{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:34:20Z","timestamp":1767339260353,"version":"3.32.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Key Research Project of Hunan Provincial Education Department","award":["21A0270"],"award-info":[{"award-number":["21A0270"]}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2023JJ60496 and S2024JJBMLH0555"],"award-info":[{"award-number":["2023JJ60496 and S2024JJBMLH0555"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scientific Research Fund Project of Hunan Provincial Health Commission","award":["B202303109577 and D202303109191"],"award-info":[{"award-number":["B202303109577 and D202303109191"]}]},{"name":"Clinical Medical Research 4310 Program of the University of South China","award":["20224310NHYCG07"],"award-info":[{"award-number":["20224310NHYCG07"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biol Toxicol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>The primary objective of this investigation is to delve into the involvement of the long noncoding RNA (lncRNA) SPACA6P-AS in breast cancer (BC) development, focusing on its expression pattern, association with clinical-pathological features, impact on prognosis, as well as its molecular and immunological implications.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Bioinformatics analysis was conducted utilizing RNA sequencing data of 1083 BC patients from the TCGA database. Functional exploration of SPACA6P-AS was carried out through the construction of survival curves, GO and KEGG enrichment analysis, and single-sample gene set enrichment analysis (ssGSEA). Furthermore, its functionality was validated through in vitro cell experiments and in vivo nude mouse model experiments.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>SPACA6P-AS showed a remarkable increase in expression levels in BC tissues (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and demonstrated a close relationship to poor prognosis (overall survival HR\u2009=\u20091.616, progression-free interval HR\u2009=\u20091.40, disease-specific survival HR\u2009=\u20091.54). Enrichment analysis revealed that SPACA6P-AS could impact biological functions such as protease regulation, endopeptidase inhibitor activity, taste receptor activity, taste transduction, and maturity-onset diabetes of the young pathway. ssGSEA analysis indicated a negative correlation between SPACA6P-AS expression and immune cell infiltration like dendritic cells and neutrophils, while a positive correlation was observed with central memory T cells and T helper 2 cells. Results from in vitro and in vivo experiments illustrated that silencing SPACA6P-AS significantly inhibited the proliferation, migration, and invasion capabilities of BC cells. In vitro experiments also highlighted that dendritic cells with silenced SPACA6P-AS exhibited enhanced capabilities in promoting the proliferation of autologous CD3\u2009+\u2009T cells and cytokine secretion. These discoveries elucidate the potential multifaceted roles of SPACA6P-AS in BC, including its potential involvement in modulating immune cell infiltration in the tumor microenvironment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The high expression of lncRNA SPACA6P-AS in BC is closely linked to poor prognosis and may facilitate tumor progression by influencing specific biological processes, signaling pathways, and the immune microenvironment. The regulatory role of SPACA6P-AS positions it as a prospective biomarker and target for therapeutic approaches for BC diagnosis and intervention.