{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:19:06Z","timestamp":1789708746502,"version":"4.0.1"},"reference-count":100,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301938"],"award-info":[{"award-number":["82301938"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2025AFD054"],"award-info":[{"award-number":["2025AFD054"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovative Research Program of Xiangyang No.1 People\u2019s Hospital","award":["XYY2025LJ02"],"award-info":[{"award-number":["XYY2025LJ02"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biol Toxicol"],"DOI":"10.1007\/s10565-025-10095-7","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T13:45:13Z","timestamp":1759499113000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["scRNA-seq deciphers molecular mechanisms of endocrine disruptor 4-nonylphenol impairing spermatogenesis in mice"],"prefix":"10.1007","volume":"41","author":[{"given":"Xue","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengxia","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaolong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"10095_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jevs.2020.103267","volume":"94","author":"V Akbarinejad","year":"2020","unstructured":"Akbarinejad V, Fathi R, Shahverdi A, Esmaeili V, Rezagholizadeh A, Ghaleno LR. The relationship of mitochondrial membrane potential, reactive oxygen species, adenosine triphosphate content, sperm plasma membrane integrity, and kinematic properties in Warmblood stallions. J Equine Vet Sci. 2020;94:103267.","journal-title":"J Equine Vet Sci"},{"issue":"2","key":"10095_CR2","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.taap.2012.02.015","volume":"261","author":"HA Aly","year":"2012","unstructured":"Aly HA, Domenech O, Banjar ZM. Effect of nonylphenol on male reproduction: analysis of rat epididymal biochemical markers and antioxidant defense enzymes. Toxicol Appl Pharmacol. 2012;261(2):134\u201341. https:\/\/doi.org\/10.1016\/j.taap.2012.02.015.","journal-title":"Toxicol Appl Pharmacol"},{"issue":"4","key":"10095_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18041464","volume":"18","author":"S Amir","year":"2021","unstructured":"Amir S, Shah STA, Mamoulakis C, Docea AO, Kalantzi OI, Zachariou A, et al. Endocrine disruptors acting on estrogen and androgen pathways cause reproductive disorders through multiple mechanisms: a review. Int J Environ Res Public Health. 2021;18(4):1464.","journal-title":"Int J Environ Res Public Health"},{"issue":"2","key":"10095_CR4","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1007\/s12020-020-02436-9","volume":"72","author":"F Cargnelutti","year":"2020","unstructured":"Cargnelutti F, Di Nisio A, Pallotti F, Sabovic I, Spaziani M, Tarsitano MG, et al. Effects of endocrine disruptors on fetal testis development, male puberty, and transition age. Endocrine. 2020;72(2):358\u201374.","journal-title":"Endocrine"},{"issue":"4","key":"10095_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/nano13040720","volume":"13","author":"CM Cary","year":"2023","unstructured":"Cary CM, DeLoid GM, Yang Z, Bitounis D, Polunas M, Goedken MJ, et al. Ingested polystyrene nanospheres translocate to placenta and fetal tissues in pregnant rats: potential health implications. Nanomaterials. 2023;13(4):720.","journal-title":"Nanomaterials"},{"key":"10095_CR6","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.envpol.2018.10.040","volume":"244","author":"WH Chang","year":"2019","unstructured":"Chang WH, Liu SC, Chen HL, Lee CC. Dietary intake of 4-nonylphenol and bisphenol A in Taiwanese population: integrated risk assessment based on probabilistic and sensitive approach. Environ Pollut. 2019;244:143\u201352.","journal-title":"Environ Pollut"},{"issue":"15","key":"10095_CR7","doi-asserted-by":"publisher","first-page":"9537","DOI":"10.1021\/acs.est.0c02428","volume":"54","author":"L Chen","year":"2020","unstructured":"Chen L, Wang Z, Gu W, Zhang X, Ren H, Wu B. Single-cell sequencing reveals heterogeneity effects of bisphenol A on zebrafish embryonic development. Environ Sci Technol. 2020;54(15):9537\u201346.","journal-title":"Environ Sci Technol"},{"key":"10095_CR8","doi-asserted-by":"publisher","first-page":"621","DOI":"10.14670\/HH-18-457","volume":"37","author":"K Chen","year":"2022","unstructured":"Chen K, Wei B, Hao S, Yang W. The PI3K\/AKT signaling pathway: How does it regulate development of Sertoli cells and spermatogenic cells? Histol Histopathol. 2022;37:621\u201336. https:\/\/doi.org\/10.14670\/HH-18-457.","journal-title":"Histol Histopathol"},{"key":"10095_CR9","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.chemosphere.2017.12.085","volume":"195","author":"JR Cheng","year":"2018","unstructured":"Cheng JR, Wang K, Yu J, Yu ZX, Yu XB, Zhang ZZ. Distribution and fate modeling of 4-nonylphenol, 4-t-octylphenol, and bisphenol A in the Yong River of China. Chemosphere. 2018;195:594\u2013605.","journal-title":"Chemosphere"},{"issue":"1","key":"10095_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10010092","volume":"10","author":"R Chianese","year":"2021","unstructured":"Chianese R, Pierantoni R. Mitochondrial reactive oxygen species (ROS) production alters sperm quality. Antioxidants. 