{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:24:42Z","timestamp":1787315082962,"version":"build-2736575974"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T00:00:00Z","timestamp":1478476800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T00:00:00Z","timestamp":1478476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA 115495"],"award-info":[{"award-number":["R01 CA 115495"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biol Toxicol"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1007\/s10565-016-9369-2","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T21:05:23Z","timestamp":1478552723000},"page":"263-282","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Disruption of endolysosomal trafficking pathways in glioma cells by methuosis-inducing indole-based chalcones"],"prefix":"10.1007","volume":"33","author":[{"given":"Nneka E.","family":"Mbah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean H.","family":"Overmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Maltese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,7]]},"reference":[{"key":"9369_CR1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s10565-012-9212-3","volume":"28","author":"T Aki","year":"2012","unstructured":"Aki T, Nara A, Uemura K. Cytoplasmic vacuolization during exposure to drugs and other substances. Cell Biol Toxicol. 2012;28:125\u201331.","journal-title":"Cell Biol Toxicol"},{"key":"9369_CR2","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1158\/1541-7786.MCR-10-0090","volume":"8","author":"H Bhanot","year":"2010","unstructured":"Bhanot H, Young AM, Overmeyer JH, Maltese WA. Induction of non-apoptotic cell death by activated Ras requires inverse regulation of Rac1 and Arf6. Mol Cancer Res. 2010;8:1358\u201374.","journal-title":"Mol Cancer Res"},{"key":"9369_CR3","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1083\/jcb.200507002","volume":"171","author":"G Bjorkoy","year":"2005","unstructured":"Bjorkoy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, et al. p62\/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol. 2005;171:603\u201314.","journal-title":"J Cell Biol"},{"key":"9369_CR4","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/sj.embor.7400243","volume":"5","author":"J Cerny","year":"2004","unstructured":"Cerny J, Feng Y, Yu A, Miyake K, Borgonovo B, Klumperman J, et al. The small chemical vacuolin-1 inhibits Ca2+-dependent lysosomal exocytosis but not cell resealing. EMBO Rep. 2004;5:883\u20138.","journal-title":"EMBO Rep"},{"key":"9369_CR5","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1073\/pnas.89.6.2252","volume":"89","author":"GL Caporaso","year":"1992","unstructured":"Caporaso GL, Gandy SE, Buxbaum JD, Greengard P. Chloroquine inhibits intracellular degradation but not secretion of Alzheimer \u03b2\/A4 amyloid precursor protein. Proc Natl Acad Sci U S A. 1992;89:2252\u20136.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9369_CR6","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/0304-3940(93)90887-Q","volume":"164","author":"PK Dash","year":"1993","unstructured":"Dash PK, Moore AN. Inhibitors of endocytosis, endosome fusion, and lysosomal processing inhibit the intracellular proteolysis of the amyloid precursor protein. Neurosci Lett. 1993;164:183\u20136.","journal-title":"Neurosci Lett"},{"key":"9369_CR7","doi-asserted-by":"publisher","first-page":"a006304","DOI":"10.1101\/cshperspect.a006304","volume":"2","author":"B De Strooper","year":"2012","unstructured":"De Strooper B, Iwatsubo T, Wolfe MS. Presenilins and gamma-secretase: structure, function, and role in Alzheimer Disease. Cold Spring Harbor Perspect Med. 2012;2:a006304.","journal-title":"Cold Spring Harbor Perspect Med."