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10565-024-09870-9","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T12:02:33Z","timestamp":1719403353000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["SPACA6P-AS: a trailblazer in breast cancer pathobiology and therapeutics"],"prefix":"10.1007","volume":"40","author":[{"given":"Wenjie","family":"Feng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiling","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhan","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanbin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lunqi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianjie","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liming","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeru","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuehua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"9870_CR1","doi-asserted-by":"publisher","first-page":"102530","DOI":"10.1016\/j.ctrv.2023.102530","volume":"115","author":"CM Ascione","year":"2023","unstructured":"Ascione CM, Napolitano F, Esposito D, et al. Role of FGFR3 in bladder cancer: treatment landscape and future challenges. Cancer Treat Rev. 2023;115:102530. https:\/\/doi.org\/10.1016\/j.ctrv.2023.102530.","journal-title":"Cancer Treat Rev"},{"issue":"4","key":"9870_CR2","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.immuni.2013.10.003","volume":"39","author":"G Bindea","year":"2013","unstructured":"Bindea G, Mlecnik B, Tosolini M, et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity. 2013;39(4):782\u201395. https:\/\/doi.org\/10.1016\/j.immuni.2013.10.003.","journal-title":"Immunity"},{"issue":"3","key":"9870_CR3","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.kjms.2017.10.002","volume":"34","author":"Y Bouraoui","year":"2018","unstructured":"Bouraoui Y, Achour M, Royuela M, Oueslati R. Immune profiling of human prostate epithelial cells determined by expression of p38\/TRAF-6\/ERK MAP kinases pathways. Kaohsiung J Med Sci. 2018;34(3):125\u201333. https:\/\/doi.org\/10.1016\/j.kjms.2017.10.002.","journal-title":"Kaohsiung J Med Sci"},{"key":"9870_CR4","doi-asserted-by":"publisher","first-page":"146791","DOI":"10.1016\/j.gene.2022.146791","volume":"843","author":"K Cervena","year":"2022","unstructured":"Cervena K, Vodenkova S, Vymetalkova V. MALAT1 in colorectal cancer: its implication as a diagnostic, prognostic, and predictive biomarker. Gene. 2022;843:146791. https:\/\/doi.org\/10.1016\/j.gene.2022.146791.","journal-title":"Gene"},{"key":"9870_CR5","doi-asserted-by":"publisher","first-page":"790608","DOI":"10.3389\/fimmu.2022.790608","volume":"13","author":"Y Chen","year":"2022","unstructured":"Chen Y, Ji H, Liu S, Xing Q, Zhu B, Wang Y. Survival prognosis, tumor immune landscape, and immune responses of ADAMTS14 in clear cell renal cell carcinoma and its potential mechanisms. Front Immunol. 2022;13:790608. https:\/\/doi.org\/10.3389\/fimmu.2022.790608. (Published 2022 Apr 29).","journal-title":"Front Immunol."},{"key":"9870_CR6","doi-asserted-by":"publisher","unstructured":"Ciabattoni A, Gregucci F, De Rose F, et al. AIRO Breast Cancer Group Best Clinical Practice 2022 Update [published correction appears in Tumori. 2022 Sep 20;:3008916221130201] [published correction appears in Tumori. 2022 Oct 21;:3008916221135922]. Tumori. 2022;108(2 suppl):1\u2013144. https:\/\/doi.org\/10.1177\/03008916221088885","DOI":"10.1177\/03008916221088885"},{"issue":"14","key":"9870_CR7","doi-asserted-by":"publisher","first-page":"5068","DOI":"10.3390\/ijms21145068","volume":"21","author":"A Di Palo","year":"2020","unstructured":"Di Palo A, Siniscalchi C, Mosca N, Russo A, Potenza N. A novel ceRNA regulatory network involving the long non-coding antisense RNA SPACA6P-AS, miR-125a and its mRNA Targets in Hepatocarcinoma Cells. Int J Mol Sci. 2020;21(14):5068. https:\/\/doi.org\/10.3390\/ijms21145068. (Published 2020 Jul 17).","journal-title":"Int J Mol Sci."},{"key":"9870_CR8","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-023-00901-x","author":"B Han","year":"2023","unstructured":"Han B, Guan X, Ma M, et al. Stiffened tumor microenvironment enhances perineural invasion in breast cancer via integrin signaling. Cell Oncol (Dordr). 