{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T12:18:28Z","timestamp":1778156308288,"version":"3.51.4"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":41,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20221526"],"award-info":[{"award-number":["BK20221526"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274200"],"award-info":[{"award-number":["82274200"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"\"Double First-Class\" University project","award":["CPU2018GY33"],"award-info":[{"award-number":["CPU2018GY33"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biol Toxicol"],"DOI":"10.1007\/s10565-026-10176-1","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T20:45:48Z","timestamp":1774644348000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unveiling a novel macrophage-driven mechanism for obeticholic acid-induced liver injury in cholestatic: targeting NLRP12Arg185 fuels Relb-TNFSF14-mediated ductular reaction"],"prefix":"10.1007","volume":"42","author":[{"given":"Jie","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoran","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianhui","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anqin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinwei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luyong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhou","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"issue":"5","key":"10176_CR1","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.jhep.2019.06.011","volume":"71","author":"S Al-Dury","year":"2019","unstructured":"Al-Dury S, Wahlstr\u00f6m A, Panzitt K, Thorell A, St\u00e5hlman M, Trauner M, et al. Obeticholic acid may increase the risk of gallstone formation in susceptible patients. J Hepatol. 2019;71(5):986\u201391.","journal-title":"J Hepatol"},{"issue":"7","key":"10176_CR2","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1111\/liv.14490","volume":"40","author":"P An","year":"2020","unstructured":"An P, Wei G, Huang P, Li W, Qi X, Lin Y, et al. A novel non\u2010bile acid FXR agonist EDP\u2010305 potently suppresses liver injury and fibrosis without worsening of ductular reaction. Liver Int. 2020;40(7):1655\u201369.","journal-title":"Liver Int"},{"issue":"5","key":"10176_CR3","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/s41575-019-0125-y","volume":"16","author":"JM Banales","year":"2019","unstructured":"Banales JM, Huebert RC, Karlsen T, Strazzabosco M, LaRusso NF, Gores GJ. Cholangiocyte pathobiology. Nat Rev Gastroenterol Hepatol. 2019;16(5):269\u201381.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"16","key":"10176_CR4","doi-asserted-by":"publisher","first-page":"6542","DOI":"10.1073\/pnas.1302168110","volume":"110","author":"TG Bird","year":"2013","unstructured":"Bird TG, Lu W-Y, Boulter L, Gordon-Keylock S, Ridgway RA, Williams MJ, et al. Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling. Proc Natl Acad Sci. 2013Apr 16;110(16):6542\u20137.","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"10176_CR5","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.jhep.2021.02.011","volume":"75","author":"JL Boyer","year":"2021","unstructured":"Boyer JL, Soroka CJ. Bile formation and secretion: an update. J Hepatol. 2021;75(1):190\u2013201.","journal-title":"J Hepatol"},{"issue":"1","key":"10176_CR6","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/s41392-020-0186-y","volume":"5","author":"X Chen","year":"2020","unstructured":"Chen X, Wang Y, Ma N, Tian J, Shao Y, Zhu B, et al. Target identification of natural medicine with chemical proteomics approach: probe synthesis, target fishing and protein identification. Signal Transduct Target Ther. 2020May 21;5(1):72.","journal-title":"Signal Transduct Target Ther"},{"issue":"5","key":"10176_CR7","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.molmed.2016.03.002","volume":"22","author":"G Cildir","year":"2016","unstructured":"Cildir G, Low KC, Tergaonkar V. Noncanonical NF-\u03baB signaling in health and disease. Trends Mol Med. 2016;22(5):414\u201329.","journal-title":"Trends Mol Med"},{"issue":"10","key":"10176_CR8","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1038\/ni842","volume":"3","author":"E Claudio","year":"2002","unstructured":"Claudio E, Brown K, Park S, Wang H, Siebenlist U. BAFF-induced NEMO-independent processing of NF-\u03baB2 in maturing B cells. Nat Immunol. 2002;3(10):958\u201365.","journal-title":"Nat Immunol"},{"issue":"20","key":"10176_CR9","doi-asserted-by":"publisher","first-page":"5375","DOI":"10.1093\/emboj\/cdf542","volume":"21","author":"HJ Coope","year":"2002","unstructured":"Coope HJ. CD40 regulates the processing of NF-kappaB2 p100 to p52. EMBO J. 2002Oct 15;21(20):5375\u201385.","journal-title":"EMBO J"},{"key":"10176_CR10","doi-asserted-by":"crossref","unstructured":"Cravatt BF, Wright AT, Kozarich JW. Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry. 2008.","DOI":"10.1146\/annurev.biochem.75.101304.124125"},{"issue":"3","key":"10176_CR11","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1002\/mc.22938","volume":"58","author":"R Das","year":"2019","unstructured":"Das R, Coupar J, Clavijo PE, Saleh A, Cheng T-F, Yang X, et al. Lymphotoxin-\u03b2 receptor-NIK signaling induces alternative RELB\/NF-\u03baB2 activation to promote metastatic gene expression and cell migration in head and neck cancer. Mol Carcinog. 2019;58(3):411\u201325.","journal-title":"Mol Carcinog"},{"issue":"1","key":"10176_CR12","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1172\/JCI200522675","volume":"115","author":"JS Duffield","year":"2005","unstructured":"Duffield JS, Forbes SJ, Constandinou CM, Clay S, Partolina M, Vuthoori S, et al. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest. 2005Jan 3;115(1):56\u201365.","journal-title":"J Clin Invest"},{"issue":"4","key":"10176_CR13","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1053\/j.gastro.2018.11.018","volume":"156","author":"C El\u00dfner","year":"2019","unstructured":"El\u00dfner C, Goeppert B, Longerich T, Scherr A-L, Stindt J, Nanduri LK, et al. Nuclear translocation of RELB is increased in diseased human liver and promotes ductular reaction and biliary fibrosis in mice. Gastroenterology. 2019;156(4):1190-1205.e14.","journal-title":"Gastroenterology"},{"key":"10176_CR14","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26937","author":"VL Gadd","year":"2014","unstructured":"Gadd VL, Skoien R, Powell EE, Fagan KJ, Winterford C, Horsfall L, et al. The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease. Hepatology. 2014. https:\/\/doi.org\/10.1002\/hep.26937.","journal-title":"Hepatology"},{"issue":"5","key":"10176_CR15","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1002\/hep.24613","volume":"54","author":"ASH Gouw","year":"2011","unstructured":"Gouw ASH, Clouston AD, Theise ND. Ductular reactions in human liver: diversity at the interface. Hepatology. 2011;54(5):1853\u201363.","journal-title":"Hepatology"},{"issue":"3","key":"10176_CR16","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.jhep.2018.05.018","volume":"69","author":"ME Guicciardi","year":"2018","unstructured":"Guicciardi ME, Trussoni CE, Krishnan A, Bronk SF, Lorenzo Pisarello MJ, O\u2019Hara SP, et al. Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice. J Hepatol. 2018;69(3):676\u201386.","journal-title":"J Hepatol"},{"issue":"6","key":"10176_CR17","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1002\/hep4.1356","volume":"3","author":"A Guillot","year":"2019","unstructured":"Guillot A, Tacke F. Liver macrophages: old dogmas and new insights. Hepatol Commun. 2019;3(6):730\u201343.","journal-title":"Hepatol Commun"},{"issue":"9","key":"10176_CR18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI132305","volume":"131","author":"A Guillot","year":"2021","unstructured":"Guillot A, Guerri L, Feng D, Kim S-J, Ahmed YA, Paloczi J, et al. Bile acid\u2013activated macrophages promote biliary epithelial cell proliferation through integrin \u03b1v\u03b26 upregulation following liver injury. J Clin Invest. 2021May 3;131(9):e132305.","journal-title":"J Clin Invest"},{"issue":"3","key":"10176_CR19","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","volume":"132","author":"MS Hayden","year":"2008","unstructured":"Hayden MS, Ghosh S. Shared principles in NF-\u03baB signaling. Cell. 2008;132(3):344\u201362.","journal-title":"Cell"},{"issue":"9","key":"10176_CR20","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1038\/nprot.2014.138","volume":"9","author":"R Jafari","year":"2014","unstructured":"Jafari R, Almqvist H, Axelsson H, Ignatushchenko M, Lundb\u00e4ck T, Nordlund P, et al. The cellular thermal shift assay for evaluating drug target interactions in cells. Nat Protoc. 2014;9(9):2100\u201322.","journal-title":"Nat Protoc"},{"key":"10176_CR21","doi-asserted-by":"publisher","unstructured":"Jalan-Sakrikar N, Guicciardi ME, O\u2019Hara SP, Azad A, LaRusso NF, Gores GJ, et al. Central role for cholangiocyte pathobiology in cholestatic liver diseases. Hepatology. 