},{"key":"9369_CR8","first-page":"7","volume":"64","author":"R Delbruck","year":"1994","unstructured":"Delbruck R, Desel C, von Figura K, Hille-Rehfeld A. Proteolytic processing of cathepsin D in prelysosomal organelles. Eur J Cell Biol. 1994;64:7\u201314.","journal-title":"Eur J Cell Biol"},{"key":"9369_CR9","doi-asserted-by":"publisher","first-page":"10982","DOI":"10.1074\/jbc.270.18.10982","volume":"270","author":"JM Dugan","year":"1995","unstructured":"Dugan JM, deWit C, McConlogue L, Maltese WA. The ras-related GTP binding protein, Rab1B, regulates early steps in exocytic transport and processing of \u03b2-amyloid precursor protein. J Biol Chem. 1995;270:10982\u20139.","journal-title":"J Biol Chem"},{"key":"9369_CR10","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1083\/jcb.110.6.1935","volume":"110","author":"WAJ Dunn","year":"1990","unstructured":"Dunn WAJ. Studies on the mechanisms of autophagy: maturation of the autophagic vacuole. J Cell Biol. 1990;110:1935\u201345.","journal-title":"J Cell Biol"},{"key":"9369_CR11","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/0962-8924(94)90069-8","volume":"4","author":"WAJ Dunn","year":"1994","unstructured":"Dunn WAJ. Autophagy and related mechanisms of lysosome-mediated protein degradation. Trends Cell Biol. 1994;4:139\u201343.","journal-title":"Trends Cell Biol"},{"key":"9369_CR12","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ncb2026","volume":"12","author":"ER Eden","year":"2010","unstructured":"Eden ER, White IJ, Tsapara A, Futter CE. Membrane contacts between endosomes and ER provide sites for PTP1B-epidermal growth factor receptor interaction. Nat Cell Biol. 2010;12:267\u201372.","journal-title":"Nat Cell Biol"},{"key":"9369_CR13","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1242\/jcs.170233","volume":"128","author":"JR Edgar","year":"2015","unstructured":"Edgar JR, Willen K, Gouras GK, Futter CE. ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-beta accumulation. J Cell Sci. 2015;128:2520\u20138.","journal-title":"J Cell Sci"},{"key":"9369_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4161\/auto.1.1.1270","volume":"1","author":"EL Eskelinen","year":"2005","unstructured":"Eskelinen EL. Maturation of autophagic vacuoles in mammalian cells. Autophagy. 2005;1:1\u201310.","journal-title":"Autophagy"},{"key":"9369_CR15","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1038\/ncb2363","volume":"13","author":"O Florey","year":"2011","unstructured":"Florey O, Kim SE, Sandoval CP, Haynes CM, Overholtzer M. Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes. Nat Cell Biol. 2011;13:1335\u201343.","journal-title":"Nat Cell Biol"},{"key":"9369_CR16","doi-asserted-by":"publisher","first-page":"2683","DOI":"10.1101\/gad.1596707","volume":"21","author":"FB Furnari","year":"2007","unstructured":"Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, et al. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev. 2007;21:2683\u2013710.","journal-title":"Genes Dev"},{"key":"9369_CR17","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1161\/ATVBAHA.108.179564","volume":"29","author":"JL Goldstein","year":"2009","unstructured":"Goldstein JL, Brown MS. The LDL receptor. Arterioscler Thromb Vasc Biol. 2009;29:431\u20138.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"9369_CR18","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/0006-291X(88)90556-6","volume":"151","author":"P Gordon","year":"1988","unstructured":"Gordon P, Seglen PO. Prelysosomal convergence of autophagic and endocytic pathways. Biochem Biophy Res Commun. 1988;151:40\u20137.","journal-title":"Biochem Biophy Res Commun"},{"key":"9369_CR19","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1158\/2159-8290.CD-11-0102","volume":"1","author":"D Guo","year":"2011","unstructured":"Guo D, Reinitz F, Youssef M, Hong C, Nathanson D, Akhavan D, et al. An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR\/AKT\/SREBP-1\/LDLR-dependent pathway. Cancer Discov. 