2023. https:\/\/doi.org\/10.1007\/s13402-023-00901-x. (Published online November 28, 2023).","journal-title":"Cell Oncol (Dordr)."},{"key":"9870_CR9","doi-asserted-by":"publisher","first-page":"113774","DOI":"10.1016\/j.biopha.2022.113774","volume":"155","author":"M Hashemi","year":"2022","unstructured":"Hashemi M, Arani HZ, Orouei S, et al. EMT mechanism in breast cancer metastasis and drug resistance: revisiting molecular interactions and biological functions. Biomed Pharmacother. 2022;155:113774. https:\/\/doi.org\/10.1016\/j.biopha.2022.113774.","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"9870_CR10","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3892\/ijo.2023.5604","volume":"64","author":"Y He","year":"2024","unstructured":"He Y, Du X, Yuan F, et al. Long non-coding RNAs in gallbladder cancer: From mechanisms to therapeutic opportunities (Review). Int J Oncol. 2024;64(2):16. https:\/\/doi.org\/10.3892\/ijo.2023.5604.","journal-title":"Int J Oncol"},{"issue":"12","key":"9870_CR11","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1136\/ijgc-2023-004944","volume":"33","author":"F Heitz","year":"2023","unstructured":"Heitz F, Marth C, Henry S, et al. AGO-OVAR 28\/ENGOT-ov57. Niraparib alone versus niraparib in combination with bevacizumab in patients with carboplatin-taxane-based chemotherapy in advanced ovarian cancer: a multicenter randomized phase III trial. Int J Gynecol Cancer. 2023;33(12):1966\u20139. https:\/\/doi.org\/10.1136\/ijgc-2023-004944. (Published 2023 Dec 4).","journal-title":"Int J Gynecol Cancer."},{"issue":"1","key":"9870_CR12","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1097\/PPO.0000000000000500","volume":"27","author":"FM Howard","year":"2021","unstructured":"Howard FM, Olopade OI. Epidemiology of triple-negative breast cancer: a review. Cancer J. 2021;27(1):8\u201316. https:\/\/doi.org\/10.1097\/PPO.0000000000000500.","journal-title":"Cancer J"},{"key":"9870_CR13","doi-asserted-by":"publisher","first-page":"1217985","DOI":"10.3389\/fcvm.2023.1217985","volume":"10","author":"B Hu","year":"2023","unstructured":"Hu B, Chen W, Zhong Y, Tuo Q. The role of lncRNA-mediated pyroptosis in cardiovascular diseases. Front Cardiovasc Med. 2023;10:1217985. https:\/\/doi.org\/10.3389\/fcvm.2023.1217985. (Published 2023 Jun 16).","journal-title":"Front Cardiovasc Med."},{"issue":"1","key":"9870_CR14","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s12885-018-4098-y","volume":"18","author":"M Ibrahim","year":"2018","unstructured":"Ibrahim M, Yadav S, Ogunleye F, Zakalik D. Male BRCA mutation carriers: clinical characteristics and cancer spectrum. BMC Cancer. 2018;18(1):179. https:\/\/doi.org\/10.1186\/s12885-018-4098-y. (Published 2018 Feb 13).","journal-title":"BMC Cancer."},{"issue":"1","key":"9870_CR15","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41572-020-00224-3","volume":"6","author":"DE Johnson","year":"2020","unstructured":"Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR. Head and neck squamous cell carcinoma [published correction appears in Nat Rev Dis Primers. 2023 Jan 19;9(1):4]. Nat Rev Dis Primers. 2020;6(1):92. https:\/\/doi.org\/10.1038\/s41572-020-00224-3. (Published 2020 Nov 26).","journal-title":"Nat Rev Dis Primers."},{"issue":"1","key":"9870_CR16","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/ni.3631","volume":"18","author":"ZB Katz","year":"2017","unstructured":"Katz ZB, Novotn\u00e1 L, Blount A, Lillemeier BF. A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli. Nat Immunol. 2017;18(1):86\u201395. https:\/\/doi.org\/10.1038\/ni.3631.","journal-title":"Nat Immunol"},{"issue":"10","key":"9870_CR17","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1038\/s41416-021-01469-9","volume":"125","author":"E Lai","year":"2021","unstructured":"Lai E, Ziranu P, Spanu D, et al. BRCA-mutant pancreatic ductal adenocarcinoma. Br J Cancer. 