{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:53:18Z","timestamp":1791377598522,"version":"4.3.2"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Natural Science Foundation of Sichuan Province, China","award":["2023YSF0083"],"award-info":[{"award-number":["2023YSF0083"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biol Toxicol"],"DOI":"10.1007\/s10565-026-10165-4","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T17:47:51Z","timestamp":1772214471000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lactate Dehydrogenase B delactylation promotes gastric cancer metastasis via enhancing glutathione-mediated resistance to ferroptosis"],"prefix":"10.1007","volume":"42","author":[{"given":"Xun","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunchao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"10165_CR1","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.ccell.2016.08.005","volume":"30","author":"L Brisson","year":"2016","unstructured":"Brisson L, Banski P, Sboarina M, Dethier C, Danhier P, Fontenille MJ, et al. Lactate dehydrogenase B controls lysosome activity and autophagy in cancer. Cancer Cell. 2016;30:418\u201331. https:\/\/doi.org\/10.1016\/j.ccell.2016.08.005.","journal-title":"Cancer Cell"},{"key":"10165_CR2","doi-asserted-by":"publisher","unstructured":"Cancer Genome Atlas Research N. Comprehensive molecular characterization of gastric adenocarcinoma. Nature. 2014;513:202\u20139. https:\/\/doi.org\/10.1038\/nature13480","DOI":"10.1038\/nature13480"},{"key":"10165_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14030258","author":"Z Chen","year":"2025","unstructured":"Chen Z, Fan J, Chen X, Yang K, Wang K. Oxidative stress and redox signaling in gastric cancer: from mechanisms to therapeutic implications. Antioxidants. 2025. https:\/\/doi.org\/10.3390\/antiox14030258.","journal-title":"Antioxidants"},{"key":"10165_CR4","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57906-3","volume":"16","author":"H Deng","year":"2025","unstructured":"Deng H, Zhao L, Ge H, Gao Y, Fu Y, Lin Y, et al. Ubiquinol-mediated suppression of mitochondria-associated ferroptosis is a targetable function of lactate dehydrogenase B in cancer. Nat Commun. 2025;16:2597. https:\/\/doi.org\/10.1038\/s41467-025-57906-3.","journal-title":"Nat Commun"},{"key":"10165_CR5","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-025-07272-x","volume":"23","author":"Z Dong","year":"2025","unstructured":"Dong Z, Yuan Z, Jin T, Gao C, Wang X, Xu F. Lactate at the crossroads of tumor metabolism and immune escape: a new frontier in cancer therapy. J Transl Med. 2025;23:1239. https:\/\/doi.org\/10.1186\/s12967-025-07272-x.","journal-title":"J Transl Med"},{"key":"10165_CR6","doi-asserted-by":"publisher","first-page":"7570","DOI":"10.7150\/thno.58380","volume":"11","author":"AC Frank","year":"2021","unstructured":"Frank AC, Raue R, Fuhrmann DC, Sirait-Fischer E, Reuse C, Weigert A, et al. Lactate dehydrogenase B regulates macrophage metabolism in the tumor microenvironment. Theranostics. 2021;11:7570\u201388. https:\/\/doi.org\/10.7150\/thno.58380.","journal-title":"Theranostics"},{"key":"10165_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217353","volume":"611","author":"H Ge","year":"2024","unstructured":"Ge H, Malsiu F, Gao Y, Losmanova T, Blank F, Ott J, et al. Inhibition of LDHB suppresses the metastatic potential of lung cancer by reducing mitochondrial GSH catabolism. Cancer Lett. 2024;611:217353. https:\/\/doi.org\/10.1016\/j.canlet.2024.217353.","journal-title":"Cancer Lett"},{"key":"10165_CR8","doi-asserted-by":"publisher","first-page":"100625","DOI":"10.1016\/j.xinn.2024.100625","volume":"5","author":"B Gyorffy","year":"2024","unstructured":"Gyorffy B. Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors. Innovation (Camb). 2024;5:100625. https:\/\/doi.org\/10.1016\/j.xinn.2024.100625.","journal-title":"Innovation (Camb)"},{"key":"10165_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.70070","volume":"14","author":"Y He","year":"2024","unstructured":"He Y, Song T, Ning J, Wang Z, Yin Z, Jiang P, et al. Lactylation in cancer: mechanisms in tumour biology and therapeutic potentials. Clin Transl Med. 2024;14:e70070. https:\/\/doi.org\/10.1002\/ctm2.70070.","journal-title":"Clin Transl Med"},{"key":"10165_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107228","volume":"205","author":"W Hong","year":"2024","unstructured":"Hong W, Zeng X, Wang H, Tan X, Tian Y, Hu H, et al. PGC-1\u03b1 loss promotes mitochondrial protein lactylation in acetaminophen-induced liver injury via the LDHB-lactate axis. Pharmacol Res. 2024;205:107228. https:\/\/doi.org\/10.1016\/j.phrs.2024.107228.","journal-title":"Pharmacol Res"},{"key":"10165_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.11.010","author":"XT Hu","year":"2024","unstructured":"Hu XT, Wu XF, Xu JY, Xu X. Lactate-mediated lactylation in human health and diseases: Progress and remaining challenges. J Adv Res. 2024b. https:\/\/doi.org\/10.1016\/j.jare.2024.11.010.","journal-title":"J Adv Res"},{"key":"10165_CR12","doi-asserted-by":"publisher","unstructured":"Hu X, Huang Z, Li L. LDHB Mediates Histone Lactylation to Activate PD-L1 and Promote Ovarian Cancer Immune Escape. Cancer Invest. 