{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T21:33:29Z","timestamp":1776548009792,"version":"3.51.2"},"reference-count":89,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F30 CA291095"],"award-info":[{"award-number":["F30 CA291095"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R44 AR081754"],"award-info":[{"award-number":["R44 AR081754"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biol Toxicol"],"DOI":"10.1007\/s10565-025-10131-6","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T22:13:22Z","timestamp":1766182402000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biosafety assessment of engineered CCL20 locked dimers in vivo"],"prefix":"10.1007","volume":"42","author":[{"given":"Donovan","family":"Drouillard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Poimenidou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marissa","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"McAllister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel T.","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis C.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian F.","family":"Volkman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Dwinell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"10131_CR1","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1084\/jem.20070663","volume":"204","author":"F Annunziato","year":"2007","unstructured":"Annunziato F, Cosmi L, Santarlasci V, Maggi L, Liotta F, Mazzinghi B, et al. Phenotypic and functional features of human Th17 cells. J Exp Med. 2007;204:1849\u201361. https:\/\/doi.org\/10.1084\/jem.20070663.","journal-title":"J Exp Med"},{"key":"10131_CR2","doi-asserted-by":"publisher","first-page":"14893","DOI":"10.1074\/jbc.272.23.14893","volume":"272","author":"M Baba","year":"1997","unstructured":"Baba M, Imai T, Nishimura M, Kakizaki M, Takagi S, Hieshima K, et al. Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. J Biol Chem. 1997;272:14893\u20138. https:\/\/doi.org\/10.1074\/jbc.272.23.14893.","journal-title":"J Biol Chem"},{"key":"10131_CR3","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2546161","volume":"2019","author":"F Bai","year":"2019","unstructured":"Bai F, Li GG, Liu Q, Niu X, Li R, Ma H. Short-term efficacy and safety of IL-17, IL-12\/23, and IL-23 inhibitors brodalumab, secukinumab, ixekizumab, ustekinumab, guselkumab, tildrakizumab, and risankizumab for the treatment of moderate to severe plaque psoriasis: a systematic review and network meta-analysis of randomized controlled trials. J Immunol Res. 2019;2019:2546161. https:\/\/doi.org\/10.1155\/2019\/2546161.","journal-title":"J Immunol Res"},{"key":"10131_CR4","doi-asserted-by":"publisher","first-page":"873586","DOI":"10.3389\/fimmu.2022.873586","volume":"13","author":"CR Bastow","year":"2022","unstructured":"Bastow CR, Kara EE, Tyllis TS, Vinuesa CG, McColl SR, Comerford I. TFR Cells Express Functional CCR6 But It Is Dispensable for Their Development and Localization During Splenic Humoral Immune Responses. Front Immunol. 2022;13:873586. https:\/\/doi.org\/10.3389\/fimmu.2022.873586.","journal-title":"Front Immunol"},{"key":"10131_CR5","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1182\/blood-2016-11-752923","volume":"129","author":"JM Bernitz","year":"2017","unstructured":"Bernitz JM, Daniel MG, Fstkchyan YS, Moore K. Granulocyte colony-stimulating factor mobilizes dormant hematopoietic stem cells without proliferation in mice. Blood. 2017;129:1901\u201312. https:\/\/doi.org\/10.1182\/blood-2016-11-752923.","journal-title":"Blood"},{"key":"10131_CR6","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.4049\/jimmunol.1601609","volume":"200","author":"L Bod","year":"2018","unstructured":"Bod L, Douguet L, Auffray C, Lengagne R, Bekkat F, Rondeau E, et al. IL-4-induced gene 1: a negative immune checkpoint controlling B cell differentiation and activation. J Immunol. 2018;200:1027\u201338. https:\/\/doi.org\/10.4049\/jimmunol.1601609.","journal-title":"J Immunol"},{"key":"10131_CR7","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1309\/EK3C7CTDKNVPXVTN","volume":"130","author":"M Buttarello","year":"2008","unstructured":"Buttarello M, Plebani M. Automated blood cell counts: state of the art. Am J Clin Pathol. 2008;130:104\u201316. https:\/\/doi.org\/10.1309\/EK3C7CTDKNVPXVTN.","journal-title":"Am J Clin Pathol"},{"key":"10131_CR8","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1084\/jem.20131831","volume":"211","author":"S Chevrier","year":"2014","unstructured":"Chevrier S, Emslie D, Shi W, Kratina T, Wellard C, Karnowski A, et al. The BTB-ZF transcription factor Zbtb20 is driven by Irf4 to promote plasma cell differentiation and longevity. J Exp Med. 2014;211:827\u201340. https:\/\/doi.org\/10.1084\/jem.20131831.","journal-title":"J Exp Med"},{"key":"10131_CR9","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1021\/acs.oprd.3c00451","volume":"28","author":"GM Chinigo","year":"2024","unstructured":"Chinigo GM, Mcinturff EL, Bagley SW, Barnhart RW, Blakemore DC, Han L, et al. Early process development of PF-07054894, a squaramide-based antagonist of C-C chemokine receptor type 6 (CCR6). Org Process Res Dev. 2024;28:2247\u201359. https:\/\/doi.org\/10.1021\/acs.oprd.3c00451.","journal-title":"Org Process Res Dev"},{"key":"10131_CR10","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/j.jid.2016.12.023","volume":"137","author":"PM Cochez","year":"2017","unstructured":"Cochez PM, Michiels C, Hendrickx E, Dauguet N, Warnier G, Renauld JC, et al. Ccr6 is dispensable for the development of skin lesions induced by imiquimod despite its effect on epidermal homing of IL-22-producing cells. J Invest Dermatol. 