2021;125(10):1321\u201332. https:\/\/doi.org\/10.1038\/s41416-021-01469-9.","journal-title":"Br J Cancer"},{"key":"9870_CR18","doi-asserted-by":"publisher","first-page":"101878","DOI":"10.1016\/j.arr.2023.101878","volume":"86","author":"K Li","year":"2023","unstructured":"Li K, Wang Z. lncRNA NEAT1: Key player in neurodegenerative diseases. Ageing Res Rev. 2023;86:101878. https:\/\/doi.org\/10.1016\/j.arr.2023.101878.","journal-title":"Ageing Res Rev"},{"issue":"1","key":"9870_CR19","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1038\/s41467-022-29151-5","volume":"13","author":"J Li","year":"2022","unstructured":"Li J, Shu X, Xu J, et al. S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy. Nat Commun. 2022a;13(1):1481. https:\/\/doi.org\/10.1038\/s41467-022-29151-5. (Published 2022 Mar 18).","journal-title":"Nat Commun."},{"issue":"1","key":"9870_CR20","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1186\/s12943-022-01654-1","volume":"21","author":"M Li","year":"2022","unstructured":"Li M, Liu G, Jin X, et al. Micropeptide MIAC inhibits the tumor progression by interacting with AQP2 and inhibiting EREG\/EGFR signaling in renal cell carcinoma. Mol Cancer. 2022b;21(1):181. https:\/\/doi.org\/10.1186\/s12943-022-01654-1. (Published 2022 Sep 19).","journal-title":"Mol Cancer."},{"issue":"174","key":"9870_CR21","doi-asserted-by":"publisher","first-page":"19","DOI":"10.24976\/Discov.Med.202335174.3","volume":"35","author":"W Li","year":"2023","unstructured":"Li W, Cheng Y, Cheng J, et al. Long Noncoding RNA LINC01614 is a diagnostic and prognostic marker for breast cancer. Discov Med. 2023;35(174):19\u201327. https:\/\/doi.org\/10.24976\/Discov.Med.202335174.3.","journal-title":"Discov Med."},{"key":"9870_CR22","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8132","author":"JK Li","year":"2024","unstructured":"Li JK, Jiang XL, Zhang Z, et al. Isoalantolactone exerts anti-melanoma effects via inhibiting PI3K\/AKT\/mTOR and STAT3 signaling in cell and mouse models. Phytother Res. 2024. https:\/\/doi.org\/10.1002\/ptr.8132. (Published online March 25, 2024).","journal-title":"Phytother Res."},{"key":"9870_CR23","doi-asserted-by":"publisher","unstructured":"Liang Y, Hao M, Guo R, et al. Sheng Wu Gong Cheng Xue Bao. 2023;39(4):1425\u20131444. https:\/\/doi.org\/10.13345\/j.cjb.220699","DOI":"10.13345\/j.cjb.220699"},{"issue":"1","key":"9870_CR24","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1186\/s13045-021-01194-z","volume":"14","author":"S Liu","year":"2021","unstructured":"Liu S, Sun Y, Hou Y, et al. A novel lncRNA ROPM-mediated lipid metabolism governs breast cancer stem cell properties. J Hematol Oncol. 2021;14(1):178. https:\/\/doi.org\/10.1186\/s13045-021-01194-z. (Published 2021 Oct 29).","journal-title":"J Hematol Oncol."},{"issue":"8","key":"9870_CR25","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1038\/s42255-022-00616-7","volume":"4","author":"F Liu","year":"2022","unstructured":"Liu F, Tian T, Zhang Z, et al. Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma [published correction appears in Nat Metab. 2022 Sep 6;:]. Nat Metab. 2022;4(8):1022\u201340. https:\/\/doi.org\/10.1038\/s42255-022-00616-7.","journal-title":"Nat Metab."},{"key":"9870_CR26","doi-asserted-by":"publisher","first-page":"10343","DOI":"10.2147\/OTT.S260848","volume":"13","author":"A Martuszewski","year":"2020","unstructured":"Martuszewski A, Paluszkiewicz P, Nowak M, Szewczyk K, Staszek-Szewczyk U. Triple discordances in receptor status during breast cancer local progression and metastases: case report and literature review [published correction appears in Onco Targets Ther. 2021 Feb 04;14:807]. Onco Targets Ther. 2020;13:10343\u20139. https:\/\/doi.org\/10.2147\/OTT.S260848. (Published 2020 Oct 13).","journal-title":"Onco Targets Ther."