{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:00:34Z","timestamp":1792270834254,"version":"4.4.0"},"reference-count":235,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biol Toxicol"],"DOI":"10.1007\/s10565-025-10098-4","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T04:43:06Z","timestamp":1762231386000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lipolysis gone rogue: the HSL connection in feeding cancer"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7203-279X","authenticated-orcid":false,"given":"Keerthana","family":"Hemadri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9604-0397","authenticated-orcid":false,"given":"Poorvi","family":"Subramanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivaroopan","family":"Aravindan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4467-4317","authenticated-orcid":false,"given":"Loganayaki","family":"Periyasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9150-3911","authenticated-orcid":false,"given":"Natarajan","family":"Aravindan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"10098_CR1","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.3390\/antiox10071090","volume":"10","author":"U Abou-Rjeileh","year":"2021","unstructured":"Abou-Rjeileh U, Contreras GA. Redox regulation of lipid mobilization in adipose tissues. Antioxidants. 2021;10:1090.","journal-title":"Antioxidants"},{"key":"10098_CR2","doi-asserted-by":"publisher","first-page":"5531","DOI":"10.1158\/0008-5472.CAN-06-4585","volume":"67","author":"T Agustsson","year":"2007","unstructured":"Agustsson T, Ryd\u00e9n M, Hoffstedt J, van Harmelen V, Dicker A, Laurencikiene J, et al. Mechanism of increased lipolysis in cancer cachexia. Cancer Res. 2007;67:5531\u20137.","journal-title":"Cancer Res"},{"key":"10098_CR3","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1111\/sms.13054","volume":"28","author":"TP Aird","year":"2018","unstructured":"Aird TP, Davies RW, Carson BP. Effects of fasted vs fed-state exercise on performance and post-exercise metabolism: a systematic review and meta-analysis. Scand J Med Sci Sports. 2018;28:1476\u201393. https:\/\/doi.org\/10.1111\/sms.13054.","journal-title":"Scand J Med Sci Sports"},{"key":"10098_CR4","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1964684","volume":"2022","author":"AR Althaher","year":"2022","unstructured":"Althaher AR. An overview of hormone-sensitive lipase (HSL). Sci World J. 2022;2022:1964684.","journal-title":"Sci World J"},{"key":"10098_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/j.2040-4603.2018.tb00008.x","volume":"8","author":"M Alves-Bezerra","year":"2018","unstructured":"Alves-Bezerra M, Cohen DE. Triglyceride metabolism in the liver. Compr Physiol. 2018;8:1\u201322.","journal-title":"Compr Physiol"},{"key":"10098_CR6","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1046\/j.1463-1326.2002.00214.x","volume":"4","author":"L Anderson","year":"2002","unstructured":"Anderson L, McTernan PG, Harte A, Barnett A, Kumar S. The regulation of HSL and LPL expression by DHT and flutamide in human subcutaneous adipose tissue. Diabetes Obes Metab. 2002;4:209\u201313.","journal-title":"Diabetes Obes Metab"},{"issue":"5","key":"10098_CR7","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.tem.2014.03.002","volume":"25","author":"P Arner","year":"2014","unstructured":"Arner P, Langin D. Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance. Trends Endocrinol Metab. 2014;25(5):255\u201362.","journal-title":"Trends Endocrinol Metab"},{"key":"10098_CR8","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.trecan.2020.03.001","volume":"6","author":"C Attan\u00e9","year":"2020","unstructured":"Attan\u00e9 C, Muller C. Drilling for oil: tumor-surrounding adipocytes fueling cancer. Trends Cancer. 2020;6:593\u2013604.","journal-title":"Trends Cancer"},{"key":"10098_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40170-016-0163-7","volume":"5","author":"S Balaban","year":"2017","unstructured":"Balaban S, Shearer RF, Lee LS, van Geldermalsen M, Schreuder M, Shtein HC, et al. Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration. Cancer Metab. 2017;5:1\u201314.","journal-title":"Cancer Metab"},{"key":"10098_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/biom11121836","author":"I Barone","year":"2021","unstructured":"Barone I, Giordano C. Leptin and beyond: actors in cancer. Biomolecules. 2021. https:\/\/doi.org\/10.3390\/biom11121836.","journal-title":"Biomolecules"},{"key":"10098_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2015.49","volume":"5","author":"S Beloribi-Djefaflia","year":"2016","unstructured":"Beloribi-Djefaflia S, Vasseur S, Guillaumond F. Lipid metabolic reprogramming in cancer cells. Oncogenesis. 2016;5:e189-e.","journal-title":"Oncogenesis"},{"key":"10098_CR12","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1017\/S0029665109990279","volume":"68","author":"V B\u00e9zaire","year":"2009","unstructured":"B\u00e9zaire V, Langin D. Regulation of adipose tissue lipolysis revisited: Symposium on \u2018Frontiers in adipose tissue biology. Proc Nutr Soc. 2009;68:350\u201360.","journal-title":"Proc Nutr Soc"},{"key":"10098_CR13","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1158\/1541-7786.MCR-19-1223","volume":"18","author":"C Bl\u00fccher","year":"2020","unstructured":"Bl\u00fccher C, Iberl S, Schwagarus N, M\u00fcller S, Liebisch G, H\u00f6ring M, et al. Secreted factors from adipose tissue reprogram tumor lipid metabolism and induce motility by modulating PPAR\u03b1\/ANGPTL4 and FAK. Mol Cancer Res. 2020;18:1849\u201362.","journal-title":"Mol Cancer Res"},{"key":"10098_CR14","doi-asserted-by":"publisher","first-page":"4250","DOI":"10.3390\/cancers15174250","volume":"15","author":"A Bocian-Jastrz\u0119bska","year":"2023","unstructured":"Bocian-Jastrz\u0119bska A, Malczewska-Herman A, Kos-Kud\u0142a B. Role of leptin and adiponectin in carcinogenesis. Cancers. 2023;15:4250.","journal-title":"Cancers"},{"key":"10098_CR15","doi-asserted-by":"publisher","first-page":"26361","DOI":"10.1074\/jbc.M115.682203","volume":"290","author":"A Boeszoermenyi","year":"2015","unstructured":"Boeszoermenyi A, Nagy HM, Arthanari H, Pillip CJ, Lindermuth H, Luna RE, et al. Structure of a CGI-58 motif provides the molecular basis of lipid droplet anchoring. J Biol Chem. 2015;290:26361\u201372.","journal-title":"J Biol Chem"},{"key":"10098_CR16","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1590\/2359-3997000000067","volume":"59","author":"A Bolsoni-Lopes","year":"2015","unstructured":"Bolsoni-Lopes A, Alonso-Vale MIC. Lipolysis and lipases in white adipose tissue\u2013an update. Arch Endocrinol Metab. 2015;59:335\u201342.","journal-title":"Arch Endocrinol Metab"},{"key":"10098_CR17","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-3-030-65768-0_1","volume":"1311","author":"S Bose","year":"2021","unstructured":"Bose S, Zhang C, Le A. Glucose metabolism in cancer: the Warburg effect and beyond. Adv Exp Med Biol. 2021;1311:3\u201315.","journal-title":"Adv Exp Med Biol"},{"key":"10098_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101510","volume":"61","author":"I Bradi\u0107","year":"2022","unstructured":"Bradi\u0107 I, Kuentzel KB, Honeder S, Grabner GF, Vuji\u0107 N, Zimmermann R, et al. Off-target effects of the lysosomal acid lipase inhibitors Lalistat-1 and Lalistat-2 on neutral lipid hydrolases. Mol Metab. 2022;61:101510.","journal-title":"Mol Metab"},{"key":"10098_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.751239","volume":"12","author":"CK Brock","year":"2021","unstructured":"Brock CK, Hebert KL, Artiles M, Wright MK, Cheng T, Windsor GO, et al. A role for adipocytes and adipose stem cells in the breast tumor microenvironment and regenerative medicine. Front Physiol. 2021;12:751239.","journal-title":"Front Physiol"},{"key":"10098_CR20","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1016\/j.bbrc.2005.12.103","volume":"340","author":"JD Bub","year":"2006","unstructured":"Bub JD, Miyazaki T, Iwamoto Y. Adiponectin as a growth inhibitor in prostate cancer cells. Biochem Biophys Res Commun. 2006;340:1158\u201366.","journal-title":"Biochem Biophys Res Commun"},{"key":"10098_CR21","doi-asserted-by":"publisher","first-page":"3259","DOI":"10.62347\/XZRI9189","volume":"14","author":"Q Cai","year":"2024","unstructured":"Cai Q, Yang J, Shen H, Xu W. Cancer-associated adipocytes in the ovarian cancer microenvironment. Am J Cancer Res. 2024;14:3259.","journal-title":"Am J Cancer Res"},{"key":"10098_CR22","doi-asserted-by":"publisher","DOI":"10.2147\/ott.s4943","author":"E Calvo","year":"2009","unstructured":"Calvo E, Bol\u00f3s V, Grande E. Multiple roles and therapeutic implications of Akt signaling in cancer. Onco Targets Ther. 2009. https:\/\/doi.org\/10.2147\/ott.s4943.","journal-title":"Onco Targets Ther"},{"key":"10098_CR23","volume":"1867","author":"CD Camell","year":"2022","unstructured":"Camell CD. Adipose tissue microenvironments during aging: effects on stimulated lipolysis. Biochimica Et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids. 2022;1867:159118.","journal-title":"Biochimica Et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids"},{"key":"10098_CR24","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.cellsig.2005.08.009","volume":"18","author":"G-Y Carmen","year":"2006","unstructured":"Carmen G-Y, V\u00edctor S-M. Signalling mechanisms regulating lipolysis. Cell Signal. 2006;18:401\u20138.","journal-title":"Cell Signal"},{"key":"10098_CR25","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1038\/s41416-019-0711-3","volume":"122","author":"JC Casciano","year":"2020","unstructured":"Casciano JC, Perry C, Cohen-Nowak AJ, Miller KD, Vande Voorde J, Zhang Q, et al. MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer. Br J Cancer. 2020;122:868\u201384.","journal-title":"Br J Cancer"},{"key":"10098_CR26","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/s41388-023-02914-0","volume":"43","author":"SS Chauhan","year":"2024","unstructured":"Chauhan SS, Casillas AL, Vizzerra AD, Liou H, Clements AN, Flores CE, et al. PIM1 drives lipid droplet accumulation to promote proliferation and survival in prostate cancer. Oncogene. 2024;43:406\u201319.","journal-title":"Oncogene"},{"key":"10098_CR27","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1038\/s41571-021-00546-5","volume":"18","author":"Y Chen","year":"2021","unstructured":"Chen Y, McAndrews KM, Kalluri R. Clinical and therapeutic relevance of cancer-associated fibroblasts. Nat Rev Clin Oncol. 2021;18:792\u2013804.","journal-title":"Nat Rev Clin Oncol"},{"key":"10098_CR28","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1002\/jcb.22787","volume":"111","author":"WC Chiu","year":"2010","unstructured":"Chiu WC, Chen CJ, Lee TS, Chen ZJ, Ke PH, Chiang AN. Oxidative stress enhances AP-1 and NF-\u03baB-mediated regulation of \u03b22-glycoprotein I gene expression in hepatoma cells. J Cell Biochem. 