2011;1:442\u201356.","journal-title":"Cancer Discov"},{"key":"9369_CR20","doi-asserted-by":"publisher","first-page":"a006270","DOI":"10.1101\/cshperspect.a006270","volume":"2","author":"C Haass","year":"2012","unstructured":"Haass C, Kaether C, Thinakaran G, Sisodia S. Trafficking and proteolytic processing of APP. Cold Spring Harbor Perspect Med. 2012;2:a006270.","journal-title":"Cold Spring Harbor Perspect Med"},{"key":"9369_CR21","doi-asserted-by":"publisher","first-page":"33729","DOI":"10.1074\/jbc.M004175200","volume":"275","author":"JT Huse","year":"2000","unstructured":"Huse JT, Pijak DS, Leslie GJ, Lee VM, Doms RW. Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer\u2019s disease beta-secretase. J Biol Chem. 2000;275:33729\u201337.","journal-title":"J Biol Chem"},{"key":"9369_CR22","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1242\/jcs.02833","volume":"119","author":"EE Johnson","year":"2006","unstructured":"Johnson EE, Overmeyer JH, Gunning WT, Maltese WA. Gene silencing reveals a specific function of hVps34 phosphatidylinositol 3-kinase in late versus early endosomes. J Cell Sci. 2006;119:1219\u201332.","journal-title":"J Cell Sci"},{"key":"9369_CR23","doi-asserted-by":"publisher","first-page":"5720","DOI":"10.1093\/emboj\/19.21.5720","volume":"19","author":"Y Kabeya","year":"2000","unstructured":"Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000;19:5720\u20138.","journal-title":"EMBO J"},{"key":"9369_CR24","doi-asserted-by":"publisher","first-page":"Article ID 3753","DOI":"10.1155\/2010\/375345","volume":"2010","author":"N Katunuma","year":"2010","unstructured":"Katunuma N. Posttranslational processing and modification of cathepsins and cystatins. J Signal Transduct. 2010;2010:Article ID 375345.","journal-title":"J Signal Transduct"},{"key":"9369_CR25","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1111\/j.1600-0854.2009.00878.x","volume":"10","author":"MC Kerr","year":"2009","unstructured":"Kerr MC, Teasdale RD. Defining macropinocytosis. Traffic. 2009;10:364\u201371.","journal-title":"Traffic"},{"key":"9369_CR26","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.cell.2014.02.021","volume":"157","author":"SS Kitambi","year":"2014","unstructured":"Kitambi SS, Toledo EM, Usoskin D, Wee S, Harisankar A, Svensson R, et al. Vulnerability of glioblastoma cells to catastrophic vacuolization and death induced by a small molecule. Cell. 2014;157:313\u201328.","journal-title":"Cell"},{"key":"9369_CR27","doi-asserted-by":"publisher","first-page":"549","DOI":"10.4161\/auto.28448","volume":"10","author":"DJ Klionsky","year":"2014","unstructured":"Klionsky DJ, Eskelinen EL, Deretic V. Autophagosomes, phagosomes, autolysosomes, phagolysosomes, autophagolysosomes... Wait, I'm confused. Autophagy. 2014;10:549\u201351.","journal-title":"Autophagy"},{"key":"9369_CR28","doi-asserted-by":"publisher","first-page":"4823","DOI":"10.1021\/jm400136m","volume":"56","author":"A Kornienko","year":"2013","unstructured":"Kornienko A, Mathieu V, Rastogi SK, Lefranc F, Kiss R. Therapeutic agents triggering nonapoptotic cancer cell death. J Med Chem. 2013;56:4823\u201339.","journal-title":"J Med Chem"},{"key":"9369_CR29","doi-asserted-by":"publisher","first-page":"3020","DOI":"10.1038\/emboj.2010.167","volume":"29","author":"PH Kuhn","year":"2010","unstructured":"Kuhn PH, Wang H, Dislich B, Colombo A, Zeitschel U, Ellwart JW, et al. ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons. EMBO J. 2010;29:3020\u201332.","journal-title":"EMBO J"},{"key":"9369_CR30","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1038\/nature03029","volume":"432","author":"A Kuma","year":"2004","unstructured":"Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, et al. The role of autophagy during the early neonatal starvation period. Nature. 