2024a:1-10https:\/\/doi.org\/10.1080\/07357907.2024.2430283","DOI":"10.1080\/07357907.2024.2430283"},{"key":"10165_CR13","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1056\/NEJMoa2405195","volume":"391","author":"T Leong","year":"2024","unstructured":"Leong T, Smithers BM, Michael M, Haustermans K, Wong R, Gebski V, et al. Preoperative chemoradiotherapy for resectable gastric cancer. N Engl J Med. 2024;391:1810\u201321. https:\/\/doi.org\/10.1056\/NEJMoa2405195.","journal-title":"N Engl J Med"},{"key":"10165_CR14","doi-asserted-by":"publisher","first-page":"2863","DOI":"10.1007\/s11010-023-04886-x","volume":"479","author":"Y Li","year":"2024","unstructured":"Li Y, Liu J, Wu S, Xiao J, Zhang Z. Ferroptosis: opening up potential targets for gastric cancer treatment. Mol Cell Biochem. 2024;479:2863\u201374. https:\/\/doi.org\/10.1007\/s11010-023-04886-x.","journal-title":"Mol Cell Biochem"},{"key":"10165_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2019.105610","volume":"116","author":"XM Lin","year":"2019","unstructured":"Lin XM, Li S, Zhou C, Li RZ, Wang H, Luo W, et al. Cisplatin induces chemoresistance through the PTGS2-mediated anti-apoptosis in gastric cancer. Int J Biochem Cell Biol. 2019;116:105610. https:\/\/doi.org\/10.1016\/j.biocel.2019.105610.","journal-title":"Int J Biochem Cell Biol"},{"key":"10165_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25354-4","volume":"12","author":"W Liu","year":"2021","unstructured":"Liu W, Chakraborty B, Safi R, Kazmin D, Chang CY, McDonnell DP. Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer. Nat Commun. 2021;12:5103. https:\/\/doi.org\/10.1038\/s41467-021-25354-4.","journal-title":"Nat Commun"},{"key":"10165_CR17","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.tcb.2023.07.009","volume":"34","author":"X Liu","year":"2024","unstructured":"Liu X, Zhuang L, Gan B. Disulfidptosis: disulfide stress-induced cell death. Trends Cell Biol. 2024;34:327\u201337. https:\/\/doi.org\/10.1016\/j.tcb.2023.07.009.","journal-title":"Trends Cell Biol"},{"key":"10165_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-025-00622-x","volume":"14","author":"M Lv","year":"2025","unstructured":"Lv M, Huang Y, Chen Y, Ding K. Lactylation modification in cancer: mechanisms, functions, and therapeutic strategies. Exp Hematol Oncol. 2025;14:32. https:\/\/doi.org\/10.1186\/s40164-025-00622-x.","journal-title":"Exp Hematol Oncol"},{"key":"10165_CR19","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1038\/s41401-024-01264-1","volume":"45","author":"X Ni","year":"2024","unstructured":"Ni X, Lu CP, Xu GQ, Ma JJ. Transcriptional regulation and post-translational modifications in the glycolytic pathway for targeted cancer therapy. Acta Pharmacol Sin. 2024;45:1533\u201355. https:\/\/doi.org\/10.1038\/s41401-024-01264-1.","journal-title":"Acta Pharmacol Sin"},{"key":"10165_CR20","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.semcancer.2022.07.004","volume":"86","author":"J Pouyssegur","year":"2022","unstructured":"Pouyssegur J, Marchiq I, Parks SK, Durivault J, Zdralevic M, Vucetic M. Warburg effect\u2019 controls tumor growth, bacterial, viral infections and immunity - genetic deconstruction and therapeutic perspectives. Semin Cancer Biol. 2022;86:334\u201346. https:\/\/doi.org\/10.1016\/j.semcancer.2022.07.004.","journal-title":"Semin Cancer Biol"},{"key":"10165_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2023.194990","volume":"1866","author":"AH Shukri","year":"2023","unstructured":"Shukri AH, Lukinovic V, Charih F, Biggar KK. Unraveling the battle for lysine: a review of the competition among post-translational modifications. Biochim Biophys Acta Gene Regul Mech. 2023;1866:194990. https:\/\/doi.org\/10.1016\/j.bbagrm.2023.194990.","journal-title":"Biochim Biophys Acta Gene Regul Mech"},{"key":"10165_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-025-02349-4","volume":"11","author":"Y Sui","year":"2025","unstructured":"Sui Y, Shen Z, Wang Z, Feng J, Zhou G. Lactylation in cancer: metabolic mechanism and therapeutic strategies. Cell Death Discov. 