2010;111:988\u201398.","journal-title":"J Cell Biochem"},{"key":"10098_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2023.102114","volume":"83","author":"CH Cho","year":"2023","unstructured":"Cho CH, Patel S, Rajbhandari P. Adipose tissue lipid metabolism: lipolysis. Curr Opin Genet Dev. 2023;83:102114. https:\/\/doi.org\/10.1016\/j.gde.2023.102114.","journal-title":"Curr Opin Genet Dev"},{"key":"10098_CR30","doi-asserted-by":"publisher","first-page":"291","DOI":"10.3390\/biom15020291","volume":"15","author":"YY Cho","year":"2025","unstructured":"Cho YY, Kim S, Kim P, Jo MJ, Park S-E, Choi Y, et al. G-protein-coupled receptor (GPCR) signaling and pharmacology in metabolism: physiology, mechanisms, and therapeutic potential. Biomolecules. 2025;15:291.","journal-title":"Biomolecules"},{"key":"10098_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2016.00030","volume":"7","author":"SS Choe","year":"2016","unstructured":"Choe SS, Huh JY, Hwang IJ, Kim JI, Kim JB. Adipose tissue remodeling: its role in energy metabolism and metabolic disorders. Front Endocrinol (Lausanne). 2016;7:30. https:\/\/doi.org\/10.3389\/fendo.2016.00030.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10098_CR32","doi-asserted-by":"publisher","first-page":"5009","DOI":"10.1128\/MCB.00797-10","volume":"30","author":"SM Choi","year":"2010","unstructured":"Choi SM, Tucker DF, Gross DN, Easton RM, DiPilato LM, Dean AS, et al. Insulin regulates adipocyte lipolysis via an Akt-independent signaling pathway. Mol Cell Biol. 2010;30:5009\u201320.","journal-title":"Mol Cell Biol"},{"key":"10098_CR33","doi-asserted-by":"crossref","unstructured":"Claridge SE, Cavallo J-A, Hopkins BD. Patient-derived in vitro and in vivo models of cancer. Computational Methods for Precision Oncology. Springer; 2022. pp. 215\u201333.","DOI":"10.1007\/978-3-030-91836-1_12"},{"key":"10098_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5937\/jomb0-24652","volume":"40","author":"E \u010colak","year":"2021","unstructured":"\u010colak E, Pap D. The role of oxidative stress in the development of obesity and obesity-related metabolic disorders. J Med Biochem. 2021;40:1.","journal-title":"J Med Biochem"},{"key":"10098_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13048-020-00718-4","volume":"13","author":"L Dai","year":"2020","unstructured":"Dai L, Song K, Di W. Adipocytes: active facilitators in epithelial ovarian cancer progression? J Ovarian Res. 2020;13:1\u201313.","journal-title":"J Ovarian Res"},{"key":"10098_CR36","doi-asserted-by":"publisher","first-page":"35910","DOI":"10.1074\/jbc.M110.155150","volume":"285","author":"M Diskar","year":"2010","unstructured":"Diskar M, Zenn H-M, Kaupisch A, Kaufholz M, Brockmeyer S, Sohmen D, et al. Regulation of cAMP-dependent protein kinases: the human protein kinase X (PrKX) reveals the role of the catalytic subunit \u03b1H-\u03b1I loop. J Biol Chem. 2010;285:35910\u20138.","journal-title":"J Biol Chem"},{"key":"10098_CR37","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1146\/annurev.nutr.27.061406.093734","volume":"27","author":"RE Duncan","year":"2007","unstructured":"Duncan RE, Ahmadian M, Jaworski K, Sarkadi-Nagy E, Sul HS. Regulation of lipolysis in adipocytes. Annu Rev Nutr. 2007;27:79\u2013101. https:\/\/doi.org\/10.1146\/annurev.nutr.27.061406.093734.","journal-title":"Annu Rev Nutr"},{"key":"10098_CR38","doi-asserted-by":"publisher","first-page":"57622","DOI":"10.18632\/oncotarget.18038","volume":"8","author":"MN Duong","year":"2017","unstructured":"Duong MN, Geneste A, Fallone F, Li X, Dumontet C, Muller C. The fat and the bad: mature adipocytes, key actors in tumor progression and resistance. Oncotarget. 2017;8:57622.","journal-title":"Oncotarget"},{"key":"10098_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12944-017-0638-8","volume":"16","author":"M Ebadi","year":"2017","unstructured":"Ebadi M, Field CJ, Lehner R, Mazurak VC. Chemotherapy diminishes lipid storage capacity of adipose tissue in a preclinical model of colon cancer. Lipids Health Dis. 2017;16:1\u201312.","journal-title":"Lipids Health Dis"},{"key":"10098_CR40","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1039\/C5MB00101C","volume":"11","author":"T Ersahin","year":"2015","unstructured":"Ersahin T, Tuncbag N, Cetin-Atalay R. The PI3K\/AKT\/mTOR interactive pathway. Mol Biosyst. 2015;11:1946\u201354.","journal-title":"Mol Biosyst"},{"key":"10098_CR41","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-019-0832-4","volume":"12","author":"H Fan","year":"2019","unstructured":"Fan H, Demirci U, Chen P. Emerging organoid models: leaping forward in cancer research. J Hematol Oncol. 2019;12:142.","journal-title":"J Hematol Oncol"},{"key":"10098_CR42","volume":"3","author":"WW Feng","year":"2020","unstructured":"Feng WW, Kurokawa M. Lipid metabolic reprogramming as an emerging mechanism of resistance to kinase inhibitors in breast cancer. Cancer Drug Resist. 2020;3:1.","journal-title":"Cancer Drug Resist"},{"key":"10098_CR43","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez LP, Gomez de Cedron M, Ramirez de Molina A. Alterations of lipid metabolism in cancer: implications in prognosis and treatment. Frontiers in oncology. 2020;10:577420.","DOI":"10.3389\/fonc.2020.577420"},{"key":"10098_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110910","author":"A Fougerat","year":"2022","unstructured":"Fougerat A, Schoiswohl G, Polizzi A, R\u00e9gnier M, Wagner C, Smati S, et al. ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPAR\u03b1 activity. Cell Rep. 2022a. https:\/\/doi.org\/10.1016\/j.celrep.2022.110910.","journal-title":"Cell Rep"},{"key":"10098_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110910","volume":"39","author":"A Fougerat","year":"2022","unstructured":"Fougerat A, Schoiswohl G, Polizzi A, Regnier M, Wagner C, Smati S, et al. ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARalpha activity. Cell Rep. 2022b;39:110910. https:\/\/doi.org\/10.1016\/j.celrep.2022.110910.","journal-title":"Cell Rep"},{"key":"10098_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2023.102079","volume":"81","author":"SK Fried","year":"2023","unstructured":"Fried SK. Adipose \u2018neighborhoods\u2019 collaborate to maintain metabolic health. Curr Opin Genet Dev. 2023;81:102079.","journal-title":"Curr Opin Genet Dev"},{"key":"10098_CR47","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00413","volume":"10","author":"KD Galsgaard","year":"2019","unstructured":"Galsgaard KD, Pedersen J, Knop FK, Holst JJ, Wewer Albrechtsen NJ. Glucagon receptor signaling and lipid metabolism. Front Physiol. 2019;10:431942.","journal-title":"Front Physiol"},{"key":"10098_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13046-020-01579-x","volume":"39","author":"L Gao","year":"2020","unstructured":"Gao L, Xu Z, Huang Z, Tang Y, Yang D, Huang J, et al. CPI-613 rewires lipid metabolism to enhance pancreatic cancer apoptosis via the AMPK-ACC signaling. J Exp Clin Cancer Res. 2020;39:1\u201312.","journal-title":"J Exp Clin Cancer Res"},{"key":"10098_CR49","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1006\/gyno.1996.0008","volume":"60","author":"C Gercel-Taylor","year":"1996","unstructured":"Gercel-Taylor C, Doering DL, Kraemer FB, Taylor DD. Aberrations in normal systemic lipid metabolism in ovarian cancer patients. Gynecol Oncol. 1996;60:35\u201341.","journal-title":"Gynecol Oncol"},{"key":"10098_CR50","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1194\/jlr.R082933","volume":"59","author":"JC Glatz","year":"2018","unstructured":"Glatz JC, Luiken JF. Dynamic role of the transmembrane glycoprotein CD36 (SR-B2) in cellular fatty acid uptake and utilization. J Lipid Res. 2018;59:1084\u201393.","journal-title":"J Lipid Res"},{"key":"10098_CR51","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.tem.2012.06.007","volume":"23","author":"I Goldstein","year":"2012","unstructured":"Goldstein I, Rotter V. Regulation of lipid metabolism by p53\u2013fighting two villains with one sword. Trends Endocrinol Metab. 2012;23:567\u201375.","journal-title":"Trends Endocrinol Metab"},{"issue":"556\u201372","key":"10098_CR52","volume":"30","author":"AM Gouw","year":"2019","unstructured":"Gouw AM, Margulis K, Liu NS, Raman SJ, Mancuso A, Toal GG, et al. The MYC oncogene cooperates with sterol-regulated element-binding protein to regulate lipogenesis essential for neoplastic growth. Cell Metab. 2019;30(556\u201372):e5.","journal-title":"Cell Metab"},{"key":"10098_CR53","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1038\/s42255-021-00493-6","volume":"3","author":"GF Grabner","year":"2021","unstructured":"Grabner GF, Xie H, Schweiger M, Zechner R. Lipolysis: cellular mechanisms for lipid mobilization from fat stores. Nat Metab. 2021;3:1445\u201365. https:\/\/doi.org\/10.1038\/s42255-021-00493-6.","journal-title":"Nat Metab"},{"key":"10098_CR54","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1074\/jbc.R114.619957","volume":"290","author":"L Guo","year":"2015","unstructured":"Guo L, Li X, Tang Q-Q. Transcriptional regulation of adipocyte differentiation: a central role for CCAAT\/enhancer-binding protein (C\/EBP) \u03b2. J Biol Chem. 2015;290:755\u201361.","journal-title":"J Biol Chem"},{"key":"10098_CR55","doi-asserted-by":"publisher","first-page":"E877","DOI":"10.1152\/ajpendo.00626.2010","volume":"300","author":"Q He","year":"2011","unstructured":"He Q, Gao Z, Yin J, Zhang J, Yun Z, Ye J. Regulation of HIF-1\u03b1 activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia. American Journal of Physiology-Endocrinology and Metabolism. 2011;300:E877\u201385.","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"key":"10098_CR56","doi-asserted-by":"publisher","first-page":"60S","DOI":"10.1177\/014860719201600605","volume":"16","author":"D Heber","year":"1992","unstructured":"Heber D, Byerley LO, Tchekmedyian NS. Hormonal and metabolic abnormalities in the malnourished cancer patient: effects on host-tumor interaction. J Parenter Enteral Nutr. 1992;16:60S-S64.","journal-title":"J Parenter Enteral Nutr"},{"key":"10098_CR57","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/s41418-022-01062-4","volume":"30","author":"X Hildebrandt","year":"2023","unstructured":"Hildebrandt X, Ibrahim M, Peltzer N. Cell death and inflammation during obesity:\u201cKnow my methods, WAT (son).\u201d Cell Death Differ. 2023;30:279\u201392.","journal-title":"Cell Death Differ"},{"key":"10098_CR58","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1042\/bst0311120","volume":"31","author":"C Holm","year":"2003","unstructured":"Holm C. Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Biochem Soc Trans. 2003;31:1120\u20134.","journal-title":"Biochem Soc Trans"},{"key":"10098_CR59","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1590\/s1677-5538.ibju.2018.0261","volume":"45","author":"X Hu","year":"2019","unstructured":"Hu X, Hu C, Zhang C, Zhang M, Long S, Cao Z. Role of adiponectin in prostate cancer. Int Braz J Urol. 2019;45:220\u20138.","journal-title":"Int Braz J Urol"},{"key":"10098_CR60","doi-asserted-by":"publisher","first-page":"924","DOI":"10.3390\/ijms16010924","volume":"16","author":"C Huang","year":"2015","unstructured":"Huang C, Freter C. Lipid metabolism, apoptosis and cancer therapy. Int J Mol Sci. 2015;16:924\u201349.","journal-title":"Int J Mol Sci"},{"key":"10098_CR61","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.7150\/ijbs.27173","volume":"14","author":"X Huang","year":"2018","unstructured":"Huang X, Liu G, Guo J, Su Z. The PI3K\/AKT pathway in obesity and type 2 diabetes. Int J Biol Sci. 2018;14:1483.","journal-title":"Int J Biol Sci"},{"key":"10098_CR62","doi-asserted-by":"publisher","DOI":"10.1177\/1533033819879905","volume":"18","author":"B Huang","year":"2019","unstructured":"Huang B, Huang M, Li Q. Cancer-associated fibroblasts promote angiogenesis of hepatocellular carcinoma by VEGF-mediated EZH2\/VASH1 pathway. Technol Cancer Res Treat. 2019;18:1533033819879905.","journal-title":"Technol Cancer Res Treat"},{"key":"10098_CR63","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00544-0","volume":"6","author":"J Huang","year":"2021","unstructured":"Huang J, Zhang L, Wan D, Zhou L, Zheng S, Lin S, et al. Extracellular matrix and its therapeutic potential for cancer treatment. Signal Transduct Target Ther. 2021;6:153.","journal-title":"Signal Transduct Target Ther"},{"key":"10098_CR64","doi-asserted-by":"publisher","first-page":"650","DOI":"10.3390\/cancers17040650","volume":"17","author":"X Huang","year":"2025","unstructured":"Huang X, Liu B, Shen S. Lipid metabolism in breast cancer: from basic research to clinical application. Cancers. 2025;17:650.","journal-title":"Cancers"},{"key":"10098_CR65","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1194\/jlr.D058438","volume":"57","author":"J Iglesias","year":"2016","unstructured":"Iglesias J, Lamontagne J, Erb H, Gezzar S, Zhao S, Joly E, et al. Simplified assays of lipolysis enzymes for drug discovery and specificity assessment of known inhibitors. J Lipid Res. 2016;57:131\u201341.","journal-title":"J Lipid Res"},{"key":"10098_CR66","doi-asserted-by":"publisher","unstructured":"Jaworski K, Sarkadi-Nagy E, Duncan RE, Ahmadian M, Sul HS. Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue. Am J Physiol Gastrointest Liver Physiol. 2007;293:G1\u20134. https:\/\/doi.org\/10.1152\/ajpgi.00554.2006","DOI":"10.1152\/ajpgi.00554.2006"},{"key":"10098_CR67","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s13045-025-01688-0","volume":"18","author":"H Jia","year":"2025","unstructured":"Jia H, Chen X, Zhang L, Chen M. Cancer associated fibroblasts in cancer development and therapy. J Hematol Oncol. 2025;18:36.","journal-title":"J Hematol Oncol"},{"key":"10098_CR68","doi-asserted-by":"publisher","first-page":"8039","DOI":"10.1038\/s41467-023-43606-3","volume":"14","author":"M Jiang","year":"2023","unstructured":"Jiang M, Huizenga MC, Wirt JL, Paloczi J, Amedi A, van den Berg RJ, et al. A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence. Nat Commun. 2023;14:8039.","journal-title":"Nat Commun"},{"key":"10098_CR69","doi-asserted-by":"publisher","DOI":"10.3390\/biom11060913","volume":"11","author":"C Jim\u00e9nez-Cortegana","year":"2021","unstructured":"Jim\u00e9nez-Cortegana C, L\u00f3pez-Saavedra A, S\u00e1nchez-Jim\u00e9nez F, P\u00e9rez-P\u00e9rez A, Casti\u00f1eiras J, Virizuela-Echaburu JA, et al. Leptin, both bad and good actor in cancer. Biomolecules. 2021;11:913.","journal-title":"Biomolecules"},{"key":"10098_CR70","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s13045-023-01498-2","volume":"16","author":"H-R Jin","year":"2023","unstructured":"Jin H-R, Wang J, Wang Z-J, Xi M-J, Xia B-H, Deng K, et al. Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics. J Hematol Oncol. 2023;16:103.","journal-title":"J Hematol Oncol"},{"key":"10098_CR71","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1101\/gad.1756509","volume":"23","author":"RG Jones","year":"2009","unstructured":"Jones RG, Thompson CB. Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev. 2009;23:537\u201348.","journal-title":"Genes Dev"},{"key":"10098_CR72","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.050814","author":"PB Jonker","year":"2024","unstructured":"Jonker PB, Muir A. Metabolic ripple effects\u2013deciphering how lipid metabolism in cancer interfaces with the tumor microenvironment. Dis Model Mech. 2024. https:\/\/doi.org\/10.1242\/dmm.050814.","journal-title":"Dis Model Mech"},{"key":"10098_CR73","doi-asserted-by":"publisher","first-page":"2883","DOI":"10.1042\/BCJ20190594","volume":"476","author":"C J\u00f6nsson","year":"2019","unstructured":"J\u00f6nsson C, Castor Batista AP, Kj\u00f8lhede P, Str\u00e5lfors P. Insulin and \u03b2-adrenergic receptors mediate lipolytic and anti-lipolytic signalling that is not altered by type 2 diabetes in human adipocytes. Biochem J. 2019;476:2883\u2013908.","journal-title":"Biochem J"},{"key":"10098_CR74","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1194\/jlr.M600471-JLR200","volume":"48","author":"L Jurga","year":"2007","unstructured":"Jurga L, Elisabet ANm, Andrea D, Lennart B, Erik Ns, Dominique L, et al. NF-\u03baB is important for TNF-\u03b1-induced lipolysis in human adipocytes. J Lipid Res. 2007;48:1069\u201377.","journal-title":"J Lipid Res"},{"key":"10098_CR75","doi-asserted-by":"publisher","first-page":"336","DOI":"10.3390\/metabo14060336","volume":"14","author":"R Karimi","year":"2024","unstructured":"Karimi R, Yanovich A, Elbarbry F, Cleven A. Adaptive effects of endocrine hormones on metabolism of macronutrients during fasting and starvation: a scoping review. Metabolites. 2024;14:336.","journal-title":"Metabolites"},{"key":"10098_CR76","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e29683","author":"J Ke","year":"2024","unstructured":"Ke J, Zhang C-j, Wang L-z, Xie F-s, Wu H-Y, Li T, et al. Lipopolysaccharide promotes cancer cell migration and invasion through METTL3\/PI3K\/AKT signaling in human cholangiocarcinoma. Heliyon. 2024. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e29683.","journal-title":"Heliyon"},{"key":"10098_CR77","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1016\/S0022-2275(20)35114-2","volume":"34","author":"JC Khoo","year":"1993","unstructured":"Khoo JC, Reue K, Steinberg D, Schotz MC. Expression of hormone-sensitive lipase mRNA in macrophages. J Lipid Res. 1993;34:1969\u201374.","journal-title":"J Lipid Res"},{"key":"10098_CR78","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00111","volume":"6","author":"SS Killen","year":"2015","unstructured":"Killen SS, Reid D, Marras S, Domenici P. The interplay between aerobic metabolism and antipredator performance: vigilance is related to recovery rate after exercise. Front Physiol. 2015;6:111.","journal-title":"Front Physiol"},{"key":"10098_CR79","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119473","volume":"10","author":"S Kim","year":"2015","unstructured":"Kim S, Lee Y, Koo JS. Differential expression of lipid metabolism-related proteins in different breast cancer subtypes. PLoS ONE. 2015;10:e0119473.","journal-title":"PLoS ONE"},{"key":"10098_CR80","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1007\/s12272-023-01473-y","volume":"46","author":"D-H Kim","year":"2023","unstructured":"Kim D-H, Song N-Y, Yim H. Targeting dysregulated lipid metabolism in the tumor microenvironment. Arch Pharm Res. 2023;46:855\u201381.","journal-title":"Arch Pharm Res"},{"key":"10098_CR81","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2020.100001","author":"U Kintscher","year":"2020","unstructured":"Kintscher U, Foryst-Ludwig A, Haemmerle G, Zechner R. The role of adipose triglyceride lipase and cytosolic lipolysis in cardiac function and heart failure. Cell Rep Med. 2020. https:\/\/doi.org\/10.1016\/j.xcrm.2020.100001.","journal-title":"Cell Rep Med"},{"key":"10098_CR82","doi-asserted-by":"crossref","unstructured":"Kirsh C, Harris AM, Simcox J. Adipocyte lipolysis and lipid-derived metabolite signaling. Lipid Signaling and Metabolism. Elsevier; 2020. pp. 115\u201329.","DOI":"10.1016\/B978-0-12-819404-1.00007-5"},{"key":"10098_CR83","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100968","author":"AS Kirstein","year":"2021","unstructured":"Kirstein AS, Kehr S, Nebe M, Hanschkow M, Barth LA, Lorenz J, et al. Pten regulates adipose progenitor cell growth, differentiation, and replicative aging. J Biol Chem. 2021. https:\/\/doi.org\/10.1016\/j.jbc.2021.100968.","journal-title":"J Biol Chem"},{"key":"10098_CR84","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.887380","volume":"13","author":"L Koppensteiner","year":"2022","unstructured":"Koppensteiner L, Mathieson L, O\u2019Connor RA, Akram AR. Cancer associated fibroblasts-an impediment to effective anti-cancer T cell immunity. Front Immunol. 2022;13:887380.","journal-title":"Front Immunol"},{"key":"10098_CR85","doi-asserted-by":"publisher","first-page":"3466","DOI":"10.1172\/JCI42845","volume":"120","author":"A Kosteli","year":"2010","unstructured":"Kosteli A, Sugaru E, Haemmerle G, Martin JF, Lei J, Zechner R, et al. Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J Clin Invest. 2010;120:3466\u201379. https:\/\/doi.org\/10.1172\/JCI42845.","journal-title":"J Clin Invest"},{"key":"10098_CR86","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41416-019-0650-z","volume":"122","author":"N Koundouros","year":"2020","unstructured":"Koundouros N, Poulogiannis G. Reprogramming of fatty acid metabolism in cancer. Br J Cancer. 2020;122:4\u201322.","journal-title":"Br J Cancer"},{"key":"10098_CR87","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1194\/jlr.R200009-JLR200","volume":"43","author":"FB Kraemer","year":"2002","unstructured":"Kraemer FB, Shen W-J. Hormone-sensitive lipase. J Lipid Res. 2002;43:1585\u201394.","journal-title":"J Lipid Res"},{"key":"10098_CR88","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1743-7075-3-12","volume":"3","author":"FB Kraemer","year":"2006","unstructured":"Kraemer FB, Shen W-J. Hormone-sensitive lipase knockouts. Nutr Metab. 2006a;3:1\u20137.","journal-title":"Nutr Metab"},{"key":"10098_CR89","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1743-7075-3-12","volume":"3","author":"FB Kraemer","year":"2006","unstructured":"Kraemer FB, Shen WJ. Hormone-sensitive lipase knockouts. Nutr Metab (Lond). 