{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:15:55Z","timestamp":1790288155798,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Natural Science Foundation","doi-asserted-by":"crossref","award":["2023JJ60073"],"award-info":[{"award-number":["2023JJ60073"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Natural Science Foundation","doi-asserted-by":"crossref","award":["2023JJ60073"],"award-info":[{"award-number":["2023JJ60073"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Natural Science Foundation","doi-asserted-by":"crossref","award":["2023JJ60073"],"award-info":[{"award-number":["2023JJ60073"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Natural Science Foundation","doi-asserted-by":"crossref","award":["2023JJ60073"],"award-info":[{"award-number":["2023JJ60073"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Natural Science Foundation","doi-asserted-by":"crossref","award":["2023JJ60073"],"award-info":[{"award-number":["2023JJ60073"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Changsha Natural Science Foundation","award":["kq2208436"],"award-info":[{"award-number":["kq2208436"]}]},{"name":"Changsha Natural Science Foundation","award":["kq2208436"],"award-info":[{"award-number":["kq2208436"]}]},{"name":"Changsha Natural Science Foundation","award":["kq2208436"],"award-info":[{"award-number":["kq2208436"]}]},{"name":"Changsha Natural Science Foundation","award":["kq2208436"],"award-info":[{"award-number":["kq2208436"]}]},{"name":"Changsha Natural Science Foundation","award":["kq2208436"],"award-info":[{"award-number":["kq2208436"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biol Toxicol"],"DOI":"10.1007\/s10565-025-10028-4","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T11:51:55Z","timestamp":1747223515000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["U2AF65 mediated circPVT1 promotes NSCLC cell proliferation and inhibits ferroptosis through the miR-338-3p\/GPX4 axis"],"prefix":"10.1007","volume":"41","author":[{"given":"Lujuan","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zezhi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jufen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiehan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenggang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"10028_CR1","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1136\/jclinpath-2019-205891","volume":"72","author":"J Adhikary","year":"2019","unstructured":"Adhikary J, Chakraborty S, Dalal S, Basu S, Dey A, Ghosh A. Circular PVT1: an oncogenic non-coding RNA with emerging clinical importance. J Clin Pathol. 2019;72:513\u20139. https:\/\/doi.org\/10.1136\/jclinpath-2019-205891.","journal-title":"J Clin Pathol"},{"key":"10028_CR2","doi-asserted-by":"publisher","first-page":"155203","DOI":"10.1016\/j.prp.2024.155203","volume":"255","author":"J Arabpour","year":"2024","unstructured":"Arabpour J, Rezaei K, Khojini JY, Razi S, Hayati MJ, Gheibihayat SM. The potential role and mechanism of circRNAs in Ferroptosis: a comprehensive review. Pathol Res Pract. 2024;255:155203. https:\/\/doi.org\/10.1016\/j.prp.2024.155203.","journal-title":"Pathol Res Pract"},{"key":"10028_CR3","doi-asserted-by":"publisher","unstructured":"Blijlevens M, Li J, van Beusechem VW. Biology of the mRNA splicing machinery and its dysregulation in cancer providing therapeutic opportunities. Int J Mol Sci. 2021;22. https:\/\/doi.org\/10.3390\/ijms22105110.","DOI":"10.3390\/ijms22105110"},{"key":"10028_CR4","doi-asserted-by":"publisher","unstructured":"Bravo JI, Nozownik S, Danthi PS, Benayoun BA. Transposable elements, circular RNAs and mitochondrial transcription in age-related genomic regulation. Development. 