2021;10(1):92.","journal-title":"Antioxidants"},{"key":"10095_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.145974","volume":"776","author":"JL Crane","year":"2021","unstructured":"Crane JL. Distribution and toxic potential of alkylphenols, nonylphenol ethoxylates, and pyrethroids in Minnesota, USA lake sediments. Sci Total Environ. 2021;776:145974.","journal-title":"Sci Total Environ"},{"issue":"8","key":"10095_CR12","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1038\/s41585-021-00472-2","volume":"18","author":"C Dai","year":"2021","unstructured":"Dai C, Zhang Z, Shan G, Chu LT, Huang Z, Moskovtsev S, et al. Advances in sperm analysis: techniques, discoveries and applications. Nat Rev Urol. 2021;18(8):447\u201367.","journal-title":"Nat Rev Urol"},{"key":"10095_CR13","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.ecoenv.2019.06.009","volume":"181","author":"W De Bruin","year":"2019","unstructured":"De Bruin W, Kritzinger Q, Bornman R, Korsten L. Occurrence, fate and toxic effects of the industrial endocrine disrupter, nonylphenol, on plants - a review. Ecotoxicol Environ Saf. 2019;181:419\u201327.","journal-title":"Ecotoxicol Environ Saf"},{"issue":"7","key":"10095_CR14","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.7150\/ijbs.82191","volume":"19","author":"F Dong","year":"2023","unstructured":"Dong F, Ping P, Ma Y, Chen XF. Application of single-cell RNA sequencing on human testicular samples: a comprehensive review. Int J Biol Sci. 2023;19(7):2167\u201397.","journal-title":"Int J Biol Sci"},{"key":"10095_CR15","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.reprotox.2016.04.016","volume":"62","author":"P Duan","year":"2016","unstructured":"Duan P, Hu C, Butler HJ, Quan C, Chen W, Huang W, et al. Effects of 4-nonylphenol on spermatogenesis and induction of testicular apoptosis through oxidative stress-related pathways. Reprod Toxicol. 2016;62:27\u201338.","journal-title":"Reprod Toxicol"},{"key":"10095_CR16","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.tox.2016.01.004","volume":"341\u2013343","author":"P Duan","year":"2016","unstructured":"Duan P, Hu C, Quan C, Yu T, Zhou W, Yuan M, et al. 4-Nonylphenol induces apoptosis, autophagy and necrosis in Sertoli cells: Involvement of ROS-mediated AMPK\/AKT-mTOR and JNK pathways. Toxicology. 2016b;341\u2013343:28\u201340. https:\/\/doi.org\/10.1016\/j.tox.2016.01.004.","journal-title":"Toxicology"},{"issue":"3","key":"10095_CR17","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1002\/tox.22274","volume":"32","author":"P Duan","year":"2017","unstructured":"Duan P, Hu C, Butler HJ, Quan C, Chen W, Huang W, et al. 4-Nonylphenol induces disruption of spermatogenesis associated with oxidative stress-related apoptosis by targeting p53-Bcl-2\/Bax-Fas\/FasL signaling. Environ Toxicol. 2017a;32(3):739\u201353. https:\/\/doi.org\/10.1002\/tox.22274.","journal-title":"Environ Toxicol"},{"key":"10095_CR18","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.toxlet.2016.12.015","volume":"267","author":"P Duan","year":"2017","unstructured":"Duan P, Hu C, Quan C, Yu T, Huang W, Chen W, et al. 4-nonylphenol induces autophagy and attenuates mTOR-p70S6K\/4EBP1 signaling by modulating AMPK activation in Sertoli cells. Toxicol Lett. 2017b;267:21\u201331.","journal-title":"Toxicol Lett"},{"key":"10095_CR19","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.chemosphere.2018.11.086","volume":"218","author":"P Duan","year":"2019","unstructured":"Duan P, Liu B, Morais CLM, Zhao J, Li X, Tu J, et al. 4-nonylphenol effects on rat testis and sertoli cells determined by spectrochemical techniques coupled with chemometric analysis. Chemosphere. 2019;218:64\u201375.","journal-title":"Chemosphere"},{"issue":"1","key":"10095_CR20","doi-asserted-by":"publisher","DOI":"10.1111\/and.13666","volume":"53","author":"D Durairajanayagam","year":"2021","unstructured":"Durairajanayagam D, Singh D, Agarwal A, Henkel R. Causes and consequences of sperm mitochondrial dysfunction. Andrologia. 2021;53(1):e13666.","journal-title":"Andrologia"},{"key":"10095_CR21","doi-asserted-by":"publisher","first-page":"107095","DOI":"10.1016\/j.anireprosci.2022.107095","volume":"247","author":"A Foutouhi","year":"2022","unstructured":"Foutouhi A, Meyers S. Comparative oxidative metabolism in mammalian sperm. Anim Reprod Sci. 2022;247:107095. https:\/\/doi.org\/10.1016\/j.anireprosci.2022.107095.","journal-title":"Anim Reprod Sci"},{"issue":"4","key":"10095_CR22","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1681\/ASN.2018090896","volume":"30","author":"J Fu","year":"2019","unstructured":"Fu J, Akat KM, Sun Z, Zhang W, Schlondorff D, Liu Z, et al. Single-cell RNA profiling of glomerular cells shows dynamic changes in experimental diabetic kidney disease. J Am Soc Nephrol. 2019;30(4):533\u201345.","journal-title":"J Am Soc Nephrol"},{"issue":"7","key":"10095_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10071131","volume":"10","author":"A Gallo","year":"2021","unstructured":"Gallo A, Esposito MC, Tosti E, Boni R. Sperm motility, oxidative status, and mitochondrial activity: exploring correlation in different species. Antioxidants. 