2006b;3:12. https:\/\/doi.org\/10.1186\/1743-7075-3-12.","journal-title":"Nutr Metab (Lond)"},{"key":"10098_CR90","doi-asserted-by":"publisher","first-page":"4752","DOI":"10.1111\/j.1742-4658.2009.07172.x","volume":"276","author":"C Krintel","year":"2009","unstructured":"Krintel C, M\u00f6rgelin M, Logan DT, Holm C. Phosphorylation of hormone-sensitive lipase by protein kinase A in vitro promotes an increase in its hydrophobic surface area. FEBS J. 2009;276:4752\u201362.","journal-title":"FEBS J"},{"key":"10098_CR91","doi-asserted-by":"publisher","DOI":"10.1177\/2042018819877300","volume":"10","author":"Y-L Lan","year":"2019","unstructured":"Lan Y-L, Lou J-C, Lyu W, Zhang B. Update on the synergistic effect of HSL and insulin in the treatment of metabolic disorders. Ther Adv Endocrinol Metab. 2019;10:2042018819877300.","journal-title":"Ther Adv Endocrinol Metab"},{"key":"10098_CR92","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1101\/gad.352753.125","volume":"39","author":"L Larue","year":"2025","unstructured":"Larue L. From fat to fear: how lipid powers cancer spread. Genes Dev. 2025;39:423\u20135.","journal-title":"Genes Dev"},{"key":"10098_CR93","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.plipres.2010.10.004","volume":"50","author":"A Lass","year":"2011","unstructured":"Lass A, Zimmermann R, Oberer M, Zechner R. Lipolysis\u2013a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores. Prog Lipid Res. 2011;50:14\u201327.","journal-title":"Prog Lipid Res"},{"key":"10098_CR94","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1194\/jlr.R083725","volume":"59","author":"I Lazar","year":"2018","unstructured":"Lazar I, Clement E, Attane C, Muller C, Nieto L. A new role for extracellular vesicles: how small vesicles can feed tumors\u2019 big appetite. J Lipid Res. 2018;59:1793\u2013804.","journal-title":"J Lipid Res"},{"key":"10098_CR95","doi-asserted-by":"publisher","DOI":"10.4046\/trd.2022.0129","volume":"86","author":"H Lee","year":"2023","unstructured":"Lee H, Hwang M, Jang S, Um S-W. Immune regulatory function of cancer-associated fibroblasts in non-small cell lung cancer. Tubercul Respir Dis. 2023a;86:304.","journal-title":"Tubercul Respir Dis"},{"key":"10098_CR96","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.175497","volume":"941","author":"J Lee","year":"2023","unstructured":"Lee J, Shin D, Roh J-L. Lipid metabolism alterations and ferroptosis in cancer: paving the way for solving cancer resistance. Eur J Pharmacol. 2023b;941:175497.","journal-title":"Eur J Pharmacol"},{"key":"10098_CR97","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2024.101930","volume":"83","author":"C Lefevre","year":"2024","unstructured":"Lefevre C, Thibaut MM, Loumaye A, Thissen J-P, Neyrinck AM, Navez B, et al. Tumoral acidosis promotes adipose tissue depletion by fostering adipocyte lipolysis. Mol Metab. 2024;83:101930.","journal-title":"Mol Metab"},{"key":"10098_CR98","doi-asserted-by":"publisher","first-page":"3667","DOI":"10.2174\/1381612823666170704124611","volume":"23","author":"A Li","year":"2017","unstructured":"Li A, Qiu M, Zhou H, Wang T, Guo W. PTEN, insulin resistance and cancer. Curr Pharm Des. 2017;23:3667\u201376.","journal-title":"Curr Pharm Des"},{"key":"10098_CR99","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax5611","volume":"6","author":"Y Li","year":"2020","unstructured":"Li Y, Mao AS, Seo BR, Zhao X, Gupta SK, Chen M, et al. Compression-induced dedifferentiation of adipocytes promotes tumor progression. Sci Adv. 2020;6:eaax5611.","journal-title":"Sci Adv"},{"key":"10098_CR100","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.826314","volume":"13","author":"Y Li","year":"2022","unstructured":"Li Y, Li Z, Ngandiri DA, Llerins Perez M, Wolf A, Wang Y. The molecular brakes of adipose tissue lipolysis. Front Physiol. 2022;13:826314. https:\/\/doi.org\/10.3389\/fphys.2022.826314.","journal-title":"Front Physiol"},{"key":"10098_CR101","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41420-024-01841-7","volume":"10","author":"S Li","year":"2024","unstructured":"Li S, Yuan J, Cheng Z, Li Y, Cheng S, Liu X, et al. Hsa_circ_0021205 enhances lipolysis via regulating miR-195-5p\/HSL axis and drives malignant progression of glioblastoma. Cell Death Discov. 2024;10:71.","journal-title":"Cell Death Discov"},{"key":"10098_CR102","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.tibs.2015.12.001","volume":"41","author":"MV Liberti","year":"2016","unstructured":"Liberti MV, Locasale JW. The warburg effect: how does it benefit cancer cells? Trends Biochem Sci. 2016;41:211\u20138.","journal-title":"Trends Biochem Sci"},{"key":"10098_CR103","unstructured":"Linton MF, Yancey PG, Davies SS, Jerome WG, Linton EF, Song WL, Doran AC, Vickers KC. The role of lipids and lipoproteins in atherosclerosis. Endotext [Internet]. 2019."},{"key":"10098_CR104","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.3390\/biomedicines13081895","volume":"13","author":"R Liu","year":"2025","unstructured":"Liu R, Wang C, Tao Z, Hu G. Lipid metabolism reprogramming in cancer: insights into tumor cells and immune cells within the tumor microenvironment. Biomedicines. 2025;13:1895.","journal-title":"Biomedicines"},{"key":"10098_CR105","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1002\/pros.21057","volume":"70","author":"JA Locke","year":"2010","unstructured":"Locke JA, Guns EST, Lehman ML, Ettinger S, Zoubeidi A, Lubik A, et al. Arachidonic acid activation of intratumoral steroid synthesis during prostate cancer progression to castration resistance. Prostate. 2010;70:239\u201351.","journal-title":"Prostate"},{"key":"10098_CR106","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1097\/CM9.0000000000001708","volume":"134","author":"Z-N Lu","year":"2021","unstructured":"Lu Z-N, Song J, Sun T-H, Sun G. Ube2c affects breast cancer proliferation through the AKT\/mTOR signaling pathway. Chin Med J. 2021;134:2465\u201374.","journal-title":"Chin Med J"},{"key":"10098_CR107","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s12943-017-0646-3","volume":"16","author":"X Luo","year":"2017","unstructured":"Luo X, Cheng C, Tan Z, Li N, Tang M, Yang L, et al. Emerging roles of lipid metabolism in cancer metastasis. Mol Cancer. 2017;16:76.","journal-title":"Mol Cancer"},{"key":"10098_CR108","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.canlet.2018.08.006","volume":"435","author":"Y Ma","year":"2018","unstructured":"Ma Y, Temkin SM, Hawkridge AM, Guo C, Wang W, Wang X-Y, et al. Fatty acid oxidation: an emerging facet of metabolic transformation in cancer. Cancer Lett. 2018;435:92\u2013100.","journal-title":"Cancer Lett"},{"key":"10098_CR109","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.bbrc.2018.02.097","volume":"504","author":"M Maan","year":"2018","unstructured":"Maan M, Peters JM, Dutta M, Patterson AD. Lipid metabolism and lipophagy in cancer. Biochem Biophys Res Commun. 2018;504:582\u20139.","journal-title":"Biochem Biophys Res Commun"},{"key":"10098_CR110","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-022-00694-0","volume":"19","author":"SA Machado","year":"2022","unstructured":"Machado SA, Pasquarelli-do-Nascimento G, Da Silva DS, Farias GR, de Oliveira Santos I, Baptista LB, et al. Browning of the white adipose tissue regulation: new insights into nutritional and metabolic relevance in health and diseases. Nutr Metab. 2022;19:61.","journal-title":"Nutr Metab"},{"key":"10098_CR111","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-004584","volume":"10","author":"G Marelli","year":"2022","unstructured":"Marelli G, Morina N, Portale F, Pandini M, Iovino M, Di Conza G, et al. Lipid-loaded macrophages as new therapeutic target in cancer. J Immunother Cancer. 2022;10:e004584.","journal-title":"J Immunother Cancer"},{"key":"10098_CR112","doi-asserted-by":"publisher","first-page":"3956","DOI":"10.1038\/s41467-022-31525-8","volume":"13","author":"LK Markussen","year":"2022","unstructured":"Markussen LK, Rondini EA, Johansen OS, Madsen JGS, Sustarsic EG, Marcher AB, et al. Lipolysis regulates major transcriptional programs in brown adipocytes. Nat Commun. 2022;13:3956. https:\/\/doi.org\/10.1038\/s41467-022-31525-8.","journal-title":"Nat Commun"},{"key":"10098_CR113","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1016\/j.cmet.2022.09.023","volume":"34","author":"M Martin-Perez","year":"2022","unstructured":"Martin-Perez M, Urdiroz-Urricelqui U, Bigas C, Benitah SA. The role of lipids in cancer progression and metastasis. Cell Metab. 2022;34:1675\u201399.","journal-title":"Cell Metab"},{"key":"10098_CR114","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.molonc.2014.11.001","volume":"9","author":"A Maya-Mendoza","year":"2015","unstructured":"Maya-Mendoza A, Ostrakova J, Kosar M, Hall A, Duskova P, Mistrik M, et al. Myc and Ras oncogenes engage different energy metabolism programs and evoke distinct patterns of oxidative and DNA replication stress. Mol Oncol. 2015;9:601\u201316.","journal-title":"Mol Oncol"},{"key":"10098_CR115","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055511","volume":"8","author":"PM McDonough","year":"2013","unstructured":"McDonough PM, Maciejewski-Lenoir D, Hartig SM, Hanna RA, Whittaker R, Heisel A, et al. Differential phosphorylation of perilipin 1A at the initiation of lipolysis revealed by novel monoclonal antibodies and high content analysis. PLoS ONE. 2013;8:e55511.","journal-title":"PLoS ONE"},{"key":"10098_CR116","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2019.06.001","volume":"62","author":"IH McKillop","year":"2019","unstructured":"McKillop IH, Girardi CA, Thompson KJ. Role of fatty acid binding proteins (FABPs) in cancer development and progression. Cell Signal. 2019;62:109336.","journal-title":"Cell Signal"},{"key":"10098_CR117","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cancers6010001","volume":"6","author":"M Medov\u00e1","year":"2013","unstructured":"Medov\u00e1 M, Aebersold DM, Zimmer Y. The molecular crosstalk between the MET receptor tyrosine kinase and the DNA damage response\u2014biological and clinical aspects. Cancers (Basel). 2013;6:1\u201327.","journal-title":"Cancers (Basel)"},{"key":"10098_CR118","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154908","volume":"117","author":"L Meihe","year":"2023","unstructured":"Meihe L, Shan G, Minchao K, Zhang X, Ping L, Xiaoling W, et al. Quercitrin alleviates lipid metabolism disorder in polycystic ovary syndrome-insulin resistance by upregulating PM20D1 in the PI3K\/Akt pathway. Phytomedicine. 2023;117:154908.","journal-title":"Phytomedicine"},{"key":"10098_CR119","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.bbalip.2009.09.005","volume":"1801","author":"JA Menendez","year":"2010","unstructured":"Menendez JA. Fine-tuning the lipogenic\/lipolytic balance to optimize the metabolic requirements of cancer cell growth: molecular mechanisms and therapeutic perspectives. Biochimica et Biophysica Acta (BBA). 