{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:18:47Z","timestamp":1784690327341,"version":"3.55.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2013,4,21]],"date-time":"2013-04-21T00:00:00Z","timestamp":1366502400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biol Toxicol"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1007\/s10565-013-9245-2","type":"journal-article","created":{"date-parts":[[2013,4,20]],"date-time":"2013-04-20T09:27:37Z","timestamp":1366450057000},"page":"175-187","source":"Crossref","is-referenced-by-count":13,"title":["Effect of N-salicyloyltryptamine (STP), a novel tryptamine analogue, on parameters of cell viability, oxidative stress, and immunomodulation in RAW 264.7 macrophages"],"prefix":"10.1007","volume":"29","author":[{"given":"Juciano","family":"Gasparotto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus Augusto","family":"de Bittencourt Pasquali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nauana","family":"Somensi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Mil\u00e1n","family":"Vasques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Claudio Fonseca","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinaldo Nobrega","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Maria","family":"Barbosa-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"de F\u00e1tima Vanderlei de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley Juan Chavez","family":"Gutierrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucindo Jos\u00e9 Quintans","family":"J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Pens","family":"Gelain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,4,21]]},"reference":[{"issue":"Suppl 2","key":"9245_CR1","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/ar2463","volume":"10","author":"SB Abramson","year":"2008","unstructured":"Abramson SB. Nitric oxide in inflammation and pain associated with osteoarthritis. Arthritis Res Ther. 2008;10 Suppl 2:S2.","journal-title":"Arthritis Res Ther"},{"key":"9245_CR2","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/sj.bjp.0705471","volume":"140","author":"DA Araujo","year":"2003","unstructured":"Araujo DA et al. N-salicyloyltryptamine, a new anticonvulsant drug, acts on voltage-dependent Na+, Ca2+, and K+ ion channels. Br J Pharmacol. 2003;140:1331\u20139.","journal-title":"Br J Pharmacol"},{"key":"9245_CR3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/cc6164","volume":"12","author":"C Bopp","year":"2008","unstructured":"Bopp C, Bierhaus A, Hofer S, Bouchon A, Nawroth PP, Martin E, et al. Bench-to-bedside review: the inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis. Crit Care. 2008;12:201.","journal-title":"Crit Care"},{"key":"9245_CR4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0006-2952(99)00296-8","volume":"59","author":"A Bowie","year":"2000","unstructured":"Bowie A, O\u2019Neill LA. Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries. Biochem Pharmacol. 2000;59:13\u201323.","journal-title":"Biochem Pharmacol"},{"key":"9245_CR5","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-079X.1997.tb00342.x","volume":"23","author":"S Cuzzocrea","year":"1997","unstructured":"Cuzzocrea S, Zingarelli B, Gilad E, Hake P, Salzman AL, Szabo C. Protective effect of melatonin in carrageenan-induced models of local inflammation: relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity. J Pineal Res. 1997;23:106\u201316.","journal-title":"J Pineal Res"},{"key":"9245_CR6","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.cellsig.2013.01.013","volume":"25","author":"MA De Bittencourt Pasquali","year":"2013","unstructured":"De Bittencourt Pasquali MA et al. Vitamin A (retinol) downregulates the receptor for advanced glycation endproducts (RAGE) by oxidant-dependent activation of p38 MAPK and NF-kB in human lung cancer A549 cells. Cell Signal. 2013;25:939\u201354.","journal-title":"Cell Signal"},{"key":"9245_CR7","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s11010-006-0639-9","volume":"281","author":"LF Souza de","year":"2006","unstructured":"de Souza LF, Gelain DP, Jardim FR, Ribeiro GR, Zim M, Bernard EA. Extracellular inosine participates in tumor necrosis factor-alpha induced nitric oxide production in cultured Sertoli cells. Mol Cell Biochem. 2006;281:123\u20138.","journal-title":"Mol Cell Biochem"},{"key":"9245_CR8","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nn.3039","volume":"15","author":"ES Deneris","year":"2012","unstructured":"Deneris ES, Wyler SC. Serotonergic transcriptional networks and potential importance to mental health. Nat Neurosci. 