2017;137:1094\u2013103. https:\/\/doi.org\/10.1016\/j.jid.2016.12.023.","journal-title":"J Invest Dermatol"},{"key":"10131_CR11","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s40744-019-0152-8","volume":"6","author":"S Cohen","year":"2019","unstructured":"Cohen S, Samad A, Karis E, Stolshek BS, Trivedi M, Zhang H, et al. Decreased injection site pain associated with phosphate-free etanercept formulation in rheumatoid arthritis or psoriatic arthritis patients: a randomized controlled trial. Rheumatol Ther. 2019;6:245\u201354. https:\/\/doi.org\/10.1007\/s40744-019-0152-8.","journal-title":"Rheumatol Ther"},{"key":"10131_CR12","first-page":"115","volume":"6","author":"C Coman","year":"2018","unstructured":"Coman C, Vlase E, Dinu A. HEMATOLOGICAL AND PLASMA BIOCHEMICAL VALUES IN FOUR SPECIFIC PATHOGEN-FREE MICE STRAINS PRODUCED IN THE ANIMAL FACILITY AT CANTACUZINO INSTITUTE, BUCHAREST. Scientific Works Series C Veterinary Medicine. 2018;6:115\u201320.","journal-title":"Scientific Works Series C Veterinary Medicine."},{"key":"10131_CR13","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/ana.25927","volume":"89","author":"G Comi","year":"2021","unstructured":"Comi G, Bar-Or A, Lassmann H, Uccelli A, Hartung HP, Montalban X, et al. Expert Panel of the 27th Annual Meeting of the European Charcot F. Role of B Cells in Multiple Sclerosis and Related Disorders. Ann Neurol. 2021;89:13\u201323. https:\/\/doi.org\/10.1002\/ana.25927.","journal-title":"Ann Neurol."},{"key":"10131_CR14","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/s1074-7613(00)80201-0","volume":"12","author":"DN Cook","year":"2000","unstructured":"Cook DN, Prosser DM, Forster R, Zhang J, Kuklin NA, Abbondanzo SJ, et al. CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Immunity. 2000;12:495\u2013503. https:\/\/doi.org\/10.1016\/s1074-7613(00)80201-0.","journal-title":"Immunity"},{"key":"10131_CR15","unstructured":"Corporation G. Mozobil FDA Label. 2008."},{"key":"10131_CR16","doi-asserted-by":"publisher","first-page":"2362","DOI":"10.4049\/jimmunol.1901453","volume":"205","author":"CA Daly","year":"2020","unstructured":"Daly CA, Spurrier MA, Jennings-Gee JE, Haas KM. B cell subsets differentially contribute to the T cell-independent memory pool. J Immunol. 2020;205:2362\u201374. https:\/\/doi.org\/10.4049\/jimmunol.1901453.","journal-title":"J Immunol"},{"key":"10131_CR17","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.3389\/fimmu.2017.01938","volume":"8","author":"S De","year":"2017","unstructured":"De S, Zhang B, Shih T, Singh S, Winkler A, Donnelly R, et al. B Cell-Intrinsic Role for IRF5 in TLR9\/BCR-Induced Human B Cell Activation, Proliferation, and Plasmablast Differentiation. Front Immunol. 2017;8:1938. https:\/\/doi.org\/10.3389\/fimmu.2017.01938.","journal-title":"Front Immunol"},{"key":"10131_CR18","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1038\/s41584-024-01179-5","volume":"20","author":"T Dorner","year":"2024","unstructured":"Dorner T, Lipsky PE. The essential roles of memory B cells in the pathogenesis of systemic lupus erythematosus. Nat Rev Rheumatol. 2024;20:770\u201382. https:\/\/doi.org\/10.1038\/s41584-024-01179-5.","journal-title":"Nat Rev Rheumatol"},{"key":"10131_CR19","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1002\/jbmr.2813","volume":"31","author":"M Doucet","year":"2016","unstructured":"Doucet M, Jayaraman S, Swenson E, Tusing B, Weber KL, Kominsky SL. CCL20\/CCR6 signaling regulates bone mass accrual in mice. J Bone Miner Res. 2016;31:1381\u201390. https:\/\/doi.org\/10.1002\/jbmr.2813.","journal-title":"J Bone Miner Res"},{"key":"10131_CR20","doi-asserted-by":"publisher","unstructured":"Drouillard D, Halyko M, Cinquegrani E, Poimenidou M, Emosivbe M, McAllister D, Peterson FC, Marchese A, Dwinell MB. CXCL12 chemokine dimer signaling modulates acute myelogenous leukemia cell migration through altered receptor internalization. bioRxiv. 2025. https:\/\/doi.org\/10.1101\/2024.08.26.609725","DOI":"10.1101\/2024.08.26.609725"},{"key":"10131_CR21","doi-asserted-by":"publisher","first-page":"17655","DOI":"10.1073\/pnas.1101133108","volume":"108","author":"LJ Drury","year":"2011","unstructured":"Drury LJ, Ziarek JJ, Gravel S, Veldkamp CT, Takekoshi T, Hwang ST, et al. Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways. Proc Natl Acad Sci USA. 2011;108:17655\u201360. https:\/\/doi.org\/10.1073\/pnas.1101133108.","journal-title":"Proc Natl Acad Sci USA"},{"key":"10131_CR22","doi-asserted-by":"publisher","first-page":"505","DOI":"10.4049\/jimmunol.1401553","volume":"194","author":"R Elgueta","year":"2015","unstructured":"Elgueta R, Marks E, Nowak E, Menezes S, Benson M, Raman VS, et al. CCR6-dependent positioning of memory B cells is essential for their ability to mount a recall response to antigen. J Immunol. 2015;194:505\u201313. https:\/\/doi.org\/10.4049\/jimmunol.1401553.","journal-title":"J Immunol"},{"key":"10131_CR23","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.2215\/CJN.16041219","volume":"15","author":"M Emmett","year":"2020","unstructured":"Emmett M. Metabolic alkalosis: a brief pathophysiologic review. Clin J Am Soc Nephrol. 2020;15:1848\u201356. https:\/\/doi.org\/10.2215\/CJN.16041219.","journal-title":"Clin J Am Soc Nephrol"},{"key":"10131_CR24","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1136\/annrheumdis-2020-217927","volume":"79","author":"M Fauny","year":"2020","unstructured":"Fauny M, Moulin D, D\u2019Amico F, Netter P, Petitpain N, Arnone D, et al. Paradoxical gastrointestinal effects of interleukin-17 blockers. Ann Rheum Dis. 2020;79:1132\u20138. https:\/\/doi.org\/10.1136\/annrheumdis-2020-217927.","journal-title":"Ann Rheum Dis"},{"key":"10131_CR25","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12846","volume":"91","author":"K Furue","year":"2020","unstructured":"Furue K, Ito T, Tsuji G, Nakahara T, Furue M. The CCL20 and CCR6 axis in psoriasis. Scand J Immunol. 2020;91:e12846. https:\/\/doi.org\/10.1111\/sji.12846.","journal-title":"Scand J Immunol"},{"key":"10131_CR26","doi-asserted-by":"publisher","unstructured":"Gene Ontology C, Aleksander SA, Balhoff J, Carbon S, Cherry JM, Drabkin HJ, Ebert D, Feuermann M, Gaudet P, Harris NL, Hill DP, Lee R, Mi H, Moxon S, Mungall CJ, Muruganugan A, Mushayahama T, Sternberg PW, Thomas PD, Van Auken K, Ramsey J, Siegele DA, Chisholm RL, Fey P, Aspromonte MC, Nugnes MV, Quaglia F, Tosatto S, Giglio M, Nadendla S, Antonazzo G, Attrill H, Dos Santos G, Marygold S, Strelets V, Tabone CJ, Thurmond J, Zhou P, Ahmed SH, Asanitthong P, Luna Buitrago D, Erdol MN, Gage MC, Ali Kadhum M, Li KYC, Long M, Michalak A, Pesala A, Pritazahra A, Saverimuttu SCC, Su R, Thurlow KE, Lovering RC, Logie C, Oliferenko S, Blake J, Christie K, Corbani L, Dolan ME, Drabkin HJ, Hill DP, Ni L, Sitnikov D, Smith C, Cuzick A, Seager J, Cooper L, Elser J, Jaiswal P, Gupta P, Jaiswal P, Naithani S, Lera-Ramirez M, Rutherford K, Wood V, De Pons JL, Dwinell MR, Hayman GT, Kaldunski ML, Kwitek AE, Laulederkind SJF, Tutaj MA, Vedi M, Wang SJ, D'Eustachio P, Aimo L, Axelsen K, Bridge A, Hyka-Nouspikel N, Morgat A, Aleksander SA, Cherry JM, Engel SR, Karra K, Miyasato SR, Nash RS, Skrzypek MS, Weng S, Wong ED, Bakker E, Berardini TZ, Reiser L, Auchincloss A, Axelsen K, Argoud-Puy G, Blatter MC, Boutet E, Breuza L, Bridge A, Casals-Casas C, Coudert E, Estreicher A, Livia Famiglietti M, Feuermann M, Gos A, Gruaz-Gumowski N, Hulo C, Hyka-Nouspikel N, Jungo F, Le Mercier P, Lieberherr D, Masson P, Morgat A, Pedruzzi I, Pourcel L, Poux S, Rivoire C, Sundaram S, Bateman A, Bowler-Barnett E, Bye AJH, Denny P, Ignatchenko A, Ishtiaq R, Lock A, Lussi Y, Magrane M, Martin MJ, Orchard S, Raposo P, Speretta E, Tyagi N, Warner K, Zaru R, Diehl AD, Lee R, Chan J, Diamantakis S, Raciti D, Zarowiecki M, Fisher M, James-Zorn C, Ponferrada V, Zorn A, Ramachandran S, Ruzicka L, Westerfield M. The Gene Ontology knowledgebase in 2023. Genetics. 2023;224. https:\/\/doi.org\/10.1093\/genetics\/iyad031","DOI":"10.1093\/genetics\/iyad031"},{"key":"10131_CR27","doi-asserted-by":"publisher","first-page":"12460","DOI":"10.1073\/pnas.1704958114","volume":"114","author":"AE Getschman","year":"2017","unstructured":"Getschman AE, Imai Y, Larsen O, Peterson FC, Wu X, Rosenkilde MM, et al. Protein engineering of the chemokine CCL20 prevents psoriasiform dermatitis in an IL-23-dependent murine model. Proc Natl Acad Sci U S A. 2017;114:12460\u20135. https:\/\/doi.org\/10.1073\/pnas.1704958114.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10131_CR28","doi-asserted-by":"publisher","first-page":"6840","DOI":"10.1158\/0008-5472.CAN-08-0402","volume":"68","author":"N Giuliani","year":"2008","unstructured":"Giuliani N, Lisignoli G, Colla S, Lazzaretti M, Storti P, Mancini C, et al. CC-chemokine ligand 20\/macrophage inflammatory protein-3alpha and CC-chemokine receptor 6 are overexpressed in myeloma microenvironment related to osteolytic bone lesions. Cancer Res. 2008;68:6840\u201350. https:\/\/doi.org\/10.1158\/0008-5472.CAN-08-0402.","journal-title":"Cancer Res"},{"key":"10131_CR29","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1084\/jem.186.6.837","volume":"186","author":"DR Greaves","year":"1997","unstructured":"Greaves DR, Wang W, Dairaghi DJ, Dieu MC, Saint-Vis B, Franz-Bacon K, et al. CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells. J Exp Med. 1997;186:837\u201344. https:\/\/doi.org\/10.1084\/jem.186.6.837.","journal-title":"J Exp Med"},{"key":"10131_CR30","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","volume":"42","author":"Y Hao","year":"2024","unstructured":"Hao Y, Stuart T, Kowalski MH, Choudhary S, Hoffman P, Hartman A, et al. Dictionary learning for integrative, multimodal and scalable single-cell analysis. Nat Biotechnol. 