{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:56:20Z","timestamp":1791244580015,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":88,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biol Toxicol"],"DOI":"10.1007\/s10565-026-10225-9","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T21:52:41Z","timestamp":1783720361000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lactylation-driven stabilization of the S100A11\/ANXA2 complex promotes pancreatic cancer metastasis"],"prefix":"10.1007","volume":"42","author":[{"given":"Bo","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"10225_CR1","doi-asserted-by":"publisher","first-page":"968164","DOI":"10.3389\/fcell.2022.968164","volume":"10","author":"APK Ashraf","year":"2022","unstructured":"Ashraf APK, Gerke V. The resealing factor S100A11 interacts with annexins and extended synaptotagmin-1 in the course of plasma membrane wound repair. Front Cell Dev Biol. 2022;10:968164.","journal-title":"Front Cell Dev Biol"},{"issue":"19","key":"10225_CR2","doi-asserted-by":"publisher","first-page":"5031","DOI":"10.1016\/j.cell.2021.08.023","volume":"184","author":"L Cao","year":"2021","unstructured":"Cao L, Huang C, Cui Zhou D, Hu Y, Lih TM, Savage SR, et al. Proteogenomic characterization of pancreatic ductal adenocarcinoma. Cell. 2021;184(19):5031-52 e26.","journal-title":"Cell"},{"issue":"7","key":"10225_CR3","doi-asserted-by":"publisher","first-page":"101246","DOI":"10.1016\/j.jpha.2025.101246","volume":"15","author":"L Chen","year":"2025","unstructured":"Chen L, Wang M, Gao Y, Lv Y, Zhai L, Dong J, et al. E3 ubiquitin ligase FBXW11-mediated downregulation of S100A11 promotes sensitivity to PARP inhibitor in ovarian cancer. J Pharm Anal. 2025;15(7):101246.","journal-title":"J Pharm Anal"},{"key":"10225_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16223764","author":"K Christofidis","year":"2024","unstructured":"Christofidis K, Pergaris A, Fioretzaki R, Charalampakis N, Kapetanakis E, Kavantzas N, et al. Annexin A2 in tumors of the gastrointestinal tract, liver, and pancreas. Cancers (Basel). 2024. https:\/\/doi.org\/10.3390\/cancers16223764.","journal-title":"Cancers (Basel)"},{"issue":"35","key":"10225_CR5","doi-asserted-by":"publisher","first-page":"e2400227","DOI":"10.1002\/advs.202400227","volume":"11","author":"Y Duan","year":"2024","unstructured":"Duan Y, Zhan H, Wang Q, Li B, Gao H, Liu D, et al. Integrated lactylome characterization reveals the molecular dynamics of protein regulation in gastrointestinal cancers. Adv Sci (Weinh). 2024;11(35):e2400227.","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"10225_CR6","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s00018-023-05049-3","volume":"81","author":"C Gounou","year":"2023","unstructured":"Gounou C, Rouyer L, Siegfried G, Harte E, Bouvet F, d\u2019Agata L, et al. Inhibition of the membrane repair protein annexin-A2 prevents tumor invasion and metastasis. Cell Mol Life Sci. 2023;81(1):7.","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"10225_CR7","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s13148-024-01682-2","volume":"16","author":"Y Hu","year":"2024","unstructured":"Hu Y, He Z, Li Z, Wang Y, Wu N, Sun H, et al. Lactylation: the novel histone modification influence on gene expression, protein function, and disease. Clin Epigenetics. 2024;16(1):72.","journal-title":"Clin Epigenetics"},{"issue":"1","key":"10225_CR8","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/s41419-025-07724-8","volume":"16","author":"Y Huang","year":"2025","unstructured":"Huang Y, Tang X, Xie H, Wu Z, Jin L, Zhang L, et al. USP14\/S100A11 axis promote colorectal cancer progression by inhibiting cell senescence. Cell Death Dis. 2025;16(1):384.","journal-title":"Cell Death Dis"},{"key":"10225_CR9","doi-asserted-by":"publisher","first-page":"3795","DOI":"10.1038\/ncomms4795","volume":"5","author":"JK Jaiswal","year":"2014","unstructured":"Jaiswal JK, Lauritzen SP, Scheffer L, Sakaguchi M, Bunkenborg J, Simon SM, et al. S100A11 is required for efficient plasma membrane repair and survival of invasive cancer cells. Nat Commun. 