{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:11:26Z","timestamp":1792894286100,"version":"4.5.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Natural Science Foundation of Hubei","award":["2018CFB472"],"award-info":[{"award-number":["2018CFB472"]}]},{"name":"Special Fund for Young and Middle-aged Research of Luo yuankai","award":["20190808"],"award-info":[{"award-number":["20190808"]}]},{"name":"Xiangyang High-Level Healthy Talent Program and Top Medical Youth Talent Program in Hubei Province"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biol Toxicol"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1007\/s10565-021-09636-7","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T08:02:52Z","timestamp":1629100972000},"page":"611-628","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Chemerin promotes the pathogenesis of preeclampsia by activating CMKLR1\/p-Akt\/CEBP\u0251 axis and inducing M1 macrophage polarization"],"prefix":"10.1007","volume":"38","author":[{"given":"Zhi-Song","family":"Ji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Peng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Fang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Hai","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Zhen","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Li","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Long","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0272-2851","authenticated-orcid":false,"given":"Xue-Zhou","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"issue":"2","key":"9636_CR1","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s13224-018-1128-2","volume":"69","author":"R Agarwal","year":"2019","unstructured":"Agarwal R, Kumari N, Kar R, Chandra N, Nimesh A, Singh A, et al. Evaluation of placental VEGFA mRNA expression in preeclampsia: a case control study. J Obstet Gynaecol India. 2019;69(2):142\u20138.","journal-title":"J Obstet Gynaecol India"},{"issue":"5\u20136","key":"9636_CR2","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.cytogfr.2011.11.004","volume":"22","author":"B Bondue","year":"2011","unstructured":"Bondue B, Wittamer V, Parmentier M. Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism. Cytokine Growth Factor Rev. 2011;22(5\u20136):331\u20138.","journal-title":"Cytokine Growth Factor Rev"},{"key":"9636_CR3","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.placenta.2016.09.004","volume":"47","author":"RJ Buckley","year":"2016","unstructured":"Buckley RJ, Whitley GS, Dumitriu IE, Cartwright JE. Macrophage polarisation affects their regulation of trophoblast behaviour. Placenta. 2016;47:73\u201380.","journal-title":"Placenta"},{"issue":"2","key":"9636_CR4","first-page":"195","volume":"37","author":"O Cetin","year":"2017","unstructured":"Cetin O, Kurdoglu Z, Kurdoglu M, Sahin HG. Chemerin level in pregnancies complicated by preeclampsia and its relation with disease severity and neonatal outcomes. J Obstet Gynaecol. 2017;37(2):195\u20139.","journal-title":"J Obstet Gynaecol"},{"issue":"1 Pt 2","key":"9636_CR5","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1161\/01.HYP.35.1.367","volume":"35","author":"JK Crews","year":"2000","unstructured":"Crews JK, Herrington JN, Granger JP, Khalil RA. Decreased endothelium-dependent vascular relaxation during reduction of uterine perfusion pressure in pregnant rat. Hypertension. 2000;35(1 Pt 2):367\u201372.","journal-title":"Hypertension"},{"issue":"2","key":"9636_CR6","first-page":"121","volume":"40","author":"DM Duan","year":"2011","unstructured":"Duan DM, Niu JM, Lei Q, Lin XH, Chen X. Serum levels of the adipokine chemerin in preeclampsia. J Perinat Med. 2011;40(2):121\u20137.","journal-title":"J Perinat Med"},{"issue":"2","key":"9636_CR7","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1111\/imm.12910","volume":"154","author":"SC Funes","year":"2018","unstructured":"Funes SC, Rios M, Escobar-Vera J, Kalergis AM. Implications of macrophage polarization in autoimmunity. Immunology. 2018;154(2):186\u201395.","journal-title":"Immunology"},{"issue":"12","key":"9636_CR8","doi-asserted-by":"publisher","first-page":"e112925","DOI":"10.1371\/journal.pone.0112925","volume":"9","author":"KL Graham","year":"2014","unstructured":"Graham KL, Zhang JV, Lewen S, Burke TM, Dang T, Zoudilova M, et al. A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease. PLoS One. 2014;9(12):e112925.","journal-title":"PLoS One."