2024;42:293\u2013304. https:\/\/doi.org\/10.1038\/s41587-023-01767-y.","journal-title":"Nat Biotechnol"},{"key":"10131_CR31","doi-asserted-by":"publisher","first-page":"7140","DOI":"10.1038\/s41598-022-10777-w","volume":"12","author":"L Hoisnard","year":"2022","unstructured":"Hoisnard L, Lebrun-Vignes B, Maury S, Mahevas M, El Karoui K, Roy L, et al. Adverse events associated with JAK inhibitors in 126,815 reports from the WHO pharmacovigilance database. Sci Rep. 2022;12:7140. https:\/\/doi.org\/10.1038\/s41598-022-10777-w.","journal-title":"Sci Rep"},{"key":"10131_CR32","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41392-023-01620-3","volume":"8","author":"L Huangfu","year":"2023","unstructured":"Huangfu L, Li R, Huang Y, Wang S. The IL-17 family in diseases: from bench to bedside. Signal Transduct Target Ther. 2023;8:402. https:\/\/doi.org\/10.1038\/s41392-023-01620-3.","journal-title":"Signal Transduct Target Ther"},{"key":"10131_CR33","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1159\/000420755","volume":"51","author":"JN Ihle","year":"1992","unstructured":"Ihle JN. Interleukin-3 and hematopoiesis. Chem Immunol. 1992;51:65\u2013106. https:\/\/doi.org\/10.1159\/000420755.","journal-title":"Chem Immunol"},{"key":"10131_CR34","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1002\/eji.200636984","volume":"37","author":"W Jiang","year":"2007","unstructured":"Jiang W, Lederman MM, Harding CV, Rodriguez B, Mohner RJ, Sieg SF. TLR9 stimulation drives naive B cells to proliferate and to attain enhanced antigen presenting function. Eur J Immunol. 2007;37:2205\u201313. https:\/\/doi.org\/10.1002\/eji.200636984.","journal-title":"Eur J Immunol"},{"key":"10131_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155186","author":"S Kadomoto","year":"2020","unstructured":"Kadomoto S, Izumi K, Mizokami A. The CCL20-CCR6 axis in cancer progression. Int J Mol Sci. 2020. https:\/\/doi.org\/10.3390\/ijms21155186.","journal-title":"Int J Mol Sci"},{"key":"10131_CR36","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1002\/eji.200636251","volume":"37","author":"T Kondo","year":"2007","unstructured":"Kondo T, Takata H, Takiguchi M. Functional expression of chemokine receptor CCR6 on human effector memory CD8+ T cells. Eur J Immunol. 2007;37:54\u201365. https:\/\/doi.org\/10.1002\/eji.200636251.","journal-title":"Eur J Immunol"},{"key":"10131_CR37","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","volume":"16","author":"I Korsunsky","year":"2019","unstructured":"Korsunsky I, Millard N, Fan J, Slowikowski K, Zhang F, Wei K, et al. Fast, sensitive and accurate integration of single-cell data with harmony. Nat Methods. 2019;16:1289\u201396. https:\/\/doi.org\/10.1038\/s41592-019-0619-0.","journal-title":"Nat Methods"},{"key":"10131_CR38","doi-asserted-by":"publisher","unstructured":"Kristyanto H, Blomberg NJ, Slot LM, van der Voort EIH, Kerkman PF, Bakker A, Burgers LE, Ten Brinck RM, van der Helm-van Mil AHM, Spits H, Baeten DL, Huizinga TWJ, Toes REM, Scherer HU. Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis. Sci Transl Med. 2020;12. https:\/\/doi.org\/10.1126\/scitranslmed.aaz5327","DOI":"10.1126\/scitranslmed.aaz5327"},{"key":"10131_CR39","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1182\/blood.V96.7.2338","volume":"96","author":"R Krzysiek","year":"2000","unstructured":"Krzysiek R, Lefevre EA, Bernard J, Foussat A, Galanaud P, Louache F, et al. Regulation of CCR6 chemokine receptor expression and responsiveness to macrophage inflammatory protein-3alpha\/CCL20 in human B cells. Blood. 2000;96:2338\u201345.","journal-title":"Blood"},{"key":"10131_CR40","unstructured":"Laboratories CR. CD-1 Mouse Hematology: North American Colonies January 2008 - December 2011. Charles River Laboratories; 2012."},{"key":"10131_CR41","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/icb.2013.97","volume":"92","author":"AY Lee","year":"2014","unstructured":"Lee AY, Korner H. CCR6 and CCL20: emerging players in the pathogenesis of rheumatoid arthritis. Immunol Cell Biol. 2014;92:354\u20138. https:\/\/doi.org\/10.1038\/icb.2013.97.","journal-title":"Immunol Cell Biol"},{"key":"10131_CR42","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.imbio.2019.01.005","volume":"224","author":"AYS Lee","year":"2019","unstructured":"Lee AYS, Korner H. The CCR6-CCL20 axis in humoral immunity and T-B cell immunobiology. Immunobiology. 2019;224:449\u201354. https:\/\/doi.org\/10.1016\/j.imbio.2019.01.005.","journal-title":"Immunobiology"},{"key":"10131_CR43","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.746396","volume":"12","author":"J Li","year":"2021","unstructured":"Li J, Zhang Z, Wu X, Zhou J, Meng D, Zhu P. Risk of adverse events after anti-TNF treatment for inflammatory rheumatological disease. A meta-analysis. Front Pharmacol. 