},{"issue":"6","key":"9870_CR27","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1002\/cncr.34615","volume":"129","author":"KA Metcalfe","year":"2023","unstructured":"Metcalfe KA, Gronwald J, Tung NM, et al. The risks of cancer in older women with BRCA pathogenic variants: how far have we come? Cancer. 2023;129(6):901\u20137. https:\/\/doi.org\/10.1002\/cncr.34615.","journal-title":"Cancer"},{"issue":"2","key":"9870_CR28","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.mcna.2022.10.007","volume":"107","author":"E Michaels","year":"2023","unstructured":"Michaels E, Worthington RO, Rusiecki J. Breast cancer: risk assessment, screening, and primary prevention. Med Clin North Am. 2023;107(2):271\u201384. https:\/\/doi.org\/10.1016\/j.mcna.2022.10.007.","journal-title":"Med Clin North Am"},{"key":"9870_CR29","doi-asserted-by":"publisher","first-page":"685641","DOI":"10.1155\/2013\/685641","volume":"2013","author":"P Mirabelli","year":"2013","unstructured":"Mirabelli P, Incoronato M. Usefulness of traditional serum biomarkers for management of breast cancer patients. Biomed Res Int. 2013;2013:685641. https:\/\/doi.org\/10.1155\/2013\/685641.","journal-title":"Biomed Res Int"},{"issue":"1","key":"9870_CR30","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s00428-022-03267-x","volume":"480","author":"S Najjar","year":"2022","unstructured":"Najjar S, Allison KH. Updates on breast biomarkers. Virchows Arch. 2022;480(1):163\u201376. https:\/\/doi.org\/10.1007\/s00428-022-03267-x.","journal-title":"Virchows Arch"},{"issue":"7","key":"9870_CR31","doi-asserted-by":"publisher","first-page":"e18221","DOI":"10.1111\/jcmm.18221","volume":"28","author":"JL Nie","year":"2024","unstructured":"Nie JL, Li Q, Yin HT, et al. NPS-2143 inhibit glioma progression by suppressing autophagy through mediating AKT-mTOR pathway. J Cell Mol Med. 2024;28(7):e18221. https:\/\/doi.org\/10.1111\/jcmm.18221.","journal-title":"J Cell Mol Med"},{"issue":"6","key":"9870_CR32","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/s41580-021-00447-6","volume":"23","author":"T Nojima","year":"2022","unstructured":"Nojima T, Proudfoot NJ. Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics [published correction appears in Nat Rev Mol Cell Biol. 2022 Dec;23(12):853]. Nat Rev Mol Cell Biol. 2022;23(6):389\u2013406. https:\/\/doi.org\/10.1038\/s41580-021-00447-6.","journal-title":"Nat Rev Mol Cell Biol."},{"issue":"8","key":"9870_CR33","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1016\/j.cell.2023.01.040","volume":"186","author":"E Nolan","year":"2023","unstructured":"Nolan E, Lindeman GJ, Visvader JE. Deciphering breast cancer: from biology to the clinic. Cell. 2023;186(8):1708\u201328. https:\/\/doi.org\/10.1016\/j.cell.2023.01.040.","journal-title":"Cell"},{"issue":"12","key":"9870_CR34","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.1016\/j.cmet.2021.11.011","volume":"33","author":"MK Park","year":"2021","unstructured":"Park MK, Zhang L, Min KW, et al. NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis. Cell Metab. 2021;33(12):2380-2397.e9. https:\/\/doi.org\/10.1016\/j.cmet.2021.11.011.","journal-title":"Cell Metab"},{"issue":"4","key":"9870_CR35","doi-asserted-by":"publisher","first-page":"100554","DOI":"10.1016\/j.esmoop.2022.100554","volume":"7","author":"CA Powell","year":"2022","unstructured":"Powell CA, Modi S, Iwata H, et al. Pooled analysis of drug-related interstitial lung disease and\/or pneumonitis in nine trastuzumab deruxtecan monotherapy studies. ESMO Open. 2022;7(4):100554. https:\/\/doi.org\/10.1016\/j.esmoop.2022.100554.","journal-title":"ESMO Open"},{"key":"9870_CR36","doi-asserted-by":"publisher","first-page":"684531","DOI":"10.3389\/fonc.2021.684531","volume":"11","author":"S Qin","year":"2021","unstructured":"Qin S, Yang L, Kong S, Xu Y, Liang B, Ju S. LncRNA HCP5: a potential biomarker for diagnosing gastric cancer. Front Oncol. 