},{"issue":"4","key":"9636_CR9","doi-asserted-by":"publisher","first-page":"e2078","DOI":"10.1371\/journal.pone.0002078","volume":"3","author":"C Gustafsson","year":"2008","unstructured":"Gustafsson C, Mjosberg J, Matussek A, Geffers R, Matthiesen L, Berg G, et al. Gene expression profiling of human decidual macrophages: evidence for immunosuppressive phenotype. PLoS One. 2008;3(4):e2078.","journal-title":"PLoS One."},{"issue":"2","key":"9636_CR10","doi-asserted-by":"publisher","first-page":"R79","DOI":"10.1530\/JOE-18-0174","volume":"238","author":"G Helfer","year":"2018","unstructured":"Helfer G, Wu QF. Chemerin: a multifaceted adipokine involved in metabolic disorders. J Endocrinol. 2018;238(2):R79\u201394.","journal-title":"J Endocrinol"},{"issue":"8","key":"9636_CR11","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1038\/nprot.2007.249","volume":"2","author":"LM Hellman","year":"2007","unstructured":"Hellman LM, Fried MG. Electrophoretic mobility shift assay (EMSA) for detecting protein-nucleic acid interactions. Nat Protoc. 2007;2(8):1849\u201361.","journal-title":"Nat Protoc"},{"issue":"5","key":"9636_CR12","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.4049\/jimmunol.1402166","volume":"194","author":"M Herova","year":"2015","unstructured":"Herova M, Schmid M, Gemperle C, Hersberger M. ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages. J Immunol. 2015;194(5):2330\u20137.","journal-title":"J Immunol"},{"issue":"1","key":"9636_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1179\/acb.2010.001","volume":"65","author":"Y Jacquemyn","year":"2010","unstructured":"Jacquemyn Y, Zemtsova O. Risk factors and prediction of preeclampsia. Acta Clin Belg. 2010;65(1):1\u201312.","journal-title":"Acta Clin Belg"},{"issue":"1","key":"9636_CR14","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s10456-013-9381-6","volume":"17","author":"N Jetten","year":"2014","unstructured":"Jetten N, Verbruggen S, Gijbels MJ, Post MJ, De Winther MP, Donners MM. Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo. Angiogenesis. 2014;17(1):109\u201318.","journal-title":"Angiogenesis"},{"issue":"3","key":"9636_CR15","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/ni.1990","volume":"12","author":"T Krausgruber","year":"2011","unstructured":"Krausgruber T, Blazek K, Smallie T, Alzabin S, Lockstone H, Sahgal N, et al. IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nat Immunol. 2011;12(3):231\u20138.","journal-title":"Nat Immunol"},{"issue":"11","key":"9636_CR16","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1053\/hupa.2002.129420","volume":"33","author":"K Kumazaki","year":"2002","unstructured":"Kumazaki K, Nakayama M, Suehara N, Wada Y. Expression of vascular endothelial growth factor, placental growth factor, and their receptors Flt-1 and KDR in human placenta under pathologic conditions. Hum Pathol. 2002;33(11):1069\u201377.","journal-title":"Hum Pathol"},{"issue":"10","key":"9636_CR17","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1093\/humrep\/dev196","volume":"30","author":"CL Lee","year":"2015","unstructured":"Lee CL, Guo Y, So KH, Vijayan M, Guo Y, Wong VH, et al. Soluble human leukocyte antigen G5 polarizes differentiation of macrophages toward a decidual macrophage-like phenotype. Hum Reprod. 2015;30(10):2263\u201374.","journal-title":"Hum Reprod"},{"issue":"4","key":"9636_CR18","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/cmi.2014.15","volume":"11","author":"Y Lin","year":"2014","unstructured":"Lin Y, Yang X, Yue W, Xu X, Li B, Zou L, et al. Chemerin aggravates DSS-induced colitis by suppressing M2 macrophage polarization. Cell Mol Immunol. 2014;11(4):355\u201366.","journal-title":"Cell Mol Immunol"},{"issue":"4","key":"9636_CR19","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4):402\u20138.","journal-title":"Methods"},{"issue":"3","key":"9636_CR20","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1161\/HYPERTENSIONAHA.114.03315","volume":"64","author":"MQ Mazzuca","year":"2014","unstructured":"Mazzuca MQ, Li W, Reslan OM, Yu P, Mata KM, Khalil RA. Downregulation of microvascular endothelial type B endothelin receptor is a central vascular mechanism in hypertensive pregnancy. Hypertension. 2014;64(3):632\u201343.","journal-title":"Hypertension"},{"issue":"6","key":"9636_CR21","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1111\/j.1600-0897.2010.00813.x","volume":"63","author":"T Nagamatsu","year":"2010","unstructured":"Nagamatsu T, Schust DJ. The contribution of macrophages to normal and pathological pregnancies. Am J Reprod Immunol. 2010;63(6):460\u201371.","journal-title":"Am J Reprod Immunol"},{"issue":"24","key":"9636_CR22","doi-asserted-by":"publisher","first-page":"e13962","DOI":"10.14814\/phy2.13962","volume":"6","author":"N Nakamura","year":"2018","unstructured":"Nakamura N, Naruse K, Kobayashi Y, Miyabe M, Saiki T, Enomoto A, et al. Chemerin promotes angiogenesis in vivo. Physiol Rep. 2018;6(24):e13962.","journal-title":"Physiol Rep."