2021;12:746396. https:\/\/doi.org\/10.3389\/fphar.2021.746396.","journal-title":"Front Pharmacol"},{"key":"10131_CR44","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1124\/jpet.122.001452","volume":"386","author":"W Li","year":"2023","unstructured":"Li W, Crouse KK, Alley J, Frisbie RK, Fish SC, Andreyeva TA, et al. A novel C-C chemoattractant cytokine (chemokine) receptor 6 (CCR6) antagonist (PF-07054894) distinguishes between homologous chemokine receptors, increases basal circulating CCR6(+) T cells, and ameliorates interleukin-23-induced skin inflammation. J Pharmacol Exp Ther. 2023;386:80\u201392. https:\/\/doi.org\/10.1124\/jpet.122.001452.","journal-title":"J Pharmacol Exp Ther"},{"key":"10131_CR45","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1006\/geno.1996.4544","volume":"40","author":"F Liao","year":"1997","unstructured":"Liao F, Lee HH, Farber JM. Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27. Genomics. 1997;40:175\u201380. https:\/\/doi.org\/10.1006\/geno.1996.4544.","journal-title":"Genomics"},{"key":"10131_CR46","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/s41573-025-01139-y","volume":"24","author":"JS Lorente","year":"2025","unstructured":"Lorente JS, Sokolov AV, Ferguson G, Schioth HB, Hauser AS, Gloriam DE. GPCR drug discovery: new agents, targets and indications. Nat Rev Drug Discov. 2025;24:458\u201379. https:\/\/doi.org\/10.1038\/s41573-025-01139-y.","journal-title":"Nat Rev Drug Discov"},{"key":"10131_CR47","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15:550. https:\/\/doi.org\/10.1186\/s13059-014-0550-8.","journal-title":"Genome Biol"},{"key":"10131_CR48","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s41592-021-01336-8","volume":"19","author":"MD Luecken","year":"2022","unstructured":"Luecken MD, Buttner M, Chaichoompu K, Danese A, Interlandi M, Mueller MF, et al. Benchmarking atlas-level data integration in single-cell genomics. Nat Methods. 2022;19:41\u201350. https:\/\/doi.org\/10.1038\/s41592-021-01336-8.","journal-title":"Nat Methods"},{"key":"10131_CR49","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.2353\/ajpath.2007.060817","volume":"170","author":"KG McDonald","year":"2007","unstructured":"McDonald KG, McDonough JS, Wang C, Kucharzik T, Williams IR, Newberry RD. CC chemokine receptor 6 expression by B lymphocytes is essential for the development of isolated lymphoid follicles. Am J Pathol. 2007;170:1229\u201340. https:\/\/doi.org\/10.2353\/ajpath.2007.060817.","journal-title":"Am J Pathol"},{"key":"10131_CR50","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.immuni.2019.03.021","volume":"50","author":"MJ McGeachy","year":"2019","unstructured":"McGeachy MJ, Cua DJ, Gaffen SL. The IL-17 family of cytokines in health and disease. Immunity. 2019;50:892\u2013906. https:\/\/doi.org\/10.1016\/j.immuni.2019.03.021.","journal-title":"Immunity"},{"key":"10131_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102846","volume":"20","author":"HT Meitei","year":"2021","unstructured":"Meitei HT, Jadhav N, Lal G. Ccr6-CCL20 axis as a therapeutic target for autoimmune diseases. Autoimmun Rev. 2021;20:102846. https:\/\/doi.org\/10.1016\/j.autrev.2021.102846.","journal-title":"Autoimmun Rev"},{"key":"10131_CR52","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.1093\/rheumatology\/kead022","volume":"62","author":"C Mortier","year":"2023","unstructured":"Mortier C, Gracey E, Coudenys J, Manuello T, Decruy T, Maelegheer M, et al. RORgammat inhibition ameliorates IL-23 driven experimental psoriatic arthritis by predominantly modulating gammadelta-T cells. Rheumatology (Oxford). 2023;62:3169\u201378. https:\/\/doi.org\/10.1093\/rheumatology\/kead022.","journal-title":"Rheumatology (Oxford)"},{"key":"10131_CR53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097566","volume":"9","author":"B Nandi","year":"2014","unstructured":"Nandi B, Pai C, Huang Q, Prabhala RH, Munshi NC, Gold JS. CCR6, the sole receptor for the chemokine CCL20, promotes spontaneous intestinal tumorigenesis. PLoS ONE. 2014;9:e97566. https:\/\/doi.org\/10.1371\/journal.pone.0097566.","journal-title":"PLoS ONE"},{"key":"10131_CR54","first-page":"709","volume":"96","author":"RC Oh","year":"2017","unstructured":"Oh RC, Hustead TR, Ali SM, Pantsari MW. Mildly elevated liver transaminase levels: causes and evaluation. Am Fam Physician. 