2020;147. https:\/\/doi.org\/10.1242\/dev.175786.","DOI":"10.1242\/dev.175786"},{"key":"10028_CR5","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s10020-023-00763-x","volume":"30","author":"J Chen","year":"2024","unstructured":"Chen J, Zhao R, Wang Y, Xiao H, Lin W, Diao M, He S, Mei P, Liao Y. G protein-coupled estrogen receptor activates PI3K\/AKT\/mTOR signaling to suppress ferroptosis via SREBP1\/SCD1-mediated lipogenesis. Mol Med. 2024;30:28. https:\/\/doi.org\/10.1186\/s10020-023-00763-x.","journal-title":"Mol Med"},{"key":"10028_CR6","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B 3rd, Stockwell BR. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149:1060\u201372. https:\/\/doi.org\/10.1016\/j.cell.2012.03.042.","journal-title":"Cell"},{"key":"10028_CR7","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1016\/j.tcb.2023.04.005","volume":"33","author":"AF Dos Santos","year":"2023","unstructured":"Dos Santos AF, Fazeli G, Xavier da Silva TN, FriedmannAngeli JP. Ferroptosis: mechanisms and implications for cancer development and therapy response. Trends Cell Biol. 2023;33:1062\u201376. https:\/\/doi.org\/10.1016\/j.tcb.2023.04.005.","journal-title":"Trends Cell Biol"},{"key":"10028_CR8","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1097\/CAD.0000000000001347","volume":"34","author":"L Du","year":"2023","unstructured":"Du L, Guo D, Sun C, Yan X, Lin S, Xu S. CircPIM3 regulates taxol resistance in non-small cell lung cancer via miR-338-3p\/TNFAIP8 axis. Anticancer Drugs. 2023;34:115\u201325. https:\/\/doi.org\/10.1097\/CAD.0000000000001347.","journal-title":"Anticancer Drugs"},{"key":"10028_CR9","doi-asserted-by":"publisher","unstructured":"Favorito V, Ricciotti I, De Giglio A, Fabbri L, Seminerio R, Di Federico A, Gariazzo E, Costabile S, Metro G. Non-small cell lung cancer: an update on emerging EGFR-targeted therapies. Expert Opin Emerg Drugs. 2024:1\u201316. https:\/\/doi.org\/10.1080\/14728214.2024.2331139.","DOI":"10.1080\/14728214.2024.2331139"},{"key":"10028_CR10","doi-asserted-by":"publisher","first-page":"216826","DOI":"10.1016\/j.canlet.2024.216826","volume":"590","author":"GB Gao","year":"2024","unstructured":"Gao GB, Chen L, Pan JF, Lei T, Cai X, Hao Z, Wang Q, Shan G, Li J. LncRNA RGMB-AS1 inhibits HMOX1 ubiquitination and NAA10 activation to induce ferroptosis in non-small cell lung cancer. Cancer Lett. 2024;590:216826. https:\/\/doi.org\/10.1016\/j.canlet.2024.216826.","journal-title":"Cancer Lett"},{"key":"10028_CR11","doi-asserted-by":"publisher","first-page":"5299","DOI":"10.1093\/nar\/gkac287","volume":"50","author":"E Glasser","year":"2022","unstructured":"Glasser E, Maji D, Biancon G, Puthenpeedikakkal AMK, Cavender CE, Tebaldi T, Jenkins JL, Mathews DH, Halene S, Kielkopf CL. Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal. Nucleic Acids Res. 2022;50:5299\u2013312. https:\/\/doi.org\/10.1093\/nar\/gkac287.","journal-title":"Nucleic Acids Res"},{"key":"10028_CR12","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/s41419-022-05137-5","volume":"13","author":"J Grube","year":"2022","unstructured":"Grube J, Woitok MM, Mohs A, Erschfeld S, Lynen C, Trautwein C, Otto T. ACSL4-dependent ferroptosis does not represent a tumor-suppressive mechanism but ACSL4 rather promotes liver cancer progression. Cell Death Dis. 2022;13:704. https:\/\/doi.org\/10.1038\/s41419-022-05137-5.","journal-title":"Cell Death Dis"},{"key":"10028_CR13","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.18632\/aging.205408","volume":"16","author":"S Han","year":"2024","unstructured":"Han S, Yang X, Zhuang J, Zhou Q, Wang J, Ru L, Niu F, Mao W. alpha-Hederin promotes ferroptosis and reverses cisplatin chemoresistance in non-small cell lung cancer. Aging (Albany NY). 2024;16:1298\u2013317. https:\/\/doi.org\/10.18632\/aging.205408.","journal-title":"Aging (Albany NY)"},{"key":"10028_CR14","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nature11993","volume":"495","author":"TB Hansen","year":"2013","unstructured":"Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK, Kjems J. Natural RNA circles function as efficient microRNA sponges. Nature. 