2012;15:519\u201327.","journal-title":"Nat Neurosci"},{"key":"9245_CR9","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1177\/107385840100700306","volume":"7","author":"S Dieudonne","year":"2001","unstructured":"Dieudonne S. Serotonergic neuromodulation in the cerebellar cortex: cellular, synaptic, and molecular basis. Neuroscientist. 2001;7:207\u201319.","journal-title":"Neuroscientist"},{"key":"9245_CR10","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","volume":"82","author":"GL Ellman","year":"1959","unstructured":"Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys. 1959;82:70\u20137.","journal-title":"Arch Biochem Biophys"},{"key":"9245_CR11","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.1526-4610.2011.02053.x","volume":"52","author":"MS Evans","year":"2012","unstructured":"Evans MS, Cheng X, Jeffry JA, Disney KE, Premkumar LS. Sumatriptan inhibits TRPV1 channels in trigeminal neurons. Headache. 2012;52:773\u201384.","journal-title":"Headache"},{"key":"9245_CR12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1006\/cyto.2001.0954","volume":"16","author":"AD Foey","year":"2001","unstructured":"Foey AD, Feldmann M, Brennan FM. CD40 ligation induces macrophage IL-10 and TNF-alpha production: differential use of the PI3K and p42\/44 MAPK-pathways. Cytokine. 2001;16:131\u201342.","journal-title":"Cytokine"},{"key":"9245_CR13","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.tiv.2008.02.016","volume":"22","author":"DP Gelain","year":"2008","unstructured":"Gelain DP, De Bittencourt Pasquali MA, Caregnato FF, Zanotto-Filho A, Moreira JC. Retinol up-regulates the receptor for advanced glycation endproducts (RAGE) by increasing intracellular reactive species. Toxicol In Vitro. 2008;22:1123\u20137.","journal-title":"Toxicol In Vitro"},{"key":"9245_CR14","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.tiv.2007.11.007","volume":"22","author":"DP Gelain","year":"2008","unstructured":"Gelain DP, Moreira JC. Evidence of increased reactive species formation by retinol, but not retinoic acid, in PC12 cells. Toxicol In Vitro. 2008;22:553\u20138.","journal-title":"Toxicol In Vitro"},{"key":"9245_CR15","volume-title":"Free radicals in biology and medicine","author":"B Halliwell","year":"2007","unstructured":"Halliwell B, Gutteridge JMC. Free radicals in biology and medicine. Oxford: Oxford University Press; 2007."},{"key":"9245_CR16","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2165\/00003088-200140030-00004","volume":"40","author":"SS Jhee","year":"2001","unstructured":"Jhee SS, Shiovitz T, Crawford AW, Cutler NR. Pharmacokinetics and pharmacodynamics of the triptan antimigraine agents: a comparative review. Clin Pharmacokinet. 2001;40:189\u2013205.","journal-title":"Clin Pharmacokinet"},{"key":"9245_CR17","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0301-0082(82)90023-5","volume":"19","author":"RS Jones","year":"1982","unstructured":"Jones RS. Tryptamine: a neuromodulator or neurotransmitter in mammalian brain? Prog Neurobiol. 1982;19:117\u201339.","journal-title":"Prog Neurobiol"},{"key":"9245_CR18","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.micpath.2009.07.002","volume":"47","author":"EH Kang","year":"2009","unstructured":"Kang EH, Gebru E, Kim MH, Cheng H, Park SC. EstA protein, a novel virulence factor of Streptococcus pneumoniae, induces nitric oxide and pro-inflammatory cytokine production in RAW 264.7 macrophages through NF-kappaB\/MAPK. Microb Pathog. 2009;47:196\u2013201.","journal-title":"Microb Pathog"},{"key":"9245_CR19","doi-asserted-by":"crossref","unstructured":"Kenneth NS, Mudie S, Naron S, Rocha S. TFR1 interacts with the IKK complex and is involved in IKK-NF-kappaB signalling. Biochem J. 2013;449:275\u201384.","DOI":"10.1042\/BJ20120625"},{"key":"9245_CR20","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.cyto.2012.05.025","volume":"60","author":"QQ Lin","year":"2012","unstructured":"Lin QQ, Yan CF, Lin R, Zhang JY, Wang WR, Yang LN, et al. SIRT1 regulates TNF-alpha-induced expression of CD40 in 3 T3-L1 adipocytes via NF-kappaB pathway. Cytokine. 2012;60:447\u201355.","journal-title":"Cytokine"},{"key":"9245_CR21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1196\/annals.1433.026","volume":"1126","author":"A Maczurek","year":"2008","unstructured":"Maczurek A, Shanmugam K, Munch G. Inflammation and the redox-sensitive AGE-RAGE pathway as a therapeutic target in Alzheimer\u2019s disease. Ann N Y Acad Sci. 2008;1126:147\u201351.","journal-title":"Ann N Y Acad Sci"},{"key":"9245_CR22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jneuroim.2005.05.002","volume":"165","author":"JC Mayo","year":"2005","unstructured":"Mayo JC, Sainz RM, Tan DX, Hardeland R, Leon J, Rodriguez C, et al. Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages. J Neuroimmunol. 2005;165:139\u201349.","journal-title":"J Neuroimmunol"},{"key":"9245_CR23","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","volume":"247","author":"HP Misra","year":"1972","unstructured":"Misra HP, Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem. 1972;247:3170\u20135.","journal-title":"J Biol Chem"},{"key":"9245_CR24","doi-asserted-by":"crossref","first-page":"13515","DOI":"10.1074\/jbc.271.23.13515","volume":"271","author":"M Missbach","year":"1996","unstructured":"Missbach M, Jagher B, Sigg I, Nayeri S, Carlberg C, Wiesenberg I. Thiazolidine diones, specific ligands of the nuclear receptor retinoid Z receptor\/retinoid acid receptor-related orphan receptor alpha with potent antiarthritic activity. J Biol Chem. 1996;271:13515\u201322.","journal-title":"J Biol Chem"},{"key":"9245_CR25","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0014-2999(97)01049-2","volume":"331","author":"F Nava","year":"1997","unstructured":"Nava F, Calapai G, Facciola G, Cuzzocrea S, Giuliani G, de Sarro A, et al. Melatonin effects on inhibition of thirst and fever induced by lipopolysaccharide in rat. Eur J Pharmacol. 1997;331:267\u201374.","journal-title":"Eur J Pharmacol"},{"key":"9245_CR26","doi-asserted-by":"crossref","first-page":"e17360","DOI":"10.1371\/journal.pone.0017360","volume":"6","author":"L Neeb","year":"2011","unstructured":"Neeb L, Hellen P, Boehnke C, Hoffmann J, Schuh-Hofer S, Dirnagl U, et al. IL-1beta stimulates COX-2 dependent PGE(2) synthesis and CGRP release in rat trigeminal ganglia cells. PLoS One. 2011;6:e17360.","journal-title":"PLoS One"},{"issue":"Suppl 2","key":"9245_CR27","first-page":"69","volume":"31","author":"R Nosal","year":"2010","unstructured":"Nosal R, Perecko T, Jancinova V, Drabikova K, Harmatha J, Svitekova K. Suppression of oxidative burst in human neutrophils with the naturally occurring serotonin derivative isomer from Leuzea carthamoides. Neuro Endocrinol Lett. 2010;31 Suppl 2:69\u201372.","journal-title":"Neuro Endocrinol Lett"},{"key":"9245_CR28","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0091-3057(00)00484-6","volume":"68","author":"FA Oliveira","year":"2001","unstructured":"Oliveira FA, de Almeida RN, Sousa MF, Barbosa-Filho JM, Diniz SA, de Medeiros IA. Anticonvulsant properties of N-salicyloyltryptamine in mice. Pharmacol Biochem Behav. 2001;68:199\u2013202.","journal-title":"Pharmacol Biochem Behav"},{"key":"9245_CR29","first-page":"230745","volume":"2010","author":"LJ Quintans","year":"2010","unstructured":"Quintans LJ et al. Bioassay-guided evaluation of antinociceptive effect of N-salicyloyltryptamine: a behavioral and electrophysiological approach. J Biomed Biotechnol. 2010;2010:230745.","journal-title":"J Biomed Biotechnol"},{"key":"9245_CR30","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1054\/plef.1999.0032","volume":"60","author":"V Raghavendra","year":"1999","unstructured":"Raghavendra V, Agrewala JN, Kulkarni SK. Role of centrally administered melatonin and inhibitors of COX and NOS in LPS-induced hyperthermia and adipsia. Prostaglandins Leukot Essent Fatty Acids. 1999;60:249\u201353.","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"9245_CR31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0014-2999(00)00196-5","volume":"395","author":"V Raghavendra","year":"2000","unstructured":"Raghavendra V, Agrewala JN, Kulkarni SK. Melatonin reversal of lipopolysacharides-induced thermal and behavioral hyperalgesia in mice. Eur J Pharmacol. 2000;395:15\u201321.","journal-title":"Eur J Pharmacol"},{"key":"9245_CR32","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1007\/s00011-012-0512-0","volume":"61","author":"MU Rehman","year":"2012","unstructured":"Rehman MU, Yoshihisa Y, Miyamoto Y, Shimizu T. The anti-inflammatory effects of platinum nanoparticles on the lipopolysaccharide-induced inflammatory response in RAW 264.7 macrophages. Inflamm Res. 2012;61:1177\u201385.","journal-title":"Inflamm Res"},{"key":"9245_CR33","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0014-2999(97)01545-8","volume":"343","author":"S Sacco","year":"1998","unstructured":"Sacco S, Aquilini L, Ghezzi P, Pinza M, Guglielmotti A. Mechanism of the inhibitory effect of melatonin on tumor necrosis factor production in vivo and in vitro. Eur J Pharmacol. 