2017;96:709\u201315.","journal-title":"Am Fam Physician"},{"key":"10131_CR55","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1038\/ni1261","volume":"6","author":"H Park","year":"2005","unstructured":"Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005;6:1133\u201341. https:\/\/doi.org\/10.1038\/ni1261.","journal-title":"Nat Immunol"},{"key":"10131_CR56","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216185","volume":"563","author":"DR Prajapati","year":"2023","unstructured":"Prajapati DR, Molczyk C, Purohit A, Saxena S, Sturgeon R, Dave BJ, et al. Small molecule antagonist of CXCR2 and CXCR1 inhibits tumor growth, angiogenesis, and metastasis in pancreatic cancer. Cancer Lett. 2023;563:216185. https:\/\/doi.org\/10.1016\/j.canlet.2023.216185.","journal-title":"Cancer Lett"},{"key":"10131_CR57","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1093\/toxres\/tfaa081","volume":"9","author":"H Prior","year":"2020","unstructured":"Prior H, Haworth R, Labram B, Roberts R, Wolfreys A, Sewell F. Justification for species selection for pharmaceutical toxicity studies. Toxicol Res. 2020;9:758\u201370. https:\/\/doi.org\/10.1093\/toxres\/tfaa081.","journal-title":"Toxicol Res"},{"key":"10131_CR58","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.172006","author":"S Reijm","year":"2023","unstructured":"Reijm S, Kwekkeboom JC, Blomberg NJ, Suurmond J, van der Woude D, Toes RE, et al. Autoreactive B cells in rheumatoid arthritis include mainly activated CXCR3+ memory B cells and plasmablasts. JCI Insight. 2023. https:\/\/doi.org\/10.1172\/jci.insight.172006.","journal-title":"JCI Insight"},{"key":"10131_CR59","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/icb.2016.68","volume":"95","author":"D Reimer","year":"2017","unstructured":"Reimer D, Lee AY, Bannan J, Fromm P, Kara EE, Comerford I, et al. Early CCR6 expression on B cells modulates germinal centre kinetics and efficient antibody responses. Immunol Cell Biol. 2017;95:33\u201341. https:\/\/doi.org\/10.1038\/icb.2016.68.","journal-title":"Immunol Cell Biol"},{"key":"10131_CR60","doi-asserted-by":"publisher","unstructured":"Rezan Kocak Ulucakoy R, Kayacan Erdogan E, Orhan K, Gurler EK, Atalar E, Ozdemir Ulusoy B, Babaoglu H, Armagan B, Dogan I, Guven SC. The role of high large unstained cell percentages in ongoing inflammation in the intercritical gout. Jt Dis Relat Surg. 2025;36:366\u201372. https:\/\/doi.org\/10.52312\/jdrs.2025.2188","DOI":"10.52312\/jdrs.2025.2188"},{"key":"10131_CR61","doi-asserted-by":"publisher","DOI":"10.3389\/frhem.2024.1371823","author":"G Rivera-Torruco","year":"2024","unstructured":"Rivera-Torruco G, Muench MO, Valle-Rios R. Exploring extramedullary hematopoiesis: unraveling the hematopoietic microenvironments. Front Hematol. 2024. https:\/\/doi.org\/10.3389\/frhem.2024.1371823.","journal-title":"Front Hematol"},{"key":"10131_CR62","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2022.101989","volume":"4","author":"MB Rowland","year":"2023","unstructured":"Rowland MB, Moore PE, Bui C, Correll RN. Assessing wound closure in mice using skin-punch biopsy. STAR Protoc. 2023;4:101989. https:\/\/doi.org\/10.1016\/j.xpro.2022.101989.","journal-title":"STAR Protoc"},{"key":"10131_CR63","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.670398","volume":"12","author":"Y Ru","year":"2021","unstructured":"Ru Y, Ding X, Luo Y, Li H, Sun X, Zhou M, et al. Adverse events associated with anti-IL-23 agents: clinical evidence and possible mechanisms. Front Immunol. 2021;12:670398. https:\/\/doi.org\/10.3389\/fimmu.2021.670398.","journal-title":"Front Immunol"},{"key":"10131_CR64","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1007\/s12026-022-09356-y","volume":"71","author":"A Ruggiero","year":"2023","unstructured":"Ruggiero A, Megna M, Fabbrocini G, Ocampo-Garza SS. Anti-IL23 biologic therapies in the treatment of psoriasis: real-world experience versus clinical trials data. Immunol Res. 2023;71:328\u201355. https:\/\/doi.org\/10.1007\/s12026-022-09356-y.","journal-title":"Immunol Res"},{"key":"10131_CR65","doi-asserted-by":"publisher","first-page":"8000","DOI":"10.1002\/jcp.30471","volume":"236","author":"U Sahu","year":"2021","unstructured":"Sahu U, Biswas D, Prajapati VK, Singh AK, Samant M, Khare P. Interleukin-17-a multifaceted cytokine in viral infections. J Cell Physiol. 2021;236:8000\u201319. https:\/\/doi.org\/10.1002\/jcp.30471.","journal-title":"J Cell Physiol"},{"key":"10131_CR66","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.cytogfr.2025.01.002","volume":"83","author":"A Saran","year":"2025","unstructured":"Saran A, Nishizaki D, Lippman SM, Kato S, Kurzrock R. Interleukin-17: a pleiotropic cytokine implicated in inflammatory, infectious, and malignant disorders. Cytokine Growth Factor Rev. 2025;83:35\u201344. https:\/\/doi.org\/10.1016\/j.cytogfr.2025.01.002.","journal-title":"Cytokine Growth Factor Rev"},{"key":"10131_CR67","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1002\/1521-4141(200107)31:7<1981::AID-IMMU1981>3.0.CO;2-X","volume":"31","author":"P Scapini","year":"2001","unstructured":"Scapini P, Laudanna C, Pinardi C, Allavena P, Mantovani A, Sozzani S, Cassatella MA. Neutrophils produce biologically active macrophage inflammatory protein-3alpha (MIP-3alpha)\/CCL20 and MIP-3beta\/CCL19. Eur J Immunol. 2001;31:1981\u20138. https:\/\/doi.org\/10.1002\/1521-4141(200107)31:7<1981::aid-immu1981>3.0.co;2-x.","journal-title":"Eur J Immunol."},{"key":"10131_CR68","doi-asserted-by":"publisher","DOI":"10.1016\/j.molpha.2025.100054","author":"RR Schlimgen","year":"2025","unstructured":"Schlimgen RR, Volkman BF. Progress Toward New Function and Design of Extracellular GPCR-Nanobodies. Mol Pharmacol. 