2021;10(7):1131.","journal-title":"Antioxidants"},{"key":"10095_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2019.151456","author":"MS Gewaily","year":"2020","unstructured":"Gewaily MS, Kassab M, Farrag FA, Almadaly EA, Atta MS, Abd-Elmaksoud A, et al. Comparative expression of cell adhesion molecule1 (CADM1) in the testes of experimental mice and some farm animals. Acta Histochem. 2020. https:\/\/doi.org\/10.1016\/j.acthis.2019.151456.","journal-title":"Acta Histochem"},{"issue":"8","key":"10095_CR25","doi-asserted-by":"publisher","first-page":"899","DOI":"10.2217\/epi-2018-0175","volume":"11","author":"K Ghosh","year":"2019","unstructured":"Ghosh K, Chatterjee B, Maheswari U, Athifa M, Kanade SR. 4-nonylphenol-enhanced EZH2 and RNF2 expression, H3K27me3 and H2AK119ub1marks resulting in silencing of p21CDKN1A in vitro. Epigenomics. 2019;11(8):899\u2013916.","journal-title":"Epigenomics"},{"issue":"1","key":"10095_CR26","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s12595-021-00412-3","volume":"75","author":"A Ghosh","year":"2022","unstructured":"Ghosh A, Tripathy A, Ghosh D. Impact of endocrine disrupting chemicals (EDCs) on reproductive health of human. Proc Zool Soc. 2022;75(1):16\u201330.","journal-title":"Proc Zool Soc"},{"key":"10095_CR27","doi-asserted-by":"publisher","unstructured":"Green CD, Q Ma, GL Manske, AN Shami, X Zheng, S Marini, et al (2018) A comprehensive roadmap of murine spermatogenesis defined by single-Cell RNA-Seq. Dev Cell 46(5): 651\u2013667 e610. https:\/\/doi.org\/10.1016\/j.devcel.2018.07.025.","DOI":"10.1016\/j.devcel.2018.07.025"},{"issue":"1","key":"10095_CR28","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-019-0510-y","volume":"17","author":"NH Gu","year":"2019","unstructured":"Gu NH, Zhao WL, Wang GS, Sun F. Comparative analysis of mammalian sperm ultrastructure reveals relationships between sperm morphology, mitochondrial functions and motility. Reprod Biol Endocrinol. 2019;17(1):66.","journal-title":"Reprod Biol Endocrinol"},{"issue":"1","key":"10095_CR29","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.repbio.2019.03.001","volume":"19","author":"MF Hamad","year":"2019","unstructured":"Hamad MF. Quantification of histones and protamines mRNA transcripts in sperms of infertile couples and their impact on sperm\u2019s quality and chromatin integrity. Reprod Biol. 2019;19(1):6\u201313.","journal-title":"Reprod Biol"},{"key":"10095_CR30","doi-asserted-by":"publisher","unstructured":"Hermann BP, Cheng K, Singh A, Roa De La Cruz L, Mutoji KN, Chen IC, et al (2018) The mammalian spermatogenesis single-cell transcriptome, from spermatogonial stem cells to spermatids. Cell Rep 25(6): 1650\u20131667 e1658. https:\/\/doi.org\/10.1016\/j.celrep.2018.10.026","DOI":"10.1016\/j.celrep.2018.10.026"},{"key":"10095_CR31","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.semcdb.2016.01.034","volume":"59","author":"K Huang","year":"2016","unstructured":"Huang K, Lui WY. Nectins and nectin-like molecules (Necls): Recent findings and their role and regulation in spermatogenesis. Semin Cell Dev Biol. 2016;59:54\u201361.","journal-title":"Semin Cell Dev Biol"},{"issue":"6","key":"10095_CR32","doi-asserted-by":"publisher","first-page":"5116","DOI":"10.3892\/mmr.2016.5880","volume":"14","author":"P Huang","year":"2016","unstructured":"Huang P, Zhou Z, Shi F, Shao G, Wang R, Wang J, et al. Effects of the IGF-1\/PTEN\/Akt\/FoxO signaling pathway on male reproduction in rats subjected to water immersion and restraint stress. Mol Med Rep. 2016;14(6):5116\u201324.","journal-title":"Mol Med Rep"},{"issue":"2","key":"10095_CR33","doi-asserted-by":"publisher","first-page":"747","DOI":"10.18632\/aging.203809","volume":"14","author":"X Huang","year":"2022","unstructured":"Huang X, Wang H, Xu F, Lv L, Wang R, Jiang B, et al. Overexpression of chaperonin containing TCP1 subunit 7 has diagnostic and prognostic value for hepatocellular carcinoma. Aging (Albany NY). 2022;14(2):747\u201369.","journal-title":"Aging (Albany NY)"},{"key":"10095_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2024.108545","volume":"124","author":"JM Hwang","year":"2024","unstructured":"Hwang JM, Bae JW, Lee WJ, Kwon WS. Effect of 4-nonylphenol (4-NP) on sperm function: insights into the PI3K\/PDK1\/AKT signaling pathway during capacitation. Reprod Toxicol. 2024;124:108545.","journal-title":"Reprod Toxicol"},{"issue":"1","key":"10095_CR35","doi-asserted-by":"publisher","first-page":"34","DOI":"10.14712\/fb2016062010034","volume":"62","author":"T Jambor","year":"2016","unstructured":"Jambor T, Lukacova J, Tvrda E, Knazicka Z, Forgacs Z, Lukac N. The impact of 4-Nonylphenol on the viability and hormone production of mouse Leydig cells. Folia Biol (Praha). 2016;62(1):34\u20139.","journal-title":"Folia Biol (Praha)"},{"key":"10095_CR36","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.envpol.2016.12.053","volume":"222","author":"T Jambor","year":"2017","unstructured":"Jambor T, Tvrd\u00e1 E, Tu\u0161imov\u00e1 E, Kov\u00e1\u010dik A, Bist\u00e1kov\u00e1 J, Forg\u00e1cs Z, et al. In vitro effect of 4-nonylphenol on human chorionic gonadotropin (hCG) stimulated hormone secretion, cell viability and reactive oxygen species generation in mice Leydig cells. Environ Pollut. 