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There are no interceptive treatment about CP until now. Germline deletion of phosphatase and tensin homolog (<jats:italic>Pten<\/jats:italic>) was related to embryonic malformation and regulated tumor cell proliferation through glycolysis. However, the role of <jats:italic>Pten<\/jats:italic> in CP and the relationship between CP, <jats:italic>Pten,<\/jats:italic> and glycolysis are unknown. In our research, we constructed <jats:italic>Pten<\/jats:italic> knockdown models in vitro and in vivo. Our results provided preliminary evidence that blocking <jats:italic>Pten<\/jats:italic> by its inhibitor such as VO-OHpic might be an effective interceptive treatment in early period of palate development when pregnant mother expose in harmful environment during the early period of palate development to reducing CP occurring which was related with the crosstalk between <jats:italic>Pten<\/jats:italic>, and glycolysis in the process.<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical Abstract<\/jats:bold>\n          <\/jats:p>","DOI":"10.1007\/s10565-025-10000-2","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T15:06:17Z","timestamp":1740755177000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Glycolysis regulates palatal mesenchyme proliferation through Pten-Glut1 axis via Pten classical and non-classical pathways"],"prefix":"10.1007","volume":"41","author":[{"given":"Yijia","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xige","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"issue":"5","key":"10000_CR1","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/j.1432-0436.2005.00022.x","volume":"73","author":"SM Behnan","year":"2005","unstructured":"Behnan SM, Guo C, Gong TW, Shum L, Gong SG. 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