2024\u00a0 9 [cited 2025 Feb 7]; Available from:https:\/\/doi.org\/10.1097\/HEP.0000000000001093","DOI":"10.1097\/HEP.0000000000001093"},{"issue":"46","key":"10176_CR22","doi-asserted-by":"publisher","first-page":"25283","DOI":"10.1021\/jacs.3c08852","volume":"145","author":"L Jiang","year":"2023","unstructured":"Jiang L, Liu S, Jia X, Gong Q, Wen X, Lu W, et al. ABPP-CoDEL: Activity-Based Proteome Profiling-Guided Discovery of Tyrosine-Targeting Covalent Inhibitors from DNA-Encoded Libraries. J Am Chem Soc. 2023Nov 22;145(46):25283\u201392.","journal-title":"J Am Chem Soc"},{"issue":"10","key":"10176_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113164","volume":"42","author":"W Li","year":"2023","unstructured":"Li W, Yang Y, Yang L, Chang N, Li L. Monocyte-derived kupffer cells dominate in the kupffer cell pool during liver injury. Cell Rep. 2023;42(10):113164.","journal-title":"Cell Rep"},{"issue":"22","key":"10176_CR24","doi-asserted-by":"publisher","first-page":"15155","DOI":"10.1021\/jacs.4c01335","volume":"146","author":"T Li","year":"2024","unstructured":"Li T, Wang A, Zhang Y, Chen W, Guo Y, Yuan X, et al. Chemoproteomic Profiling of Signaling Metabolite Fructose-1,6-Bisphosphate Interacting Proteins in Living Cells. J Am Chem Soc. 2024June 5;146(22):15155\u201366.","journal-title":"J Am Chem Soc"},{"issue":"3","key":"10176_CR25","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.4049\/jimmunol.178.3.1256","volume":"178","author":"JD Lich","year":"2007","unstructured":"Lich JD, Williams KL, Moore CB, Arthur JC, Davis BK, Taxman DJ, et al. Cutting Edge: Monarch-1 Suppresses Non-Canonical NF-\u03baB Activation and p52-Dependent Chemokine Expression in Monocytes. J Immunol. 2007Feb 1;178(3):1256\u201360.","journal-title":"J Immunol"},{"issue":"16","key":"10176_CR26","doi-asserted-by":"publisher","first-page":"3611","DOI":"10.1111\/bph.15178","volume":"177","author":"E Lilley","year":"2020","unstructured":"Lilley E, Stanford SC, Kendall DE, Alexander SPH, Cirino G, Docherty JR, et al. ARRIVE 2.0 and the British journal of pharmacology: updated guidance for 2020. Br J Pharmacol. 2020;177(16):3611\u20136.","journal-title":"Br J Pharmacol"},{"issue":"5","key":"10176_CR27","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1136\/gut.2009.182345","volume":"59","author":"S Lorenzini","year":"2010","unstructured":"Lorenzini S, Bird TG, Boulter L, Bellamy C, Samuel K, Aucott R, et al. Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver. Gut. 2010May 1;59(5):645\u201354.","journal-title":"Gut"},{"issue":"2","key":"10176_CR28","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nrgastro.2010.213","volume":"8","author":"T Luedde","year":"2011","unstructured":"Luedde T, Schwabe RF. NF-\u03baB in the liver\u2014linking injury, fibrosis and hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol. 2011;8(2):108\u201318.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10176_CR29","doi-asserted-by":"crossref","unstructured":"Novack DV, Yin L, Hagen-Stapleton A, Schreiber RD, Goeddel DV, Ross FP, et al. The I\u03baB Function of NF-\u03baB2 p100 Controls Stimulated Osteoclastogenesis. J. Exp. Med. 2003 1;198(5):771\u201381.","DOI":"10.1084\/jem.20030116"},{"issue":"16","key":"10176_CR30","doi-asserted-by":"publisher","first-page":"3617","DOI":"10.1111\/bph.15193","volume":"177","author":"N Percie Du Sert","year":"2020","unstructured":"Percie Du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, et al. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. Br J Pharmacol. 2020;177(16):3617\u201324.","journal-title":"Br J Pharmacol"},{"issue":"3","key":"10176_CR31","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1002\/hep.28932","volume":"65","author":"S Samur","year":"2017","unstructured":"Samur S, Klebanoff M, Banken R, Pratt DS, Chapman R, Ollendorf DA, et al. Long\u2010term clinical impact and cost\u2010effectiveness of obeticholic acid for the treatment of primary biliary cholangitis. Hepatology. 2017;65(3):920\u20138.","journal-title":"Hepatology"},{"issue":"1","key":"10176_CR32","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1002\/hep.30150","volume":"69","author":"K Sato","year":"2019","unstructured":"Sato K, Marzioni M, Meng F, Francis H, Glaser S, Alpini G. Ductular reaction in liver diseases: pathological mechanisms and translational significances: liver injury and regeneration. Hepatology. 2019;69(1):420\u201330.","journal-title":"Hepatology"},{"issue":"8","key":"10176_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2015.33","volume":"6","author":"SN Sclair","year":"2015","unstructured":"Sclair SN, Little E, Levy C. Current concepts in primary biliary cirrhosis and primary sclerosing cholangitis. Clin Transl Gastroenterol. 