2014;5:3795.","journal-title":"Nat Commun"},{"issue":"6","key":"10225_CR10","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1016\/j.bbamcr.2016.12.007","volume":"1864","author":"SN Koerdt","year":"2017","unstructured":"Koerdt SN, Gerke V. Annexin A2 is involved in Ca(2+)-dependent plasma membrane repair in primary human endothelial cells. Biochimica Et Biophysica Acta (BBA) Mol Cell Res. 2017;1864(6):1046\u201353.","journal-title":"Biochimica Et Biophysica Acta (BBA) Mol Cell Res"},{"key":"10225_CR11","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.semcdb.2015.10.028","volume":"45","author":"SP Lauritzen","year":"2015","unstructured":"Lauritzen SP, Boye TL, Nylandsted J. Annexins are instrumental for efficient plasma membrane repair in cancer cells. Semin Cell Dev Biol. 2015;45:32\u20138.","journal-title":"Semin Cell Dev Biol"},{"issue":"7","key":"10225_CR12","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1111\/bph.12978","volume":"172","author":"Y Liu","year":"2015","unstructured":"Liu Y, Myrvang HK, Dekker LV. Annexin A2 complexes with S100 proteins: structure, function and pharmacological manipulation. Br J Pharmacol. 2015;172(7):1664\u201376.","journal-title":"Br J Pharmacol"},{"issue":"1","key":"10225_CR13","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/s41467-023-36128-5","volume":"14","author":"J Liu","year":"2023","unstructured":"Liu J, van der Hoeven R, Kattan WE, Chang JT, Montufar-Solis D, Chen W, et al. Glycolysis regulates KRAS plasma membrane localization and function through defined glycosphingolipids. Nat Commun. 2023;14(1):465.","journal-title":"Nat Commun"},{"issue":"1","key":"10225_CR14","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s13062-024-00519-5","volume":"19","author":"XM Liu","year":"2024","unstructured":"Liu XM, Wang ZH, Wei QX, Song Y, Ma XX. Equol exerts anti-tumor effects on choriocarcinoma cells by promoting TRIM21-mediated ubiquitination of ANXA2. Biol Direct. 2024;19(1):78.","journal-title":"Biol Direct"},{"issue":"34","key":"10225_CR15","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1038\/s41388-025-03483-0","volume":"44","author":"H Liu","year":"2025","unstructured":"Liu H, Zhao Z, Wu C, Chen J, He Z, Jiang K. ZMYND8 promotes the Warburg effect and tumorigenesis through c-Myc activation in pancreatic cancer. Oncogene. 2025;44(34):3083\u201395.","journal-title":"Oncogene"},{"key":"10225_CR16","doi-asserted-by":"publisher","first-page":"115504","DOI":"10.1016\/j.intimp.2025.115504","volume":"165","author":"M Liu","year":"2025","unstructured":"Liu M, Wang G, Gao J, Peng M, Feng H, Liang X, et al. Targeting annexin A2 enhances anti-PD-1 immunotherapy in pancreatic ductal adenocarcinoma by remodeling the tumor immune microenvironment. Int Immunopharmacol. 2025;165:115504.","journal-title":"Int Immunopharmacol"},{"issue":"9","key":"10225_CR17","doi-asserted-by":"publisher","first-page":"3870","DOI":"10.1038\/s44319-024-00195-6","volume":"25","author":"MI Prislusky","year":"2024","unstructured":"Prislusky MI, Lam JGT, Contreras VR, Ng M, Chamberlain M, Pathak-Sharma S, et al. The septin cytoskeleton is required for plasma membrane repair. EMBO Rep. 2024;25(9):3870\u201395.","journal-title":"EMBO Rep"},{"key":"10225_CR18","doi-asserted-by":"publisher","first-page":"e31","DOI":"10.1017\/erm.2025.10019","volume":"27","author":"H Raeisi","year":"2025","unstructured":"Raeisi H, Rejali L, Fatemi N, Sadeghi A, Sadeghloo Z, Zali MR, et al. Role of S100 family proteins in colorectal cancer (CRC): an overview of their potential function as new biomarkers and therapeutic agents. Expert Rev Mol Med. 2025;27:e31.","journal-title":"Expert Rev Mol Med"},{"issue":"4","key":"10225_CR19","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/s42255-025-01259-0","volume":"7","author":"H Ren","year":"2025","unstructured":"Ren H, Tang Y, Zhang D. The emerging role of protein L-lactylation in metabolic regulation and cell signalling. Nat Metab. 2025;7(4):647\u201364.","journal-title":"Nat Metab"},{"issue":"49","key":"10225_CR20","doi-asserted-by":"publisher","first-page":"14695","DOI":"10.1021\/bi061754e","volume":"45","author":"AC Rintala-Dempsey","year":"2006","unstructured":"Rintala-Dempsey AC, Santamaria-Kisiel L, Liao Y, Lajoie G, Shaw GS. Insights into S100 target specificity examined by a new interaction between S100A11 and annexin A2. Biochemistry. 2006;45(49):14695\u2013705.","journal-title":"Biochemistry"},{"issue":"1","key":"10225_CR21","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41392-025-02499-y","volume":"11","author":"E Rozengurt","year":"2026","unstructured":"Rozengurt E, Eibl G. Pancreatic cancer: molecular pathogenesis and emerging therapeutic strategies. Signal Transduct Target Ther. 2026;11(1):6.","journal-title":"Signal Transduct Target Ther"},{"key":"10225_CR22","doi-asserted-by":"publisher","first-page":"101248","DOI":"10.1016\/j.drup.2025.101248","volume":"81","author":"Y Sun","year":"2025","unstructured":"Sun Y, Wang H, Cui Z, Yu T, Song Y, Gao H, et al. Lactylation in cancer progression and drug resistance. Drug Resist Updat. 