2013;495:384\u20138. https:\/\/doi.org\/10.1038\/nature11993.","journal-title":"Nature"},{"key":"10028_CR15","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3233\/CBM-203252","volume":"31","author":"M Huang","year":"2021","unstructured":"Huang M, Li T, Wang Q, Li C, Zhou H, Deng S, Lv Z, He Y, Hou B, Zhu G. Silencing circPVT1 enhances radiosensitivity in non-small cell lung cancer by sponging microRNA-1208. Cancer Biomark. 2021;31:263\u201379. https:\/\/doi.org\/10.3233\/CBM-203252.","journal-title":"Cancer Biomark"},{"key":"10028_CR16","doi-asserted-by":"publisher","first-page":"111901","DOI":"10.1016\/j.intimp.2024.111901","volume":"132","author":"X Huang","year":"2024","unstructured":"Huang X, Wu S, Chen S, Qiu M, Zhao Y, Wei J, He J, Zhao W, Tan L, Su C, Zhou S. Prognostic impact of age in advanced non-small cell lung cancer patients undergoing first-line checkpoint inhibitor immunotherapy and chemotherapy treatment. Int Immunopharmacol. 2024;132:111901. https:\/\/doi.org\/10.1016\/j.intimp.2024.111901.","journal-title":"Int Immunopharmacol"},{"key":"10028_CR17","doi-asserted-by":"publisher","first-page":"4893","DOI":"10.1158\/1078-0432.CCR-22-0992","volume":"28","author":"K Hummelink","year":"2022","unstructured":"Hummelink K, van der Noort V, Muller M, Schouten RD, Lalezari F, Peters D, Theelen W, Koelzer VH, Mertz KD, Zippelius A, van den Heuvel MM, Broeks A, Haanen J, Schumacher TN, Meijer GA, Smit EF, Monkhorst K, Thommen DS. PD-1T TILs as a Predictive biomarker for clinical benefit to PD-1 blockade in patients with advanced NSCLC. Clin Cancer Res. 2022;28:4893\u2013906. https:\/\/doi.org\/10.1158\/1078-0432.CCR-22-0992.","journal-title":"Clin Cancer Res"},{"key":"10028_CR18","doi-asserted-by":"publisher","first-page":"e2530","DOI":"10.1002\/rmv.2530","volume":"34","author":"MJ Kamali","year":"2024","unstructured":"Kamali MJ, Salehi M, Mostafavi M, Morovatshoar R, Akbari M, Latifi N, Barzegari O, Ghadimi F, Daraei A. Hijacking and rewiring of host CircRNA\/miRNA\/mRNA competitive endogenous RNA (ceRNA) regulatory networks by oncoviruses during development of viral cancers. Rev Med Virol. 2024;34:e2530. https:\/\/doi.org\/10.1002\/rmv.2530.","journal-title":"Rev Med Virol"},{"key":"10028_CR19","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1007\/s12325-024-02799-9","volume":"41","author":"M Khasraw","year":"2024","unstructured":"Khasraw M, Yalamanchili P, Santhanagopal A, Wu C, Salas M, Meng J, Karnoub M, Esker S, Felip E. Clinical management of patients with non-small cell lung cancer, brain metastases, and actionable genomic alterations: a systematic literature review. Adv Ther. 2024;41:1815\u201342. https:\/\/doi.org\/10.1007\/s12325-024-02799-9.","journal-title":"Adv Ther"},{"key":"10028_CR20","doi-asserted-by":"publisher","first-page":"4624","DOI":"10.1038\/s41467-021-24795-1","volume":"12","author":"GI Laliotis","year":"2021","unstructured":"Laliotis GI, Chavdoula E, Paraskevopoulou MD, Kaba A, La Ferlita A, Singh S, Anastas V, Nair KA 2nd, Orlacchio A, Taraslia V, Vlachos I, Capece M, Hatzigeorgiou A, Palmieri D, Tsatsanis C, Alaimo S, Sehgal L, Carbone DP, Coppola V, Tsichlis PN. AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing. Nat Commun. 2021;12:4624. https:\/\/doi.org\/10.1038\/s41467-021-24795-1.","journal-title":"Nat Commun"},{"key":"10028_CR21","doi-asserted-by":"publisher","first-page":"179","DOI":"10.7150\/thno.29545","volume":"9","author":"J Li","year":"2019","unstructured":"Li J, Cheng D, Zhu M, Yu H, Pan Z, Liu L, Geng Q, Pan H, Yan M, Yao M. OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT\/mTOR signaling pathway in non-small cell lung cancer. Theranostics. 2019;9:179\u201395. https:\/\/doi.org\/10.7150\/thno.29545.","journal-title":"Theranostics"},{"key":"10028_CR22","doi-asserted-by":"publisher","DOI":"10.1007\/s12033-024-01059-z","author":"Z Li","year":"2024","unstructured":"Li Z, Fan M, Zhou Z, Sang X. Circ_0082374 promotes the tumorigenesis and suppresses ferroptosis in non-small cell lung cancer by up-regulating GPX4 through sequestering miR-491-5p. Mol Biotechnol. 