2004;432:1032\u20136.","journal-title":"Nature"},{"key":"9369_CR31","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1158\/1535-7163.MCT-13-0868","volume":"13","author":"OF Kuzu","year":"2014","unstructured":"Kuzu OF, Gowda R, Sharma A, Robertson GP. Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport. Mol Cancer Ther. 2014;13:1690\u2013703.","journal-title":"Mol Cancer Ther"},{"key":"9369_CR32","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"UK Laemmli","year":"1970","unstructured":"Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680\u20135.","journal-title":"Nature"},{"key":"9369_CR33","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1242\/jcs.102.3.515","volume":"102","author":"B Lawrence","year":"1992","unstructured":"Lawrence B, Brown W. Autophagic vacuoles rapidly fuse with pre-existing lysosomes in cultured hepatocytes. J Cell Sci. 1992;102:515\u201326.","journal-title":"J Cell Sci"},{"key":"9369_CR34","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/0092-8674(89)90685-5","volume":"56","author":"J Lippincott-Schwartz","year":"1989","unstructured":"Lippincott-Schwartz J, Yuan LC, Bonifacino JS, Klausner RD. Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin a: evidence for membrane cycling from Golgi to ER. Cell. 1989;56:801\u201313.","journal-title":"Cell"},{"key":"9369_CR35","doi-asserted-by":"publisher","first-page":"3433","DOI":"10.1242\/jcs.050260","volume":"122","author":"IH Madshus","year":"2009","unstructured":"Madshus IH, Stang E. Internalization and intracellular sorting of the EGF receptor: a model for understanding the mechanisms of receptor trafficking. J Cell Sci. 2009;122:3433\u20139.","journal-title":"J Cell Sci"},{"key":"9369_CR36","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1016\/j.ajpath.2014.02.028","volume":"184","author":"WA Maltese","year":"2014","unstructured":"Maltese WA, Overmeyer JH. Methuosis: nonapoptotic cell death associated with vacuolization of macropinosome and endosome compartments. Am J Pathol. 2014;184:1630\u201342.","journal-title":"Am J Pathol"},{"key":"9369_CR37","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3389\/fphys.2015.00038","volume":"6","author":"WA Maltese","year":"2015","unstructured":"Maltese WA, Overmeyer JH. Non-apoptotic cell death associated with perturbations of macropinocytosis. Front Physiol. 2015;6:38.","journal-title":"Front Physiol"},{"key":"9369_CR38","first-page":"20267","volume":"276","author":"WA Maltese","year":"2001","unstructured":"Maltese WA, Wilson S, Tan Y, Suomensaari S, Sinha S, Barbour R, et al. Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide. J BiolChem. 2001;276:20267\u201379.","journal-title":"J BiolChem"},{"key":"9369_CR39","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1074\/jbc.271.3.1343","volume":"271","author":"L McConlogue","year":"1996","unstructured":"McConlogue L, Castellano F, deWit C, Schenk D, Maltese WA. Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer\u2019s b-amyloid precursor protein. J Biol Chem. 1996;271:1343\u20138.","journal-title":"J Biol Chem"},{"key":"9369_CR40","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.18632\/oncotarget.1830","volume":"5","author":"E Minna","year":"2014","unstructured":"Minna E, Romeo P, De CL, Dugo M, Cassinelli G, Pilotti S, et al. miR-199a-3p displays tumor suppressor functions in papillary thyroid carcinoma. Oncotarget. 2014;5:2513\u201328.","journal-title":"Oncotarget"},{"key":"9369_CR41","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1016\/j.biocel.2004.02.005","volume":"36","author":"N Mizushima","year":"2004","unstructured":"Mizushima N. Methods for monitoring autophagy. Int J Biochem Cell Biol. 2004;36:2491\u2013502.","journal-title":"Int J Biochem Cell Biol"},{"key":"9369_CR42","doi-asserted-by":"publisher","first-page":"542","DOI":"10.4161\/auto.4600","volume":"3","author":"N Mizushima","year":"2007","unstructured":"Mizushima N, Yoshimori T. How to interpret LC3 immunoblotting. Autophagy. 