2017;222:219\u201325.","journal-title":"Environ Pollut"},{"issue":"4","key":"10095_CR37","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1007\/s12595-021-00410-5","volume":"74","author":"R Jasrotia","year":"2021","unstructured":"Jasrotia R, Langer S, Dhar M. Endocrine disrupting chemicals in aquatic ecosystem: an emerging threat to wildlife and human health. Proc Zool Soc. 2021;74(4):634\u201347.","journal-title":"Proc Zool Soc"},{"key":"10095_CR38","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.theriogenology.2019.07.026","volume":"139","author":"Z Kang","year":"2019","unstructured":"Kang Z, Zhang S, He L, Zhu H, Wang Z, Yan H, et al. A 14-bp functional deletion within the CMTM2 gene is significantly associated with litter size in goat. Theriogenology. 2019;139:49\u201357.","journal-title":"Theriogenology"},{"issue":"3","key":"10095_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2021.100531","volume":"21","author":"A Khan","year":"2021","unstructured":"Khan A, Yuewen W, Dil S, Shah W, Shi Q, Khan R. The evolutionarily conserved gene, Fam114a2, is dispensable for fertility in mouse. Reprod Biol. 2021;21(3):100531.","journal-title":"Reprod Biol"},{"issue":"2","key":"10095_CR40","doi-asserted-by":"publisher","first-page":"93","DOI":"10.12717\/DR.2019.23.2.093","volume":"23","author":"YB Kim","year":"2019","unstructured":"Kim YB, Cheon YP, Lee SH. Adverse effect of nonylphenol on the reproductive system in F1 male mice: a subchronic low-dose exposure model. Development & Reproduction. 2019;23(2):93\u20139.","journal-title":"Development & Reproduction"},{"key":"10095_CR41","doi-asserted-by":"publisher","first-page":"110909","DOI":"10.1016\/j.cbpb.2023.110909","volume":"270","author":"H Kong","year":"2024","unstructured":"Kong H, Im S. Oxidative phosphorylation rather than glycolysis is the primary energy source for sperm motility in the mussels Mytilus edulis. Comp Biochem Physiol B Biochem Mol Biol. 2024;270:110909.","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"issue":"12","key":"10095_CR42","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/j.bbagrm.2018.10.002","volume":"1861","author":"S Kumar","year":"2018","unstructured":"Kumar S, Kang H, Park E, Park HS, Lee K. The expression of CKLFSF2B is regulated by GATA1 and CREB in the Leydig cells, which modulates testicular steroidogenesis. Biochimica Et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2018;1861(12):1063\u201375.","journal-title":"Biochimica Et Biophysica Acta (BBA) - Gene Regulatory Mechanisms"},{"issue":"7","key":"10095_CR43","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25074121","volume":"25","author":"MA Kyrgiafini","year":"2024","unstructured":"Kyrgiafini MA, Giannoulis T, Chatziparasidou A, Mamuris Z. Elucidating the role of OXPHOS variants in asthenozoospermia: insights from whole genome sequencing and an in silico analysis. Int J Mol Sci. 2024;25(7):4121.","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10095_CR44","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1002\/tox.22385","volume":"32","author":"JW Lee","year":"2017","unstructured":"Lee JW, Han HK, Park S, Moon EY. Nonylphenol increases tumor formation and growth by suppressing gender-independent lymphocyte proliferation and macrophage activation. Environ Toxicol. 2017;32(6):1679\u201387.","journal-title":"Environ Toxicol"},{"key":"10095_CR45","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.theriogenology.2021.12.012","volume":"180","author":"YJ Lee","year":"2022","unstructured":"Lee YJ, Lin W, Peng SY, Lee JW, Lin YH, Yu C, et al. Effects of intracytoplasmic sperm injection timing and fertilization methods on the development of bovine spindle transferred embryos. Theriogenology. 2022;180:63\u201371.","journal-title":"Theriogenology"},{"key":"10095_CR46","doi-asserted-by":"publisher","unstructured":"Lehtiniemi T, Kotaja N. The genetics of postmeiotic male germ cell differentiation from round spermatids to mature sperm. Genetics Human Infertility 2017;101\u2013115. https:\/\/doi.org\/10.1159\/000477281.","DOI":"10.1159\/000477281"},{"issue":"5","key":"10095_CR47","doi-asserted-by":"publisher","first-page":"F147","DOI":"10.1530\/REP-20-0592","volume":"162","author":"H Li","year":"2021","unstructured":"Li H, Spade DJ. Reproductive toxicology: environmental exposures, fetal testis development and function: phthalates and beyond. Reproduction. 2021;162(5):F147\u201367.","journal-title":"Reproduction"},{"issue":"3","key":"10095_CR48","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1039\/C6TX00450D","volume":"6","author":"X Li","year":"2017","unstructured":"Li X, Zhou L, Ni Y, Wang A, Hu M, Lin Y, et al. Nonylphenol induces pancreatic damage in rats through mitochondrial dysfunction and oxidative stress. Toxicol Res. 2017;6(3):353\u201360.","journal-title":"Toxicol Res"},{"key":"10095_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.117903","volume":"244","author":"J Li","year":"2024","unstructured":"Li J, Zhang H, Li J, Qin N, Wei Q, Li Y, et al. Assessment of nonylphenol exposure based on global urinary concentration data and its risk analysis. Environ Res. 2024;244:117903.","journal-title":"Environ Res"},{"issue":"3","key":"10095_CR50","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.bbagrm.2018.10.016","volume":"1862","author":"Z Lin","year":"2019","unstructured":"Lin Z, Tong MH. M6A mRNA modification regulates mammalian spermatogenesis. Biochimica Et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2019;1862(3):403\u201311.","journal-title":"Biochimica Et Biophysica Acta (BBA) - Gene Regulatory Mechanisms"},{"key":"10095_CR51","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.1020757","volume":"13","author":"J Lin","year":"2022","unstructured":"Lin J, Liu L, Zheng F, Chen S, Yang W, Li J, et al. Exploration the global single-cell ecological landscape of adenomyosis-related cell clusters by single-cell RNA sequencing. Front Genet. 