004","volume":"5","author":"C Wang","year":"2020","unstructured":"Wang C, Huang W, Zhou Y et al (2020) 3D printing of bone tissue engineering scaffolds. Bioact Mater 5(1):82\u201391. https:\/\/doi.org\/10.1016\/j.bioactmat.2020.01.004","journal-title":"Bioact Mater"},{"key":"10255_CR62","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6693906","volume":"2021","author":"G Wang","year":"2021","unstructured":"Wang G, Luo W, Zhou Y et al (2021) Custom-made antibiotic cement-coated nail for the treatment of infected bone defect. BioMed Res Int 2021:6693906. https:\/\/doi.org\/10.1155\/2021\/6693906","journal-title":"BioMed Res Int"},{"issue":"8","key":"10255_CR63","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v16.i8.109149","volume":"16","author":"RX Xie","year":"2025","unstructured":"Xie RX, Xing YX, Sun NZ (2025) Advancing bone regeneration: clinical implications of synthetic biomaterials and fibrin derivatives. World J Orthop 16(8):109149. https:\/\/doi.org\/10.5312\/wjo.v16.i8.109149","journal-title":"World J Orthop"},{"issue":"35","key":"10255_CR64","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000043008","volume":"104","author":"Y Xing","year":"2025","unstructured":"Xing Y, Huang Z, Cao L (2025) Application of tissue engineering in wound healing: a 20-year bibliometric and visualized study. Medicine (Baltimore) 104(35):e43008. https:\/\/doi.org\/10.1097\/MD.0000000000043008","journal-title":"Medicine (Baltimore)"},{"key":"10255_CR65","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1232427","volume":"11","author":"K Xu","year":"2023","unstructured":"Xu K, Yu S, Wang Z, Zhang Z, Zhang Z (2023) Bibliometric and visualized analysis of 3D printing bioink in bone tissue engineering. Front Bioeng Biotechnol 11:1232427. https:\/\/doi.org\/10.3389\/fbioe.2023.1232427","journal-title":"Front Bioeng Biotechnol"},{"issue":"7","key":"10255_CR66","doi-asserted-by":"publisher","DOI":"10.3390\/ph15070879","volume":"15","author":"N Xue","year":"2022","unstructured":"Xue N, Ding X, Huang R et al (2022) Bone tissue engineering in the treatment of bone defects. Pharmaceuticals (Basel) 15(7):879. https:\/\/doi.org\/10.3390\/ph15070879","journal-title":"Pharmaceuticals (Basel)"},{"key":"10255_CR67","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1016\/j.ijbiomac.2021.05.215","volume":"183","author":"LR Yadav","year":"2021","unstructured":"Yadav LR, Chandran SV, Lavanya K, Selvamurugan N (2021) Chitosan-based 3D-printed scaffolds for bone tissue engineering. Int J Biol Macromol 183:1925\u20131938. https:\/\/doi.org\/10.1016\/j.ijbiomac.2021.05.215","journal-title":"Int J Biol Macromol"},{"key":"10255_CR68","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.biomaterials.2018.10.033","volume":"190","author":"Y Yan","year":"2019","unstructured":"Yan Y, Chen H, Zhang H et al (2019) Vascularized 3D printed scaffolds for promoting bone regeneration. Biomaterials 190:97\u2013110. https:\/\/doi.org\/10.1016\/j.biomaterials.2018.10.033","journal-title":"Biomaterials"},{"issue":"2","key":"10255_CR69","doi-asserted-by":"publisher","first-page":"79","DOI":"10.36922\/ijb.4986","volume":"11","author":"J Yang","year":"2025","unstructured":"Yang J, Wang J, Yang Y et al (2025) 3D-printed bioactive scaffolds: an emerging strategy for the regeneration of infectious bone defects. Int J Bioprint 11(2):79\u2013138. https:\/\/doi.org\/10.36922\/ijb.4986","journal-title":"Int J Bioprint"},{"key":"10255_CR70","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.824156","volume":"10","author":"Z Yazdanpanah","year":"2022","unstructured":"Yazdanpanah Z, Johnston JD, Cooper DML, Chen X (2022) 3D bioprinted scaffolds for bone tissue engineering: state-of-the-art and emerging technologies. Front Bioeng Biotechnol 10:824156. https:\/\/doi.org\/10.3389\/fbioe.2022.824156","journal-title":"Front Bioeng Biotechnol"},{"issue":"34","key":"10255_CR71","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202403641","volume":"36","author":"X Yuan","year":"2024","unstructured":"Yuan X, Zhu W, Yang Z et al (2024) Recent advances