},{"issue":"2","key":"9636_CR23","first-page":"69","volume":"23","author":"KR Palmer","year":"2017","unstructured":"Palmer KR, Tong S, Kaitu\u2019u-Lino TJ. Placental-specific sFLT-1: role in pre-eclamptic pathophysiology and its translational possibilities for clinical prediction and diagnosis. Mol Hum Reprod. 2017;23(2):69\u201378.","journal-title":"Mol Hum Reprod"},{"issue":"2","key":"9636_CR24","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1080\/14767058.2017.1378325","volume":"32","author":"T Raia-Barjat","year":"2019","unstructured":"Raia-Barjat T, Prieux C, Gris JC, Chapelle C, Laporte S, Chauleur C. Angiogenic factors for prediction of preeclampsia and intrauterine growth restriction onset in high-risk women: AngioPred study. J Matern Fetal Neonatal Med. 2019;32(2):248\u201357.","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"2\u20133","key":"9636_CR25","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1053\/plac.1998.0373","volume":"20","author":"F Reister","year":"1999","unstructured":"Reister F, Frank HG, Heyl W, Kosanke G, Huppertz B, Schroder W, et al. The distribution of macrophages in spiral arteries of the placental bed in pre-eclampsia differs from that in healthy patients. Placenta. 1999;20(2\u20133):229\u201333.","journal-title":"Placenta"},{"issue":"5","key":"9636_CR26","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1080\/08820130802191375","volume":"37","author":"SJ Renaud","year":"2008","unstructured":"Renaud SJ, Graham CH. The role of macrophages in utero-placental interactions during normal and pathological pregnancy. Immunol Invest. 2008;37(5):535\u201364.","journal-title":"Immunol Invest"},{"issue":"5","key":"9636_CR27","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1177\/1753944715624853","volume":"10","author":"L Saleh","year":"2016","unstructured":"Saleh L, Verdonk K, Visser W, van den Meiracker AH, Danser AH. The emerging role of endothelin-1 in the pathogenesis of pre-eclampsia. Ther Adv Cardiovasc Dis. 2016;10(5):282\u201393.","journal-title":"Ther Adv Cardiovasc Dis"},{"issue":"10","key":"9636_CR28","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1038\/ni.1920","volume":"11","author":"T Satoh","year":"2010","unstructured":"Satoh T, Takeuchi O, Vandenbon A, Yasuda K, Tanaka Y, Kumagai Y, et al. The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat Immunol. 2010;11(10):936\u201344.","journal-title":"Nat Immunol"},{"key":"9636_CR29","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.molimm.2018.12.016","volume":"106","author":"DS Serafin","year":"2019","unstructured":"Serafin DS, Allyn B, Sassano MF, Timoshchenko RG, Mattox D, Brozowski JM, et al. Chemerin-activated functions of CMKLR1 are regulated by G protein-coupled receptor kinase 6 (GRK6) and beta-arrestin 2 in inflammatory macrophages. Mol Immunol. 2019;106:12\u201321.","journal-title":"Mol Immunol"},{"issue":"1","key":"9636_CR30","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/j.1600-0897.2007.00486.x","volume":"58","author":"A Sharma","year":"2007","unstructured":"Sharma A, Satyam A, Sharma JB. Leptin, IL-10 and inflammatory markers (TNF-alpha, IL-6 and IL-8) in pre-eclamptic, normotensive pregnant and healthy non-pregnant women. Am J Reprod Immunol. 2007;58(1):21\u201330.","journal-title":"Am J Reprod Immunol"},{"key":"9636_CR31","doi-asserted-by":"publisher","first-page":"2772","DOI":"10.3389\/fimmu.2018.02772","volume":"9","author":"WJ Shin","year":"2018","unstructured":"Shin WJ, Zabel BA, Pachynski RK. Mechanisms and functions of chemerin in cancer: potential roles in therapeutic intervention. Front Immunol. 2018;9:2772.","journal-title":"Front Immunol"},{"issue":"1\u20133","key":"9636_CR32","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.regpep.2011.03.005","volume":"168","author":"H Stepan","year":"2011","unstructured":"Stepan H, Philipp A, Roth I, Kralisch S, Jank A, Schaarschmidt W, et al. Serum levels of the adipokine chemerin are increased in preeclampsia during and 6 months after pregnancy. Regul Pept. 2011;168(1\u20133):69\u201372.","journal-title":"Regul Pept"},{"issue":"7","key":"9636_CR33","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.theriogenology.2014.07.025","volume":"82","author":"W Tan","year":"2014","unstructured":"Tan W, Chen L, Guo L, Ou X, Xie D, Quan S. Relationship between macrophages in mouse uteri and angiogenesis in endometrium during the peri-implantation period. Theriogenology. 