2022;13:1020757.","journal-title":"Front Genet"},{"key":"10095_CR52","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.644204","volume":"12","author":"W Liu","year":"2021","unstructured":"Liu W, Wang Z, Hu X. Identification of competing endogenous RNA and micro-RNA profiles and regulatory networks in 4-Nonylphenol-induced impairment of Sertoli cells. Front Pharmacol. 2021;12:644204.","journal-title":"Front Pharmacol"},{"issue":"2","key":"10095_CR53","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s41574-020-00436-3","volume":"17","author":"D Lopez Rodriguez","year":"2020","unstructured":"Lopez Rodriguez D, Franssen D, Bakker J, Lomniczi A, Parent AS. Cellular and molecular features of EDC exposure: consequences for the GnRH network. Nat Rev Endocrinol. 2020;17(2):83\u201396.","journal-title":"Nat Rev Endocrinol"},{"issue":"17","key":"10095_CR54","doi-asserted-by":"publisher","first-page":"10255","DOI":"10.1093\/nar\/gkae701","volume":"52","author":"C Luo","year":"2024","unstructured":"Luo C, Xu H, Yu Z, Liu D, Zhong D, Zhou S, et al. Meiotic chromatin-associated HSF5 is indispensable for pachynema progression and male fertility. Nucleic Acids Res. 2024;52(17):10255\u201375.","journal-title":"Nucleic Acids Res"},{"key":"10095_CR55","doi-asserted-by":"publisher","unstructured":"Malmir M, Faraji T, Ghafarizadeh AA, Khodabandelo H. Effect of nonylphenol on spermatogenesis: A systematic review. Andrologia 2020;52(10). https:\/\/doi.org\/10.1111\/and.13748","DOI":"10.1111\/and.13748"},{"key":"10095_CR56","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/bs.ctdb.2014.11.019","volume":"112","author":"K Mandai","year":"2015","unstructured":"Mandai K, Rikitake Y, Mori M, Takai Y. Nectins and nectin-like molecules in development and disease. Curr Top Dev Biol. 2015;112:197\u2013231. https:\/\/doi.org\/10.1016\/bs.ctdb.2014.11.019.","journal-title":"Curr Top Dev Biol"},{"issue":"4","key":"10095_CR57","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1097\/CM9.0000000000003126","volume":"138","author":"K Meng","year":"2024","unstructured":"Meng K, Liu Q, Qin Y, Qin W, Zhu Z, Sun L, et al. Mechanism of mitochondrial oxidative phosphorylation disorder in male infertility. Chin Med J (Engl). 2024;138(4):379\u201388.","journal-title":"Chin Med J (Engl)"},{"issue":"3","key":"10095_CR58","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1093\/biolre\/ioad168","volume":"110","author":"F Ni","year":"2024","unstructured":"Ni F, Wang F, Li J, Liu Y, Sun X, Chen J, et al. BNC1 deficiency induces mitochondrial dysfunction-triggered spermatogonia apoptosis through the CREB\/SIRT1\/FOXO3 pathway: the therapeutic potential of nicotinamide riboside and metformindagger. Biol Reprod. 2024;110(3):615\u201331. https:\/\/doi.org\/10.1093\/biolre\/ioad168.","journal-title":"Biol Reprod"},{"key":"10095_CR59","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.foodchem.2014.06.115","volume":"167","author":"Y Niu","year":"2015","unstructured":"Niu Y, Zhang J, Duan H, Wu Y, Shao B. Bisphenol A and nonylphenol in foodstuffs: Chinese dietary exposure from the 2007 total diet study and infant health risk from formulas. Food Chem. 2015;167:320\u20135.","journal-title":"Food Chem"},{"key":"10095_CR60","doi-asserted-by":"publisher","unstructured":"Nowicka Bauer K, Lepczynski A, Ozgo M, Kamieniczna M, Fraczek M, Stanski L, et al. Sperm mitochondrial dysfunction and oxidative stress as possible reasons for isolated asthenozoospermia. J Physiol Pharmacol. 2018;69(3). https:\/\/doi.org\/10.26402\/jpp.2018.3.05","DOI":"10.26402\/jpp.2018.3.05"},{"issue":"1","key":"10095_CR61","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10010098","volume":"10","author":"YJ Park","year":"2021","unstructured":"Park YJ, Pang MG. Mitochondrial functionality in male fertility: from spermatogenesis to fertilization. Antioxidants. 2021;10(1):98.","journal-title":"Antioxidants"},{"key":"10095_CR62","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010307","author":"HJ Park","year":"2020","unstructured":"Park HJ, Lee R, Yoo H, Hong K, Song H. Nonylphenol induces apoptosis through ROS\/JNK signaling in a spermatogonia cell line. Int J Mol Sci. 2020a. https:\/\/doi.org\/10.3390\/ijms22010307.","journal-title":"Int J Mol Sci"},{"key":"10095_CR63","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103491","author":"HJ Park","year":"2020","unstructured":"Park HJ, Zhang M, Lee WY, Hong KH, Do JT, Park C, et al. Toxic effects of nonylphenol on neonatal testicular development in mouse organ culture. Int J Mol Sci. 2020b. https:\/\/doi.org\/10.3390\/ijms21103491.","journal-title":"Int J Mol Sci"},{"issue":"33","key":"10095_CR64","first-page":"7","volume":"8","author":"A Rajan","year":"2020","unstructured":"Rajan A, Tonk S, Bose C, Singh S, Swarup S, Chavali S, et al. Chromosomal alterations of pediatric malignancy in a West Texas population. Southwest Respir Crit Care Chron. 