2025;11:68. https:\/\/doi.org\/10.1038\/s41420-025-02349-4.","journal-title":"Cell Death Discov"},{"key":"10165_CR23","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1038\/s41556-025-01673-2","volume":"27","author":"J Wan","year":"2025","unstructured":"Wan J, Shi JH, Shi M, Huang H, Zhang Z, Li W, et al. Lactate dehydrogenase B facilitates disulfidptosis and exhaustion of tumour-infiltrating CD8(+) T cells. Nat Cell Biol. 2025;27:972\u201382. https:\/\/doi.org\/10.1038\/s41556-025-01673-2.","journal-title":"Nat Cell Biol"},{"key":"10165_CR24","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","volume":"569","author":"W Wang","year":"2019","unstructured":"Wang W, Green M, Choi JE, Gijon M, Kennedy PD, Johnson JK, et al. CD8(+) T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 2019;569:270\u20134. https:\/\/doi.org\/10.1038\/s41586-019-1170-y.","journal-title":"Nature"},{"key":"10165_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2019.108138","volume":"676","author":"Z Wu","year":"2019","unstructured":"Wu Z, Huang R, Yuan L. Crosstalk of intracellular post-translational modifications in cancer. Arch Biochem Biophys. 2019;676:108138. https:\/\/doi.org\/10.1016\/j.abb.2019.108138.","journal-title":"Arch Biochem Biophys"},{"key":"10165_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39901-8","volume":"14","author":"Z Yang","year":"2023","unstructured":"Yang Z, Zou S, Zhang Y, Zhang J, Zhang P, Xiao L, et al. ACTL6A protects gastric cancer cells against ferroptosis through induction of glutathione synthesis. Nat Commun. 2023;14:4193. https:\/\/doi.org\/10.1038\/s41467-023-39901-8.","journal-title":"Nat Commun"},{"key":"10165_CR27","doi-asserted-by":"publisher","first-page":"15947","DOI":"10.1074\/jbc.RA118.004180","volume":"293","author":"M Zdralevic","year":"2018","unstructured":"Zdralevic M, Brand A, Di Ianni L, Dettmer K, Reinders J, Singer K, et al. Double genetic disruption of lactate dehydrogenases A and B is required to ablate the \u201cWarburg effect\u201d restricting tumor growth to oxidative metabolism. J Biol Chem. 2018;293:15947\u201361. https:\/\/doi.org\/10.1074\/jbc.RA118.004180.","journal-title":"J Biol Chem"},{"key":"10165_CR28","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","volume":"574","author":"D Zhang","year":"2019","unstructured":"Zhang D, Tang Z, Huang H, Zhou G, Cui C, Weng Y, et al. Metabolic regulation of gene expression by histone lactylation. Nature. 2019;574:575\u201380. https:\/\/doi.org\/10.1038\/s41586-019-1678-1.","journal-title":"Nature"},{"key":"10165_CR29","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1038\/s41418-024-01427-x","volume":"32","author":"L Zhao","year":"2025","unstructured":"Zhao L, Deng H, Zhang J, Zamboni N, Yang H, Gao Y, et al. Lactate dehydrogenase B noncanonically promotes ferroptosis defense in KRAS-driven lung cancer. Cell Death Differ. 2025;32:632\u201345. https:\/\/doi.org\/10.1038\/s41418-024-01427-x.","journal-title":"Cell Death Differ"},{"key":"10165_CR30","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1002\/cac2.12487","volume":"43","author":"Y Zheng","year":"2023","unstructured":"Zheng Y, Sun L, Guo J, Ma J. The crosstalk between ferroptosis and anti-tumor immunity in the tumor microenvironment: molecular mechanisms and therapeutic controversy. Cancer Commun. 2023;43:1071\u201396. https:\/\/doi.org\/10.1002\/cac2.12487.","journal-title":"Cancer Commun"}],"container-title":["Cell Biology and Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10565-026-10165-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10565-026-10165-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10565-026-10165-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T10:36:15Z","timestamp":1773830175000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10565-026-10165-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,27]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["10165"],"URL":"https:\/\/doi.org\/10.1007\/s10565-026-10165-4","relation":{},"ISSN":["1573-6822"],"issn-type":[{"value":"1573-6822","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,27]]},"assertion":[{"value":"15 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval was obtained from the Ethics Committee of Sichuan Provincial People\u2019s Hospital (approval number: 2025478).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}],"article-number":"46"}}