2010;1801:381\u201391.","journal-title":"Biochimica et Biophysica Acta (BBA)"},{"key":"10098_CR120","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/134059","volume":"2008","author":"L Michalik","year":"2008","unstructured":"Michalik L, Wahli W. Ppars mediate lipid signaling in inflammation and cancer. PPAR Res. 2008;2008:134059.","journal-title":"PPAR Res"},{"key":"10098_CR121","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3389\/fphys.2019.00026","volume":"10","author":"A Mika","year":"2019","unstructured":"Mika A, Macaluso F, Barone R, Di Felice V, Sledzinski T. Effect of exercise on fatty acid metabolism and adipokine secretion in adipose tissue. Front Physiol. 2019;10:26. https:\/\/doi.org\/10.3389\/fphys.2019.00026.","journal-title":"Front Physiol"},{"key":"10098_CR122","doi-asserted-by":"publisher","first-page":"7057","DOI":"10.1021\/jm801051t","volume":"51","author":"A Minkkila","year":"2008","unstructured":"Minkkila A, Saario SM, Kasnanen H, Leppanen J, Poso A, Nevalainen T. Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008;51:7057\u201360.","journal-title":"J Med Chem"},{"key":"10098_CR123","doi-asserted-by":"crossref","unstructured":"Modak S, Aktar T, Majumder D, Singha AK, Maiti D. A systemic review on leptin\u2019s role in defining cancer: special emphasis on immunomodulation, inflammation, and therapeutic interventions. Genes & Immunity. 2025:1\u201321.","DOI":"10.1038\/s41435-025-00333-7"},{"key":"10098_CR124","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1136\/gutjnl-2015-310798","volume":"65","author":"A Montagner","year":"2016","unstructured":"Montagner A, Polizzi A, Fouch\u00e9 E, Ducheix S, Lippi Y, Lasserre F, et al. Liver PPAR\u03b1 is crucial for whole-body fatty acid homeostasis and is protective against NAFLD. Gut. 2016;65:1202\u201314.","journal-title":"Gut"},{"key":"10098_CR125","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1038\/s41416-019-0451-4","volume":"120","author":"R Munir","year":"2019","unstructured":"Munir R, Lisec J, Swinnen JV, Zaidi N. Lipid metabolism in cancer cells under metabolic stress. Br J Cancer. 2019;120:1090\u20138.","journal-title":"Br J Cancer"},{"key":"10098_CR126","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s40170-020-00237-2","volume":"9","author":"SR Nagarajan","year":"2021","unstructured":"Nagarajan SR, Butler LM, Hoy AJ. The diversity and breadth of cancer cell fatty acid metabolism. Cancer Metab. 2021;9:2.","journal-title":"Cancer Metab"},{"key":"10098_CR127","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00691.2006","author":"J Nedergaard","year":"2007","unstructured":"Nedergaard J, Bengtsson T, Cannon B. Unexpected evidence for active brown adipose tissue in adult humans. American Journal of Physiology-Endocrinology and Metabolism. 2007. https:\/\/doi.org\/10.1152\/ajpendo.00691.2006.","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"key":"10098_CR128","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1038\/nm.2492","volume":"17","author":"KM Nieman","year":"2011","unstructured":"Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med. 2011;17:1498\u2013503.","journal-title":"Nat Med"},{"key":"10098_CR129","first-page":"1533","volume":"1831","author":"KM Nieman","year":"2013","unstructured":"Nieman KM, Romero IL, Van Houten B, Lengyel E. Adipose tissue and adipocytes support tumorigenesis and metastasis. Biochimica Et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids. 2013;1831:1533\u201341.","journal-title":"Biochimica Et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids"},{"key":"10098_CR130","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.cell.2009.11.027","volume":"140","author":"DK Nomura","year":"2010","unstructured":"Nomura DK, Long JZ, Niessen S, Hoover HS, Ng S-W, Cravatt BF. Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell. 2010;140:49\u201361.","journal-title":"Cell"},{"key":"10098_CR131","doi-asserted-by":"publisher","first-page":"3801","DOI":"10.1016\/j.bmc.2016.06.022","volume":"24","author":"T Ogiyama","year":"2016","unstructured":"Ogiyama T, Yamaguchi M, Kurikawa N, Honzumi S, Yamamoto Y, Sugiyama D, et al. Identification of a novel boronic acid as a potent, selective, and orally active hormone sensitive lipase inhibitor. Bioorg Med Chem. 2016;24:3801\u20137.","journal-title":"Bioorg Med Chem"},{"key":"10098_CR132","doi-asserted-by":"publisher","first-page":"4817","DOI":"10.1016\/j.bmc.2017.07.028","volume":"25","author":"T Ogiyama","year":"2017","unstructured":"Ogiyama T, Yamaguchi M, Kurikawa N, Honzumi S, Terayama K, Nagaoka N, et al. Design, synthesis, and pharmacological evaluation of a novel series of hormone sensitive lipase inhibitor. Bioorg Med Chem. 2017;25:4817\u201328.","journal-title":"Bioorg Med Chem"},{"key":"10098_CR133","doi-asserted-by":"publisher","first-page":"3368","DOI":"10.2337\/diabetes.51.12.3368","volume":"51","author":"H Okazaki","year":"2002","unstructured":"Okazaki H, Osuga J-i, Tamura Y, Yahagi N, Tomita S, Shionoiri F, et al. Lipolysis in the absence of hormone-sensitive lipase: evidence for a common mechanism regulating distinct lipases. Diabetes. 2002;51:3368\u201375.","journal-title":"Diabetes"},{"key":"10098_CR134","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100559","volume":"9","author":"T Okumura","year":"2014","unstructured":"Okumura T, Harada K, Oue K, Zhang J, Asano S, Hayashiuchi M, et al. Phospholipase C-related catalytically inactive protein (PRIP) regulates lipolysis in adipose tissue by modulating the phosphorylation of hormone-sensitive lipase. PLoS ONE. 2014;9:e100559.","journal-title":"PLoS ONE"},{"key":"10098_CR135","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1046\/j.1432-1327.2001.02097.x","volume":"268","author":"T \u00d8sterlund","year":"2001","unstructured":"\u00d8sterlund T. Structure\u2013function relationships of hormone-sensitive lipase. Eur J Biochem. 2001;268:1899\u2013907.","journal-title":"Eur J Biochem"},{"key":"10098_CR136","first-page":"799","volume":"85","author":"M Ottosson","year":"2000","unstructured":"Ottosson M, L\u00f6nnroth P, Bj\u00f6rntorp P, Ed\u00e9n S. Effects of cortisol and growth hormone on lipolysis in human adipose tissue. J Clin Endocrinol Metab. 2000;85:799\u2013803.","journal-title":"J Clin Endocrinol Metab"},{"key":"10098_CR137","doi-asserted-by":"publisher","first-page":"4278","DOI":"10.1210\/en.2012-1127","volume":"153","author":"J Pagnon","year":"2012","unstructured":"Pagnon J, Matzaris M, Stark R, Meex RC, Macaulay SL, Brown W, et al. Identification and functional characterization of protein kinase A phosphorylation sites in the major lipolytic protein, adipose triglyceride lipase. Endocrinology. 2012;153:4278\u201389.","journal-title":"Endocrinology"},{"key":"10098_CR138","volume":"28","author":"A Pandey","year":"2021","unstructured":"Pandey A, Yadav P, Shukla S. Unfolding the role of autophagy in the cancer metabolism. Biochem Biophys Rep. 2021;28:101158.","journal-title":"Biochem Biophys Rep"},{"key":"10098_CR139","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01608-z","volume":"8","author":"V Panwar","year":"2023","unstructured":"Panwar V, Singh A, Bhatt M, Tonk RK, Azizov S, Raza AS, et al. Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease. Signal Transduct Target Ther. 2023;8:375.","journal-title":"Signal Transduct Target Ther"},{"key":"10098_CR140","doi-asserted-by":"crossref","unstructured":"Pardo JC, Ruiz de Porras V, Gil J, Font A, Puig-Domingo M, Jord\u00e0 M. Lipid metabolism and epigenetics crosstalk in prostate cancer. Nutrients. 2022;14:851.","DOI":"10.3390\/nu14040851"},{"key":"10098_CR141","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12885-020-07273-7","volume":"20","author":"M Par\u00e9","year":"2020","unstructured":"Par\u00e9 M, Darini CY, Yao X, Chignon-Sicard B, Rekima S, Lachambre S, et al. Breast cancer mammospheres secrete adrenomedullin to induce lipolysis and browning of adjacent adipocytes. BMC Cancer. 2020;20:1\u201315.","journal-title":"BMC Cancer"},{"key":"10098_CR142","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20102519","volume":"20","author":"S Parida","year":"2019","unstructured":"Parida S, Siddharth S, Sharma D. Adiponectin, obesity, and cancer: clash of the bigwigs in health and disease. Int J Mol Sci. 2019;20:2519.","journal-title":"Int J Mol Sci"},{"key":"10098_CR143","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.molmet.2019.07.006","volume":"33","author":"VL Payen","year":"2020","unstructured":"Payen VL, Mina E, Van H\u00e9e VF, Porporato PE, Sonveaux P. Monocarboxylate transporters in cancer. Mol Metab. 2020;33:48\u201366.","journal-title":"Mol Metab"},{"key":"10098_CR144","doi-asserted-by":"publisher","first-page":"3965","DOI":"10.7150\/jca.42663","volume":"11","author":"T Peng","year":"2020","unstructured":"Peng T, Wang G, Cheng S, Xiong Y, Cao R, Qian K, et al. The role and function of PPAR\u03b3 in bladder cancer. J Cancer. 2020;11:3965.","journal-title":"J Cancer"},{"key":"10098_CR145","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3390\/biom14040483","volume":"14","author":"Y Peng","year":"2024","unstructured":"Peng Y, Zhao L, Li M, Liu Y, Shi Y, Zhang J. Plasticity of adipose tissues: interconversion among white, brown, and beige fat and its role in energy homeostasis. Biomolecules. 2024;14:483.","journal-title":"Biomolecules"},{"key":"10098_CR146","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3579143","volume":"2020","author":"Z Ping","year":"2020","unstructured":"Ping Z, Peng Y, Lang H, Xinyong C, Zhiyi Z, Xiaocheng W, et al. Oxidative stress in radiation-induced cardiotoxicity. Oxid Med Cell Longev. 2020;2020:3579143.","journal-title":"Oxid Med Cell Longev"},{"key":"10098_CR147","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1111778","volume":"13","author":"P Ping","year":"2023","unstructured":"Ping P, Li J, Lei H, Xu X. Fatty acid metabolism: a new therapeutic target for cervical cancer. Front Oncol. 2023;13:1111778.","journal-title":"Front Oncol"},{"key":"10098_CR148","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1158\/2159-8290.CD-24-0002","volume":"14","author":"J Prakash","year":"2024","unstructured":"Prakash J, Shaked Y. The interplay between extracellular matrix remodeling and cancer therapeutics. Cancer Discov. 