2007;3:542\u20135.","journal-title":"Autophagy"},{"key":"9369_CR43","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1038\/ncb3112","volume":"17","author":"L Murrow","year":"2015","unstructured":"Murrow L, Malhotra R, Debnath J. ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function. Nat Cell Biol. 2015;17:300\u201310.","journal-title":"Nat Cell Biol"},{"key":"9369_CR44","first-page":"965","volume":"6","author":"JH Overmeyer","year":"2008","unstructured":"Overmeyer JH, Kaul A, Johnson EE, Maltese WA. Active ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis. MolCancer Res. 2008;6:965\u201377.","journal-title":"MolCancer Res"},{"key":"9369_CR45","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/1476-4598-10-69","volume":"10","author":"JH Overmeyer","year":"2011","unstructured":"Overmeyer JH, Young AM, Bhanot H, Maltese WA. A chalcone-related small molecule that induces methuosis, a novel form of non-apoptotic cell death, in glioblastoma cells. Mol Cancer. 2011;10:69.","journal-title":"Mol Cancer"},{"key":"9369_CR46","doi-asserted-by":"publisher","first-page":"24131","DOI":"10.1074\/jbc.M702824200","volume":"282","author":"S Pankiv","year":"2007","unstructured":"Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, et al. p62\/SQSTM1 binds directly to Atg8\/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem. 2007;282:24131\u201345.","journal-title":"J Biol Chem"},{"key":"9369_CR47","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3233\/JAD-2004-6107","volume":"6","author":"SH Pasternak","year":"2004","unstructured":"Pasternak SH, Callahan JW, Mahuran DJ. The role of the endosomal\/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer\u2019s disease: reexamining the spatial paradox from a lysosomal perspective. J Alzheimers Dis. 2004;6:53\u201365.","journal-title":"J Alzheimers Dis"},{"key":"9369_CR48","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1124\/mol.114.096602","volume":"87","author":"N Pasupuleti","year":"2015","unstructured":"Pasupuleti N, Grodzki AC, Gorin F. Mis-trafficking of endosomal urokinase proteins triggers drug-induced glioma nonapoptotic cell death. Mol Pharmacol. 2015;87:683\u201396.","journal-title":"Mol Pharmacol"},{"key":"9369_CR49","first-page":"2787","volume":"8","author":"MX Piao","year":"2015","unstructured":"Piao MX, Bai JW, Zhang PF, Zhang YZ. PCSK9 regulates apoptosis in human neuroglioma u251 cells via mitochondrial signaling pathways. Int J Clin Exp Pathol. 2015;8:2787\u201394.","journal-title":"Int J Clin Exp Pathol"},{"key":"9369_CR50","doi-asserted-by":"publisher","first-page":"28856","DOI":"10.1074\/jbc.M109.037085","volume":"284","author":"S Poirier","year":"2009","unstructured":"Poirier S, Mayer G, Poupon V, McPherson PS, Desjardins R, Ly K, et al. Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route. J Biol Chem. 2009;284:28856\u201364.","journal-title":"J Biol Chem"},{"key":"9369_CR51","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1083\/jcb.200810098","volume":"185","author":"M Razi","year":"2009","unstructured":"Razi M, Chan EY, Tooze SA. Early endosomes and endosomal coatomer are required for autophagy. J Cell Biol. 2009;185:305\u201321.","journal-title":"J Cell Biol"},{"key":"9369_CR52","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1016\/j.molonc.2015.03.012","volume":"9","author":"EM Reyes-Reyes","year":"2015","unstructured":"Reyes-Reyes EM, Salipur FR, Shams M, Forsthoefel MK, Bates PJ. Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation. Mol Oncol. 