2025. https:\/\/doi.org\/10.1016\/j.molpha.2025.100054.","journal-title":"Mol Pharmacol"},{"key":"10131_CR69","doi-asserted-by":"publisher","first-page":"4611","DOI":"10.1038\/s41467-024-49000-x","volume":"15","author":"RR Schlimgen","year":"2024","unstructured":"Schlimgen RR, Peterson FC, Heukers R, Smit MJ, McCorvy JD, Volkman BF. Structural basis for selectivity and antagonism in extracellular GPCR-nanobodies. Nat Commun. 2024;15:4611. https:\/\/doi.org\/10.1038\/s41467-024-49000-x.","journal-title":"Nat Commun"},{"key":"10131_CR70","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1182\/blood-2016-03-706010","volume":"128","author":"KB Schoedel","year":"2016","unstructured":"Schoedel KB, Morcos MNF, Zerjatke T, Roeder I, Grinenko T, Voehringer D, et al. The bulk of the hematopoietic stem cell population is dispensable for murine steady-state and stress hematopoiesis. Blood. 2016;128:2285\u201396. https:\/\/doi.org\/10.1182\/blood-2016-03-706010.","journal-title":"Blood"},{"key":"10131_CR71","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/s1359-6101(03)00049-2","volume":"14","author":"E Schutyser","year":"2003","unstructured":"Schutyser E, Struyf S, Van Damme J. The CC chemokine CCL20 and its receptor CCR6. Cytokine Growth Factor Rev. 2003;14:409\u201326. https:\/\/doi.org\/10.1016\/s1359-6101(03)00049-2.","journal-title":"Cytokine Growth Factor Rev"},{"key":"10131_CR72","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2023.101818","volume":"70","author":"I Shchukina","year":"2023","unstructured":"Shchukina I, Bohacova P, Artyomov MN. T cell control of inflammaging. Semin Immunol. 2023;70:101818. https:\/\/doi.org\/10.1016\/j.smim.2023.101818.","journal-title":"Semin Immunol"},{"key":"10131_CR73","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1002\/art.41882","volume":"73","author":"Z Shi","year":"2021","unstructured":"Shi Z, Garcia-Melchor E, Wu X, Getschman AE, Nguyen M, Rowland DJ, et al. Targeting the CCR6\/CCL20 Axis in Entheseal and Cutaneous Inflammation. Arthritis Rheumatol. 2021;73:2271\u201381. https:\/\/doi.org\/10.1002\/art.41882.","journal-title":"Arthritis Rheumatol"},{"key":"10131_CR74","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1177\/24755303231159106","volume":"8","author":"ZR Shi","year":"2023","unstructured":"Shi ZR, Mabuchi T, Riutta SJ, Wu X, Peterson FC, Volkman BF, et al. The chemokine, CCL20, and its receptor, CCR6, in the pathogenesis and treatment of psoriasis and psoriatic arthritis. J Psoriasis Psoriatic Arthritis. 2023;8:107\u201317. https:\/\/doi.org\/10.1177\/24755303231159106.","journal-title":"J Psoriasis Psoriatic Arthritis"},{"key":"10131_CR75","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141710","volume":"10","author":"HK Skovdahl","year":"2015","unstructured":"Skovdahl HK, Granlund A, Ostvik AE, Bruland T, Bakke I, Torp SH, et al. Expression of CCL20 and Its Corresponding Receptor CCR6 Is Enhanced in Active Inflammatory Bowel Disease, and TLR3 Mediates CCL20 Expression in Colonic Epithelial Cells. PLoS ONE. 2015;10:e0141710. https:\/\/doi.org\/10.1371\/journal.pone.0141710.","journal-title":"PLoS ONE"},{"key":"10131_CR76","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.ejphar.2014.06.060","volume":"746","author":"R Solari","year":"2015","unstructured":"Solari R, Pease JE, Begg M. Chemokine receptors as therapeutic targets: why aren\u2019t there more drugs? Eur J Pharmacol. 2015;746:363\u20137. https:\/\/doi.org\/10.1016\/j.ejphar.2014.06.060.","journal-title":"Eur J Pharmacol"},{"key":"10131_CR77","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1084\/jem.20092695","volume":"207","author":"CL Swanson","year":"2010","unstructured":"Swanson CL, Wilson TJ, Strauch P, Colonna M, Pelanda R, Torres RM. Type I IFN enhances follicular B cell contribution to the T cell-independent antibody response. J Exp Med. 2010;207:1485\u2013500. https:\/\/doi.org\/10.1084\/jem.20092695.","journal-title":"J Exp Med"},{"key":"10131_CR78","first-page":"1100","volume":"45","author":"P Thirup","year":"1999","unstructured":"Thirup P. LUC, what is that? Large Unstained Cells Clin Chem. 1999;45:1100.","journal-title":"Large Unstained Cells Clin Chem"},{"key":"10131_CR79","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.993057","volume":"14","author":"J Wang","year":"2023","unstructured":"Wang J, Wang C, Liu L, Hong S, Ru Y, Sun X, et al. Adverse events associated with anti-IL-17 agents for psoriasis and psoriatic arthritis: a systematic scoping review. Front Immunol. 2023;14:993057. https:\/\/doi.org\/10.3389\/fimmu.2023.993057.","journal-title":"Front Immunol"},{"key":"10131_CR80","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1182\/blood-2018-06-856500","volume":"133","author":"G Weiss","year":"2019","unstructured":"Weiss G, Ganz T, Goodnough LT. Anemia of inflammation. Blood. 