in 3D printing of smart scaffolds for bone tissue engineering and regeneration. Adv Mater 36(34):e2403641. https:\/\/doi.org\/10.1002\/adma.202403641","journal-title":"Adv Mater"},{"key":"10255_CR72","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.actbio.2018.11.039","volume":"84","author":"L Zhang","year":"2019","unstructured":"Zhang L, Yang G, Johnson BN, Jia X (2019) Three-dimensional (3D) printed scaffold and material selection for bone repair. Acta Biomater 84:16\u201333. https:\/\/doi.org\/10.1016\/j.actbio.2018.11.039","journal-title":"Acta Biomater"},{"issue":"12","key":"10255_CR73","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz6725","volume":"6","author":"M Zhang","year":"2020","unstructured":"Zhang M, Lin R, Wang X et al (2020) 3D printing of Haversian bone\u2013mimicking scaffolds for multicellular delivery in bone regeneration. Sci Adv 6(12):eaaz6725. https:\/\/doi.org\/10.1126\/sciadv.aaz6725","journal-title":"Sci Adv"},{"issue":"8","key":"10255_CR74","doi-asserted-by":"publisher","DOI":"10.3390\/gels11080582","volume":"11","author":"Z Zhang","year":"2025","unstructured":"Zhang Z, Wang Y, Wang W (2025) Machine learning in gel-based additive manufacturing: from material design to process optimization. Gels 11(8):582. https:\/\/doi.org\/10.3390\/gels11080582","journal-title":"Gels"},{"key":"10255_CR75","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.bioactmat.2022.02.010","volume":"18","author":"C Zhao","year":"2022","unstructured":"Zhao C, Liu W, Zhu M, Wu C, Zhu Y (2022) Bioceramic-based scaffolds with antibacterial function for bone tissue engineering: a review. Bioact Mater 18:383\u2013398. https:\/\/doi.org\/10.1016\/j.bioactmat.2022.02.010","journal-title":"Bioact Mater"},{"issue":"1","key":"10255_CR76","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02759-z","volume":"22","author":"X Zhao","year":"2024","unstructured":"Zhao X, Li N, Zhang Z et al (2024) Beyond hype: unveiling the real challenges in clinical translation of 3D printed bone scaffolds and the fresh prospects of bioprinted organoids. J Nanobiotechnol 22(1):500. https:\/\/doi.org\/10.1186\/s12951-024-02759-z","journal-title":"J Nanobiotechnol"}],"container-title":["Cell and Tissue Banking"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10561-026-10255-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10561-026-10255-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10561-026-10255-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:23:57Z","timestamp":1791998637000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10561-026-10255-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":76,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["10255"],"URL":"https:\/\/doi.org\/10.1007\/s10561-026-10255-x","relation":{},"ISSN":["1573-6814"],"issn-type":[{"value":"1573-6814","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,14]]},"assertion":[{"value":"3 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors agreed with the content and gave explicit consent to submit and they obtained consent from the responsible authorities at the institute\/organization where the work has been carried out.","order":2,"name":"Ethics","label":"Consent for publications","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval was not required for this study, as all data were downloaded from public data bases and did not involve any human or animal participants.","order":3,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"During the preparation and revision of this manuscript, the authors used a generative AI tool to assist with language editing and improve the clarity of the text. The tool was not used for data collection, bibliometric analysis, interpretation of the results, or generation of scientific conclusions. All AI-assisted content was critically reviewed and revised by the authors, who take full responsibility for the final content of the manuscript.","order":4,"name":"Ethics","label":"Statement on the use of generative AI","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"55"}}