2015;9:1392\u2013405.","journal-title":"Mol Oncol"},{"key":"9369_CR53","doi-asserted-by":"crossref","first-page":"15665","DOI":"10.1016\/S0021-9258(19)49587-2","volume":"267","author":"S Rijnboutt","year":"1992","unstructured":"Rijnboutt S, Stoorvogel W, Geuze HJ, Strous GJ. Identification of subcellular compartments involved in biosynthetic processing of cathepsin D. J Biol Chem. 1992;267:15665\u201372.","journal-title":"J Biol Chem"},{"key":"9369_CR54","doi-asserted-by":"publisher","first-page":"1940","DOI":"10.1021\/jm201006x","volume":"55","author":"MW Robinson","year":"2012","unstructured":"Robinson MW, Overmeyer JH, Young AM, Erhardt PW, Maltese WA. Synthesis and evaluation of indole-based chalcones as inducers of methuosis, a novel type of nonapoptotic cell death. J Med Chem. 2012;55:1940\u201356.","journal-title":"J Med Chem"},{"key":"9369_CR55","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1128\/MCB.01716-12","volume":"33","author":"E Scotti","year":"2013","unstructured":"Scotti E, Calamai M, Goulbourne CN, Zhang L, Hong C, Lin RR, et al. IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor. Mol Cell Biol. 2013;33:1503\u201314.","journal-title":"Mol Cell Biol"},{"key":"9369_CR56","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/990114","volume":"402","author":"S Sinha","year":"1999","unstructured":"Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, et al. Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature. 1999;402:537\u201340.","journal-title":"Nature"},{"key":"9369_CR57","doi-asserted-by":"publisher","first-page":"6075","DOI":"10.1073\/pnas.89.13.6075","volume":"89","author":"SS Sisodia","year":"1992","unstructured":"Sisodia SS. \u03b2-amyloid precursor protein cleavage by a membrane-bound protease. Proc Natl Acad Sci U S A. 1992;89:6075\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9369_CR58","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1042\/bj2620931","volume":"262","author":"SM Smith","year":"1989","unstructured":"Smith SM, Kane SE, Gal S, Mason RW, Gottesman MM. Glycosylation of procathepsin L does not account for species molecular-mass differences and is not required for proteolytic activity. Biochem J. 1989;262:931\u20138.","journal-title":"Biochem J"},{"key":"9369_CR59","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/S0962-8924(00)89101-1","volume":"5","author":"JA Swanson","year":"1995","unstructured":"Swanson JA, Watts C. Macropinocytosis. Trends Cell Biol. 1995;5:424\u20138.","journal-title":"Trends Cell Biol"},{"key":"9369_CR60","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13041-014-0054-1","volume":"7","author":"JH Tam","year":"2014","unstructured":"Tam JH, Seah C, Pasternak SH. The amyloid precursor protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid. Molecular Brain. 2014;7:54.","journal-title":"Molecular Brain."},{"key":"9369_CR61","doi-asserted-by":"publisher","first-page":"84","DOI":"10.4161\/auto.1.2.1697","volume":"1","author":"I Tanida","year":"2005","unstructured":"Tanida I, Minematsu-Ikeguchi N, Ueno T, Kominami E. Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy. Autophagy. 2005;1:84\u201391.","journal-title":"Autophagy"},{"key":"9369_CR62","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.tcb.2013.11.002","volume":"24","author":"A Tomas","year":"2014","unstructured":"Tomas A, Futter CE, Eden ER. EGF receptor trafficking: consequences for signaling and cancer. Trends Cell Biol. 2014;24:26\u201334.","journal-title":"Trends Cell Biol"},{"key":"9369_CR63","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1021\/ml4003925","volume":"5","author":"CJ Trabbic","year":"2014","unstructured":"Trabbic CJ, Dietsch HM, Alexander EM, Nagy PI, Robinson MW, Overmeyer JH, et al. Differential induction of cytoplasmic vacuolization and methuosis by novel 2-indolyl-substituted pyridinylpropenones. ACS Med Chem Lett. 2014;5:73\u20137.","journal-title":"ACS Med Chem Lett"},{"key":"9369_CR64","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1021\/jm501997q","volume":"58","author":"CJ Trabbic","year":"2015","unstructured":"Trabbic CJ, Overmeyer JH, Alexander EM, Crissman EJ, Kvale HM, Smith