2020;8(33):7\u201320.","journal-title":"Southwest Respir Crit Care Chron"},{"issue":"11","key":"10095_CR65","doi-asserted-by":"publisher","first-page":"2392","DOI":"10.1021\/acs.chemrestox.1c00301","volume":"34","author":"B Ringbeck","year":"2021","unstructured":"Ringbeck B, Belov VN, Schmidtkunz C, Kupper K, Gries W, Weiss T, et al. Human metabolism and urinary excretion kinetics of nonylphenol in three volunteers after a single oral dose. Chem Res Toxicol. 2021;34(11):2392\u2013403.","journal-title":"Chem Res Toxicol"},{"issue":"1","key":"10095_CR66","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04722-2","volume":"21","author":"N Salehi","year":"2023","unstructured":"Salehi N, Totonchi M. The construction of a testis transcriptional cell atlas from embryo to adult reveals various somatic cells and their molecular roles. J Transl Med. 2023;21(1):859.","journal-title":"J Transl Med"},{"issue":"1","key":"10095_CR67","doi-asserted-by":"publisher","first-page":"21","DOI":"10.12691\/ajbr-7-1-5","volume":"7","author":"BA SaraHoungu\u00e8","year":"2019","unstructured":"SaraHoungu\u00e8 BA, Callinice D. Capo chichi, dynamism of ribosomal protein RPL28 as biomarker for monitoring epigenetic-initiated-breast-cancer therapy. Am J Biomed Res. 2019;7(1):21\u20136. https:\/\/doi.org\/10.12691\/ajbr-7-1-5.","journal-title":"Am J Biomed Res"},{"issue":"1","key":"10095_CR68","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08182-x","volume":"10","author":"Y Shen","year":"2019","unstructured":"Shen Y, Zhang F, Li F, Jiang X, Yang Y, Li X, et al. Loss-of-function mutations in QRICH2 cause male infertility with multiple morphological abnormalities of the sperm flagella. Nat Commun. 2019;10(1):433.","journal-title":"Nat Commun"},{"issue":"10","key":"10095_CR69","doi-asserted-by":"publisher","first-page":"e22522","DOI":"10.1096\/fj.202200640RR","volume":"36","author":"Z Shen","year":"2022","unstructured":"Shen Z, Chen M, Gao Y, Dong F, Cen C, Wu H, et al. The function of Foxo1 in spermatogonia development is independent of PI3K\/PTEN signaling. FASEB J. 2022;36(10):e22522. https:\/\/doi.org\/10.1096\/fj.202200640RR.","journal-title":"FASEB J"},{"key":"10095_CR70","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.685694","volume":"11","author":"Y Shi","year":"2021","unstructured":"Shi Y, Wang X, Zhu Q, Chen G. The ribosomal protein L28 gene induces sorafenib resistance in hepatocellular carcinoma. Front Oncol. 2021;11:685694.","journal-title":"Front Oncol"},{"issue":"1","key":"10095_CR71","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/j.1745-7262.2008.00370.x","volume":"10","author":"SC Sikka","year":"2008","unstructured":"Sikka SC, Wang R. Endocrine disruptors and estrogenic effects on male reproductive axis. Asian J Androl. 2008;10(1):134\u201345.","journal-title":"Asian J Androl"},{"key":"10095_CR72","doi-asserted-by":"publisher","unstructured":"Sohni A, Tan K, Song HW, Burow D, de Rooij DG, Laurent L, et al. The neonatal and adult human testis defined at the single-cell level. Cell Rep. 2019;26(6):1501\u20131517 e1504. https:\/\/doi.org\/10.1016\/j.celrep.2019.01.045","DOI":"10.1016\/j.celrep.2019.01.045"},{"key":"10095_CR73","doi-asserted-by":"publisher","first-page":"106311","DOI":"10.1016\/j.envint.2020.106311","volume":"147","author":"C Talia","year":"2021","unstructured":"Talia C. L Connolly, PA Fowler, The insulin-like growth factor system: A target for endocrine disruptors? Environ Int. 2021;147:106311. https:\/\/doi.org\/10.1016\/j.envint.2020.106311.","journal-title":"Environ Int"},{"key":"10095_CR74","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.115612","volume":"266","author":"S Tao","year":"2023","unstructured":"Tao S, Yao Z, Li H, Wang Y, Qiao X, Yu Y, et al. Exposure to 4-nonylphenol compromises Leydig cell development in pubertal male mice. Ecotoxicol Environ Saf. 2023;266:115612.","journal-title":"Ecotoxicol Environ Saf"},{"key":"10095_CR75","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.116825","volume":"236","author":"A Thacharodi","year":"2023","unstructured":"Thacharodi A, Hassan S, Acharya G, Vithlani A, Le QH, Pugazhendhi A. Endocrine disrupting chemicals and their effects on the reproductive health in men. Environ Res. 2023;236:116825.","journal-title":"Environ Res"},{"issue":"33","key":"10095_CR76","doi-asserted-by":"publisher","first-page":"20613","DOI":"10.1074\/jbc.M115.664813","volume":"290","author":"M Tourmente","year":"2015","unstructured":"Tourmente M, Villar Moya P, Rial E, Roldan ERS. Differences in ATP generation via glycolysis and oxidative phosphorylation and relationships with sperm motility in mouse species. J Biol Chem. 2015;290(33):20613\u201326.","journal-title":"J Biol Chem"},{"key":"10095_CR77","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.mito.2020.06.003","volume":"54","author":"S Vertika","year":"2020","unstructured":"Vertika S, Singh KK, Rajender S. Mitochondria, spermatogenesis, and male infertility - an update. Mitochondrion. 