2024;14:1375\u201388.","journal-title":"Cancer Discov"},{"key":"10098_CR149","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12944-023-01807-1","volume":"22","author":"X Qiao","year":"2023","unstructured":"Qiao X, Hu Z, Xiong F, Yang Y, Peng C, Wang D, et al. Lipid metabolism reprogramming in tumor-associated macrophages and implications for therapy. Lipids Health Dis. 2023;22:45.","journal-title":"Lipids Health Dis"},{"key":"10098_CR150","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/s41574-018-0126-x","volume":"15","author":"DF Quail","year":"2019","unstructured":"Quail DF, Dannenberg AJ. The obese adipose tissue microenvironment in cancer development and progression. Nat Rev Endocrinol. 2019;15:139\u201354.","journal-title":"Nat Rev Endocrinol"},{"key":"10098_CR151","doi-asserted-by":"publisher","first-page":"634","DOI":"10.3389\/fendo.2020.00634","volume":"11","author":"A Rabiee","year":"2020","unstructured":"Rabiee A. Beige fat maintenance; toward a sustained metabolic health. Front Endocrinol. 2020;11:634.","journal-title":"Front Endocrinol"},{"key":"10098_CR152","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2020.101084","volume":"82","author":"E Recazens","year":"2021","unstructured":"Recazens E, Mouisel E, Langin D. Hormone-sensitive lipase: sixty years later. Prog Lipid Res. 2021;82:101084.","journal-title":"Prog Lipid Res"},{"key":"10098_CR153","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112319","volume":"135","author":"Y Ren","year":"2024","unstructured":"Ren Y, Wang M, Yuan H, Wang Z, Yu L. A novel insight into cancer therapy: lipid metabolism in tumor-associated macrophages. Int Immunopharmacol. 2024;135:112319.","journal-title":"Int Immunopharmacol"},{"key":"10098_CR154","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1053\/meta.2000.6738","volume":"49","author":"B Richelsen","year":"2000","unstructured":"Richelsen B, Pedersen SB, Kristensen K, B\u00f8rglum JD, N\u00f8rrelund H, Christiansen JS, et al. Regulation of lipoprotein lipase and hormone-sensitive lipase activity and gene expression in adipose and muscle tissue by growth hormone treatment during weight loss in obese patients. Metabolism. 2000;49:906\u201311.","journal-title":"Metabolism"},{"key":"10098_CR155","doi-asserted-by":"publisher","first-page":"4932","DOI":"10.1158\/0008-5472.CAN-20-1255","volume":"80","author":"CN Rozeveld","year":"2020","unstructured":"Rozeveld CN, Johnson KM, Zhang L, Razidlo GL. KRAS controls pancreatic cancer cell lipid metabolism and invasive potential through the lipase HSL. Cancer Res. 2020;80:4932\u201345.","journal-title":"Cancer Res"},{"key":"10098_CR156","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1038\/sj.bjc.6602404","volume":"92","author":"ST Russell","year":"2005","unstructured":"Russell ST, Tisdale MJ. The role of glucocorticoids in the induction of zinc-\u03b12-glycoprotein expression in adipose tissue in cancer cachexia. Br J Cancer. 2005;92:876\u201381.","journal-title":"Br J Cancer"},{"key":"10098_CR157","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073775","volume":"22","author":"I Rybinska","year":"2021","unstructured":"Rybinska I, Mangano N, Tagliabue E, Triulzi T. Cancer-associated adipocytes in breast cancer: causes and consequences. Int J Mol Sci. 2021;22:3775.","journal-title":"Int J Mol Sci"},{"key":"10098_CR158","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1002\/1873-3468.14820","volume":"598","author":"R Safi","year":"2024","unstructured":"Safi R, Men\u00e9ndez P, Pol A. Lipid droplets provide metabolic flexibility for cancer progression. FEBS Lett. 2024;598:1301\u201327.","journal-title":"FEBS Lett"},{"key":"10098_CR159","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.cell.2021.12.016","volume":"185","author":"A Sakers","year":"2022","unstructured":"Sakers A, De Siqueira MK, Seale P, Villanueva CJ. Adipose-tissue plasticity in health and disease. Cell. 2022;185:419\u201346.","journal-title":"Cell"},{"key":"10098_CR160","doi-asserted-by":"crossref","unstructured":"Saltiel AR. Insulin signaling in the control of glucose and lipid homeostasis. Metabolic control. 2016:51\u201371.","DOI":"10.1007\/164_2015_14"},{"key":"10098_CR161","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1194\/jlr.M800198-JLR200","volume":"49","author":"M Sekiya","year":"2008","unstructured":"Sekiya M, Osuga J-i, Yahagi N, Okazaki H, Tamura Y, Igarashi M, et al. Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis. J Lipid Res. 2008;49:1829\u201338.","journal-title":"J Lipid Res"},{"key":"10098_CR162","first-page":"1057","volume":"1863","author":"S Senga","year":"2018","unstructured":"Senga S, Kobayashi N, Kawaguchi K, Ando A, Fujii H. Fatty acid-binding protein 5 (FABP5) promotes lipolysis of lipid droplets, de novo fatty acid (FA) synthesis and activation of nuclear factor-kappa B (NF-\u03baB) signaling in cancer cells. Biochimica Et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids. 2018;1863:1057\u201367.","journal-title":"Biochimica Et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids"},{"key":"10098_CR163","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/s42003-020-01367-5","volume":"3","author":"J Seo","year":"2020","unstructured":"Seo J, Jeong D-W, Park J-W, Lee K-W, Fukuda J, Chun Y-S. Fatty-acid-induced FABP5\/HIF-1 reprograms lipid metabolism and enhances the proliferation of liver cancer cells. Commun Biol. 2020;3:638.","journal-title":"Commun Biol"},{"key":"10098_CR164","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1007\/s00424-022-02683-x","volume":"474","author":"J Seo","year":"2022","unstructured":"Seo J, Yun J-E, Kim SJ, Chun Y-S. Lipid metabolic reprogramming by hypoxia-inducible factor-1 in the hypoxic tumour microenvironment. Pfl\u00fcgers Archiv-European Journal of Physiology. 2022;474:591\u2013601.","journal-title":"Pfl\u00fcgers Archiv-European Journal of Physiology"},{"key":"10098_CR165","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13045-023-01454-0","volume":"16","author":"T Setiawan","year":"2023","unstructured":"Setiawan T, Sari IN, Wijaya YT, Julianto NM, Muhammad JA, Lee H, et al. Cancer cachexia: molecular mechanisms and treatment strategies. J Hematol Oncol. 2023;16:54.","journal-title":"J Hematol Oncol"},{"key":"10098_CR166","doi-asserted-by":"crossref","unstructured":"Shafi VAQ, Khan NA, Siddiqui I. The impact of obesity-related genetic variants on NF-\u03baB signaling in cardiovascular disease: a systematic review. medRxiv. 2024:2024.12. 11.24318855.","DOI":"10.1101\/2024.12.11.24318855"},{"key":"10098_CR167","doi-asserted-by":"publisher","first-page":"6137","DOI":"10.1113\/jphysiol.2013.265199","volume":"591","author":"C Shaw","year":"2013","unstructured":"Shaw C, Clark J, Shepherd S. HSL and ATGL: the movers and shakers of muscle lipolysis. J Physiol. 2013;591:6137.","journal-title":"J Physiol"},{"key":"10098_CR168","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.1194\/jlr.M900176-JLR200","volume":"50","author":"W-J Shen","year":"2009","unstructured":"Shen W-J, Patel S, Miyoshi H, Greenberg AS, Kraemer FB. Functional interaction of hormone-sensitive lipase and perilipin in lipolysis. J Lipid Res. 2009;50:2306\u201313.","journal-title":"J Lipid Res"},{"key":"10098_CR169","first-page":"9","volume":"1811","author":"W-J Shen","year":"2011","unstructured":"Shen W-J, Yu Z, Patel S, Jue D, Liu L-F, Kraemer FB. Hormone-sensitive lipase modulates adipose metabolism through PPAR\u03b3. Biochimica Et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids. 2011;1811:9\u201316.","journal-title":"Biochimica Et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids"},{"key":"10098_CR170","doi-asserted-by":"publisher","first-page":"6271","DOI":"10.1038\/onc.2016.162","volume":"35","author":"J Shen","year":"2016","unstructured":"Shen J, Tsoi H, Liang Q, Chu E, Liu D, Yu A, et al. Oncogenic mutations and dysregulated pathways in obesity-associated hepatocellular carcinoma. Oncogene. 2016;35:6271\u201380.","journal-title":"Oncogene"},{"key":"10098_CR171","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20180764","volume":"38","author":"JP Shyu","year":"2018","unstructured":"Shyu JP, Wong XFA, Crasta K, Thibault G. Dropping in on lipid droplets: insights into cellular stress and cancer. Biosci Rep. 2018;38:BSR20180764.","journal-title":"Biosci Rep"},{"key":"10098_CR172","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2020.188359","volume":"1873","author":"JA Siddiqui","year":"2020","unstructured":"Siddiqui JA, Pothuraju R, Jain M, Batra SK, Nasser MW. Advances in cancer cachexia: intersection between affected organs, mediators, and pharmacological interventions. Biochimica Et Biophysica Acta (BBA)-Reviews on Cancer. 2020;1873:188359.","journal-title":"Biochimica Et Biophysica Acta (BBA)-Reviews on Cancer"},{"key":"10098_CR173","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1172\/JCI78362","volume":"125","author":"L Sidossis","year":"2015","unstructured":"Sidossis L, Kajimura S. Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. J Clin Invest. 2015;125:478\u201386.","journal-title":"J Clin Invest"},{"key":"10098_CR174","doi-asserted-by":"publisher","first-page":"4293","DOI":"10.3390\/cancers14174293","volume":"14","author":"A Siltari","year":"2022","unstructured":"Siltari A, Syv\u00e4l\u00e4 H, Lou Y-R, Gao Y, Murtola TJ. Role of lipids and lipid metabolism in prostate cancer progression and the tumor\u2019s immune environment. Cancers (Basel). 2022;14:4293.","journal-title":"Cancers (Basel)"},{"key":"10098_CR175","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.3390\/cancers13091997","volume":"13","author":"K Sitarz","year":"2021","unstructured":"Sitarz K, Czamara K, Bialecka J, Klimek M, Szostek S, Kaczor A. Dual switch in lipid metabolism in cervical epithelial cells during dysplasia development observed using raman microscopy and molecular methods. Cancers. 2021;13:1997.","journal-title":"Cancers"},{"key":"10098_CR176","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094713","volume":"23","author":"CT Socol","year":"2022","unstructured":"Socol CT, Chira A, Martinez-Sanchez MA, Nu\u00f1ez-Sanchez MA, Maerescu CM, Mierlita D, et al. Leptin signaling in obesity and colorectal cancer. Int J Mol Sci. 2022;23:4713.","journal-title":"Int J Mol Sci"},{"key":"10098_CR177","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.cmet.2014.08.003","volume":"20","author":"N Srivastava","year":"2014","unstructured":"Srivastava N, Kollipara RK, Singh DK, Sudderth J, Hu Z, Nguyen H, et al. Inhibition of cancer cell proliferation by PPAR\u03b3 is mediated by a metabolic switch that increases reactive oxygen species levels. Cell Metab. 2014;20:650\u201361.","journal-title":"Cell Metab"},{"key":"10098_CR178","doi-asserted-by":"publisher","first-page":"2827","DOI":"10.3390\/cimb46040177","volume":"46","author":"D Stefanoudakis","year":"2024","unstructured":"Stefanoudakis D, Frountzas M, Schizas D, Michalopoulos NV, Drakaki A, Toutouzas KG. Significance of TP53, CDKN2A, SMAD4 and KRAS in pancreatic cancer. Curr Issues Mol Biol. 2024;46:2827\u201344.","journal-title":"Curr Issues Mol Biol"},{"key":"10098_CR179","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1158\/2159-8290.CD-15-0507","volume":"5","author":"ZE Stine","year":"2015","unstructured":"Stine ZE, Walton ZE, Altman BJ, Hsieh AL, Dang CV. MYC, metabolism, and cancer. Cancer Discov. 