2021;11:684531. https:\/\/doi.org\/10.3389\/fonc.2021.684531. (Published 2021 Jun 18).","journal-title":"Front Oncol."},{"issue":"1","key":"9870_CR37","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.molcel.2018.08.014","volume":"72","author":"LJ Sang","year":"2018","unstructured":"Sang LJ, Ju HQ, Liu GP, et al. LncRNA CamK-A regulates ca2+-signaling-mediated tumor microenvironment remodeling [published correction appears in Mol Cell. 2018 Nov 1;72(3):601]. Mol Cell. 2018;72(1):71-83.e7. https:\/\/doi.org\/10.1016\/j.molcel.2018.08.014.","journal-title":"Mol Cell."},{"issue":"Suppl 2","key":"9870_CR38","doi-asserted-by":"publisher","first-page":"S60","DOI":"10.1038\/modpathol.2010.33","volume":"23","author":"SJ Schnitt","year":"2010","unstructured":"Schnitt SJ. Classification and prognosis of invasive breast cancer: from morphology to molecular taxonomy. Mod Pathol. 2010;23(Suppl 2):S60\u20134. https:\/\/doi.org\/10.1038\/modpathol.2010.33.","journal-title":"Mod Pathol"},{"issue":"11","key":"9870_CR39","doi-asserted-by":"publisher","first-page":"2562","DOI":"10.3390\/cancers13112562","volume":"13","author":"M Sekine","year":"2021","unstructured":"Sekine M, Nishino K, Enomoto T. BRCA genetic test and risk-reducing salpingo-oophorectomy for hereditary breast and ovarian cancer: state-of-the-art. Cancers (Basel). 2021;13(11):2562. https:\/\/doi.org\/10.3390\/cancers13112562. (Published 2021 May 23).","journal-title":"Cancers (Basel)."},{"issue":"Pt 3","key":"9870_CR40","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.semcancer.2022.05.013","volume":"86","author":"H Shaath","year":"2022","unstructured":"Shaath H, Vishnubalaji R, Elango R, et al. Long non-coding RNA and RNA-binding protein interactions in cancer: experimental and machine learning approaches. Semin Cancer Biol. 2022;86(Pt 3):325\u201345. https:\/\/doi.org\/10.1016\/j.semcancer.2022.05.013.","journal-title":"Semin Cancer Biol"},{"key":"9870_CR41","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1146\/annurev-pathmechdis-031621-024600","volume":"18","author":"MH Sherman","year":"2023","unstructured":"Sherman MH, Beatty GL. Tumor microenvironment in pancreatic cancer pathogenesis and therapeutic resistance. Annu Rev Pathol. 2023;18:123\u201348. https:\/\/doi.org\/10.1146\/annurev-pathmechdis-031621-024600.","journal-title":"Annu Rev Pathol"},{"issue":"7","key":"9870_CR42","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1161\/CIRCRESAHA.122.321960","volume":"132","author":"H Shi","year":"2023","unstructured":"Shi H, Nguyen T, Zhao Q, et al. Discovery of transacting long noncoding RNAs that regulate smooth muscle cell phenotype. Circ Res. 2023;132(7):795\u2013811. https:\/\/doi.org\/10.1161\/CIRCRESAHA.122.321960.","journal-title":"Circ Res"},{"issue":"1","key":"9870_CR43","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21708","volume":"72","author":"RL Siegel","year":"2022","unstructured":"Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72(1):7\u201333. https:\/\/doi.org\/10.3322\/caac.21708.","journal-title":"CA Cancer J Clin"},{"issue":"2","key":"9870_CR44","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/cac2.12108","volume":"41","author":"YT Tan","year":"2021","unstructured":"Tan YT, Lin JF, Li T, Li JJ, Xu RH, Ju HQ. LncRNA-mediated posttranslational modifications and reprogramming of energy metabolism in cancer. Cancer Commun (lond). 2021;41(2):109\u201320. https:\/\/doi.org\/10.1002\/cac2.12108.","journal-title":"Cancer Commun (lond)"},{"issue":"1","key":"9870_CR45","doi-asserted-by":"publisher","first-page":"3856","DOI":"10.1038\/s41598-024-54132-7","volume":"14","author":"R Vieira Costa","year":"2024","unstructured":"Vieira Costa R, Balbinot KM, da Silveira GCAR, et al. Prognostic value of the expression and localization of cell proliferation and apoptosis markers in unicystic ameloblastomas. Sci Rep. 2024;14(1):3856. https:\/\/doi.org\/10.1038\/s41598-024-54132-7. (Published 2024 Feb 15).","journal-title":"Sci Rep."