2015;6(8):e109.","journal-title":"Clin Transl Gastroenterol"},{"key":"10176_CR34","doi-asserted-by":"crossref","unstructured":"Seglen PO. Chapter 4 Preparation of Isolated Rat Liver Cells. Methods Cell Biol. Elsevier; 1976 [cited 2024 Sept 18]. p. 29\u201383. Available from: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091679X08617975","DOI":"10.1016\/S0091-679X(08)61797-5"},{"key":"10176_CR35","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000026","author":"C Short","year":"2023","unstructured":"Short C, Zhong A, Xu J, Mahdi E, Glazier A, Malkoff N, et al. TWEAK\/FN14 promotes profibrogenic pathway activation in Prominin-1-expressing hepatic progenitor cells in biliary atresia. Hepatology. 2023. https:\/\/doi.org\/10.1097\/HEP.0000000000000026.","journal-title":"Hepatology"},{"issue":"1","key":"10176_CR36","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/j.1600-065X.2011.01088.x","volume":"246","author":"S-C Sun","year":"2012","unstructured":"Sun S-C. The noncanonical NF-\u03baB pathway: the noncanonical NF-\u03baB signaling pathway. Immunol Rev. 2012;246(1):125\u201340.","journal-title":"Immunol Rev"},{"issue":"9","key":"10176_CR37","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/nri.2017.52","volume":"17","author":"S-C Sun","year":"2017","unstructured":"Sun S-C. The non-canonical NF-\u03baB pathway in immunity and inflammation. Nat Rev Immunol. 2017;17(9):545\u201358.","journal-title":"Nat Rev Immunol"},{"key":"10176_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2020.100887","volume":"76","author":"S Tuladhar","year":"2020","unstructured":"Tuladhar S, Kanneganti T-D. Nlrp12 in innate immunity and inflammation. Mol Aspects Med. 2020;76:100887.","journal-title":"Mol Aspects Med"},{"issue":"9","key":"10176_CR39","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00353","volume":"9","author":"S Wang","year":"2018","unstructured":"Wang S, Tian Y, Wang M, Wang M, Sun G, Sun X. Advanced activity-based protein profiling application strategies for drug development. Front Pharmacol. 2018;9(9):353.","journal-title":"Front Pharmacol"},{"key":"10176_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120882","volume":"307","author":"J Wang","year":"2022","unstructured":"Wang J, Yuan Z, Zhang H, Wu Q, Miao Y, Xu Y, et al. Obeticholic acid aggravates liver injury by up-regulating the liver expression of osteopontin in obstructive cholestasis. Life Sci. 2022;307:120882.","journal-title":"Life Sci"},{"key":"10176_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2025.111752","volume":"421","author":"J Wang","year":"2025","unstructured":"Wang J, Tang Q, Yuan Z, Zhang H, Miao Y, Chen Q, et al. Obeticholic acid exacerbates liver injury through hepatocyte-mediated release of HMGB1 by inducing lysosomal membrane permeabilization in cholestasis. Chem Biol Interact. 2025;421:111752.","journal-title":"Chem Biol Interact"},{"issue":"1","key":"10176_CR42","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1111\/j.1600-065X.2008.00629.x","volume":"223","author":"CF Ware","year":"2008","unstructured":"Ware CF. Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways. Immunol Rev. 2008;223(1):186\u2013201.","journal-title":"Immunol Rev"},{"key":"10176_CR43","doi-asserted-by":"crossref","unstructured":"Yoo K-S, Lim WT, Choi HS. Biology of Cholangiocytes: From Bench to Bedside. Gut Liver. 2016 15;10(5):687\u201398.","DOI":"10.5009\/gnl16033"},{"issue":"1","key":"10176_CR44","doi-asserted-by":"publisher","first-page":"5111","DOI":"10.1038\/s41467-022-32575-8","volume":"13","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, Zhong X, Shen H, Sheng L, Liangpunsakul S, Lok AS, et al. Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice. Nat Commun. 2022Aug 30;13(1):5111.","journal-title":"Nat Commun"}],"container-title":["Cell Biology and Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10565-026-10176-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10565-026-10176-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10565-026-10176-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T12:04:10Z","timestamp":1778155450000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10565-026-10176-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,27]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["10176"],"URL":"https:\/\/doi.org\/10.1007\/s10565-026-10176-1","relation":{},"ISSN":["1573-6822"],"issn-type":[{"value":"1573-6822","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,27]]},"assertion":[{"value":"7 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal procedures were performed as approved by the Animal Ethics Committee of China Pharmaceutical University (Approval number: 2019\u201307-002) and in accordance with the ARRIVE guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interests"}}],"article-number":"57"}}