2015;5:1024\u201339.","journal-title":"Cancer Discov"},{"key":"10098_CR180","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/j.bbalip.2017.07.009","volume":"1862","author":"C Sztalryd","year":"2017","unstructured":"Sztalryd C, Brasaemle DL. The perilipin family of lipid droplet proteins: gatekeepers of intracellular lipolysis. Biochimica et Biophysica Acta (BBA). 2017;1862:1221\u201332. https:\/\/doi.org\/10.1016\/j.bbalip.2017.07.009.","journal-title":"Biochimica et Biophysica Acta (BBA)"},{"key":"10098_CR181","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1083\/jcb.200210169","volume":"161","author":"C Sztalryd","year":"2003","unstructured":"Sztalryd C, Xu G, Dorward H, Tansey JT, Contreras JA, Kimmel AR, et al. Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation. J Cell Biol. 2003;161:1093\u2013103.","journal-title":"J Cell Biol"},{"key":"10098_CR182","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1056\/NEJMe1706907","volume":"377","author":"AR Tall","year":"2017","unstructured":"Tall AR. Increasing lipolysis and reducing atherosclerosis. N Engl J Med. 2017;377:280\u20133. https:\/\/doi.org\/10.1056\/NEJMe1706907.","journal-title":"N Engl J Med"},{"key":"10098_CR183","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40170-023-00329-9","volume":"12","author":"F Tambaro","year":"2024","unstructured":"Tambaro F, Imbimbo G, Ferraro E, Andreini M, Belli R, Amabile MI, et al. Assessment of lipolysis biomarkers in adipose tissue of patients with gastrointestinal cancer. Cancer Metab. 2024;12:1.","journal-title":"Cancer Metab"},{"key":"10098_CR184","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.12408","volume":"24","author":"Y Tang","year":"2021","unstructured":"Tang Y, Zhang W, Sheng T, He X, Xiong X. Overview of the molecular mechanisms contributing to the formation of cancer-associated adipocytes. Mol Med Rep. 2021;24:768.","journal-title":"Mol Med Rep"},{"key":"10098_CR185","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1080\/15216540400009968","volume":"56","author":"J Tansey","year":"2004","unstructured":"Tansey J, Sztalryd C, Hlavin E, Kimmel A, Londos C. The central role of perilipin A in lipid metabolism and adipocyte lipolysis. IUBMB Life. 2004;56:379\u201385.","journal-title":"IUBMB Life"},{"key":"10098_CR186","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1194\/jlr.M093252","volume":"60","author":"X-R Tao","year":"2019","unstructured":"Tao X-R, Rong J-B, Lu HS, Daugherty A, Shi P, Ke C-L, et al. Angiotensinogen in hepatocytes contributes to Western diet-induced liver steatosis. J Lipid Res. 2019;60:1983\u201395.","journal-title":"J Lipid Res"},{"key":"10098_CR187","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.bbapap.2007.10.002","volume":"1784","author":"SS Taylor","year":"2008","unstructured":"Taylor SS, Kim C, Cheng CY, Brown SH, Wu J, Kannan N. Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design. Biochimica Et Biophysica Acta (BBA). 2008;1784:16\u201326.","journal-title":"Biochimica Et Biophysica Acta (BBA)"},{"key":"10098_CR188","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.tips.2024.04.007","volume":"45","author":"AR Terry","year":"2024","unstructured":"Terry AR, Hay N. Emerging targets in lipid metabolism for cancer therapy. Trends Pharmacol Sci. 2024;45:537\u201351.","journal-title":"Trends Pharmacol Sci"},{"key":"10098_CR189","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1158\/1541-7786.MCR-18-1147","volume":"17","author":"KD Tousignant","year":"2019","unstructured":"Tousignant KD, Rockstroh A, Taherian Fard A, Lehman ML, Wang C, McPherson SJ, et al. Lipid uptake is an androgen-enhanced lipid supply pathway associated with prostate cancer disease progression and bone metastasis. Mol Cancer Res. 2019;17:1166\u201379.","journal-title":"Mol Cancer Res"},{"key":"10098_CR190","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.10.039","author":"M Tsoli","year":"2016","unstructured":"Tsoli M, Swarbrick MM, Robertson GR, Elsevier. Lipolytic and thermogenic depletion of adipose tissue in cancer cachexia. Semin Cell Dev Biol. 2016. https:\/\/doi.org\/10.1016\/j.semcdb.2015.10.039.","journal-title":"Semin Cell Dev Biol"},{"key":"10098_CR191","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20122863","volume":"20","author":"A Tumminia","year":"2019","unstructured":"Tumminia A, Vinciguerra F, Parisi M, Graziano M, Sciacca L, Baratta R, et al. Adipose tissue, obesity and adiponectin: role in endocrine cancer risk. Int J Mol Sci. 2019;20:2863.","journal-title":"Int J Mol Sci"},{"key":"10098_CR192","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/s41574-023-00947-9","volume":"20","author":"O Tysoe","year":"2024","unstructured":"Tysoe O. Oxytocin regulates adipose tissue lipolysis. Nat Rev Endocrinol. 2024;20:126.","journal-title":"Nat Rev Endocrinol"},{"key":"10098_CR193","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.18632\/oncotarget.3058","volume":"6","author":"A Valli","year":"2014","unstructured":"Valli A, Rodriguez M, Moutsianas L, Fischer R, Fedele V, Huang H-L, et al. Hypoxia induces a lipogenic cancer cell phenotype via HIF1\u03b1-dependent and-independent pathways. Oncotarget. 2014;6:1920.","journal-title":"Oncotarget"},{"key":"10098_CR194","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1158\/1078-0432.CCR-12-0930","volume":"19","author":"MN VanSaun","year":"2013","unstructured":"VanSaun MN. Molecular pathways: adiponectin and leptin signaling in cancer. Clin Cancer Res. 2013;19:1926\u201332.","journal-title":"Clin Cancer Res"},{"key":"10098_CR195","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-022-00420-8","volume":"11","author":"S Vasseur","year":"2022","unstructured":"Vasseur S, Guillaumond F. Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance. Oncogenesis. 2022;11:46.","journal-title":"Oncogenesis"},{"key":"10098_CR196","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241512032","volume":"24","author":"E Vassiliou","year":"2023","unstructured":"Vassiliou E, Farias-Pereira R. Impact of lipid metabolism on macrophage polarization: implications for inflammation and tumor immunity. Int J Mol Sci. 2023;24:12032.","journal-title":"Int J Mol Sci"},{"key":"10098_CR197","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1113\/JP278810","volume":"599","author":"P Vaupel","year":"2021","unstructured":"Vaupel P, Multhoff G. Revisiting the Warburg effect: historical dogma versus current understanding. J Physiol. 2021;599:1745\u201357.","journal-title":"J Physiol"},{"key":"10098_CR198","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/s42003-025-07754-0","volume":"8","author":"E Vecchio","year":"2025","unstructured":"Vecchio E, Gallo R, Mimmi S, Gentile D, Giordano C, Straface E, et al. FABP5 is a key player in metabolic modulation and NF-\u03baB dependent inflammation driving pleural mesothelioma. Commun Biol. 2025;8:324.","journal-title":"Commun Biol"},{"key":"10098_CR199","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s10555-024-10170-1","volume":"43","author":"R Vishwa","year":"2024","unstructured":"Vishwa R, BharathwajChetty B, Girisa S, Aswani BS, Alqahtani MS, Abbas M, et al. Lipid metabolism and its implications in tumor cell plasticity and drug resistance: what we learned thus far? Cancer Metastasis Rev. 2024;43:293\u2013319.","journal-title":"Cancer Metastasis Rev"},{"key":"10098_CR200","doi-asserted-by":"publisher","first-page":"701","DOI":"10.3389\/fphys.2019.00701","volume":"10","author":"J Wang","year":"2019","unstructured":"Wang J, Ji Y, Zhou L, Xiang Y, Heinonen I, Zhang P. A new method to improve running economy and maximal aerobic power in athletes: endurance training with periodic carbon monoxide inhalation. Front Physiol. 2019;10:701.","journal-title":"Front Physiol"},{"key":"10098_CR201","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.605154","volume":"10","author":"W Wang","year":"2020","unstructured":"Wang W, Bai L, Li W, Cui J. The lipid metabolic landscape of cancers and new therapeutic perspectives. Front Oncol. 2020a;10:605154.","journal-title":"Front Oncol"},{"key":"10098_CR202","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-020-00581-2","volume":"18","author":"W Wang","year":"2020","unstructured":"Wang W, Zhu N, Yan T, Shi Y-N, Chen J, Zhang C-J, et al. The crosstalk: exosomes and lipid metabolism. Cell Commun Signal. 2020b;18:119.","journal-title":"Cell Commun Signal"},{"key":"10098_CR203","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.574706","volume":"8","author":"X Wang","year":"2020","unstructured":"Wang X, Peng H, Huang Y, Kong W, Cui Q, Du J, et al. Post-translational modifications of I\u03bab\u03b1: the state of the art. Front Cell Dev Biol. 2020c;8:574706.","journal-title":"Front Cell Dev Biol"},{"key":"10098_CR204","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00659-4","volume":"6","author":"S Wang","year":"2021","unstructured":"Wang S, Zheng Y, Yang F, Zhu L, Zhu X-Q, Wang Z-F, et al. The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives. Signal Transduct Target Ther. 2021;6:249.","journal-title":"Signal Transduct Target Ther"},{"key":"10098_CR205","doi-asserted-by":"publisher","first-page":"7713","DOI":"10.18632\/oncotarget.3481","volume":"6","author":"H-J Wei","year":"2015","unstructured":"Wei H-J, Zeng R, Lu J-H, Lai W-FT, Chen W-H, Liu H-Y, et al. Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production. Oncotarget. 2015;6:7713.","journal-title":"Oncotarget"},{"key":"10098_CR206","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-17-S1-O100","volume":"17","author":"P Wespi","year":"2015","unstructured":"Wespi P, Busch J, Wissmann L, Sigfridsson A, Weiss K, Messroghli D, et al. Hyperpolarized metabolic imaging of myocardial ischemia-reperfusion in a small-animal model at 9.4 T. J Cardiovasc Magn Reson. 