},{"issue":"7578","key":"9870_CR46","doi-asserted-by":"publisher","first-page":"S101","DOI":"10.1038\/527S101a","volume":"527","author":"C Woolston","year":"2015","unstructured":"Woolston C. Breast cancer. Nature. 2015;527(7578):S101. https:\/\/doi.org\/10.1038\/527S101a.","journal-title":"Nature"},{"key":"9870_CR47","doi-asserted-by":"publisher","first-page":"154610","DOI":"10.1016\/j.phymed.2022.154610","volume":"110","author":"Y Wu","year":"2023","unstructured":"Wu Y, Li Q, Lv LL, et al. Nobiletin inhibits breast cancer cell migration and invasion by suppressing the IL-6-induced ERK-STAT and JNK-c-JUN pathways. Phytomedicine. 2023;110:154610. https:\/\/doi.org\/10.1016\/j.phymed.2022.154610.","journal-title":"Phytomedicine"},{"issue":"9","key":"9870_CR48","doi-asserted-by":"publisher","first-page":"4033","DOI":"10.21037\/tcr-21-747","volume":"10","author":"M Xu","year":"2021","unstructured":"Xu M, Chen Z, Lin B, Zhang S, Qu J. A seven-lncRNA signature for predicting prognosis in breast carcinoma. Transl Cancer Res. 2021;10(9):4033\u201346. https:\/\/doi.org\/10.21037\/tcr-21-747.","journal-title":"Transl Cancer Res."},{"key":"9870_CR49","doi-asserted-by":"publisher","first-page":"154762","DOI":"10.1016\/j.phymed.2023.154762","volume":"114","author":"S Yang","year":"2023","unstructured":"Yang S, Wang L, Zeng Y, et al. Salidroside alleviates cognitive impairment by inhibiting ferroptosis via activation of the Nrf2\/GPX4 axis in SAMP8 mice. Phytomedicine. 2023;114:154762. https:\/\/doi.org\/10.1016\/j.phymed.2023.154762.","journal-title":"Phytomedicine"},{"issue":"5","key":"9870_CR50","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16(5):284\u20137. https:\/\/doi.org\/10.1089\/omi.2011.0118.","journal-title":"OMICS"},{"issue":"2","key":"9870_CR51","doi-asserted-by":"publisher","first-page":"153","DOI":"10.3390\/genes10020153","volume":"10","author":"VA Zavala","year":"2019","unstructured":"Zavala VA, Serrano-Gomez SJ, Dutil J, Fejerman L. Genetic epidemiology of breast cancer in Latin America. Genes (Basel). 2019;10(2):153. https:\/\/doi.org\/10.3390\/genes10020153. (Published 2019 Feb 18).","journal-title":"Genes (Basel)."},{"key":"9870_CR52","doi-asserted-by":"publisher","first-page":"106936","DOI":"10.1016\/j.ijsu.2022.106936","volume":"107","author":"Y Zou","year":"2022","unstructured":"Zou Y, Xie J, Zheng S, et al. Leveraging diverse cell-death patterns to predict the prognosis and drug sensitivity of triple-negative breast cancer patients after surgery. Int J Surg. 2022;107:106936. https:\/\/doi.org\/10.1016\/j.ijsu.2022.106936.","journal-title":"Int J Surg"}],"container-title":["Cell Biology and Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10565-024-09870-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10565-024-09870-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10565-024-09870-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T01:30:29Z","timestamp":1735867829000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10565-024-09870-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,26]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["9870"],"URL":"https:\/\/doi.org\/10.1007\/s10565-024-09870-9","relation":{},"ISSN":["1573-6822"],"issn-type":[{"type":"electronic","value":"1573-6822"}],"subject":[],"published":{"date-parts":[[2024,6,26]]},"assertion":[{"value":"23 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The animal experimental processes were approved by the Ethnic Committee of the First Affiliated Hospital, Hengyang Medical School, University of South China (No. 2023ll0306001) and conducted in strict accordance to the standard of the Guide for the Care and Use of Laboratory Animals published by the Ministry of Science and Technology of the People \u2018s Republic of China in 2006.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"49"}}