2024. https:\/\/doi.org\/10.1007\/s12033-024-01059-z.","journal-title":"Mol Biotechnol"},{"key":"10028_CR23","first-page":"3662","volume":"12","author":"H Lin","year":"2022","unstructured":"Lin H, Gao Y, Sun K, Zhang Q, Li Y, Chen M, Jin F. COA3 overexpression promotes non-small cell lung cancer metastasis by reprogramming glucose metabolism. Am J Cancer Res. 2022;12:3662\u201378.","journal-title":"Am J Cancer Res"},{"key":"10028_CR24","doi-asserted-by":"publisher","unstructured":"Livanou ME, Nikolaidou V, Skouras V, Fiste O, Kotteas E. Efficacy of NSCLC rechallenge with immune checkpoint inhibitors following disease progression or relapse. Cancers (Basel). 2024;16. https:\/\/doi.org\/10.3390\/cancers16061196.","DOI":"10.3390\/cancers16061196"},{"key":"10028_CR25","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1177\/0300891620941940","volume":"107","author":"H Lu","year":"2021","unstructured":"Lu H, Xie X, Chen Q, Cai S, Liu S, Bao C, Luo J, Kong J. Clinical significance of circPVT1 in patients with non-small cell lung cancer who received cisplatin combined with gemcitabine chemotherapy. Tumori. 2021;107:204\u20138. https:\/\/doi.org\/10.1177\/0300891620941940.","journal-title":"Tumori"},{"key":"10028_CR26","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1084\/jem.20140857","volume":"212","author":"M Matsushita","year":"2015","unstructured":"Matsushita M, Freigang S, Schneider C, Conrad M, Bornkamm GW, Kopf M. T cell lipid peroxidation induces ferroptosis and prevents immunity to infection. J Exp Med. 2015;212:555\u201368. https:\/\/doi.org\/10.1084\/jem.20140857.","journal-title":"J Exp Med"},{"key":"10028_CR27","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.bbrc.2021.06.051","volume":"567","author":"J Ni","year":"2021","unstructured":"Ni J, Chen K, Zhang J, Zhang X. Inhibition of GPX4 or mTOR overcomes resistance to Lapatinib via promoting ferroptosis in NSCLC cells. Biochem Biophys Res Commun. 2021;567:154\u201360. https:\/\/doi.org\/10.1016\/j.bbrc.2021.06.051.","journal-title":"Biochem Biophys Res Commun"},{"key":"10028_CR28","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s13073-020-00812-8","volume":"12","author":"TLH Okholm","year":"2020","unstructured":"Okholm TLH, Sathe S, Park SS, Kamstrup AB, Rasmussen AM, Shankar A, Chua ZM, Fristrup N, Nielsen MM, Vang S, Dyrskjot L, Aigner S, Damgaard CK, Yeo GW, Pedersen JS. Transcriptome-wide profiles of circular RNA and RNA-binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression. Genome Med. 2020;12:112. https:\/\/doi.org\/10.1186\/s13073-020-00812-8.","journal-title":"Genome Med"},{"key":"10028_CR29","doi-asserted-by":"publisher","first-page":"104341","DOI":"10.1016\/j.critrevonc.2024.104341","volume":"198","author":"H Padinharayil","year":"2024","unstructured":"Padinharayil H, George A. Small extracellular vesicles: multi-functional aspects in non-small cell lung carcinoma. Crit Rev Oncol Hematol. 2024;198:104341. https:\/\/doi.org\/10.1016\/j.critrevonc.2024.104341.","journal-title":"Crit Rev Oncol Hematol"},{"key":"10028_CR30","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.freeradbiomed.2018.09.014","volume":"133","author":"TM Seibt","year":"2019","unstructured":"Seibt TM, Proneth B, Conrad M. Role of GPX4 in ferroptosis and its pharmacological implication. Free Radic Biol Med. 2019;133:144\u201352. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2018.09.014.","journal-title":"Free Radic Biol Med"},{"key":"10028_CR31","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/s41419-022-04933-3","volume":"13","author":"W Tian","year":"2022","unstructured":"Tian W, Yang X, Yang H, Lv M, Sun X, Zhou B. Correction: exosomal miR-338-3p suppresses non-small-cell lung cancer cells metastasis by inhibiting CHL1 through the MAPK signaling pathway. Cell Death Dis. 2022;13:473. https:\/\/doi.org\/10.1038\/s41419-022-04933-3.","journal-title":"Cell Death Dis"},{"key":"10028_CR32","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/0005-2760(82)90150-3","volume":"710","author":"F Ursini","year":"1982","unstructured":"Ursini F, Maiorino M, Valente M, Ferri L, Gregolin C. Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides. Biochim Biophys Acta. 1982;710:197\u2013211. https:\/\/doi.org\/10.1016\/0005-2760(82)90150-3.","journal-title":"Biochim Biophys Acta"},{"key":"10028_CR33","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1038\/s41419-021-03743-3","volume":"12","author":"L Verduci","year":"2021","unstructured":"Verduci L, Tarcitano E, Strano S, Yarden Y, Blandino G. CircRNAs: role in human diseases and potential use as biomarkers. Cell Death Dis. 2021;12:468. https:\/\/doi.org\/10.1038\/s41419-021-03743-3.","journal-title":"Cell Death Dis"},{"key":"10028_CR34","doi-asserted-by":"publisher","first-page":"682862","DOI":"10.3389\/fchem.2021.682862","volume":"9","author":"Y Wang","year":"2021","unstructured":"Wang Y, Zhang Y, Wang Y, Shu X, Lu C, Shao S, Liu X, Yang C, Luo J, Du Q. Using network pharmacology and molecular docking to explore the mechanism of Shan Ci Gu (Cremastra appendiculata) against non-small cell lung cancer. Front Chem. 2021;9:682862. https:\/\/doi.org\/10.3389\/fchem.2021.682862.","journal-title":"Front Chem"},{"key":"10028_CR35","doi-asserted-by":"publisher","first-page":"e2204133","DOI":"10.1002\/smll.202204133","volume":"19","author":"L Wang","year":"2023","unstructured":"Wang L, Fu H, Song L, Wu Z, Yu J, Guo Q, Chen C, Yang X, Zhang J, Wang Q, Duan Y, Yang Y. Overcoming AZD9291 resistance and metastasis of NSCLC via ferroptosis and multitarget interference by nanocatalytic sensitizer plus AHP-DRI-12. Small. 2023;19:e2204133. https:\/\/doi.org\/10.1002\/smll.202204133.","journal-title":"Small"},{"key":"10028_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1615\/JEnvironPatholToxicolOncol.2023049084","volume":"43","author":"Z Wang","year":"2024","unstructured":"Wang Z, Yao X, Wang K, Wang B. TFR1-mediated iron metabolism orchestrates tumor ferroptosis and immunity in non-small cell lung cancer. J Environ Pathol Toxicol Oncol. 2024;43:1\u201312. https:\/\/doi.org\/10.1615\/JEnvironPatholToxicolOncol.2023049084.","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"10028_CR37","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/s41420-023-01407-z","volume":"9","author":"N Xing","year":"2023","unstructured":"Xing N, Du Q, Guo S, Xiang G, Zhang Y, Meng X, Xiang L, Wang S. Ferroptosis in lung cancer: a novel pathway regulating cell death and a promising target for drug therapy. Cell Death Discov. 2023;9:110. https:\/\/doi.org\/10.1038\/s41420-023-01407-z.","journal-title":"Cell Death Discov"},{"key":"10028_CR38","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","volume":"26","author":"WS Yang","year":"2016","unstructured":"Yang WS, Stockwell BR. Ferroptosis: death by lipid peroxidation. Trends Cell Biol. 2016;26:165\u201376. https:\/\/doi.org\/10.1016\/j.tcb.2015.10.014.","journal-title":"Trends Cell Biol"},{"key":"10028_CR39","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","volume":"156","author":"WS Yang","year":"2014","unstructured":"Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, Stockwell BR. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156:317\u201331. https:\/\/doi.org\/10.1016\/j.cell.2013.12.010.","journal-title":"Cell"},{"key":"10028_CR40","doi-asserted-by":"publisher","first-page":"780938","DOI":"10.3389\/fonc.2021.780938","volume":"11","author":"W Yao","year":"2021","unstructured":"Yao W, Wang J, Meng F, Zhu Z, Jia X, Xu L, Zhang Q, Wei L. Circular RNA CircPVT1 inhibits 5-fluorouracil chemosensitivity by regulating ferroptosis through MiR-30a-5p\/FZD3 axis in esophageal cancer cells. Front Oncol. 