2015;17:O100.","journal-title":"J Cardiovasc Magn Reson"},{"key":"10098_CR207","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1146\/annurev-nutr-080508-141056","volume":"29","author":"M Westerterp-Plantenga","year":"2009","unstructured":"Westerterp-Plantenga M, Nieuwenhuizen A, Tome D, Soenen S, Westerterp K. Dietary protein, weight loss, and weight maintenance. Annu Rev Nutr. 2009;29:21\u201341.","journal-title":"Annu Rev Nutr"},{"key":"10098_CR208","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1741-7007-8-47","volume":"8","author":"AJ Whitmarsh","year":"2010","unstructured":"Whitmarsh AJ. A central role for p38 MAPK in the early transcriptional response to stress. BMC Biol. 2010;8:1\u20133.","journal-title":"BMC Biol"},{"key":"10098_CR209","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911093","volume":"23","author":"M Wilhelm","year":"2022","unstructured":"Wilhelm M, Rossmeislov\u00e1 L, \u0160iklov\u00e1 M. Approaches to measuring the activity of major lipolytic and lipogenic enzymes in vitro and ex vivo. Int J Mol Sci. 2022;23:11093.","journal-title":"Int J Mol Sci"},{"key":"10098_CR210","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.3390\/cancers15061899","volume":"15","author":"K Wright","year":"2023","unstructured":"Wright K, Ly T, Kriet M, Czirok A, Thomas SM. Cancer-associated fibroblasts: master tumor microenvironment modifiers. Cancers (Basel). 2023;15:1899.","journal-title":"Cancers (Basel)"},{"key":"10098_CR211","first-page":"111","volume":"2","author":"X Wu","year":"2014","unstructured":"Wu X, Daniels G, Lee P, Monaco ME. Lipid metabolism in prostate cancer. Am J Clin Exp Urol. 2014;2:111.","journal-title":"Am J Clin Exp Urol"},{"key":"10098_CR212","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13045-019-0778-6","volume":"12","author":"Q Wu","year":"2019","unstructured":"Wu Q, Li B, Li Z, Li J, Sun S, Sun S. Cancer-associated adipocytes: key players in breast cancer progression. J Hematol Oncol. 2019;12:1\u201315.","journal-title":"J Hematol Oncol"},{"key":"10098_CR213","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40364-020-00257-6","volume":"9","author":"Q Wu","year":"2021","unstructured":"Wu Q, Li B, Li J, Sun S, Yuan J, Sun S. Cancer-associated adipocytes as immunomodulators in cancer. Biomark Res. 2021;9:1\u201321.","journal-title":"Biomark Res"},{"key":"10098_CR214","doi-asserted-by":"publisher","first-page":"726","DOI":"10.3390\/cancers15030726","volume":"15","author":"C Wu","year":"2023","unstructured":"Wu C, Dong S, Huang R, Chen X. Cancer-associated adipocytes and breast cancer: intertwining in the tumor microenvironment and challenges for cancer therapy. Cancers. 2023;15:726.","journal-title":"Cancers"},{"key":"10098_CR215","volume":"1865","author":"H Xie","year":"2020","unstructured":"Xie H, Heier C, Kien B, Vesely PW, Tang Z, Sexl V, et al. Adipose triglyceride lipase activity regulates cancer cell proliferation via AMP-kinase and mTOR signaling. Biochimica Et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids. 2020;1865:158737.","journal-title":"Biochimica Et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids"},{"key":"10098_CR216","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12885-018-4713-y","volume":"18","author":"M Xu","year":"2018","unstructured":"Xu M, Chang H-H, Jung X, Moro A, Chou CEN, King J, et al. Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice. BMC Cancer. 2018;18:1\u20139.","journal-title":"BMC Cancer"},{"key":"10098_CR217","doi-asserted-by":"publisher","DOI":"10.1172\/JCI171788","author":"X Xu","year":"2024","unstructured":"Xu X, Wang J, Xu L, Li P, Jiang P. P53 suppresses lipid droplet\u2013fueled tumorigenesis through phosphatidylcholine. J Clin Invest. 2024. https:\/\/doi.org\/10.1172\/JCI171788.","journal-title":"J Clin Invest"},{"key":"10098_CR218","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1042\/BCJ20190468","volume":"477","author":"A Yang","year":"2020","unstructured":"Yang A, Mottillo EP. Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics. Biochem J. 2020;477:985\u20131008. https:\/\/doi.org\/10.1042\/BCJ20190468.","journal-title":"Biochem J"},{"key":"10098_CR219","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2024.155905","author":"Y Yang","year":"2024","unstructured":"Yang Y, Liu X, Yang D, Li L, Li S, Lu S, et al. Interplay of CD36, autophagy, and lipid metabolism: insights into cancer progression. Metabolism. 2024. https:\/\/doi.org\/10.1016\/j.metabol.2024.155905.","journal-title":"Metabolism"},{"key":"10098_CR220","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cytogfr.2023.05.002","volume":"73","author":"L Ye","year":"2023","unstructured":"Ye L, Li Y, Zhang S, Wang J, Lei B. Exosomes-regulated lipid metabolism in tumorigenesis and cancer progression. Cytokine Growth Factor Rev. 2023;73:27\u201339.","journal-title":"Cytokine Growth Factor Rev"},{"key":"10098_CR221","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/0065-2571(94)90022-1","volume":"34","author":"SJ Yeaman","year":"1994","unstructured":"Yeaman SJ, Smith GM, Jepson CA, Wood SL, Emmison N. The multifunctional role of hormone-sensitive lipase in lipid metabolism. Adv Enzyme Regul. 1994;34:355\u201370.","journal-title":"Adv Enzyme Regul"},{"key":"10098_CR222","doi-asserted-by":"publisher","first-page":"3963","DOI":"10.1111\/jcmm.16349","volume":"25","author":"H Yin","year":"2021","unstructured":"Yin H, Li W, Mo L, Deng S, Lin W, Ma C, et al. Adipose triglyceride lipase promotes the proliferation of colorectal cancer cells via enhancing the lipolytic pathway. J Cell Mol Med. 2021;25:3963\u201375.","journal-title":"J Cell Mol Med"},{"key":"10098_CR223","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.plipres.2013.08.005","volume":"52","author":"N Zaidi","year":"2013","unstructured":"Zaidi N, Lupien L, Kuemmerle NB, Kinlaw WB, Swinnen JV, Smans K. Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids. Prog Lipid Res. 2013;52:585\u20139.","journal-title":"Prog Lipid Res"},{"key":"10098_CR224","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1194\/jlr.R800031-JLR200","volume":"50","author":"R Zechner","year":"2009","unstructured":"Zechner R, Kienesberger PC, Haemmerle G, Zimmermann R, Lass A. Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores. J Lipid Res. 2009;50:3\u201321. https:\/\/doi.org\/10.1194\/jlr.R800031-JLR200.","journal-title":"J Lipid Res"},{"key":"10098_CR225","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.cmet.2011.12.018","volume":"15","author":"R Zechner","year":"2012","unstructured":"Zechner R, Zimmermann R, Eichmann TO, Kohlwein SD, Haemmerle G, Lass A, et al. FAT SIGNALS\u2013lipases and lipolysis in lipid metabolism and signaling. Cell Metab. 2012;15:279\u201391. https:\/\/doi.org\/10.1016\/j.cmet.2011.12.018.","journal-title":"Cell Metab"},{"key":"10098_CR226","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nrm.2017.76","volume":"18","author":"R Zechner","year":"2017","unstructured":"Zechner R, Madeo F, Kratky D. Cytosolic lipolysis and lipophagy: two sides of the same coin. Nat Rev Mol Cell Biol. 2017;18:671\u201384.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10098_CR227","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1002\/j.2040-4603.2021.tb00161.x","volume":"11","author":"A Zeigerer","year":"2021","unstructured":"Zeigerer A, Sekar R, Kleinert M, Nason S, Habegger KM, M\u00fcller TD. Glucagon\u2019s metabolic action in health and disease. Compr Physiol. 2021;11:1759.","journal-title":"Compr Physiol"},{"key":"10098_CR228","doi-asserted-by":"publisher","first-page":"467","DOI":"10.3389\/fimmu.2018.00467","volume":"9","author":"S Zhang","year":"2018","unstructured":"Zhang S, Liu G, Xu C, Liu L, Zhang Q, Xu Q, et al. Perilipin 1 mediates lipid metabolism homeostasis and inhibits inflammatory cytokine synthesis in bovine adipocytes. Front Immunol. 2018;9:467.","journal-title":"Front Immunol"},{"key":"10098_CR229","doi-asserted-by":"publisher","first-page":"6561","DOI":"10.7150\/thno.44868","volume":"10","author":"C Zhang","year":"2020","unstructured":"Zhang C, Liao Y, Liu P, Du Q, Liang Y, Ooi S, et al. Fabp5 promotes lymph node metastasis in cervical cancer by reprogramming fatty acid metabolism. Theranostics. 2020;10:6561.","journal-title":"Theranostics"},{"key":"10098_CR230","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101529","volume":"63","author":"C Zhang","year":"2022","unstructured":"Zhang C, Zhu N, Li H, Gong Y, Gu J, Shi Y, et al. New dawn for cancer cell death: emerging role of lipid metabolism. Mol Metab. 2022;63:101529.","journal-title":"Mol Metab"},{"key":"10098_CR231","doi-asserted-by":"publisher","first-page":"74","DOI":"10.3892\/ijo.2023.5522","volume":"62","author":"Z Zhang","year":"2023","unstructured":"Zhang Z, Wang W, Kong P, Feng K, Liu C, Sun T, et al. New insights into lipid metabolism and prostate cancer. Int J Oncol. 2023;62:74.","journal-title":"Int J Oncol"},{"key":"10098_CR232","doi-asserted-by":"publisher","first-page":"e924328","DOI":"10.12659\/MSM.924328","volume":"26","author":"Y Zheng","year":"2020","unstructured":"Zheng Y, Jin J, Gao Y, Luo C, Wu X, Liu J. Phospholipase C\u025b Regulates Prostate Cancer Lipid Metabolism and Proliferation by Targeting AMP-Activated Protein Kinase (AMPK)\/Sterol Regulatory Element-Binding Protein 1 (SREBP-1) Signaling Pathway. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research. 2020;26:e924328\u201331.","journal-title":"Medical Science Monitor: International Medical Journal of Experimental and Clinical Research"},{"key":"10098_CR233","doi-asserted-by":"crossref","unstructured":"Zhou X, Yang X, Sun X, Xu X, Li Xa, Guo Y, Wang J, Li X, Yao L, Wang H. Effect of PTEN loss on metabolic reprogramming in prostate cancer cells. Oncology letters. 2019;17:2856\u201366.","DOI":"10.3892\/ol.2019.9932"},{"key":"10098_CR234","volume":"1867","author":"H Zhou","year":"2022","unstructured":"Zhou H, Yan Z, Qu M, Zhang G, Han J, Wang F, et al. Decr1 directly activates HSL to promote lipolysis in cervical cancer cells. Biochimica Et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids. 2022;1867:159090.","journal-title":"Biochimica Et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids"},{"key":"10098_CR235","doi-asserted-by":"publisher","first-page":"531","DOI":"10.3390\/molecules29020531","volume":"29","author":"X Zhou","year":"2024","unstructured":"Zhou X, Su M, Lu J, Li D, Niu X, Wang Y. CD36: the bridge between lipids and tumors. Molecules. 2024;29:531.","journal-title":"Molecules"}],"container-title":["Cell Biology and Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10565-025-10098-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10565-025-10098-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10565-025-10098-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T06:03:16Z","timestamp":1762236196000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10565-025-10098-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":235,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["10098"],"URL":"https:\/\/doi.org\/10.1007\/s10565-025-10098-4","relation":{},"ISSN":["1573-6822"],"issn-type":[{"value":"1573-6822","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,4]]},"assertion":[{"value":"22 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors have nothing to disclose. No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article.\nThe authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"149"}}