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All original studies included in this analysis had obtained approval from their respective ethical review boards, ensuring compliance with ethical research standards. Furthermore, all participants in the original studies provided informed consent. Since this study did not involve the use of individual-level data and relied solely on aggregated, de-identified datasets, no additional ethical review board approval was required for this research.The animal experiments were ethically approved by the Institutional Review Board of Hubei Minzu University.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"93"}}