2019;133:40\u201350. https:\/\/doi.org\/10.1182\/blood-2018-06-856500.","journal-title":"Blood"},{"key":"10131_CR81","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1084\/jem.20152002","volume":"213","author":"M Wohner","year":"2016","unstructured":"Wohner M, Tagoh H, Bilic I, Jaritz M, Poliakova DK, Fischer M, et al. Molecular functions of the transcription factors E2A and E2\u20132 in controlling germinal center B cell and plasma cell development. J Exp Med. 2016;213:1201\u201321. https:\/\/doi.org\/10.1084\/jem.20152002.","journal-title":"J Exp Med"},{"key":"10131_CR82","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1084\/jem.20011284","volume":"195","author":"DE Wright","year":"2002","unstructured":"Wright DE, Bowman EP, Wagers AJ, Butcher EC, Weissman IL. Hematopoietic stem cells are uniquely selective in their migratory response to chemokines. J Exp Med. 2002;195:1145\u201354. https:\/\/doi.org\/10.1084\/jem.20011284.","journal-title":"J Exp Med"},{"key":"10131_CR83","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2023.113453","volume":"515","author":"X Wu","year":"2023","unstructured":"Wu X, Clarke WR, Koplinski CA, Peterson FC, Dwinell MB, Wei G, et al. A modified ELISA assay differentiates CCL20 locked dimers from wild-type monomers. J Immunol Methods. 2023;515:113453. https:\/\/doi.org\/10.1016\/j.jim.2023.113453.","journal-title":"J Immunol Methods"},{"key":"10131_CR84","doi-asserted-by":"publisher","first-page":"8391","DOI":"10.4049\/jimmunol.181.12.8391","volume":"181","author":"T Yamazaki","year":"2008","unstructured":"Yamazaki T, Yang XO, Chung Y, Fukunaga A, Nurieva R, Pappu B, et al. CCR6 regulates the migration of inflammatory and regulatory T cells. J Immunol. 2008;181:8391\u2013401. https:\/\/doi.org\/10.4049\/jimmunol.181.12.8391.","journal-title":"J Immunol"},{"key":"10131_CR85","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY. ClusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16:284\u20137. https:\/\/doi.org\/10.1089\/omi.2011.0118.","journal-title":"OMICS"},{"key":"10131_CR86","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1006\/bbrc.1996.1595","volume":"227","author":"A Zaballos","year":"1996","unstructured":"Zaballos A, Varona R, Gutierrez J, Lind P, Marquez G. Molecular cloning and RNA expression of two new human chemokine receptor-like genes. Biochem Biophys Res Commun. 1996;227:846\u201353. https:\/\/doi.org\/10.1006\/bbrc.1996.1595.","journal-title":"Biochem Biophys Res Commun"},{"key":"10131_CR87","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.jpha.2023.05.009","volume":"13","author":"J Zeng","year":"2023","unstructured":"Zeng J, Li M, Zhao Q, Chen M, Zhao L, Wei S, et al. Small molecule inhibitors of RORgammat for Th17 regulation in inflammatory and autoimmune diseases. J Pharm Anal. 2023;13:545\u201362. https:\/\/doi.org\/10.1016\/j.jpha.2023.05.009.","journal-title":"J Pharm Anal"},{"key":"10131_CR88","doi-asserted-by":"publisher","first-page":"1479505","DOI":"10.3389\/fimmu.2024.1479505","volume":"15","author":"X Zhang","year":"2024","unstructured":"Zhang X, Li B, Lan T, Chiari C, Ye X, Wang K, et al. The role of interleukin-17 in inflammation-related cancers. Front Immunol. 2024;15:1479505. https:\/\/doi.org\/10.3389\/fimmu.2024.1479505.","journal-title":"Front Immunol"},{"key":"10131_CR89","doi-asserted-by":"publisher","unstructured":"Zheng GX, Terry JM, Belgrader P, Ryvkin P, Bent ZW, Wilson R, et al. Massively parallel digital transcriptional profiling of single cells. Nat Commun. 2017;8:14049. https:\/\/doi.org\/10.1038\/ncomms14049.","DOI":"10.1038\/ncomms14049"}],"container-title":["Cell Biology and Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10565-025-10131-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10565-025-10131-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10565-025-10131-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:14:15Z","timestamp":1768342455000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10565-025-10131-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":89,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["10131"],"URL":"https:\/\/doi.org\/10.1007\/s10565-025-10131-6","relation":{},"ISSN":["1573-6822"],"issn-type":[{"value":"1573-6822","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,19]]},"assertion":[{"value":"6 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Preclinical experimental procedures involving animals were conducted in accordance with the NIH Guide for the Care and Use of Laboratory Animals and were formally reviewed and approved by the Medical College of Wisconsin Institutional Animal Care and Use Committee (IACUC) (approval No. AUA000076).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The studies completed solely utilize preclinical approaches.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement and patient consent"}},{"value":"MBD, BFV, FCP, STH, WFC have financial interests in Protein Foundry, LLC and XLock Biosciences, Inc which produced CCL20LD. The remaining authors have no conflicts to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14"}}