2021;11:780938. https:\/\/doi.org\/10.3389\/fonc.2021.780938.","journal-title":"Front Oncol"},{"key":"10028_CR41","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s00432-024-05683-9","volume":"150","author":"R Zhao","year":"2024","unstructured":"Zhao R, Guan X, Zhang P, Liu Y, Xu Y, Sun C, Qiu S, Zhu W, Yang Z, Wang X. Development of postoperative bronchopleural fistula after neoadjuvant immunochemotherapy in non-small cell lung cancer: case reports and review of the literature. J Cancer Res Clin Oncol. 2024;150:175. https:\/\/doi.org\/10.1007\/s00432-024-05683-9.","journal-title":"J Cancer Res Clin Oncol"},{"key":"10028_CR42","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/s41420-024-01892-w","volume":"10","author":"S Zhen","year":"2024","unstructured":"Zhen S, Jia Y, Zhao Y, Wang J, Zheng B, Liu T, Duan Y, Lv W, Wang J, Xu F, Liu Y, Zhang Y, Liu L. NEAT1_1 confers gefitinib resistance in lung adenocarcinoma through promoting AKR1C1-mediated ferroptosis defence. Cell Death Discov. 2024;10:131. https:\/\/doi.org\/10.1038\/s41420-024-01892-w.","journal-title":"Cell Death Discov"},{"key":"10028_CR43","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1186\/s12935-019-0985-9","volume":"19","author":"R Zhong","year":"2019","unstructured":"Zhong R, Chen Z, Mo T, Li Z, Zhang P. Potential Role of circPVT1 as a proliferative factor and treatment target in esophageal carcinoma. Cancer Cell Int. 2019;19:267. https:\/\/doi.org\/10.1186\/s12935-019-0985-9.","journal-title":"Cancer Cell Int"},{"key":"10028_CR44","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1080\/14737159.2021.1964959","volume":"21","author":"J Zhou","year":"2021","unstructured":"Zhou J, Zhang H, Zou D, Zhou Z, Wang W, Luo Y, Liu T. Clinicopathologic and prognostic roles of circular RNA plasmacytoma variant translocation 1 in various cancers. Expert Rev Mol Diagn. 2021;21:1095\u2013104. https:\/\/doi.org\/10.1080\/14737159.2021.1964959.","journal-title":"Expert Rev Mol Diagn"},{"key":"10028_CR45","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s10735-022-10070-0","volume":"53","author":"J Zhou","year":"2022","unstructured":"Zhou J, Sun C, Dong X, Wang H. A novel miR-338-3p\/SLC1A5 axis reprograms retinal pigment epithelium to increases its resistance to high glucose-induced cell ferroptosis. J Mol Histol. 2022;53:561\u201371. https:\/\/doi.org\/10.1007\/s10735-022-10070-0.","journal-title":"J Mol Histol"},{"key":"10028_CR46","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1080\/07853890.2021.1925736","volume":"53","author":"Y Zhu","year":"2021","unstructured":"Zhu Y, Ma C, Lv A, Kou C. Circular RNA circ_0010235 sponges miR-338-3p to play oncogenic role in proliferation, migration and invasion of non-small-cell lung cancer cells through modulating KIF2A. Ann Med. 2021;53:693\u2013706. https:\/\/doi.org\/10.1080\/07853890.2021.1925736.","journal-title":"Ann Med"}],"container-title":["Cell Biology and Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10565-025-10028-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10565-025-10028-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10565-025-10028-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T11:51:56Z","timestamp":1747223516000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10565-025-10028-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,14]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["10028"],"URL":"https:\/\/doi.org\/10.1007\/s10565-025-10028-4","relation":{},"ISSN":["1573-6822"],"issn-type":[{"value":"1573-6822","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,14]]},"assertion":[{"value":"4 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The patients involved in this study have written the informed consent. And the study was approved by the Ethics Committee of The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China (No. 2022-S0181).The study was approved by the Ethics Committee of The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China (No. 2022-S0181).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"84"}}