MA, et al. Synthesis and biological evaluation of indolyl-pyridinyl-propenones having either methuosis or microtubule disruption activity. J Med Chem. 2015;58:2489\u2013512.","journal-title":"J Med Chem"},{"key":"9369_CR65","first-page":"38","volume":"54","author":"JB Ulmer","year":"1991","unstructured":"Ulmer JB, Palade GE. Effects of Brefeldin A on the Golgi complex, endoplasmic reticulum and viral envelope glycoproteins in murine erythroleukemia cells. Eur J Cell Biol. 1991;54:38\u201354.","journal-title":"Eur J Cell Biol"},{"key":"9369_CR66","doi-asserted-by":"publisher","first-page":"e06907","DOI":"10.7554\/eLife.06907","volume":"4","author":"AM Unni","year":"2015","unstructured":"Unni AM, Lockwood WW, Zejnullahu K, Lee-Lin SQ, Varmus H. Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma. eLife. 2015;4:e06907.","journal-title":"eLife"},{"key":"9369_CR67","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1126\/science.286.5440.735","volume":"286","author":"R Vassar","year":"1999","unstructured":"Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, et al. Beta-secretase cleavage of Alzheimer\u2019s amyloid precursor protein by the transmembrane aspartic protease BACE. Science. 1999;286:735\u201341.","journal-title":"Science"},{"key":"9369_CR68","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.ccr.2009.12.020","volume":"17","author":"RG Verhaak","year":"2010","unstructured":"Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell. 2010;17:98\u2013110.","journal-title":"Cancer Cell"},{"key":"9369_CR69","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/0092-8674(89)90177-3","volume":"57","author":"A Weidemann","year":"1989","unstructured":"Weidemann A, Konig G, Bunke D, Fischer P, Salbaum JM, Masters CL, et al. Identification, biogenesis, and localization of precursors of Alzheimer\u2019s disease A4 amyloid protein. Cell. 1989;57:115\u201326.","journal-title":"Cell"},{"key":"9369_CR70","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1083\/jcb.200505082","volume":"171","author":"WH Yu","year":"2005","unstructured":"Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee JH, et al. Macroautophagy\u2014a novel Beta-amyloid peptide-generating pathway activated in Alzheimer\u2019s disease. J Cell Biol. 2005;171:87\u201398.","journal-title":"J Cell Biol"},{"key":"9369_CR71","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1016\/j.biocel.2004.05.010","volume":"36","author":"WH Yu","year":"2004","unstructured":"Yu WH, Kumar A, Peterhoff C, Shapiro Kulnane L, Uchiyama Y, Lamb BT, et al. Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer\u2019s disease. Int J Biochem Cell Biol. 2004;36:2531\u201340.","journal-title":"Int J Biochem Cell Biol"},{"key":"9369_CR72","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1756-6606-4-3","volume":"4","author":"YW Zhang","year":"2011","unstructured":"Zhang YW, Thompson R, Zhang H, Xu H. APP processing in Alzheimer\u2019s disease. Molecular Brain. 2011;4:3.","journal-title":"Molecular Brain"}],"container-title":["Cell Biology and Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10565-016-9369-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10565-016-9369-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10565-016-9369-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T17:45:04Z","timestamp":1657647904000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10565-016-9369-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,7]]},"references-count":72,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["9369"],"URL":"https:\/\/doi.org\/10.1007\/s10565-016-9369-2","relation":{},"ISSN":["0742-2091","1573-6822"],"issn-type":[{"value":"0742-2091","type":"print"},{"value":"1573-6822","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,7]]},"assertion":[{"value":"1 August 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}