2025;81:101248.","journal-title":"Drug Resist Updat"},{"issue":"10","key":"10225_CR23","doi-asserted-by":"publisher","first-page":"6907","DOI":"10.1111\/jcmm.14574","volume":"23","author":"Y Tu","year":"2019","unstructured":"Tu Y, Xie P, Du X, Fan L, Bao Z, Sun G, et al. S100A11 functions as novel oncogene in glioblastoma via S100A11\/ANXA2\/NF-kappaB positive feedback loop. J Cell Mol Med. 2019;23(10):6907\u201318.","journal-title":"J Cell Mol Med"},{"key":"10225_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-026-00472-x","author":"X Wang","year":"2026","unstructured":"Wang X, Liu C, Chen Y, Fang Y, Li J, Liu Y, et al. Lactate and lactylation: mechanisms, function, diseases, and therapeutic targets. Mol Biomed. 2026. https:\/\/doi.org\/10.1186\/s43556-026-00472-x.","journal-title":"Mol Biomed"},{"key":"10225_CR25","doi-asserted-by":"publisher","first-page":"123712","DOI":"10.1016\/j.biomaterials.2025.123712","volume":"327","author":"L Xue","year":"2026","unstructured":"Xue L, Zhang Q, Wang Y, Zhan W, Cui M, Peng N, et al. S100A11\/ANXA2 axis mediates electrotransduction to promote electrically-induced contraction in engineered myocardial tissues. Biomaterials. 2026;327:123712.","journal-title":"Biomaterials"},{"issue":"6","key":"10225_CR26","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1038\/s41419-022-05004-3","volume":"13","author":"X Zeng","year":"2022","unstructured":"Zeng X, Guo H, Liu Z, Qin Z, Cong Y, Ren N, et al. S100A11 activates the pentose phosphate pathway to induce malignant biological behaviour of pancreatic ductal adenocarcinoma. Cell Death Dis. 2022;13(6):568.","journal-title":"Cell Death Dis"},{"issue":"1","key":"10225_CR27","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1186\/s12967-025-06813-8","volume":"23","author":"D Zhang","year":"2025","unstructured":"Zhang D, Liang C, Wu C, Hawanga M, Wan S, Xu L, et al. Nonhistone lactylation: a hub for tumour metabolic reprogramming and epigenetic regulation. J Transl Med. 2025;23(1):901.","journal-title":"J Transl Med"},{"issue":"7","key":"10225_CR28","first-page":"100914","volume":"6","author":"S Zhang","year":"2025","unstructured":"Zhang S, Xie B, Zhu X, Dong S, Li M. Lactylation in cancer: unveiling new layers of complexity. Innovation. 2025;6(7):100914.","journal-title":"Innovation"},{"key":"10225_CR29","doi-asserted-by":"publisher","first-page":"105034","DOI":"10.1016\/j.critrevonc.2025.105034","volume":"217","author":"C Zhang","year":"2026","unstructured":"Zhang C, Meng Q, Jiao H, Liu H, Wang X, Zhou H, et al. Lactylation in cancer: metabolic-epigenetic nexus and therapeutic frontiers. Crit Rev Oncol Hematol. 2026;217:105034.","journal-title":"Crit Rev Oncol Hematol"},{"issue":"6","key":"10225_CR30","doi-asserted-by":"publisher","first-page":"3006","DOI":"10.1111\/jcmm.16343","volume":"25","author":"H Zhuang","year":"2021","unstructured":"Zhuang H, Chen X, Dong F, Zhang Z, Zhou Z, Ma Z, et al. Prognostic values and immune suppression of the S100A family in pancreatic cancer. J Cell Mol Med. 2021;25(6):3006\u201318.","journal-title":"J Cell Mol Med"}],"container-title":["Cell Biology and Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10565-026-10225-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10565-026-10225-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10565-026-10225-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:25:50Z","timestamp":1791242750000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10565-026-10225-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,10]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["10225"],"URL":"https:\/\/doi.org\/10.1007\/s10565-026-10225-9","relation":{},"ISSN":["1573-6822"],"issn-type":[{"value":"1573-6822","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,10]]},"assertion":[{"value":"30 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal experiments were approved by the Basic and Clinical Research Ethics Committee of Sichuan Provincial People\u2019s Hospital (approval no. 2026336) and performed in accordance with relevant guidelines.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Conflict of interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"114"}}