2020;54:26\u201340.","journal-title":"Mitochondrion"},{"issue":"8","key":"10095_CR78","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.3390\/antiox11081617","volume":"11","author":"K Virant","year":"2022","unstructured":"Virant K, Senka IIK, Pinter B. From oxidative stress to male infertility: review of the associations of endocrine-disrupting chemicals (bisphenols, phthalates, and parabens) with human semen quality. Antioxidants. 2022;11(8):1617. https:\/\/doi.org\/10.3390\/antiox11081617.","journal-title":"Antioxidants"},{"issue":"4","key":"10095_CR79","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03676-x","volume":"12","author":"X Wang","year":"2021","unstructured":"Wang X, Lai F, Shang D, Cheng Y, Lan T, Cheng H, et al. Cellular fate of intersex differentiation. Cell Death Dis. 2021;12(4):388.","journal-title":"Cell Death Dis"},{"key":"10095_CR80","doi-asserted-by":"publisher","unstructured":"Wang L, Zhou W, Li H, Yang H, Shan N. RETRACTED: Clinical significance, cellular function, and potential molecular pathways of CCT7 in endometrial cancer. Front Oncol. 2020;10(1468). https:\/\/doi.org\/10.3389\/fonc.2020.01468.","DOI":"10.3389\/fonc.2020.01468"},{"issue":"7","key":"10095_CR81","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1369\/00221554231185626","volume":"71","author":"A Wanta","year":"2023","unstructured":"Wanta A, Noguchi K, Sugawara T, Sonoda K, Duangchit S, Wakayama T. Expression of protein markers in spermatogenic and supporting Sertoli cells affected by high abdominal temperature in cryptorchidism model mice. J Histochem Cytochem. 2023;71(7):387\u2013408.","journal-title":"J Histochem Cytochem"},{"key":"10095_CR82","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2020.461765","volume":"1635","author":"FF Wu","year":"2021","unstructured":"Wu FF, Zhu Y, Zhao XY, Qian LQ, Wei YL, Ma XJ, et al. Preparation of sheet-like covalent organic frameworks and their application for efficient preconcentration of 4-(tert-octyl)-phenol and 4-nonylphenol in textiles. J Chromatogr A. 2021;1635:461765.","journal-title":"J Chromatogr A"},{"issue":"1","key":"10095_CR83","doi-asserted-by":"publisher","first-page":"115867","DOI":"10.1016\/j.jep.2022.115867","volume":"302","author":"D Wu","year":"2023","unstructured":"Wu D, Wang T, Liu H, Xu F, Xie S, Tong X, et al. Wuzi-Yanzong-Wan prevents oligoasthenospermia due to TAp73 suppression by affecting cellular junction remodeling in testicular tissue in mice. J Ethnopharmacol. 2023;302(1):115867. https:\/\/doi.org\/10.1016\/j.jep.2022.115867.","journal-title":"J Ethnopharmacol"},{"key":"10095_CR84","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.145080","volume":"764","author":"Y Xie","year":"2021","unstructured":"Xie Y, Wei BH, Ni FD, Yang WX. Conversion from spermatogonia to spermatocytes: Extracellular cues and downstream transcription network. Gene. 2021;764:145080.","journal-title":"Gene"},{"issue":"8","key":"10095_CR85","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1002\/mrd.23180","volume":"86","author":"W Xiong","year":"2019","unstructured":"Xiong W, Wang Z, Shen C. An update of the regulatory factors of sperm migration from the uterus into the oviduct by genetically manipulated mice. Mol Reprod Dev. 2019;86(8):935\u201355.","journal-title":"Mol Reprod Dev"},{"issue":"11","key":"10095_CR86","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1002\/mc.23807","volume":"63","author":"W Xiong","year":"2024","unstructured":"Xiong W, Zheng B, Liu D, Pu M, Zhou S, Deng Y. Quercetin inhibits endothelial & hepatocellular carcinoma cell crosstalk via reducing extracellular vesicle-mediated VEGFR2 mRNA transfer. Mol Carcinog. 2024;63(11):2254\u201368.","journal-title":"Mol Carcinog"},{"issue":"2","key":"10095_CR87","doi-asserted-by":"publisher","first-page":"239","DOI":"10.7150\/ijbs.38232","volume":"16","author":"C Xu","year":"2020","unstructured":"Xu C, Shah MA, Mipam T, Wu S, Yi C, Luo H, et al. Bovid microRNAs involved in the process of spermatogonia differentiation into spermatocytes. Int J Biol Sci. 2020;16(2):239\u201350.","journal-title":"Int J Biol Sci"},{"issue":"5","key":"10095_CR88","doi-asserted-by":"publisher","first-page":"13458","DOI":"10.1111\/cpr.13458","volume":"56","author":"C Xu","year":"2023","unstructured":"Xu C, Qi J, Hu X, Zhang L, Sun Q, Li N, et al. Rps14 upregulation promotes inner ear progenitor proliferation and hair cell regeneration in the neonatal mouse cochlea. Cell Proliferation. 2023;56(5):13458. https:\/\/doi.org\/10.1111\/cpr.13458.","journal-title":"Cell Proliferation"},{"key":"10095_CR89","doi-asserted-by":"publisher","unstructured":"Yoshitaka Fujihara AO, Kanako Kojima Kita TL, Ikawa M. Co-expression of sperm membrane proteins CMTM2A and CMTM2B is essential for ADAM3 localization and male fertility in mice. J Cell Sci. 2018;131(19). https:\/\/doi.org\/10.1242\/jcs.221481.","DOI":"10.1242\/jcs.221481"},{"key":"10095_CR90","doi-asserted-by":"publisher","first-page":"109002","DOI":"10.1016\/j.cbpc.2021.109002","volume":"244","author":"HH You","year":"2021","unstructured":"You HH, Song G. Review of endocrine disruptors on male and female reproductive systems. Comparative Biochem Physiol Part C: Toxicol Pharmacol. 