2014;82(7):1021\u20137.","journal-title":"Theriogenology"},{"issue":"2","key":"9636_CR34","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/aji.12112","volume":"70","author":"Z Tang","year":"2013","unstructured":"Tang Z, Buhimschi IA, Buhimschi CS, Tadesse S, Norwitz E, Niven-Fairchild T, et al. Decreased levels of folate receptor-beta and reduced numbers of fetal macrophages (Hofbauer cells) in placentas from pregnancies with severe pre-eclampsia. Am J Reprod Immunol. 2013;70(2):104\u201315.","journal-title":"Am J Reprod Immunol"},{"issue":"3","key":"9636_CR35","doi-asserted-by":"publisher","first-page":"312","DOI":"10.3109\/10641955.2013.807818","volume":"32","author":"PG Teixeira","year":"2013","unstructured":"Teixeira PG, Reis ZS, Andrade SP, Rezende CA, Lage EM, Velloso EP, et al. Presymptomatic prediction of preeclampsia with angiogenic factors, in high risk pregnant women. Hypertens Pregnancy. 2013;32(3):312\u201320.","journal-title":"Hypertens Pregnancy"},{"key":"9636_CR36","first-page":"467","volume":"7","author":"J Uzan","year":"2011","unstructured":"Uzan J, Carbonnel M, Piconne O, Asmar R, Ayoubi JM. Pre-eclampsia: pathophysiology, diagnosis, and management. Vasc Health Risk Manag. 2011;7:467\u201374.","journal-title":"Vasc Health Risk Manag"},{"issue":"4","key":"9636_CR37","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1161\/ATVBAHA.119.312386","volume":"39","author":"EPC van der Vorst","year":"2019","unstructured":"van der Vorst EPC, Mandl M, Muller M, Neideck C, Jansen Y, Hristov M, et al. Hematopoietic ChemR23 (chemerin receptor 23) fuels atherosclerosis by sustaining an M1 macrophage-phenotype and guidance of plasmacytoid dendritic cells to murine lesions-brief report. Arterioscler Thromb Vasc Biol. 2019;39(4):685\u201393.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"9636_CR38","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.jri.2009.08.001","volume":"82","author":"PJ Williams","year":"2009","unstructured":"Williams PJ, Searle RF, Robson SC, Innes BA, Bulmer JN. Decidual leucocyte populations in early to late gestation normal human pregnancy. J Reprod Immunol. 2009;82(1):24\u201331.","journal-title":"J Reprod Immunol"},{"issue":"7","key":"9636_CR39","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/ni.2304","volume":"13","author":"H Xu","year":"2012","unstructured":"Xu H, Zhu J, Smith S, Foldi J, Zhao B, Chung AY, et al. Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization. Nat Immunol. 2012;13(7):642\u201350.","journal-title":"Nat Immunol"},{"key":"9636_CR40","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.jri.2017.09.012","volume":"124","author":"SW Yang","year":"2017","unstructured":"Yang SW, Cho EH, Choi SY, Lee YK, Park JH, Kim MK, et al. DC-SIGN expression in Hofbauer cells may play an important role in immune tolerance in fetal chorionic villi during the development of preeclampsia. J Reprod Immunol. 2017;124:30\u20137.","journal-title":"J Reprod Immunol"},{"key":"9636_CR41","doi-asserted-by":"publisher","first-page":"792","DOI":"10.3389\/fimmu.2019.00792","volume":"10","author":"Y Yao","year":"2019","unstructured":"Yao Y, Xu XH, Jin L. Macrophage polarization in physiological and pathological pregnancy. Front Immunol. 2019;10:792.","journal-title":"Front Immunol"}],"container-title":["Cell Biology and Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10565-021-09636-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10565-021-09636-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10565-021-09636-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T12:10:41Z","timestamp":1659355841000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10565-021-09636-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,16]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["9636"],"URL":"https:\/\/doi.org\/10.1007\/s10565-021-09636-7","relation":{},"ISSN":["0742-2091","1573-6822"],"issn-type":[{"value":"0742-2091","type":"print"},{"value":"1573-6822","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,16]]},"assertion":[{"value":"29 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal protocols were reviewed and approved by the Animal Care and Use Committee of Xiangyang Central Hospital (No. 2020\u2013011, Xiangyang, China).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from the Animal Care and Use Committee of Xiangyang Central Hospital (Xiangyang, China).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable. This article does not contain any studies with human participants performed by any of the authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}