1998;343:249\u201355.","journal-title":"Eur J Pharmacol"},{"key":"9245_CR34","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1042\/BST0340965","volume":"34","author":"D Salvemini","year":"2006","unstructured":"Salvemini D, Doyle TM, Cuzzocrea S. Superoxide, peroxynitrite and oxidative\/nitrative stress in inflammation. Biochem Soc Trans. 2006;34:965\u201370.","journal-title":"Biochem Soc Trans"},{"key":"9245_CR35","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1365-2249.2004.02547.x","volume":"137","author":"MJ Scott","year":"2004","unstructured":"Scott MJ, Hoth JJ, Stagner MK, Gardner SA, Peyton JC, Cheadle WG. CD40\u2013CD154 interactions between macrophages and natural killer cells during sepsis are critical for macrophage activation and are not interferon gamma dependent. Clin Exp Immunol. 2004;137:469\u201377.","journal-title":"Clin Exp Immunol"},{"key":"9245_CR36","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/039463201202500106","volume":"25","author":"MF Shih","year":"2012","unstructured":"Shih MF, Chen LY, Tsai PJ, Cherng JY. In vitro and in vivo therapeutics of beta-thujaplicin on LPS-induced inflammation in macrophages and septic shock in mice. Int J Immunopathol Pharmacol. 2012;25:39\u201348.","journal-title":"Int J Immunopathol Pharmacol"},{"key":"9245_CR37","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.jocn.2011.10.011","volume":"19","author":"G Silveira","year":"2012","unstructured":"Silveira G, de Oliveira AC, Teixeira AL. Insights into inflammation and epilepsy from the basic and clinical sciences. J Clin Neurosci. 2012;19:1071\u20135.","journal-title":"J Clin Neurosci"},{"key":"9245_CR38","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev.immunol.021908.132603","volume":"28","author":"GP Sims","year":"2010","unstructured":"Sims GP, Rowe DC, Rietdijk ST, Herbst R, Coyle AJ. HMGB1 and RAGE in inflammation and cancer. Annu Rev Immunol. 2010;28:367\u201388.","journal-title":"Annu Rev Immunol"},{"key":"9245_CR39","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/jnci\/82.13.1107","volume":"82","author":"P Skehan","year":"1990","unstructured":"Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D, et al. New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst. 1990;82:1107\u201312.","journal-title":"J Natl Cancer Inst"},{"key":"9245_CR40","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.smim.2009.05.011","volume":"21","author":"J Suttles","year":"2009","unstructured":"Suttles J, Stout RD. Macrophage CD40 signaling: a pivotal regulator of disease protection and pathogenesis. Semin Immunol. 2009;21:257\u201364.","journal-title":"Semin Immunol"},{"key":"9245_CR41","doi-asserted-by":"crossref","unstructured":"Vendramini-Costa DB, Carvalho JE. Molecular Link Mechanisms between Inflammation and Cancer. Curr Pharm Des. 2012;18:3831\u201352.","DOI":"10.2174\/138161212802083707"},{"key":"9245_CR42","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jep.2012.08.041","volume":"144","author":"Z Wang","year":"2012","unstructured":"Wang Z, Jiang W, Zhang Z, Qian M, Du B. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kappaB pathway in RAW 264.7 cells. J Ethnopharmacol. 2012;144:145\u201350.","journal-title":"J Ethnopharmacol"},{"key":"9245_CR43","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1159\/000343318","volume":"30","author":"L Yang","year":"2012","unstructured":"Yang L, Zhang J, Yan C, Zhou J, Lin R, Lin Q, et al. SIRT1 regulates CD40 expression induced by TNF-alpha via NF-kB pathway in endothelial cells. Cell Physiol Biochem. 2012;30:1287\u201398.","journal-title":"Cell Physiol Biochem"},{"key":"9245_CR44","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1208\/s12248-008-9028-5","volume":"10","author":"AM Yu","year":"2008","unstructured":"Yu AM. Indolealkylamines: biotransformations and potential drug\u2013drug interactions. AAPS J. 2008;10:242\u201353.","journal-title":"AAPS J"}],"container-title":["Cell Biology and Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10565-013-9245-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10565-013-9245-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10565-013-9245-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T13:25:54Z","timestamp":1644845154000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10565-013-9245-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,21]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["9245"],"URL":"https:\/\/doi.org\/10.1007\/s10565-013-9245-2","relation":{},"ISSN":["0742-2091","1573-6822"],"issn-type":[{"value":"0742-2091","type":"print"},{"value":"1573-6822","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,21]]}}}