2021;244:109002. https:\/\/doi.org\/10.1016\/j.cbpc.2021.109002.","journal-title":"Comparative Biochem Physiol Part C: Toxicol Pharmacol"},{"issue":"1","key":"10095_CR91","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1017\/S0967199420000556","volume":"29","author":"Y Yu","year":"2021","unstructured":"Yu Y, Wang J, Zhou L, Li H, Zheng B, Yang S. CFAP43-mediated intra-manchette transport is required for sperm head shaping and flagella formation. Zygote. 2021;29(1):75\u201381. https:\/\/doi.org\/10.1017\/S0967199420000556.","journal-title":"Zygote"},{"key":"10095_CR92","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9103296","author":"A Zahra","year":"2020","unstructured":"Zahra A, Sisu C, Silva E, De Aguiar Greca SC, Randeva HS, Chatha K, et al. Is there a link between bisphenol A (BPA), a key endocrine disruptor, and the risk for SARS-CoV-2 infection and severe COVID-19? J Clin Med. 2020. https:\/\/doi.org\/10.3390\/jcm9103296.","journal-title":"J Clin Med"},{"issue":"1","key":"10095_CR93","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/mrd.23432","volume":"88","author":"Pf Zhang","year":"2020","unstructured":"Zhang Pf, Huang Yl, Fu Q, He Wt, Xiao K, Zhang M. Integrated analysis of phosphoproteome and ubiquitylome in epididymal sperm of buffalo (Bubalus bubalis). Mol Reprod Dev. 2020;88(1):15\u201333.","journal-title":"Mol Reprod Dev"},{"key":"10095_CR94","doi-asserted-by":"publisher","first-page":"5731","DOI":"10.2147\/ott.S250370","volume":"13","author":"S Zhang","year":"2020","unstructured":"Zhang S, Tian R, Bei C, Zhang H, Kong J, Zheng C, et al. Down-regulated CMTM2 promotes epithelial-mesenchymal transition in hepatocellular carcinoma. OncoTargets Therapy. 2020b;13:5731\u201341. https:\/\/doi.org\/10.2147\/ott.S250370.","journal-title":"OncoTargets Therapy"},{"issue":"4","key":"10095_CR95","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1002\/jat.4241","volume":"42","author":"Q Zhang","year":"2021","unstructured":"Zhang Q, Wu S, Xiao Q, Kang C, Hu H, Hou X, et al. Effects of 4-nonylphenol on adipogenesis in 3T3-L1 preadipocytes and C3H\/10T1\/2 mesenchymal stem cells. J Appl Toxicol. 2021;42(4):588\u201399.","journal-title":"J Appl Toxicol"},{"key":"10095_CR96","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112449","volume":"145","author":"N Zhang","year":"2022","unstructured":"Zhang N, Wang Y, Chen Z, Ren J, Rehman A, Ahmad DW, et al. Single-cell transcriptome analysis of Bisphenol A exposure reveals the key roles of the testicular microenvironment in male reproduction. Biomed Pharmacother. 2022;145:112449.","journal-title":"Biomed Pharmacother"},{"issue":"10","key":"10095_CR97","doi-asserted-by":"publisher","first-page":"2775","DOI":"10.1111\/cns.14280","volume":"29","author":"C Zhang","year":"2023","unstructured":"Zhang C, Tan G, Zhang Y, Zhong X, Zhao Z, Peng Y, et al. Comprehensive analyses of brain cell communications based on multiple scRNA-seq and snRNA-seq datasets for revealing novel mechanism in neurodegenerative diseases. CNS Neurosci Ther. 2023;29(10):2775\u201386.","journal-title":"CNS Neurosci Ther"},{"issue":"9","key":"10095_CR98","doi-asserted-by":"publisher","first-page":"332","DOI":"10.31083\/j.fbl2909332","volume":"29","author":"B Zhang","year":"2024","unstructured":"Zhang B, Xiang L, Chen J, Zhang J, Dong R, Mo G, et al. GRN activates TNFR2 to promote macrophage M2 polarization aggravating Mycobacterium tuberculosis infection. Front Biosci (Landmark Ed). 2024a;29(9):332.","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"1","key":"10095_CR99","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-024-02845-8","volume":"25","author":"H Zhang","year":"2024","unstructured":"Zhang H, Yang Y, Cao Y, Guan J. IPF-related new macrophage subpopulations and diagnostic biomarker identification - combine machine learning with single-cell analysis. Respir Res. 2024b;25(1):241.","journal-title":"Respir Res"},{"issue":"1","key":"10095_CR100","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-019-3783-2","volume":"12","author":"YX Zheng","year":"2019","unstructured":"Zheng YX, Zhang XX, Hernandez JA, Mahmmod YS, Huang WY, Li GF, et al. Transcriptomic analysis of reproductive damage in the epididymis of male Kunming mice induced by chronic infection of Toxoplasma gondii PRU strain. Parasit Vectors. 2019;12(1):529.","journal-title":"Parasit Vectors"}],"container-title":["Cell Biology and Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10565-025-10095-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10565-025-10095-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10565-025-10095-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T15:03:32Z","timestamp":1759503812000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10565-025-10095-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,3]]},"references-count":100,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["10095"],"URL":"https:\/\/doi.org\/10.1007\/s10565-025-10095-7","relation":{},"ISSN":["1573-6822"],"issn-type":[{"value":"1573-6822","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,3]]},"assertion":[{"value":"17 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}],"article-number":"134"}}